Immunomodulatory effects of therapeutic gold compounds. Gold sodium thiomalate inhibits the activity of T cell protein kinase C.

Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.

1968 • 5,084 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Inositol phosphates and cell signalling

1989 • 4,058 citations

Monoclonal Antibodies Defining Distinctive Human T Cell Surface Antigens

1979 • 1,480 citations

"Panning" for lymphocytes: a method for cell selection.

1978 • 1,319 citations

Two populations of Ia-like molecules on a human B cell line.

1980 • 1,112 citations

The Complete Primary Structure of Protein Kinase C—the Major Phorbol Ester Receptor

1986 • 878 citations

Proteolytic activation of calcium-activated, phospholipid-dependent protein kinase by calcium-dependent neutral protease.

1983 • 601 citations

Inhibitory action of chlorpromazine, dibucaine, and other phospholipid-interacting drugs on calcium-activated, phospholipid-dependent protein kinase.

1980 • 464 citations

Phenotype of the accessory cell necessary for mitogen-stimulated T and B cell responses in human peripheral blood: delineation by its sensitivity to the lysosomotropic agent, L-leucine methyl ester.

1983 • 353 citations

A synthetic peptide substrate for selective assay of protein kinase C

1990 • 292 citations

An immunohistological analysis of lymphocyte subpopulations and their microenvironment in the synovial membranes of patients with rheumatoid arthritis using monoclonal antibodies.

1982 • 273 citations

Activators of protein kinase C down-regulate and phosphorylate the T3/T-cell antigen receptor complex of human T lymphocytes.

1985 • 267 citations

Monomorphic anti-HLA-A,B,C monoclonal antibodies detecting molecular subunits and combinatorial determinants.

1982 • 262 citations

Mode of Activation and Kinetic Properties of Three Distinct Forms of Protein Kinase C from Rat Brain1

1988 • 225 citations

Treatment of Intractable Rheumatoid Arthritis with Total Lymphoid Irradiation

1981 • 210 citations

Oral gold. Antiarthritic properties of alkylphosphinegold coordination complexes

1972 • 203 citations

Lymphocyte Involvement in Rheumatoid Arthritis

1977 • 198 citations

Inhibition of antigen- and mitogen-induced human lymphocyte proliferation by gold compounds.

1977 • 195 citations

The Formation of Stable E Rosettes After Neuraminidase Treatment of Either Human Peripheral Blood Lymphocytes or of Sheep Red Blood Cells

1974 • 185 citations

Protein kinase C and T cell activation

1990 • 183 citations

A modified procedure for fractionating histones

1972 • 177 citations

Two distinct Ca2+ proteases (calpain I and calpain II) purified concurrently by the same method from rat kidney.

1983 • 172 citations

Relationships between HLA‐DR‐expressing Cells and T Lymphocytes of Different Subsets in Rheumatoid Synovial Tissue

1982 • 171 citations

T cell activation: differences in the signals required for IL 2 production by nonactivated and activated T cells.

1985 • 147 citations

Multiplicity of Adenosine 3′,5′-Monophosphate-dependent Protein Kinases from Rat Liver and Mode of Action of Nucleoside 3′,5′-Monophosphate

1972 • 144 citations

Tissue gold concentration in a rheumatoid arthritic receiving chrysotherapy

1972 • 135 citations

Gold metabolism in patients with rheumatoid arthritis treated with gold compounds—reinvestigated

1972 • 122 citations

Immunohistochemical studies of interleukin‐2 and γ‐interferon in rheumatoid arthritis

1985 • 96 citations

Regulation of cellular function by products of lysosomal enzyme activity: elimination of human natural killer cells by a dipeptide methyl ester generated from L-leucine methyl ester by monocytes or polymorphonuclear leukocytes.

1985 • 88 citations

Immune interferon in serum and synovial fluid in rheumatoid arthritis and related disorders.

1983 • 79 citations

Gold determination in biological fluids by atomic absorption spectrophotometry: application to chrysotherapy in rheumatoid arthritis patients

1968 • 78 citations

Antiarthritic properties and unique pharmacologic profile of a potential chrysotherapeutic agent: S K & F D-30162.

1976 • 75 citations

1 Immunopharmacology of Gold

1982 • 75 citations

Clinical response and serum gold levels in chrysotherapy. Lack of correlation.

1972 • 71 citations

Comparative pharmacokinetics of parenteral and oral gold compounds.

1982 • 67 citations

Chrysotherapy. suppression of immunoglobulin synthesis

1978 • 67 citations

Inhibition of human endothelial cell proliferation by gold compounds.

1987 • 66 citations

Do drugs change the course of rheumatoid arthritis?

1980 • 65 citations

A protein kinase C pseudosubstrate peptide inhibits phosphorylation of the CD3 antigen in streptolysin-O-permeabilized human T lymphocytes

1989 • 62 citations

Serum gold. II. Levels in rheumatoid arthritis.

1973 • 60 citations

Isolation of protein kinase C subspecies from a preparation of human T lymphocytes

1988 • 60 citations

Tissue gold levels after chrysotherapy.

1974 • 60 citations

Serum gold determinations in patients with rheumatoid arthritis receiving sodium aurothiomalate.

1973 • 54 citations

Properties of protein kinase c subspecies in human platelets

1988 • 54 citations

Salt-induced conformational changes in the catalytic subunit of adenosine 3',5'-phosphate dependent protein kinase. Use for establishing a connection between one sulfhydryl group and the .gamma.-P subsite in the ATP site of this subunit

1982 • 52 citations

Cellular and molecular pharmacology of auranofin and related gold complexes

1986 • 46 citations

Heterogeneity of protein kinase C expression and regulation in T lymphocytes

1990 • 46 citations

A hepatic soluble cyclic nucleotide-independent protein kinase. Stimulation by basic polypeptides.

1979 • 45 citations

Molecular signaling mechanisms in T-lymphocyte activation pathways: A review and future prospects

1987 • 34 citations

Inhibition of in vitro proliferative response of cultured t lymphocytes to interleukin‐2 by gold sodium thiomalate

1988 • 30 citations

Comparative pharmacology and biological effects of different gold compounds.

1982 • 30 citations

Effects of gold coordination complexes on neutrophil function are mediated via inhibition of protein kinase C.

1989 • 29 citations

BLOOD AND URINE GOLD LEVELS DURING CHRYSOTHERAPY FOR RHEUMATOID ARTHRITIS

1975 • 28 citations

Inhibition of protein kinase C activity by the antirheumatic drug auranofin

1989 • 28 citations

Effects of gold sodium thiomalate and tenidap sodium (CP‐66,248–2) on a model of macrophage differentiation using HL‐60 cells

1990 • 22 citations

Gold inhibition of the production of the second complement component by lymphokine‐stimulated human monocytes

1982 • 19 citations

Reduction of peripheral blood lymphocytes in patients receiving gold therapy for rheumatoid arthritis.

1985 • 16 citations

Effect of metal containing compounds on superoxide release from phorbol myristate acetate stimulated murine peritoneal macrophages: inhibition by auranofin and spirogermanium.

1988 • 8 citations

Inhibitory effects of anti-CD2 monoclonal antibodies on interleukin 2 production and interleukin 2 receptor expression in anti-CD3-induced T cell activation

1989 • 5 citations

Specific Therapy for Rheumatoid Arthritis

1980 • 1 citations

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