Tenascin-C in development and disease: gene regulation and cell function

Geometric Control of Cell Life and Death

1997 • 4,614 citations

A gene complex controlling segmentation in Drosophila

1978 • 3,668 citations

Role of cell shape in growth control

1978 • 2,434 citations

ECM and Cell Surface Proteolysis: Regulating Cellular Ecology

1997 • 1,311 citations

Induction of Cell Migration by Matrix Metalloprotease-2 Cleavage of Laminin-5

1997 • 1,227 citations

Tenascin: an extracellular matrix protein involved in tissue interactions during fetal development and oncogenesis

1986 • 989 citations

The molecular elasticity of the extracellular matrix protein tenascin

1998 • 835 citations

The tenascin family of ECM glycoproteins: Structure, function, and regulation during embryonic development and tissue remodeling

2000 • 636 citations

Disruption of Angiogenesis by PEX, a Noncatalytic Metalloproteinase Fragment with Integrin Binding Activity

1998 • 618 citations

Tenascin: An Extracellular Matrix Protein Prominent in Specialized Embryonic Tissues and Tumors

1989 • 604 citations

Smooth muscle cell migration and matrix metalloproteinase expression after arterial injury in the rat.

1994 • 599 citations

The J1 glycoprotein—a novel nervous system cell adhesion molecule of the L2/HNK-1 family

1985 • 590 citations

Mice develop normally without tenascin.

1992 • 590 citations

Induction of tenascin in healing wounds.

1988 • 563 citations

Extracellular matrix remodelling and cellular differentiation

1999 • 512 citations

Structure of a Fibronectin Type III Domain from Tenascin Phased by MAD Analysis of the Selenomethionyl Protein

1992 • 500 citations

Extracellular matrix-dependent tissue-specific gene expression in mammary epithelial cells requires both physical and biochemical signal transduction.

1994 • 466 citations

Tenascin: cDNA cloning and induction by TGF-beta.

1988 • 453 citations

Regulation of extracellular matrix gene expression by mechanical stress

1999 • 425 citations

Two contrary functions of tenascin: Dissection of the active sites by recombinant tenascin fragments

1989 • 415 citations

Cytotactin, an extracellular matrix protein of neural and non-neural tissues that mediates glia-neuron interaction.

1985 • 391 citations

A hierarchy of ECM-mediated signalling regulates tissue-specific gene expression

1995 • 378 citations

Human glioma-mesenchymal extracellular matrix antigen defined by monoclonal antibody.

1983 • 370 citations

Vascular Matrix Metalloproteinase-2 Cleaves Big Endothelin-1 Yielding a Novel Vasoconstrictor

1999 • 365 citations

Tenascin–X deficiency is associated with Ehlers–Danlos syndrome

1997 • 353 citations

Regulation of Tenascin-C, a Vascular Smooth Muscle Cell Survival Factor that Interacts with the αvβ3 Integrin to Promote Epidermal Growth Factor Receptor Phosphorylation and Growth

1997 • 341 citations

Role of integrins in cellular responses to mechanical stress and adhesion

1997 • 335 citations

Suppression of apoptosis by basement membrane requires three-dimensional tissue organization and withdrawal from the cell cycle.

1996 • 333 citations

Affinity of integrins for damaged extracellular matrix: αvβ3 binds to denatured collagen type I through RGD sites

1992 • 326 citations

The solution structure of human epidermal growth factor

1987 • 322 citations

Chick myotendinous antigen. II. A novel extracellular glycoprotein complex consisting of large disulfide-linked subunits.

1984 • 315 citations

Elastase and matrix metalloproteinase inhibitors induce regression, and tenascin-C antisense prevents progression, of vascular disease

2000 • 305 citations

Site-restricted expression of cytotactin during development of the chicken embryo.

1986 • 302 citations

Growth factor activation of MAP kinase requires cell adhesion

1997 • 301 citations

Tenascin-X: a novel extracellular matrix protein encoded by the human XB gene overlapping P450c21B

1993 • 299 citations

Reversible unfolding of fibronectin type III and immunoglobulin domains provides the structural basis for stretch and elasticity of titin and fibronectin.

