SNAP-23 Is Not Cleaved by Botulinum Neurotoxin E and Can Replace SNAP-25 in the Process of Insulin Secretion

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

SNAP receptors implicated in vesicle targeting and fusion

1993 • 3,220 citations

Coated Charcoal Immunoassay of Insulin

1965 • 3,018 citations

Mechanisms of intracellular protein transport

1994 • 2,280 citations

A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion

1993 • 1,893 citations

Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25

1993 • 1,200 citations

The identification of a novel synaptosomal-associated protein, SNAP-25, differentially expressed by neuronal subpopulations.

1989 • 819 citations

Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly.

1994 • 798 citations

The syntaxin family of vesicular transport receptors

1993 • 656 citations

Vesicle fusion from yeast to man

1994 • 635 citations

Specificity and regulation of a synaptic vesicle docking complex

1994 • 601 citations

Lysosomes Behave as Ca2+-regulated Exocytic Vesicles in Fibroblasts and Epithelial Cells

1997 • 520 citations

Cellubrevin is a ubiquitous tetanus-toxin substrate homologous to a putative synaptic vesicle fusion protein

1993 • 504 citations

Botulinum neurotoxins serotypes A and E cleave SNAP‐25 at distinct COOH‐terminal peptide bonds

1993 • 433 citations

Proteolysis of SNAP-25 by types E and A botulinal neurotoxins.

1994 • 428 citations

Identification of the nerve terminal targets of botulinum neurotoxin serotypes A, D, and E.

1993 • 417 citations

Insulin synthesis in a clonal cell line of simian virus 40-transformed hamster pancreatic beta cells.

1981 • 381 citations

Identification of a Novel Syntaxin- and Synaptobrevin/VAMP-binding Protein, SNAP-23, Expressed in Non-neuronal Tissues

1996 • 356 citations

Binding of the synaptic vesicle v-SNARE, synaptotagmin, to the plasma membrane t-SNARE, SNAP-25, can explain docked vesicles at neurotoxin-treated synapses

1997 • 309 citations

SNAP-25, a t-SNARE which binds to both syntaxin and synaptobrevin via domains that may form coiled coils.

1994 • 288 citations

Botulinum Neurotoxin C1 Cleaves both Syntaxin and SNAP-25 in Intact and Permeabilized Chromaffin Cells: Correlation with Its Blockade of Catecholamine Release

1996 • 252 citations

SNAP-25 is expressed in islets of Langerhans and is involved in insulin release.

1995 • 243 citations

VAMP-2 and cellubrevin are expressed in pancreatic beta-cells and are essential for Ca(2+)-but not for GTP gamma S-induced insulin secretion.

1995 • 223 citations

Common and distinct fusion proteins in axonal growth and transmitter release

1996 • 209 citations

Clostridial Neurotoxins and Substrate Proteolysis in Intact Neurons

1996 • 196 citations

Characterization of SNARE protein expression in beta cell lines and pancreatic islets.

1996 • 195 citations

Insulin-stimulated translocation of GLUT4 glucose transporters requires SNARE-complex proteins

1996 • 175 citations

Direct demonstration of insulin-induced GLUT4 translocation to the surface of intact cells by insertion of a c-myc epitope into an exofacial GLUT4 domain

1993 • 156 citations

Human cDNA clones encoding two different isoforms of the nerve terminal protein SNAP-25

1994 • 144 citations

Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits.

1995 • 130 citations

Ca2+ triggers massive exocytosis in Chinese hamster ovary cells.

1996 • 129 citations

Syndet is a novel SNAP-25 related protein expressed in many tissues

1997 • 110 citations

Inhibition of the Binding of SNAP-23 to Syntaxin 4 by Munc18c

1997 • 92 citations

A peptide that mimics the carboxy‐terminal domain of SNAP‐25 blocks Ca²⁺‐dependent exocytosis in chromaffin cells

1995 • 76 citations

Stimulus-response coupling in insulin-secreting HIT cells. Effects of secretagogues on cytosolic Ca2+, diacylglycerol, and protein kinase C activity.

1990 • 76 citations

Expression of Active Streptolysin O in Escherichia coli as a Maltose‐Binding‐Protein‐Streptolysin‐O Fusion Protein

1996 • 69 citations

Tissue Distribution of SNAP-23 and Its Subcellular Localization in 3T3-L1 Cells

1997 • 68 citations

The Effect of Botulinum Neurotoxins on the Release of Insulin from the Insulinoma Cell Lines HIT-15 and RINm5F

1995 • 65 citations

Role of syntaxin in mouse pancreatic beta cells

1995 • 63 citations

Botulinum Neurotoxin B Inhibits Insulin-Stimulated Glucose Uptake into 3T3-L1 Adipocytes and Cleaves Cellubrevin Unlike Type A Toxin Which Failed To Proteolyze the SNAP-23 Present

1997 • 54 citations

Identification of Two Isoforms of the Vesicle-Membrane Fusion Protein SNAP-23 in Human Neutrophils and HL-60 Cells

1997 • 52 citations

Inhibition of neurotransmitter release by clostridial neurotoxins correlates with specific proteolysis of synaptosomal proteins

1994 • 47 citations