Amino Acid Neurotransmitters and New Approaches to Anticonvulsant Drug Action

Excitatory Amino Acid Transmitters

1981 • 2,488 citations

Handbook of Experimental Pharmacology.

1971 • 1,547 citations

Amino acid transmitters in the mammalian central nervous system

1974 • 1,169 citations

(–)Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor

1980 • 1,091 citations

Receptors for the Age of Anxiety: Pharmacology of the Benzodiazepines

1980 • 866 citations

DRUG INTERACTIONS AT THE GABA RECEPTOR-IONOPHORE COMPLEX

1982 • 696 citations

Anticonvulsant Action of Excitatory Amino Acid Antagonists

1982 • 692 citations

Glutamine, glutamate and gaba in the central nervous system

1986 • 673 citations

Diazepam and (--)-pentobarbital: fluctuation analysis reveals different mechanisms for potentiation of gamma-aminobutyric acid responses in cultured central neurons.

1981 • 559 citations

Pharmacological evidence for two kinds of GABA receptors on rat hippocampal pyramidal cells studied in vitro

1982 • 527 citations

Epilepsy and γ-Aminobutyric Acid-Mediated Inhibition

1975 • 491 citations

THE EFFECTS OF A SERIES OF ω‐PHOSPHONIC α‐CARBOXYLIC AMINO ACIDS ON ELECTRICALLY EVOKED AND EXCITANT AMINO ACID‐INDUCED RESPONSES IN ISOLATED SPINAL CORD PREPARATIONS

1982 • 463 citations

Mechanism of anticonvulsant action of valproate

1982 • 344 citations

Protection against chemically induced seizures by 2-amino-7-phosphonoheptanoic acid

1982 • 258 citations

TWO TYPES OF γ‐AMINOBUTYRIC ACID RECEPTOR ON EMBRYONIC SENSORY NEURONES

1981 • 213 citations

δ-Aminolaevulinic acid is a potent agonist for GABA autoreceptors

1979 • 212 citations

Effects of excitatory amino acids and their antagonists on membrane and action potentials of cat caudate neurones.

1983 • 182 citations

BACLOFEN: EFFECTS ON AMINO ACID RELEASE AND METABOLISM IN SLICES OF GUINEA PIG CEREBRAL CORTEX

1979 • 180 citations

Antiepileptic action of excitatory amino acid antagonists in the photosensitive baboon, papio papio

1983 • 179 citations

Diazepam enhancement of low affinity GABA binding to rat brain membranes

1982 • 166 citations

Is GABA release modulated by presynaptic receptors?

1978 • 144 citations

Inhibitors of the GABA uptake systems

1980 • 131 citations

Influence of inhibitors of the high affinity GABA uptake on seizure thresholds in mice

1979 • 128 citations

Gamma hydroxybutyrate in the monkey

1978 • 126 citations

Improvement in Tardive Dyskinesia After Muscimol Therapy

1979 • 123 citations

An allosteric model for benzodiazepine receptor function

1983 • 102 citations

Gamma-vinyl-GABA: A single-blind trial in patients with epilepsy

1983 • 98 citations

Convulsions induced in 10-day-old rats by intraperitional injection of monosodium glutamate and related excitant amino acids

1973 • 98 citations

Evaluation of anticonvulsant drugs in DBA/2 mice with sound-induced seizures.

1984 • 95 citations

GABA Analogues Activate Channels of Different Duration on Cultured Mouse Spinal Neurons

1981 • 94 citations

Anticonvulsant activity of GABA uptake inhibitors and their prodrugs following central or systemic administration

1983 • 93 citations

A comparison of the anticonvulsant potency of (±) 2-amino-5-phosphono-pentanoic acid and (±) 2-amino-7-phosphonoheptanoic acid

1983 • 93 citations

Convulsant and anticonvulsant actions in DBA/2 mice of compounds blocking the reuptake of GABA

1979 • 92 citations

Blockade of epileptic responses in the photosensitive baboon, Papio papio, by two irreversible inhibitors of GABA-transaminase, ?-acetylenic GABA (4-amino-hex-5-ynoic acid) and ?-vinyl GABA (4-amino-hex-5-enoic acid)

1978 • 86 citations

Glutamate-preferring receptors regulate the release of D-[3H]aspartate from rat hippocampal slices

1981 • 86 citations

Comparative assay of anticonvulsant and toxic potencies of sixteen GABAmimetic drugs

1982 • 86 citations

Acute effects of sodium valproate and ?-vinyl gaba on regional amino acid metabolism in the rat brain: Incorporation of 2-[14C]glucose into amino acids

1982 • 83 citations

Acute anticonvulsant activity of structural analogues of valproic acid and changes in brain GABA and aspartate content

1983 • 75 citations

SELECTIVE DEPRESSION OF SYNAPTIC TRANSMISSION OF SPINAL NEURONES IN THE CAT BY A NEW CENTRALLY ACTING MUSCLE RELAXANT, 5‐CHLORO‐4‐(2‐IMIDAZOLIN‐2‐YL‐AMINO)‐2, 1, 3‐BENZOTHIODAZOLE (DS103–282)

1982 • 75 citations

Neurotransmitters, seizures, and epilepsy, II

1985 • 72 citations

Antagonists of synaptic and amino acid excitation of neurones in the cat spinal cord

1983 • 69 citations

Anticonvulsant‐like actions of baclofen in the rat hippocampal slice

1983 • 65 citations

Release of amino acids from chronic epileptic and sub-epileptic foci in vivo

1980 • 64 citations

2-Amino-phosphonoheptanoic acid protects against the high pressure neurological syndrome

1983 • 64 citations

Effects of the bicyclic GABA agonist, THIP, on myoclonic and seizure responses in mice and baboons with reflex epilepsy

1980 • 63 citations

Cetyl GABA: Effect on convulsant thresholds in mice and acute toxicity

1980 • 62 citations

Anticonvulsant action in mice with sound-induced seizures of the optical isomers of γ-vinyl GABA

1983 • 55 citations

GABA agonists

1981 • 54 citations

Anticonvulsant actions of DS 103–282 Pharmacological studies in rodents and the baboon, Papio papio

1984 • 51 citations

Convulsions and activation of epileptic foci induced by monosodium glutamate and related compounds

1977 • 51 citations

Electroencephalographic and Behavioral Effects of a GABA Agonist (Muscimol) on Photosensitive Epilepsy in the Baboon, Papio papio

1979 • 48 citations

Inhibition by Diazepam and γ‐Aminobutyric Acid of Depolarization‐Induced Release of [¹⁴C]Cysteine Sulfinate and [³H]Glutamate in Rat Hippocampal Slices

1983 • 44 citations

Anticonvulsant action in the photosensitive baboon, Papio papio, of a novel β-carboline derivative, ZK 91296

1983 • 43 citations

THIP: A single-blind controlled trial in patients with epilepsy

1983 • 41 citations

Asparagine as Precursor for Transmitter Aspartate in Corticostriatal Fibres

1980 • 36 citations

Uptake of a novel anticonvulsant compound, 2-amino-7-phosphono-[4,5-3H]Heptanoic acid, into mouse brain

1983 • 35 citations

Studies on sound-induced epilepsy in mice

1984 • 25 citations

Anticonvulsant and proconvulsant properties of a series of structural isomers of piperidine dicarboxylic acid

1984 • 19 citations

Effect on cerebral D-[3H]aspartate release of 3-mercaptopropionic acid and methyl-6,7-dimethoxy-4-ethyl-β-carboline-3-carboxylate

1983 • 16 citations