Drosophila in cancer research: the first fifty tumor suppressor genes

Basic local alignment search tool

1990 • 87,358 citations

Improved tools for biological sequence comparison.

1988 • 11,455 citations

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1993 • 9,476 citations

The Genetics and Biology of Drosophila

1978 • 3,910 citations

The Genome of Drosophila Melanogaster

1992 • 3,126 citations

Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

1991 • 2,774 citations

Amino Acid Sequences Common to Rapidly Degraded Proteins: The PEST Hypothesis

1986 • 2,566 citations

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

1991 • 1,693 citations

Molecular themes in oncogenesis

1991 • 1,663 citations

E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells.

1991 • 1,592 citations

Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site

1993 • 1,205 citations

The rat brain postsynaptic density fraction contains a homolog of the drosophila discs-large tumor suppressor protein

1992 • 1,180 citations

Nucleotide sequence from the neurogenic locus Notch implies a gene product that shares homology with proteins containing EGF-like repeats

1985 • 1,063 citations

A workbench for multiple alignment construction and analysis

1991 • 1,005 citations

The FLP recombinase of yeast catalyzes site-specific recombination in the drosophila genome

1989 • 939 citations

The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions

1991 • 902 citations

Specific EGF repeats of Notch mediate interactions with Delta and serrate: Implications for notch as a multifunctional receptor

1991 • 770 citations

Dynamin-like protein encoded by the Drosophila shibire gene associated with vesicular traffic

1991 • 757 citations

Expression of E-cadherin cell adhesion molecules in human breast cancer tissues and its relationship to metastasis.

1993 • 658 citations

The 220-kD protein colocalizing with cadherins in non-epithelial cells is identical to ZO-1, a tight junction-associated protein in epithelial cells: cDNA cloning and immunoelectron microscopy.

1993 • 567 citations

Multiple forms of dynamin are encoded by shibire, a Drosophila gene involved in endocytosis

1991 • 543 citations

E-cadherin expression in squamous cell carcinomas of head and neck: inverse correlation with tumor dedifferentiation and lymph node metastasis.

1991 • 536 citations

Identification of a 160-kDa polypeptide that binds to the tight junction protein ZO-1.

1991 • 520 citations

Allelotype of breast cancer: cumulative allele losses promote tumor progression in primary breast cancer.

1990 • 511 citations

Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development

1989 • 487 citations

The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions.

1993 • 467 citations

Sex-lethal, a Drosophila sex determination switch gene, exhibits sex-specific RNA splicing and sequence similarity to RNA binding proteins

1988 • 461 citations

Allelic loss of chromosomes 16q and 10q in human prostate cancer.

1990 • 456 citations

The fat tumor suppressor gene in Drosophila encodes a novel member of the cadherin gene superfamily

1991 • 455 citations

The Genetics Of Biogenic Amine Metabolism, Sclerotization, And Melanization In Drosophila Melanogaster

1987 • 452 citations

Distribution of the wingless gene product in drosophila embryos: A protein involved in cell-cell communication

1989 • 452 citations

Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor protein

1994 • 452 citations

Mitogen-activated protein kinases: versatile transducers for cell signaling

1992 • 439 citations

E-cadherin expression in primary and metastatic gastric cancer: down-regulation correlates with cellular dedifferentiation and glandular disintegration.

1993 • 434 citations

Sequence of the notch locus of Drosophila melanogaster: relationship of the encoded protein to mammalian clotting and growth factors.

1986 • 427 citations

SAP90, a rat presynaptic protein related to the product of the Drosophila tumor suppressor gene dlg-A.

1993 • 415 citations

Structure of the PBL

1988 • 412 citations

opa: A novel family of transcribed repeats shared by the Notch locus and other developmentally regulated loci in D. melanogaster

1985 • 404 citations

bag-of-marbles: a Drosophila gene required to initiate both male and female gametogenesis.

1990 • 394 citations

Characterization of ZO-1, a protein component of the tight junction from mouse liver and Madin-Darby canine kidney cells.

1988 • 366 citations

Similarity between cell-cycle genes of budding yeast and fission yeast and the Notch gene of Drosophila

1987 • 366 citations

Decreased E-cadherin immunoreactivity correlates with poor survival in patients with bladder tumors.

