Response of Saccharomyces cerevisiae to changes in external osmolarity

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1994 • 1,684 citations

Physiological and genetic responses of bacteria to osmotic stress

1989 • 1,433 citations

An Osmosensing Signal Transduction Pathway in Yeast

1993 • 1,252 citations

A two-component system that regulates an osmosensing MAP kinase cascade in yeast

1994 • 1,091 citations

A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf

1993 • 1,086 citations

Parallel signal processing among mammalian MAPKs

1995 • 1,015 citations

MAP kinase pathways in yeast: For mating and more

1995 • 1,009 citations

Protein disaggregation mediated by heat-shock protein Hspl04

1994 • 861 citations

PROKARYOTIC OSMOREGULATION: Genetics and Physiology

1991 • 779 citations

Activation of Yeast PBS2 MAPKK by MAPKKKs or by Binding of an SH3-Containing Osmosensor

1995 • 649 citations

GPD1, Which Encodes Glycerol-3-Phosphate Dehydrogenase, Is Essential for Growth under Osmotic Stress in Saccharomyces cerevisiae, and Its Expression Is Regulated by the High-Osmolarity Glycerol Response Pathway

1994 • 630 citations

An Osmosensing Signal Transduction Pathway in Mammalian Cells

1994 • 584 citations

Hsp104 is required for tolerance to many forms of stress.

1992 • 546 citations

GPD1, which encodes glycerol-3-phosphate dehydrogenase, is essential for growth under osmotic stress in Saccharomyces cerevisiae, and its expression is regulated by the high-osmolarity glycerol response pathway.

1994 • 539 citations

Trehalose in yeast, stress protectant rather than reserve carbohydrate

1990 • 537 citations

Crystal structure of the zeta isoform of the 14-3-3 protein

1995 • 516 citations

The HOG pathway controls osmotic regulation of transcription via the stress response element (STRE) of the Saccharomyces cerevisiae CTT1 gene.

1994 • 511 citations

Cloning and characterization of BCY1, a locus encoding a regulatory subunit of the cyclic AMP-dependent protein kinase in Saccharomyces cerevisiae.

1987 • 504 citations

The protein kinase C-activated MAP kinase pathway of Saccharomyces cerevisiae mediates a novel aspect of the heat shock response.

1995 • 498 citations

Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways

1995 • 473 citations

A Saccharomyces cerevisiae UAS element controlled by protein kinase A activates transcription in response to a variety of stress conditions.

1993 • 470 citations

Diversity in function and regulation of MAP kinase pathways

1994 • 469 citations

Physiology of Osmotolerance in Fungi

1992 • 449 citations

A Yeast Protein Similar to Bacterial Two-Component Regulators

1993 • 431 citations

Calcineurin-dependent growth control in Saccharomyces cerevisiae mutants lacking PMC1, a homolog of plasma membrane Ca2+ ATPases

1994 • 430 citations

Fps1, a yeast member of the MIP family of channel proteins, is a facilitator for glycerol uptake and efflux and is inactive under osmotic stress.

1995 • 418 citations

Stress signaling in yeast

1995 • 415 citations

Signal transduction in yeast

1994 • 385 citations

A Mechanosensitive Ion Channel in the Yeast Plasma Membrane

1988 • 382 citations

The role of trehalose synthesis for the acquisition of thermotolerance in yeast

1994 • 379 citations

A yeast mitogen-activated protein kinase homolog (Mpk1p) mediates signalling by protein kinase C.

1993 • 373 citations

Mutants in the S. cerevisiae PKC1 gene display a cell cycle-specific osmotic stability defect.

1992 • 371 citations

A novel P‐type ATPase from yeast involved in sodium transport

1991 • 362 citations

The protein phosphatase calcineurin is essential for NaCl tolerance of Saccharomyces cerevisiae.

1994 • 362 citations

Dual system for potassium transport in Saccharomyces cerevisiae

1984 • 341 citations

Stress-induced transcriptional activation

1995 • 325 citations

Dominant Mutations in a Gene Encoding a Putative Protein Kinase (BCKT) Bypass the Requirement for a Saccharomyces cerevisiae Protein Kinase C Homolog

1992 • 322 citations

MKK1 and MKK2, Which Encode Saccharomyces cerevisiae Mitogen-Activated Protein Kinase-Kinase Homologs, Function in the Pathway Mediated by Protein Kinase C

1993 • 306 citations

Yeast has homologs (CNA1 and CNA2 gene products) of mammalian calcineurin, a calmodulin-regulated phosphoprotein phosphatase.

1991 • 297 citations

An Ancient Developmental Induction: Heat-Shock Proteins Induced in Sporulation and Oogenesis

1986 • 294 citations

TRK1 encodes a plasma membrane protein required for high-affinity potassium transport in Saccharomyces cerevisiae.