1994 • 294 citations

MHox: a mesodermally restricted homeodomain protein that binds an essential site in the muscle creatine kinase enhancer

1992 • 290 citations

Focal adhesion integrity is downregulated by the alternatively spliced domain of human tenascin [published erratum appears in J Cell Biol 1992 Feb;116(3):833]

1991 • 281 citations

A six-armed oligomer isolated from cell surface fibronectin preparations

1984 • 274 citations

Matrix metalloproteinases of vascular wall cells are increased in balloon-injured rat carotid artery

1994 • 270 citations

Forced unfolding of the fibronectin type III module reveals a tensile molecular recognition switch

1999 • 269 citations

Asymmetric expression in somites of cytotactin and its proteoglycan ligand is correlated with neural crest cell distribution.

1987 • 255 citations

The matrix metalloproteinase stromelysin-1 acts as a natural mammary tumor promoter

2000 • 255 citations

TGF beta in murine morphogenetic processes: the early embryo and cardiogenesis

1990 • 239 citations

Interaction of voltage-gated sodium channels with the extracellular matrix molecules tenascin-C and tenascin-R

1998 • 238 citations

Skin wounds and severed nerves heal normally in mice lacking tenascin-C.

1996 • 235 citations

Cell surface annexin II is a high affinity receptor for the alternatively spliced segment of tenascin-C.

1994 • 228 citations

The extracellular matrix ligands fibronectin and tenascin collaborate in regulating collagenase gene expression in fibroblasts.

1994 • 222 citations

Antibody-guided three-step therapy for high grade glioma with yttrium-90 biotin

1999 • 211 citations

Mitogenesis, cell migration, and loss of focal adhesions induced by tenascin-C interacting with its cell surface receptor, annexin II.

1996 • 208 citations

Induction of the Angiogenic Phenotype by Hox D3

1997 • 208 citations

Tenascin-R Is a Functional Modulator of Sodium Channel β Subunits

1999 • 207 citations

Focal Adhesion Kinase Mediates the Integrin Signaling Requirement for Growth Factor Activation of Map Kinase

1999 • 205 citations

Mechanotransduction of Rat Aortic Vascular Smooth Muscle Cells Requires RhoA and Intact Actin Filaments

1999 • 203 citations

A detailed structural model of cytotactin: protein homologies, alternative RNA splicing, and binding regions.

1989 • 198 citations

Cortical Neurons Require Otx1 for the Refinement of Exuberant Axonal Projections to Subcortical Targets

1999 • 196 citations

Tenascin-C, proliferation and subendothelial fibronectin in progressive pulmonary vascular disease.

1997 • 194 citations

Iodine-131-labeled antitenascin monoclonal antibody 81C6 treatment of patients with recurrent malignant gliomas: phase I trial results.

1998 • 193 citations

Regulation of extracellular matrix synthesis by mechanical stress

1996 • 189 citations

Amino acid sequence of mouse tenascin and differential expression of two tenascin isoforms during embryogenesis.

1991 • 186 citations

Epithelial induction of stromal tenascin in the mouse mammary gland: From embryogenesis to carcinogenesis

1988 • 186 citations

Rho Family Small G Proteins Play Critical Roles in Mechanical Stress–Induced Hypertrophic Responses in Cardiac Myocytes

1999 • 186 citations

Tenascin-C Is Induced With Progressive Pulmonary Vascular Disease in Rats and Is Functionally Related to Increased Smooth Muscle Cell Proliferation

1996 • 183 citations

Localization during development of alternatively spliced forms of cytotactin mRNA by in situ hybridization.

1990 • 179 citations

Modular Variations of the Human Major Histocompatibility Complex Class III Genes for Serine/Threonine Kinase RP, Complement Component C4, Steroid 21-Hydroxylase CYP21, and Tenascin TNX (the RCCX Module)

1999 • 176 citations

Tenascin-C expression by fibroblasts is elevated in stressed collagen gels.

1994 • 176 citations

A cDNA clone for cytotactin contains sequences similar to epidermal growth factor-like repeats and segments of fibronectin and fibrinogen.

1988 • 175 citations

Expression of different tenascin isoforms in normal, hyperplastic and neoplastic human breast tissues

1992 • 173 citations

Characterization of multiple adhesive and counteradhesive domains in the extracellular matrix protein cytotactin.