1993 • 362 citations

LOSS OF CONSTITUTIONAL HETEROZYGOSITY IN HUMAN CANCER

1991 • 318 citations

Stripe-specific regulation of pair-rule genes by hopscotch, a putative Jak family tyrosine kinase in Drosophila.

1994 • 308 citations

Reduction of E-cadherin levels and deletion of the alpha-catenin gene in human prostate cancer cells.

1993 • 294 citations

Oogenesis in adult Drosophila melanogaster.

1956 • 293 citations

Allele loss on chromosome 16 associated with progression of human hepatocellular carcinoma.

1990 • 292 citations

E-cadherin gene mutations in human gastric carcinomacell lines.

1994 • 288 citations

SH3 — an abundant protein domain in search of a function

1992 • 280 citations

HUMAN TUMOR SUPPRESSOR GENES

1990 • 266 citations

Structure, expression, and regulation of protein kinases involved in the phosphorylation of ribosomal protein S6.

1991 • 265 citations

Molecular cloning of lethal(2)giant larvae, a recessive oncogene of Drosophila melanogaster.

1985 • 251 citations

The function of the neurogenic genes during epithelial development in the Drosophila embryo

1992 • 248 citations

Secretion and movement of wingless protein in the epidermis of the Drosophila embryo

1991 • 244 citations

Chromosomal Deficiencies and the Embryonic Development of Drosophila Melanogaster

1937 • 235 citations

Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins

1992 • 230 citations

The gene Serrate encodes a putative EGF-like transmembrane protein essential for proper ectodermal development in Drosophila melanogaster.

1990 • 222 citations

Seven genes of the Enhancer of split complex of Drosophila melanogaster encode helix-loop-helix proteins.

1992 • 220 citations

ZO-1, DlgA and PSD-95/SAP90: homologous proteins in tight, septate and synaptic cell junctions

1993 • 214 citations

The Serrate locus of Drosophila and its role in morphogenesis of the wing imaginal discs: control of cell proliferation

1994 • 209 citations

A deduced gene product from the Drosophila neurogenic locus, Enhancer of split, shows homology to mammalian G-protein β subunit

1988 • 197 citations

Septate and Scalariform Junctions in Arthropods

1980 • 197 citations

Mutations at the fat locus interfere with cell proliferation control and epithelial morphogenesis in Drosophila

1988 • 193 citations

P-lacW insertional mutagenesis on the second chromosome of Drosophila melanogaster: isolation of lethals with different overgrowth phenotypes.

1993 • 185 citations

Cadherin intercellular adhesion molecule in hepatocellular carcinomas: loss of E-cadherin expression in an undifferentiated carcinoma

1991 • 180 citations

The Enhancer of split [E(spl)] locus of Drosophila encodes seven independent helix-loop-helix proteins.

1992 • 179 citations

The bride of sevenless and sevenless interaction: Internalization of a transmembrane ligand

1992 • 172 citations

In vitro binding studies suggest a membrane-associated complex between erythroid p55, protein 4.1, and glycophorin C.

1994 • 167 citations

Drosophila homolog of the human S6 ribosomal protein is required for tumor suppression in the hematopoietic system.

1992 • 167 citations

Oncogenes and tumour-suppressor genes in squamous cell carcinoma of the head and neck

1992 • 165 citations

Intrinsic growth control in the imaginal primordia of Drosophila, and the autonomous action of a lethal mutation causing overgrowth

1985 • 158 citations

Similarity of the product of the Drosophila neurogenic gene big brain to transmembrane channel proteins

1990 • 154 citations

Mitogen-activated 70K S6 kinase. Identification of in vitro 40 S ribosomal S6 phosphorylation sites.

1991 • 152 citations

The notch gene product is a glycoprotein expressed on the cell surface of both epidermal and neuronal precursor cells during Drosophila development.

1989 • 150 citations

Molecular identification of a major palmitoylated erythrocyte membrane protein containing the src homology 3 motif.