1988 • 291 citations

Protein phosphatase type 2B (calcineurin)-mediated, FK506-sensitive regulation of intracellular ions in yeast is an important determinant for adaptation to high salt stress conditions.

1993 • 274 citations

14-3-3 proteins on the MAP

1995 • 255 citations

Isoforms of 14‐3‐3 protein can form homo‐ and heterodimers in vivo and in vitro: implications for function as adapter proteins

1995 • 254 citations

Regulatory subunit (CNB1 gene product) of yeast Ca2+/calmodulin-dependent phosphoprotein phosphatases is required for adaptation to pheromone.

1992 • 244 citations

A synthetic lethal screen identifies SLK1, a novel protein kinase homolog implicated in yeast cell morphogenesis and cell growth.

1992 • 235 citations

The osmotic integrity of the yeast cell requires a functional PKC1 gene product.

1992 • 229 citations

Disruption of TPS2, the gene encoding the 100‐kDa subunit of the trehalose‐6‐phosphate synthase/phosphatase complex in Saccharomyces cerevisiae, causes accumulation of trehalose‐6‐phosphate and loss of trehalose‐6‐phosphate phosphatase activity

1993 • 225 citations

Two Homologous Zinc Finger Genes Identified by Multicopy Suppression in a SNF1 Protein Kinase Mutant of Saccharomyces cerevisiae

1993 • 218 citations

Stress response of yeast

1993 • 211 citations

The Saccharomyces cerevisiae HSP12 Gene Is Activated by the High-Osmolarity Glycerol Pathway and Negatively Regulated by Protein Kinase A

1995 • 207 citations

Differential expression of two genes encoding isoforms of the ATPase involved in sodium efflux in Saccharomyces cerevisiae

1993 • 206 citations

A novel and conserved salt-induced protein is an important determinant of salt tolerance in yeast.

1992 • 203 citations

The SLT2 (MPK1) MAP kinase homolog is involved in polarized cell growth in Saccharomyces cerevisiae.

1993 • 197 citations

A protein kinase gene complements the lytic phenotype of Saccharomyces cerevisiae lyt2 mutants

1991 • 197 citations

Counteractive roles of protein phosphatase 2C (PP2C) and a MAP kinase kinase homolog in the osmoregulation of fission yeast.

1995 • 192 citations

A novel gene, STT4, encodes a phosphatidylinositol 4-kinase in the PKC1 protein kinase pathway of Saccharomyces cerevisiae.

1994 • 191 citations

Calcineurin, the Ca²⁺/Calmodulin-Dependent Protein Phosphatase, Is Essential in Yeast Mutants with Cell Integrity Defects and in Mutants That Lack a Functional Vacuolar H⁺-Atpase

1995 • 189 citations

HSP12, a new small heat shock gene of Saccharomyces cerevisiae: Analysis of structure, regulation and function

1990 • 187 citations

MKK1 and MKK2, which encode Saccharomyces cerevisiae mitogen-activated protein kinase-kinase homologs, function in the pathway mediated by protein kinase C.

1993 • 187 citations

Dominant mutations in a gene encoding a putative protein kinase (BCK1) bypass the requirement for a Saccharomyces cerevisiae protein kinase C homolog.

1992 • 181 citations

Identification of cis and trans Components of a Novel Heat Shock Stress Regulatory Pathway in Saccharomyces cerevisiae

1993 • 180 citations

TheSaccharomyces cerevisiae genes (CMP1 andCMP2) encoding calmodulin-binding proteins homologous to the catalytic subunit of mammalian protein phosphatase 2B

1991 • 179 citations

cDNA cloning of MAP kinase kinase reveals kinase cascade pathways in yeasts to vertebrates.

1993 • 179 citations

Deletion of SNF1 affects the nutrient response of yeast and resembles mutations which activate the adenylate cyclase pathway.

1991 • 168 citations

Two homologous zinc finger genes identified by multicopy suppression in a SNF1 protein kinase mutant of Saccharomyces cerevisiae.

1993 • 162 citations

Osmoregulation in Saccharomyces cerevisiae Studies on the osmotic induction of glycerol production and glycerol 3‐phosphate dehydrogenase (NAD⁺)

1991 • 158 citations

The 14‐3‐3 Proteins Encoded by the BMH1 and BMH2 Genes are Essential in the Yeast Saccharomyces cerevisiae and Can be Replaced by a Plant Homologue

1995 • 156 citations

Cloning of two related genes encoding the 56-kDa and 123-kDa subunits of trehalose synthase from the yeast Saccharomyces cerevisiae

1993 • 156 citations

Activity of the yeast MAP kinase homologue Slt2 is critically required for cell integrity at 37° C

1993 • 149 citations

Ca2+ Transport in Saccharomyces Cerevisiae

1994 • 149 citations

Identification of cis and trans components of a novel heat shock stress regulatory pathway in Saccharomyces cerevisiae.