1992 • 173 citations

Transcript encoded on the opposite strand of the human steroid 21-hydroxylase/complement component C4 gene locus.

1989 • 164 citations

The chicken neural extracellular matrix molecule restrictin: Similarity with EGF-, fibronectin type III-, and fibrinogen-like motifs

1992 • 161 citations

Pulsatile Stretch Activates Mitogen-Activated Protein Kinase (MAPK) Family Members and Focal Adhesion Kinase (p125FAK) in Cultured Rat Cardiac Myocytes

1999 • 160 citations

Tenascin variants: differential binding to fibronectin and distinct distribution in cell cultures and tissues.

1991 • 160 citations

Gene knockouts of c-src, transforming growth factor beta 1, and tenascin suggest superfluous, nonfunctional expression of proteins.

1993 • 157 citations

Expression of Autoactivated Stromelysin-1 in Mammary Glands of Transgenic Mice Leads to a Reactive Stroma During Early Development

1998 • 152 citations

Participation of tenascin and transforming growth factor-beta in reciprocal epithelial-mesenchymal interactions of MCF7 cells and fibroblasts.

1989 • 150 citations

The tenascin-C knockout revisited

1999 • 149 citations

Functional mapping of cytotactin: proteolytic fragments active in cell-substrate adhesion.

1988 • 149 citations

Expression patterns of the paired-related homeobox genes MHox/Prx1 and S8/Prx2 suggest roles in development of the heart and the forebrain

1995 • 146 citations

Differential Effects of the Integrins α9β1, αvβ3, and αvβ6 on Cell Proliferative Responses to Tenascin

1996 • 141 citations

New Aspects of Stroma-Parenchyma Relations in Mammary Gland Differentiation

1991 • 140 citations

Restrictin: a chick neural extracellular matrix protein involved in cell attachment co-purifies with the cell recognition molecule F11

1991 • 139 citations

Transcriptional Profile of Mechanically Induced Genes in Human Vascular Smooth Muscle Cells

1999 • 136 citations

Mechanical Forces Induce Scar Remodeling

1999 • 133 citations

Regression of Hypertrophied Rat Pulmonary Arteries in Organ Culture Is Associated With Suppression of Proteolytic Activity, Inhibition of Tenascin-C, and Smooth Muscle Cell Apoptosis

1999 • 125 citations

Tenascin and extracellular matrix glycoproteins: from promotion to polarization of neurite growth in vitro

1993 • 124 citations

Activation of the cytotactin promoter by the homeobox-containing gene Evx-1.

1992 • 121 citations

prx-1 functions cooperatively with another paired-related homeobox gene,prx-2, to maintain cell fates within the craniofacial mesenchyme

1999 • 121 citations

Induction of human tenascin (neuronectin) by growth factors and cytokines: cell type-specific signals and signalling pathways

1994 • 119 citations

Induction of Tenascin-C in Cardiac Myocytes by Mechanical Deformation

1999 • 114 citations

Mechanical loading regulates tenascin-C expression in the osteotendinous junction

1999 • 110 citations

Mouse Ten-m/Odz Is a New Family of Dimeric Type II Transmembrane Proteins Expressed in Many Tissues

1999 • 110 citations

Conformation dependence of integrin-type II collagen binding: Inability of collagen peptides to support α2β1 binding, and mediation of adhesion to denatured collagen by a novel α5β1-fibronectin bridge

1994 • 109 citations

Glycosaminoglycans modulate fibronectin matrix assembly and are essential for matrix incorporation of tenascin-C

1997 • 109 citations

Tenascin-C Hexabrachion Assembly Is a Sequential Two-step Process Initiated by Coiled-coil α-Helices

1998 • 108 citations

Expression and cellular localization of glucose transporters (GLUT1, GLUT3, GLUT4) during differentiation of myogenic cells isolated from rat fœtuses

1994 • 106 citations

Pervasive conformational fluctuations on microsecond time scales in a fibronectin type III domain

1998 • 104 citations

Suppression of hematopoietic activity in tenascin-C-deficient mice

1998 • 103 citations

Induction of tenascin in rat arterial injury. Relationship to altered smooth muscle cell phenotype.