1991 • 148 citations

Developmental capacities of benign and malignant neoplasms ofDrosophila

1974 • 146 citations

The Drosophila Tumorous lethal hematopoietic oncogene is a dominant mutation in the hopscotch locus

1993 • 145 citations

The Drosophila neurogenic locus mastermind encodes a nuclear protein unusually rich in amino acid homopolymers.

1990 • 138 citations

Loss of cell-cell and cell-matrix adhesion molecules in colorectal cancer

1993 • 137 citations

The Notch Locus and the Cell Biology of Neuroblast Segregation

1991 • 131 citations

Evidence that red blood cell protein p55 may participate in the skeleton-membrane linkage that involves protein 4.1 and glycophorin C

1993 • 130 citations

Heat shock induces rapid dephosphorylation of a ribosomal protein in Drosophila.

1982 • 126 citations

Association of Ash/Grb-2 with dynamin through the Src homology 3 domain.

1994 • 125 citations

Frequent Loss of Heterozygosity on Chromosomes 16 and 4 in Human Hepatocellular Carcinoma

1990 • 116 citations

The ovo gene of Drosophila encodes a zinc finger protein required for female germ line development.

1991 • 111 citations

A mouse homologue of the Drosophila tumour-suppressor gene l(2)gl controlled by Hox-C8 in vivo

1993 • 108 citations

Structure of the I(2)gl gene of Drosophila and delimitation of its tumor suppressor domain

1987 • 106 citations

Mutation of twins encoding a regulator of protein phosphatase 2A leads to pattern duplication in Drosophila imaginal discs.

1993 • 101 citations

Molecular signal integration. Interplay between serine, threonine, and tyrosine phosphorylation.

1992 • 101 citations

Mutations in the Drosophila Gene Encoding Ribosomal Protein S6 Cause Tissue Overgrowth

1993 • 101 citations

Genetic and Molecular Analysis of hyperplastic discs, a Gene Whose Product Is Required for Regulation of Cell Proliferation in Drosophila melanogaster Imaginal Discs and Germ Cells

1994 • 99 citations

Increased expression of human ribosomal phosphoprotein P0 messenger RNA in hepatocellular carcinoma and colon carcinoma.

1992 • 94 citations

Regional assignment of the human loci for uvomorulin (UVO) and chymotrypsinogen B (CTRB) with the help of two overlapping deletions on the long arm of chromosome 16

1989 • 93 citations

shibire, a neurogenic mutant of Drosophila

1990 • 91 citations

Regulation of Protein Synthesis by Phosphorylation of Ribosomal Protein S6 and Aminoacyl-†RNA Synthetases1

1986 • 82 citations

The role of the ovarian tumor locus in Drosophila melanogaster germ line sex determination

1993 • 78 citations

A genetic melanotic neoplasm of Drosophila melanogaster

1981 • 78 citations

A temperature-sensitive brain tumor suppressor mutation of Drosophila melanogaster: Developmental studies and molecular localization of the gene

1993 • 73 citations

Giant and duplicated imaginal discs in a new lethal mutant ofDrosophila melanogaster

1971 • 73 citations

Toward Cloning And Mapping the Genome of Drosophila

1991 • 71 citations

A product of the prune locus of Drosophila is similar to mammalian GTPase-activating protein

1991 • 70 citations

Tumor suppressor genes encoding proteins required for cell interactions and signal transduction in Drosophila

1993 • 69 citations

Sequence and structure of the Drosophila melanogaster ovarian tumor gene and generation of an antibody specific for the ovarian tumor protein.

1989 • 68 citations

Germ-line sex determination in Drosophila melanogaster

1990 • 63 citations

The genetic analysis of snf: a Drosophila sex determination gene required for activation of Sex-lethal in both the germline and the soma.

1992 • 62 citations

Characterization of a region of the X chromosome of Drosophila including multi sex combs (mxc), a Polycomb group gene which also functions as a tumour suppressor

1995 • 62 citations

Tumor-suppressor genes of Drosophila melanogaster.

