Botulinum neurotoxins serotypes A and E cleave SNAP‐25 at distinct COOH‐terminal peptide bonds

SNAP receptors implicated in vesicle targeting and fusion

1993 • 3,220 citations

Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin

1992 • 1,792 citations

Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25

1993 • 1,200 citations

The identification of a novel synaptosomal-associated protein, SNAP-25, differentially expressed by neuronal subpopulations.

1989 • 819 citations

Extent of N-terminal methionine excision from Escherichia coli proteins is governed by the side-chain length of the penultimate amino acid.

1989 • 744 citations

Inhibition of axonal growth by SNAP-25 antisense oligonucleotides in vitro and in vivo

1993 • 440 citations

Identification of the nerve terminal targets of botulinum neurotoxin serotypes A, D, and E.

1993 • 417 citations

Botulinum Neurotoxin and Tetanus Toxin

1989 • 393 citations

Tetanus toxin action: Inhibition of neurotransmitter release linked to synaptobrevin proteolysis

1992 • 340 citations

The 25 kDa synaptosomal-associated protein SNAP-25 is the major methionine-rich polypeptide in rapid axonal transport and a major substrate for palmitoylation in adult CNS

1992 • 314 citations

Botulinum neurotoxin serotype F is a zinc endopeptidase specific for VAMP/synaptobrevin.

1993 • 300 citations

Tetanus toxin is a zinc protein and its inhibition of neurotransmitter release and protease activity depend on zinc.

1992 • 299 citations

Botulinum neurotoxin serotype F is a zinc endopeptidase specific for VAMP/synaptobrevin

1993 • 283 citations

Botulinum neurotoxins are zinc proteins.

1992 • 249 citations

Botulinum neurotoxins are zinc proteins.

1992 • 243 citations

Tetanus and botulism neurotoxins: a new group of zinc proteases

1993 • 233 citations

Separation, purification, partial characterization and comparison of the heavy and light chains of botulinum neurotoxin types A, B, and E.

1985 • 161 citations

Structure of the Chicken Gene for SNAP-25 Reveals Duplicated Exons Encoding Distinct Isoforms of the Protein

1993 • 115 citations

Expression of a conserved cell-type-specific protein in nerve terminals coincides with synaptogenesis.

1991 • 114 citations

Effect of pH on the interaction of botulinum neurotoxins A, B and E with liposomes

1989 • 70 citations

Novel targets and catalytic activities of bacterial protein toxins

1993 • 41 citations

Surface topography of histidine residues of tetanus toxin probed by immobilized-metal-ion affinity chromatography

1992 • 33 citations