Physical properties of DNA in vivo as probed by the length dependence of the lac operator looping process

Culture Medium for Enterobacteria

1974 • 3,002 citations

Röntgenuntersuchung gelöster Fadenmoleküle

1949 • 1,888 citations

The locus of sequence-directed and protein-induced DNA bending

1984 • 1,453 citations

Intramolecular Reaction in Polycondensations. I. The Theory of Linear Systems

1950 • 1,354 citations

DNA bending at adenine · thymine tracts

1986 • 1,032 citations

Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of Yeast

1986 • 946 citations

Gene regulation by proteins acting nearby and at a distance

1986 • 886 citations

How crowded is the cytoplasm?

1982 • 807 citations

A eukaryotic transcriptional activator bearing the DNA specificity of a prokaryotic repressor

1985 • 686 citations

The effect of volume occupancy upon the thermodynamic activity of proteins: some biochemical consequences

1983 • 503 citations

Helical repeat of DNA in solution.

1979 • 481 citations

Cooperative binding of λ repressors to sites separated by integral turns of the DNA helix

1986 • 450 citations

Transcription of glnA in E. coli is stimulated by activator bound to sites far from the promoter

1986 • 444 citations

Energetics of DNA twisting

1983 • 410 citations

Torsional rigidity of DNA and length dependence of the free energy of DNA supercoiling

1984 • 397 citations

Torsional tension in the DNA double helix measured with trimethylpsoralen in living E. coli cells: Analogous measurements in insect and human cells

1980 • 394 citations

Theory of twisting and bending of chain macromolecules; analysis of the fluorescence depolarization of DNA

1979 • 382 citations

An operator at -280 base pairs that is required for repression of araBAD operon promoter: addition of DNA helical turns between the operator and promoter cyclically hinders repression.

1984 • 375 citations

Mutants that make more lac repressor.

1968 • 354 citations

lac repressor forms loops with linear DNA carrying two suitably spaced lac operators.

1987 • 353 citations

Helical periodicity of DNA determined by enzyme digestion

1980 • 347 citations

Statistical Mechanics of Wormlike Chains. II. Excluded Volume Effects

1972 • 333 citations

The DNA binding domain and bending angle of E. coli CAP protein

1986 • 322 citations

Interaction of the Escherichia coli HU protein with DNA

1986 • 321 citations

Ring-closure probabilities for twisted wormlike chains. Application to DNA

1984 • 305 citations

Curved DNA: design, synthesis, and circularization.

1986 • 303 citations

Use of site-specific recombination as a probe of DNA structure and metabolism in vivo

1987 • 297 citations

Iron(II) EDTA Used to Measure the Helical Twist Along Any DNA Molecule

1985 • 274 citations

The properties of repressor and the kinetics of its action

1965 • 257 citations

DNA supercoiling promotes formation of a bent repression loop in lac DNA

1987 • 252 citations

Energetics of DNA twisting

1983 • 223 citations

Left-Handed DNA in Vivo

1987 • 214 citations

Cruciform formation in a negatively supercoiled DNA may be kinetically forbidden under physiological conditions

1983 • 212 citations

A control element within a structural gene: The gal operon of Escherichia coli

1983 • 206 citations

Upstream Operators Enhance Repression of the lac Promoter

1986 • 197 citations

The DNA loop model for ara repression: AraC protein occupies the proposed loop sites in vivo and repression-negative mutations lie in these same sites.

1986 • 167 citations

The helical periodicity of DNA on the nucleosome

1981 • 166 citations

Torsion and bending of nucleic acids studied by subnanosecond time-resolved fluorescence depolarization of intercalated dyes

1982 • 151 citations

The nature of Lactose operator constitutive mutations

1971 • 141 citations

Torsion dynamics and depolarization of fluorescence of linear macromolecules

1980 • 139 citations

Supercoils in prokaryotic DNA restrained in vivo.

1980 • 133 citations

DNA supercoiling changes the spacing requirement of two lac operators for DNA loop formation with lac repressor.

1988 • 132 citations

Demonstration of two operator elements in gal: in vitro repressor binding studies.

1984 • 130 citations

Effects of promoter strengths and growth conditions on copy number of transcription-fusion vectors.

1984 • 127 citations

Association of DNA-bound progesterone receptors

1987 • 116 citations

On the probability of ring closure of lambda DNA

1966 • 113 citations

A native cruciform DNA structure probed in bacteria by recombinant T7 endonuclease.

1987 • 105 citations

DNA Bending Induced by the Catabolite Activator Protein Allows Ring Formation of a 144 bp DNA

1987 • 88 citations

Synthetic lac operator mediates repression through lac repressor when introduced upstream and downstream from lac promoter.

1986 • 87 citations

Influence of sequence and distance between two operators on interaction with the lac repressor.

1987 • 79 citations

Two operator sites separated by 599 base pairs are required for deoR repression of the deo operon of Escherichia coli.

1985 • 79 citations

Variations of intramolecular ligation rates allow the detection of protein-induced bends in DNA.

1986 • 74 citations

lac repressor-operator interaction

1972 • 73 citations

lac Promoter mutations located downstream from the transcription start site

1980 • 64 citations

Supercoiling facilitates lac operator-repressor-pseudooperator interactions.

1987 • 60 citations

Why should DNA loop?

1987 • 57 citations

Influence of supercoiling and sequence context on operator DNA binding with lac repressor.

1987 • 54 citations

Analysis of the ring‐closure probabilities of isotropic wormlike chains: Application to duplex DNA

1985 • 44 citations

DNA–topoisomer analysis on the basis of the helical wormlike chain

1984 • 18 citations