Genetic association between the PRKCH gene encoding protein kinase Cη isozyme and rheumatoid arthritis in the Japanese population

The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis

1988 • 19,632 citations

Revised Criteria for the Classification of Rheumatoid Arthritis

1990 • 7,730 citations

The Structure of Haplotype Blocks in the Human Genome

2002 • 5,744 citations

A Comparison of Bayesian Methods for Haplotype Reconstruction from Population Genotype Data

2003 • 3,515 citations

The shared epitope hypothesis. an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis

1987 • 2,539 citations

Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

2000 • 1,487 citations

Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies

2006 • 1,269 citations

TRANSFAC: an integrated system for gene expression regulation

2000 • 1,236 citations

Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis

2003 • 1,143 citations

Patterns of linkage disequilibrium in the human genome

2002 • 1,132 citations

Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins

2000 • 1,129 citations

Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness

2002 • 1,108 citations

Haplotype Variation and Linkage Disequilibrium in 313 Human Genes

2001 • 879 citations

GOLD—Graphical Overview of Linkage Disequilibrium

2000 • 781 citations

Protein kinase C isozymes and the regulation of diverse cell responses

2000 • 730 citations

Autoimmune disease: why and where it occurs

2001 • 584 citations

New susceptibility locus for rheumatoid arthritis suggested by a genome-wide linkage study

1998 • 480 citations

Familial aggregation of systemic lupus erythematosus, rheumatoid arthritis, and other autoimmune diseases in 1,177 lupus patients from the GLADEL cohort

2005 • 403 citations

The contribution of H LA to rheumatoid arthritis

1989 • 386 citations

HLA-DR4 subtype frequencies in rheumatoid arthritis indicate that DRB1 is the major susceptibility locus within the HLA class II region.

1989 • 376 citations

A Genomewide Screen in Multiplex Rheumatoid Arthritis Families Suggests Genetic Overlap with Other Autoimmune Diseases

2001 • 368 citations

A genome-wide search for susceptibility genes in human systemic lupus erythematosus sib-pair families

1998 • 362 citations

Genome-Wide Screen for Systemic Lupus Erythematosus Susceptibility Genes in Multiplex Families

1999 • 319 citations

The genetics revolution and the assault on rheumatoid arthritis

1999 • 285 citations

Screening the genome for rheumatoid arthritis susceptibility genes: A replication study and combined analysis of 512 multicase families

2003 • 241 citations

Whole‐genome linkage analysis of rheumatoid arthritis susceptibility loci in 252 affected sibling pairs in the United Kingdom

2002 • 203 citations

HLA-DRB1*0401/0404 genotype and rheumatoid arthritis: increased association in men, young age at onset, and disease severity.

1995 • 201 citations

A Susceptibility Locus for Human Systemic Lupus Erythematosus (hSLE1) on Chromosome 2q

2000 • 201 citations

Identification of the gene loci that predispose to rheumatoid arthritis.

1998 • 199 citations

The first linkage disequilibrium (LD) maps: Delineation of hot and cold blocks by diplotype analysis

2002 • 188 citations

Crucial importance of PKC-β(I) in LFA-1–mediated locomotion of activated T cells

2001 • 146 citations

A point mutation at the putative ATP-binding site of protein kinase C alpha abolishes the kinase activity and renders it down-regulation-insensitive. A molecular link between autophosphorylation and down-regulation.

1990 • 145 citations

Genome scan meta-analysis of rheumatoid arthritis

2005 • 144 citations

Whole genome association study of rheumatoid arthritis using 27 039 microsatellites

2005 • 135 citations

The PKC gene module: molecular biosystematics to resolve its T cell functions

2003 • 134 citations

The linkage disequilibrium maps of three human chromosomes across four populations reflect their demographic history and a common underlying recombination pattern

2005 • 114 citations

'Rhupus' Syndrome

1988 • 110 citations

Characterization of a Protein Kinase C-δ (PKC-δ) ATP Binding Mutant

1995 • 95 citations

Dense genome‐wide linkage analysis of rheumatoid arthritis, including covariates

2004 • 94 citations

Meta‐analysis of four rheumatoid arthritis genome‐wide linkage studies: Confirmation of a susceptibility locus on chromosome 16

2003 • 84 citations

Physical association and functional relationship between protein kinase Cζ and the actin cytoskeleton

1995 • 59 citations

Elevated serum nitric oxide levels in patients with inflammatory arthritis associated with co-expression of inducible nitric oxide synthase and protein kinase C-eta in peripheral blood monocyte-derived macrophages.

2003 • 53 citations

Immunomodulatory effects of therapeutic gold compounds. Gold sodium thiomalate inhibits the activity of T cell protein kinase C.

1992 • 50 citations

Investigation of susceptibility loci identified in the UK rheumatoid arthritis whole‐genome scan in a further series of 217 UK affected sibling pairs

2004 • 45 citations

Genome-wide meta-analysis for rheumatoid arthritis

2006 • 42 citations

Association of single-nucleotide polymorphisms in the suppressor of cytokine signaling 2 (SOCS2) gene with type 2 diabetes in the Japanese

2006 • 40 citations

Weighting Schemes in Pooled Linkage Analysis

2001 • 20 citations

Occurrence of Autoimmune Diseases and Relationship of Autoantibody Expression with HLA Phenotypes in Mutticase Rheumatoid Arthritis Families

1993 • 19 citations

Association between single‐nucleotide polymorphisms in the SEC8L1 gene, which encodes a subunit of the exocyst complex, and rheumatoid arthritis in a Japanese population

2005 • 18 citations