1993 • 146 citations

The PPZ Protein Phosphatases Are Important Determinants of Salt Tolerance in Yeast Cells

1995 • 145 citations

Characterization of the yeast (1-->6)-beta-glucan biosynthetic components, Kre6p and Skn1p, and genetic interactions between the PKC1 pathway and extracellular matrix assembly.

1994 • 141 citations

Yap1p, a yeast transcriptional activator that mediates multidrug resistance, regulates the metabolic stress response.

1994 • 132 citations

Regulation of a yeast HSP70 gene by a cAMP responsive transcriptional control element.

1990 • 127 citations

A pair of functionally redundant yeast genes (PPZ1 and PPZ2) encoding type 1-related protein phosphatases function within the PKC1-mediated pathway.

1993 • 127 citations

Characterization of the yeast BMH1 gene encoding a putative protein homologous to mammalian protein kinase II activators and protein kinase C inhibitors

1992 • 127 citations

Sequential activation of Raf-1 kinase, mitogen-activated protein (MAP) kinase kinase, MAP kinase, and S6 kinase by hyperosmolality in renal cells.

1994 • 116 citations

Osmostress‐induced changes in yeast gene expression

1992 • 115 citations

Osmostress response of the yeast Saccharomyces

1993 • 111 citations

TRK2 is required for low affinity K+ transport in Saccharomyces cerevisiae.

1990 • 108 citations

Activation of CLN1 and CLN2 G₁ Cyclin Gene Expression by BCK2

1995 • 108 citations

Glucose induces cAMP-independent growth-related changes in stationary-phase cells of Saccharomyces cerevisiae.

1991 • 100 citations

Isobutylmethylxanthine stimulates adenylate cyclase by blocking the inhibitory regulatory protein, Gi.

1988 • 99 citations

Genes that can bypass the CLN requirement for Saccharomyces cerevisiae cell cycle START.

1994 • 97 citations

Genetic basis of sodium exclusion and sodium tolerance in yeast. A model for plants

1993 • 96 citations

cDNA cloning of a calcineurin B homolog in Saccharomyces cerevisiae

1991 • 95 citations

Genetic interactions among genes involved in the STT4-PKC1 pathway of Saccharomyces cerevisiae

1994 • 92 citations

The PPZ protein phosphatases are involved in the maintenance of osmotic stability of yeast cells

1993 • 83 citations

The correlative evidence suggesting that trehalose stabilizes membrane structure in the yeast Saccharomyces cerevisiae.

1995 • 74 citations

MAP kinase activation during heat shock in quiescent and exponentially growing mammalian cells

1993 • 73 citations

The yeast and mammalian Ras pathways control transcription of heat shock genes independently of heat shock transcription factor.

1994 • 72 citations

A pair of functionally redundant yeast genes (PPZ1 and PPZ2) encoding type 1-related protein phosphatases function within the PKC1-mediated pathway.

1993 • 71 citations

Mutations in LIS1 (ERG6) gene confer increased sodium and lithium uptake in Saccharomyces cerevisiae

1994 • 67 citations

The hypo-osmolarity-sensitive phenotype of the Saccharomyces cerevisiae hpo2 mutant is due to a mutation in PKC1, which regulates expression of β-glucanase

1994 • 63 citations

Evolutionary implications of the family of 14-3-3 brain protein homologs in Arabidopsis thaliana

1994 • 58 citations

Na+-ATPases and Na+/H+ antiporters in fungi

1994 • 54 citations

The Yak1 protein kinase of Saccharomyces cerevisiae moderates thermotolerance and inhibits growth by an Sch9 protein kinase-independent mechanism.

1994 • 53 citations

SLK1, a yeast homolog of MAP kinase activators, has a RAS/cAMP-independent role in nutrient sensing

1994 • 48 citations

The mechanism of sodium efflux in yeast

1982 • 40 citations

Isolation and characterization of osmosensitive vacuolar mutants of Saccharomyces cerevisiae

1991 • 34 citations

Biochemical characterization of recombinant yeast PPZ1, a protein phosphatase involved in salt tolerance

1995 • 29 citations

HOL1 mutations confer novel ion transport in Saccharomyces cerevisiae.

1990 • 26 citations

STT10, a novel class-D VPS yeast gene required for osmotic integrity related to the PKC1/STT1 protein kinase pathway

1995 • 21 citations

Calmodulin-dependent protein kinase II and calmodulin are required for induced thermotolerance in Saccharomyces cerevisiae

1995 • 21 citations

Epitopes of Bordetella pertussis lipopolysaccharides as potential markers for typing of isolates with monoclonal antibodies

1996 • 20 citations

Nobel for oncogenes

1989 • 3 citations