Essential role for mammalian copper transporter Ctr1 in copper homeostasis and embryonic development

Current protocols in molecular biology

1988 • 7,584 citations

Cloning and characterization of a mammalian proton-coupled metal-ion transporter

1997 • 3,130 citations

Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.

1993 • 2,370 citations

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

1991 • 1,317 citations

The cellular prion protein binds copper in vivo

1997 • 1,263 citations

Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse

1999 • 1,068 citations

Metals and neuroscience

2000 • 724 citations

Altered Reactivity of Superoxide Dismutase in Familial Amyotrophic Lateral Sclerosis

1996 • 718 citations

A Delicate Balance: Homeostatic Control of Copper Uptake and Distribution

1999 • 715 citations

Metal Ion Chaperone Function of the Soluble Cu(I) Receptor Atx1

1997 • 675 citations

A Permease-Oxidase Complex Involved in High-Affinity Iron Uptake in Yeast

1996 • 666 citations

Molecular characterization of a copper transport protein in S. cerevisiae: An unexpected role for copper in iron transport

1994 • 660 citations

The FET3 gene of S. cerevisiae encodes a multicopper oxidase required for ferrous iron uptake

1994 • 659 citations

The Amyloid Precursor Protein of Alzheimer's Disease in the Reduction of Copper(II) to Copper(I)

1996 • 657 citations

Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux

1999 • 572 citations

Fatal infantile cardioencephalomyopathy with COX deficiency and mutations in SCO2, a COX assembly gene

1999 • 565 citations

h CTR1 : A human gene for copper uptake identified by complementation in yeast

1997 • 541 citations

Noradrenaline is essential for mouse fetal development

1995 • 534 citations

Biochemistry of Copper

1991 • 473 citations

Evidence for Cu(II) Reduction as a Component of Copper Uptake by Saccharomyces cerevisiae

1995 • 357 citations

Mutations of the SCO1 Gene in Mitochondrial Cytochrome c Oxidase Deficiency with Neonatal-Onset Hepatic Failure and Encephalopathy

2000 • 348 citations

Reduced Fertility in Female Mice Lacking Copper-Zinc Superoxide Dismutase

1998 • 328 citations

SCO1 and SCO2 Act as High Copy Suppressors of a Mitochondrial Copper Recruitment Defect in Saccharomyces cerevisiae

1996 • 326 citations

Copper chaperone for superoxide dismutase is essential to activate mammalian Cu/Zn superoxide dismutase

2000 • 326 citations

Primary defect in copper transport underlies mottled mutants in the mouse

1974 • 318 citations

Biochemistry of Copper

1991 • 300 citations

Fatal haemorrhage and incomplete block to embryogenesis in mice lacking coagulation factor V

1996 • 270 citations

Interaction of the copper chaperone HAH1 with the Wilson disease protein is essential for copper homeostasis

1999 • 267 citations

Molecular Characterization of a Putative Arabidopsis thaliana Copper Transporter and Its Yeast Homologue

1995 • 266 citations

Iron metabolism in copper-deficient swine

1968 • 258 citations

A widespread transposable element masks expression of a yeast copper transport gene.

1996 • 248 citations

Intracellular copper routing: the role of copper chaperones

2000 • 247 citations

The Copper Chaperone CCS Directly Interacts with Copper/Zinc Superoxide Dismutase

1998 • 247 citations

Iron and copper transport in yeast and its relevance to human disease

1998 • 224 citations

The metallochaperone Atox1 plays a critical role in perinatal copper homeostasis

2001 • 220 citations

Isolation of a murine copper transporter gene, tissue specific expression and functional complementation of a yeast copper transport mutant

2000 • 198 citations

Null Mutation of the Murine ATP7B (Wilson Disease) Gene Results in Intracellular Copper Accumulation and Late-Onset Hepatic Nodular Transformation

1999 • 195 citations

Metalloregulation of FRE1 and FRE2Homologs in Saccharomyces cerevisiae

1998 • 194 citations

Copper transport and its alterations in Menkes and Wilson diseases

1997 • 186 citations

Negative Control of Heavy Metal Uptake by the Saccharomyces cerevisiae BSD2 Gene

1997 • 184 citations

The toxic milk mouse is a murine model of Wilson disease

1996 • 178 citations

Changes in Cu,Zn-Superoxide Dismutase, Cytochrome c Oxidase, Glutathione Peroxidase and Glutathione Transferase Activities in Copper-Deficient Mice and Rats

1991 • 177 citations

Iron Metabolism in Eukaryotes—Mars and Venus at It Again

1996 • 126 citations

The Fe(II) permease Fet4p functions as a low affinity copper transporter and supports normal copper trafficking in Saccharomyces cerevisiae

2000 • 126 citations

A Copper-sensing Transcription Factor Regulates Iron Uptake Genes in Schizosaccharomyces pombe

1999 • 119 citations

Neuropeptide amidation in Drosophila: separate genes encode the two enzymes catalyzing amidation.

1997 • 116 citations

Neuropeptide Amidation inDrosophila: Separate Genes Encode the Two Enzymes Catalyzing Amidation

1997 • 107 citations

IV. Wilson’s disease and Menkes disease

1999 • 81 citations

Intracellular Pathways of Copper Trafficking in Yeast and Humans

1999 • 77 citations

Characterization of the hCTR1 gene: Genomic organization, functional expression, and identification of a highly homologous processed gene

2000 • 67 citations

Persistent Regional Changes in Brain Copper, Cuproenzymes and Catecholamines Following Perinatal Copper Deficiency in Mice

1993 • 50 citations