Epigenetic Instability of Cytokine and Transcription Factor Gene Loci Underlies Plasticity of the T Helper 17 Cell Lineage

Chromatin Modifications and Their Function

2007 • 10,144 citations

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

2006 • 4,815 citations

Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

2005 • 4,573 citations

VISTA: computational tools for comparative genomics

2004 • 2,367 citations

Combinatorial patterns of histone acetylations and methylations in the human genome

2008 • 2,214 citations

Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

2008 • 1,695 citations

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

2008 • 1,544 citations

T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

2008 • 1,524 citations

Genome Regulation by Polycomb and Trithorax Proteins

2007 • 1,404 citations

Global Mapping of H3K4me3 and H3K27me3 Reveals Specificity and Plasticity in Lineage Fate Determination of Differentiating CD4+ T Cells

2009 • 1,098 citations

Late Developmental Plasticity in the T Helper 17 Lineage

2009 • 1,022 citations

Epigenetic control of T-helper-cell differentiation

2009 • 658 citations

Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells

2006 • 629 citations

REGULATION OF TH2 DIFFERENTIATION ANDIl4LOCUS ACCESSIBILITY

2006 • 625 citations

Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3− precursor cells in the absence of interleukin 10

2007 • 576 citations

The AP-1 transcription factor Batf controls TH17 differentiation

2009 • 568 citations

Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice

2009 • 545 citations

Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus

2009 • 521 citations

Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells

2008 • 498 citations

Interactions among the transcription factors Runx1, RORγt and Foxp3 regulate the differentiation of interleukin 17–producing T cells

2008 • 474 citations

An epigenetic view of helper T cell differentiation

2003 • 429 citations

Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells

2009 • 361 citations

Chromatin Remodeling of Interleukin-17 (IL-17)-IL-17F Cytokine Gene Locus during Inflammatory Helper T Cell Differentiation

2007 • 296 citations

Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-γ

2007 • 289 citations

IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype

2008 • 280 citations

DNase-chip: a high-resolution method to identify DNase I hypersensitive sites using tiled microarrays

2006 • 221 citations

The role of the nuclear hormone receptor RORγt in the development of lymph nodes and Peyer's patches

2003 • 193 citations

A Distal Conserved Sequence Element Controls Ifng Gene Expression by T Cells and NK Cells

2006 • 182 citations

Phenotype Switching by Inflammation-Inducing Polarized Th17 Cells, but Not by Th1 Cells

2008 • 153 citations

Th memory for interleukin-17 expression is stablein vivo

2008 • 152 citations

CCCTC-Binding Factor and the Transcription Factor T-bet Orchestrate T Helper 1 Cell-Specific Structure and Function at the Interferon-γ Locus

2009 • 143 citations

A Distal Enhancer in the Interferon-γ (IFN-γ) Locus Revealed by Genome Sequence Comparison

2004 • 137 citations

Evolutionarily conserved sequence elements that positively regulate IFN-γ expression in T cells

2004 • 134 citations

Histone hyperacetylated domains across the Ifng gene region in natural killer cells and T cells

2005 • 91 citations

Ebf1-mediated down-regulation of Id2 and Id3 is essential for specification of the B cell lineage

2009 • 86 citations

Pax5 determines B- versus T-cell fate and does not block early myeloid-lineage development

2003 • 62 citations

Mapping Regulatory Elements by DNaseI Hypersensitivity Chip (DNase-Chip)

2009 • 19 citations

Rapid receptor-proximal signaling assays for FcRγ-containing receptors

2005 • 2 citations