1991 • 102 citations

Induction of vascular smooth muscle cell tenascin-C gene expression by denatured type I collagen is dependent upon a β3 integrin-mediated mitogen-activated protein kinase pathway and a 122-base pair promoter element

1999 • 101 citations

The Fibrinogen-like Globe of Tenascin-C Mediates Its Interactions with Neurocan and Phosphacan/Protein-tyrosine Phosphatase-ζ/β

1997 • 98 citations

Proton NMR assignment and secondary structure of the cell adhesion type III module of fibronectin

1992 • 98 citations

Tenascin‐C Synthesis and Influence on Axonal Growth During Rat Cortical Development

1997 • 98 citations

Effects of collagenase-cleavage of type I collagen on α2β1 integrin-mediated cell adhesion

1998 • 96 citations

Tenascin-Y: a protein of novel domain structure is secreted by differentiated fibroblasts of muscle connective tissue.

1996 • 95 citations

Zebrafish tenascin-W, a new member of the tenascin family

1998 • 94 citations

Tenascin M r 220000 isoform expression correlates with corneal cell migration

1991 • 93 citations

Abnormal Behavior and Neurotransmissions of Tenascin Gene Knockout Mouse

1996 • 93 citations

Regulated Expression of the Ets-1 Transcription Factor in Vascular Smooth Muscle Cells In Vivo and In Vitro

1996 • 93 citations

Tenascin-C promotes healing of Habu-snake venom-induced glomerulonephritis: studies in knockout congenic mice and in culture.

1998 • 92 citations

Tenascin-C

1997 • 92 citations

Stimulation of tenascin expression in mesenchyme by epithelial-mesenchymal interactions.

1989 • 91 citations

Evidence for Combinatorial Variability of Tenascin-C Isoforms and Developmental Regulation in the Mouse Central Nervous System

1999 • 89 citations

Bergmann glial development in the mouse cerebellum as revealed by tenascin expression

1996 • 89 citations

Regulation of gene expression and cell function by extracellular matrix.

1993 • 85 citations

Backbone dynamics of homologous fibronectin type III cell adhesion domains from fibronectin and tenascin

1997 • 84 citations

Ets transcription factors cooperate with Sp1 to activate the human Tenascin-C promoter

1999 • 84 citations

TENASCIN EXPRESSION DURING WOUND HEALING IN HUMAN SKIN

1996 • 83 citations

Tenascin-C modulates tumor stroma and monocyte/macrophage recruitment but not tumor growth or metastasis in a mouse strain with spontaneous mammary cancer

1999 • 82 citations

Gene regulation of cell adhesion: a key step in neural morphogenesis1Published on the World Wide Web on 4 November 1997.1

1998 • 80 citations

Three-stranded α-fibrous proteins: the heptad repeat and its implications for structure

1991 • 79 citations

Homeodomain protein MHox and MADS protein myocyte enhancer-binding factor-2 converge on a common element in the muscle creatine kinase enhancer

1994 • 76 citations

The junction between cytokines and cell adhesion

1992 • 76 citations

Tenascin-c inhibits extracellular matrix-dependent gene expression in mammary epithelial cells: localization of active regions using recombinant tenascin fragments

1995 • 73 citations

Tenascin-C matrix assembly in oral squamous cell carcinoma

1998 • 73 citations

Concerted action of tenascin-C domains in cell adhesion, anti-adhesion and promotion of neurite outgrowth

1997 • 72 citations

Cell-Adhesive Responses to Tenascin-C Splice Variants Involve Formation of Fascin Microspikes

1997 • 70 citations

The c-Jun-Induced Transformation Process Involves Complex Regulation of Tenascin-C Expression†

1997 • 70 citations

Structure of the human hexabrachion (tenascin) gene.

1991 • 67 citations

Identification and characterization of the promoter for the cytotactin gene.

