A 40‐kDa myelin basic protein kinase, distinct from erk1 and erk2, is activated in mitotic HeLa cells

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Universal control mechanism regulating onset of M-phase

1990 • 2,882 citations

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1991 • 1,901 citations

Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics

1988 • 1,699 citations

ANIMAL CELL CYCLES AND THEIR CONTROL

1992 • 1,239 citations

Multiple, Distinct Forms of Bovine and Human Protein Kinase C Suggest Diversity in Cellular Signaling Pathways

1986 • 1,044 citations

Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase).

1991 • 1,041 citations

Crystal structure of cyclin-dependent kinase 2

1993 • 946 citations

The Complete Primary Structure of Protein Kinase C—the Major Phorbol Ester Receptor

1986 • 878 citations

Activation of the MAP kinase pathway by the protein kinase raf

1992 • 816 citations

Activation of cdc2 protein kinase during mitosis in human cells: Cell cycle-dependent phosphorylation and subunit rearrangement

1988 • 786 citations

The structure, expression, and properties of additional members of the protein kinase C family.

1988 • 706 citations

Cyclin activation of p34cdc2

1990 • 690 citations

Extracellular signal-regulated kinases: ERKs in progress.

1991 • 519 citations

Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein.

1992 • 490 citations

A sensitive method for detection of calmodulin-dependent protein kinase II activity in sodium dodecyl sulfate-polyacrylamide gel

1989 • 466 citations

A candidate protein kinase C gene, PKC1, is required for the S. cerevisiae cell cycle

1990 • 422 citations

In vitro effects on microtubule dynamics of purified Xenopus M phase-activated MAP kinase

1991 • 422 citations

Driving the cell cycle: M phase kinase, its partners, and substrates

1990 • 404 citations

Production of large numbers of mitotic mammalian cells by use of the reversible microtubule inhibitor Nocodazole

1980 • 389 citations

Microtubule‐associated‐protein (MAP) kinase activated by nerve growth factor and epidermal growth factor in PC12 cells

1990 • 386 citations

Cell cycle tyrosine phosphorylation of p34cdc2 and a microtubule-associated protein kinase homolog in Xenopus oocytes and eggs.

1991 • 352 citations

Purified maturation promoting factor phosphorylates pp60c-src at the sites phosphorylated during fibroblast mitosis

1989 • 319 citations

Requirements for Phosphorylation of Map Kinase During Meiosis in Xenopus Oocytes

1992 • 316 citations

The c-mos proto-oncogene protein kinase turns on and maintains the activity of MAP kinase, but not MPF, in cell-free extracts of Xenopus oocytes and eggs.

1993 • 297 citations

Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase.

1987 • 287 citations

Okadaic acid, a potent inhibitor of type 1 and type 2A protein phosphatases, activates cdc2/H1 kinase and transiently induces a premature mitosis-like state in BHK21 cells.

1990 • 280 citations

Xenopus M phase MAP kinase: isolation of its cDNA and activation by MPF.

1991 • 274 citations

Xenopus MAP kinase activator: identification and function as a key intermediate in the phosphorylation cascade.

1992 • 264 citations

Altered phosphorylation and activation of PP60c-src during fibroblast mitosis

1988 • 249 citations

Identification by mass spectrometry of threonine 97 in bovine myelin basic protein as a specific phosphorylation site for mitogen-activated protein kinase.

1990 • 245 citations

Cdc2 H1 kinase is negatively regulated by a type 2A phosphatase in the Xenopus early embryonic cell cycle: evidence from the effects of okadaic acid.

1990 • 244 citations

Mitosis-specific phosphorylation of p60c-src by p34cdc2-associated protein kinase

1989 • 239 citations

Molecular Cloning of a Tissue-Specific Protein Kinase (C_γ) from Human Testis—Representing a Third Isoform for the Catalytic Subunit of cAMP-Dependent Protein Kinase

1990 • 232 citations

INH, a negative regulator of MPF, is a form of protein phosphatase 2A

1991 • 231 citations

Tyrosine phosphorylation and activation of homologous protein kinases during oocyte maturation and mitogenic activation of fibroblasts.

1991 • 202 citations

Surface functions during mitosis I: Phagocytosis, pinocytosis and mobility of surface-bound ConA

1978 • 185 citations

A mitotic form of the Golgi apparatus in HeLa cells

1987 • 183 citations

Activation of multiple protein kinases during the burst in protein phosphorylation that precedes the first meiotic cell division in Xenopus oocytes.

1988 • 174 citations

Multifunctional Ca2+/calmodulin-dependent protein kinase is necessary for nuclear envelope breakdown.

1990 • 173 citations

Activation of p42 MAP kinase and the release of oocytes from cell cycle arrest.

1992 • 163 citations

Biphasic activation of two mitogen-activated protein kinases during the cell cycle in mammalian cells.

1992 • 153 citations

A conserved mitotic kinase active at late anaphase—telophase in syncytial Drosophila embryos

1993 • 128 citations

Evidence for the regulation of exocytic transport by protein phosphorylation.

1992 • 126 citations

Assembly/disassembly of the nuclear envelope membrane: Cell cycle-dependent binding of nuclear membrane vesicles to chromatin in vitro

1991 • 126 citations

Phosphorylation of selected serine and threonine residues in myelin basic protein by endogenous and exogenous protein kinases

1974 • 115 citations

Inhibition of cAMP-dependent protein kinase plays a key role in the induction of mitosis and nuclear envelope breakdown in mammalian cells.

1991 • 113 citations

Okadaic acid induces golgi apparatus fragmentation and arrest of intracellular transport

1991 • 113 citations

The phorbol ester-dependent activator of the mitogen-activated protein kinase p42mapk is a kinase with specificity for the threonine and tyrosine regulatory sites.

1992 • 111 citations

Phorbol ester stimulates a protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product.

1992 • 109 citations

Mitotic control

1991 • 104 citations

Unscrambling the puzzle of biological machines: The importance of the details

1992 • 103 citations

Okadaic acid activates microtubule‐associated protein kinase in quiescent fibroblastic cells

1990 • 96 citations

Sequence of pp42/MAP kinase, a serine/threonine kinase regulated by tyrosine phosphorylation

1991 • 96 citations

Immunological characterization of avian MAP kinases: evidence for nuclear localization.

1992 • 89 citations

Cell-free fusion of endocytic vesicles is regulated by phosphorylation.

1992 • 87 citations

A cDNA clone encoding human cAMP-dependent protein kinase catalytic subunit Cα

1988 • 84 citations

Growth factor-induced activation of a kinase activity which causes regulatory phosphorylation of p42/microtubule-associated protein kinase.

1992 • 72 citations

Okadaic acid mimics a nuclear component required for cyclin B-cdc2 kinase microinjection to drive starfish oocytes into M phase.

1991 • 71 citations

The cell cycle then and now

1992 • 69 citations

Phospholipid‐Sensitive Ca²⁺‐Dependent Protein Kinase Preferentially Phosphorylates Serine‐115 of Bovine Myelin Basic Protein

1984 • 57 citations

Phosphorylation Sites of Bovine Brain Myelin Basic Protein Phosphorylated with Ca2+-Calmodulin-Dependent Protein Kinase from Rat Brain1

1987 • 18 citations

Mitosis-specific phosphorylation of myosin light chain kinase.

1991 • 16 citations

Weismann on Germinal Selection

1896 • 2 citations