1989 • 60 citations

How do germ cells choose their sex? Drosophila as a paradigm

1992 • 59 citations

Defective gap-junctional communication associated with imaginal disc overgrowth and degeneration caused by mutations of the dco gene in Drosophila

1990 • 59 citations

Studies of l(3)c43hs1 a polyphasic, temperature-sensitive mutant of Drosophila melanogaster with a variety of imaginal disc defects

1977 • 56 citations

Oogenesis in adult Drosophila melanogaster. IV. Hereditary ovarian tumors.

1957 • 53 citations

Mechanism of adenylate kinase. Demonstration of a functional relationship between aspartate 93 and magnesium by site-directed mutagenesis and proton, phosphorus-31, and magnesium-25 NMR

1991 • 53 citations

Guanylate kinase from Saccharomyces cerevisiae

1989 • 50 citations

The Expression of the Drosophila awd Gene during Normal Development and in Neoplastic Brain Tumors Caused by lgl Mutations

1993 • 50 citations

Expanded, a negative regulator of cell proliferation in drosophila, shows homology to the NF2 tumor suppressor

1993 • 49 citations

The Drosophila melanogaster l(2)gl gene encodes a protein homologous to the cadherin cell-adhesion molecule family

1989 • 44 citations

Evidence for Sex Transformation of Germline Cells in Ovarian Tumor Mutants of Drosophila

1994 • 41 citations

The Drosophila neuralized gene encodes a C3HC4 zinc finger.

1993 • 41 citations

Developmental expression and tissue distribution of the lethal (2) giant larvae protein of Drosophila melanogaster.

1986 • 38 citations

Molecular organisation and expression pattern of the segment polarity gene fused of Drosophila melanogaster

1993 • 38 citations

Genetic, cytogenetic and developmental analysis of the Drosophila melanogaster tumor suppressor gene lethal(2)tumorous imaginal discs (l(2)tid)

1992 • 35 citations

Studies offs(1)1621, a mutation producing ovarian tumors in Drosophila melanogaster

1981 • 31 citations

The gene encoding the palmitoylated erythrocyte membrane protein, p55, originates at the CpG island 3′ to the factor VIII gene

1992 • 28 citations

Molecular genetics of Delta, a locus required for ectodermal differentiation in Drosophila

1989 • 26 citations

Cellular Immune Responses and Their Genetic Aspects in Drosophila

1986 • 25 citations

Genetic and molecular characterization of P element-induced mutations reveals that the Drosophila ovarian tumor gene has maternal activity and a variable null phenotype.

1993 • 25 citations

Cloning, Structure, Cellular Localization, and Possible Function of the Tumor Suppressor Gene lethal(3)malignant blood neoplasm-1 of Drosophila melanogaster

1994 • 25 citations

P element transposition and targeted manipulation of the Drosophila genome

1992 • 24 citations

The organization of the intron-containing human S6 ribosomal protein (rpS6) gene and determination of its location at chromosome 9p21

1992 • 23 citations

Structure and expression of hybrid dysgenesis-induced alleles of the ovarian tumor (otu) gene in Drosophila melanogaster.

1993 • 22 citations

Induced neuroma formation and target muscle perturbation in the giant fiber pathway of the Drosophila temperature-sensitive mutant shibire

1988 • 19 citations

Isolation and characterization of the prune locus of Drosophila melanogaster.

1991 • 18 citations

The lethal prune/Killer-of-prune interaction of Drosophila causes a syndrome resembling human neurofibromatosis (NF1).

1992 • 18 citations

Alterations in the production of hemocytes due to a neoplastic mutation of Drosophila melanogaster

1984 • 17 citations

Ultrastructure and cytochemistry of the tumorous blood cells in the mutant Lethal(3)malignant blood neoplasm of Drosophila melanogaster

1986 • 12 citations

The fruit fly Drosophila and the fish Xiphophorus as model systems for cancer studies.

1990 • 12 citations

Tumor suppression in Drosophila.

1990 • 11 citations

Dynamin: A microtubule-associated GTP-binding protein

1991 • 9 citations

Control of S6 Phosphorylation during the Mitogenic Response

1988 • 7 citations

Genetic and molecular analysis of six tumor suppressor genes in Drosophila melanogaster

1990 • 4 citations

Comparative Ultrastructure of Wild-Type and Tumorous Cells of Drosophila

1984 • 4 citations