1990 • 67 citations

Myelination and behaviour of tenascin‐C null transgenic mice

1999 • 65 citations

A novel tenascin type III repeat is part of a complex of tenascin mRNA alternative splices

1993 • 65 citations

The Fibrinogen Globe of Tenascin-C Promotes Basic Fibroblast Growth Factor-induced Endothelial Cell Elongation

1999 • 61 citations

Cyclic GMP-dependent protein kinase is required for thrombospondin and tenascin mediated focal adhesion disassembly

1996 • 61 citations

Expression of Tenascin-C in Bones Responding to Mechanical Load

1997 • 59 citations

Tenascin-C Expression in the Cyst Wall and Fluid of Human Brain Tumors Correlates with Angiogenesis

1997 • 58 citations

Human Tenascin Gene

1995 • 57 citations

Cytotactin binding: inhibition of stimulated proliferation and intracellular alkalinization in fibroblasts.

1991 • 54 citations

DNA-binding specificity of the S8 homeodomain

1993 • 51 citations

Mechanical Forces: Their Effects on Cells and Tissues

1997 • 49 citations

Tenascin mRNA isoforms in the developing mouse brain

1994 • 48 citations

Patterns of paired-related homeobox genesPRX1 andPRX2 suggest involvement in matrix modulation in the developing chick vascular system

1998 • 47 citations

Multiple promoter elements differentially regulate the expression of the mouse tenascin gene

1997 • 43 citations

Binding properties of the human homeodomain protein OTX2 to a DNA target sequence

1999 • 42 citations

Structural and functional similarities between the promoters for mouse tenascin and chicken cytotactin.

1995 • 40 citations

The Human Homeodomain Protein OTX2 Binds to the Human Tenascin-C Promoter and Trans-Represses Its Activity in Transfected Cells

1997 • 37 citations

An Unequal Crossover between the RCCX Modules of the Human MHC Leading to the Presence of a <i>CYP21B</i> Gene and a Tenascin <i>TNXB/TNXA-RP2</i> Recombinant between <i>C4A</i> and <i>C4B</i> Genes in a Patient with Juvenile Rheumatoid Arthritis

1999 • 34 citations

Complete primary structure of porcine tenascin

1991 • 33 citations

Role for myelin-associated glycoprotein as a functional tenascin-R receptor

1999 • 32 citations

Homozygous deletion of the CYP21A-TNXA-RP2-C4B gene region conferring C4B deficiency associated with recurrent respiratory infections

1999 • 30 citations

Tyrosine Hydroxylase Activity and Its mRNA Level in Dopaminergic Neurons of Tenascin Gene Knockout Mouse

1997 • 30 citations

The sequential expression of tenascin mRNA in epithelium and mesenchyme during feather morphogenesis

1991 • 29 citations

Stimulation of human neuronectin secretion by brain-derived growth factors

1989 • 26 citations

Tenascin Expression and Angiogenesis in Breast Cancers

1999 • 25 citations

Rapid intracellular assembly of tenascin hexabrachions suggests a novel co-translational process

1995 • 25 citations

Identification of a cDNA clone specific for the oligodendrocyte‐derived repulsive extracellular matrix molecule J1‐160/180

1991 • 24 citations

Down-regulation of tenascin expression by antiprogestins during terminal differentiation of rat mammary tumors.

1992 • 22 citations

Effects of peptide vasoconstrictors on vessel structure.

1993 • 22 citations

Tenascin-Y, a Component of Distinctive Connective Tissues, Supports Muscle Cell Growth

1999 • 21 citations

Association of cell and substrate adhesion molecules with connexin43 during intramembranous bone formation.

1998 • 16 citations

Mhox and vertebrate skeletogenesis: The long and the short of it

1995 • 16 citations

rHox: A homeobox gene expressed in osteoblastic cells

1995 • 16 citations

Tenascin-Y in the Developing and Adult Avian Nervous System

1999 • 15 citations

Preprotachykinin A and cholecystokinin mRNAs in tenascin-gene knockout mouse brain

1997 • 14 citations

Reduced mRNA expression of neuropeptide Y in the limbic system of tenascin gene disrupted mouse brain

1998 • 14 citations

A Single Cysteine, Cys-64, Is Essential for Assembly of Tenascin-C Hexabrachions

1998 • 14 citations

Differential effects of cytotactin/tenascin fusion proteins on intracellular pH and cell morphology

1994 • 11 citations