Lysophosphatidylcholine induces apoptotic and non-apoptotic death in vascular smooth muscle cells: in comparison with oxidized LDL

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

THE DISTRIBUTION AND CHEMICAL COMPOSITION OF ULTRACENTRIFUGALLY SEPARATED LIPOPROTEINS IN HUMAN SERUM

1955 • 8,846 citations

A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

1995 • 5,208 citations

Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.

1989 • 1,914 citations

Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids.

1984 • 1,631 citations

The smooth muscle cell in culture

1979 • 1,546 citations

Kinetics of cellular proliferation after arterial injury. I. Smooth muscle growth in the absence of endothelium.

1983 • 1,441 citations

Minimally modified low density lipoprotein stimulates monocyte endothelial interactions.

1990 • 930 citations

Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cells.

1992 • 828 citations

Apoptosis in Human Atherosclerosis and Restenosis

1995 • 684 citations

Evidence for apoptosis in advanced human atheroma. Colocalization with interleukin-1 beta-converting enzyme.

1995 • 643 citations

Low density lipoprotein cytotoxicity induced by free radical peroxidation of lipid.

1983 • 623 citations

Lipoprotein oxidation and lipoprotein-induced cytotoxicity.

1983 • 545 citations

Evidence for apoptosis in human atherogenesis and in a rat vascular injury model.

1995 • 484 citations

Modification of human serum low density lipoprotein by oxidation — Characterization and pathophysiological implications

1987 • 400 citations

Why do plaques rupture?

1992 • 385 citations

High-Glucose–Triggered Apoptosis in Cultured Endothelial Cells

1995 • 342 citations

Oxidized low density lipoproteins cause contraction and inhibit endothelium-dependent relaxation in the pig coronary artery.

1990 • 312 citations

Evidence for the Rapid Onset of Apoptosis in Medial Smooth Muscle Cells After Balloon Injury

1997 • 282 citations

Biochemical and cytotoxic characteristics of an in vivo circulating oxidized low density lipoprotein (LDL-).

1994 • 280 citations

Oxygen-mediated heterogeneity of apo-low-density lipoprotein.

1978 • 276 citations

The relationship between coronary artery lesions and myocardial infarcts: Ulceration of atherosclerotic plaques precipitating coronary thrombosis

1977 • 275 citations

Minimally modified low density lipoprotein is biologically active in vivo in mice.

1991 • 212 citations

Dietary probucol preserves endothelial function in cholesterol-fed rabbits by limiting vascular oxidative stress and superoxide generation.

1995 • 202 citations

Lysophosphatidylcholine plays an essential role in the mitogenic effect of oxidized low density lipoprotein on murine macrophages.

1994 • 196 citations

Effects of native and oxidized low density lipoproteins on formation and inactivation of endothelium-derived relaxing factor.

1991 • 190 citations

Cytotoxicity of oxidized LDL to porcine aortic smooth muscle cells is associated with the oxysterols 7-ketocholesterol and 7-hydroxycholesterol.

1994 • 190 citations

Lysophosphatidylcholine concentrations and metabolism in aortic intima plus inner media: effect of nutritionally induced atherosclerosis

1969 • 181 citations

Contrary Effects of Lightly and Strongly Oxidized LDL With Potent Promotion of Growth Versus Apoptosis on Arterial Smooth Muscle Cells, Macrophages, and Fibroblasts

1996 • 178 citations

Cell death in human atherosclerotic plaques involves both oncosis and apoptosis

1997 • 169 citations

FOAM CELL APOPTOSIS AND THE DEVELOPMENT OF THE LIPID CORE OF HUMAN ATHEROSCLEROSIS

1996 • 169 citations

Effects of lysolipids and oxidatively modified low density lipoprotein on endothelium-dependent relaxation of rabbit aorta.

1993 • 145 citations

Oxysterols Induced Apoptosis in Cultured Smooth Muscle Cells through CPP32 Protease Activation and bcl-2 Protein Downregulation

1996 • 145 citations

Oxidized Low Density Lipoprotein and Lysophosphatidylcholine Stimulate Cell Cycle Entry in Vascular Smooth Muscle Cells

1996 • 142 citations

Lysophosphatidylcholine increases vascular superoxide anion production via protein kinase C activation.

1994 • 139 citations

The binding of lysophospholipids to rat liver fatty acid-binding protein and albumin

1994 • 137 citations

Induction by Lysophosphatidylcholine, a Major Phospholipid Component of Atherogenic Lipoproteins, of Human Coronary Artery Smooth Muscle Cell Migration

1998 • 128 citations

Lysophosphatidylcholine Promotes P-Selectin Expression in Platelets and Endothelial Cells

1996 • 127 citations

Lipoxygenase-mediated transformation of human low density lipoprotein to an oxidized and cytotoxic complex.

1991 • 123 citations

Necrosis and apoptosis induced by oxidized low density lipoproteins occur through two calcium‐dependent pathways in lymphoblastoid cells

1994 • 120 citations

Oxidized low density lipoprotein inhibits the migration of aortic endothelial cells in vitro.

1993 • 115 citations

Oxidized LDL Induces Apoptosis in Cultured Smooth Muscle Cells: A Possible Role for 7-Ketocholesterol

1996 • 115 citations

Roles of multiple oxidized LDL lipids in cellular injury: dominance of 7 beta-hydroperoxycholesterol

1996 • 100 citations

Transitional features in human atherosclerosis. Intimal thickening, cholesterol clefts, and cell loss in human aortic fatty streaks.

1993 • 96 citations

Apoptosis of vascular smooth muscle cells in atherosclerosis

1998 • 94 citations

Active Oxygen Species and Lysophosphatidylcholine Are Involved in Oxidized Low Density Lipoprotein Activation of Smooth Muscle Cell DNA Synthesis

1996 • 78 citations

High-glucose--triggered apoptosis in cultured endothelial cells

1995 • 78 citations

Protective role of glutathione synthesis in response to oxidized low density lipoprotein in human vascular endothelial cells

1999 • 56 citations

Effects of amphiphiles on erythrocytes, coronary arteries, and perfused hearts

1981 • 45 citations

Toxicity of oxidized low density lipoproteins for vascular smooth muscle cells and partial protection by antioxidants

1995 • 43 citations

Involvement of lipoproteins, free radicals, and calcium in cardiovascular disease processes.

1995 • 41 citations

Lysophosphatidylcholine causes cGMP-dependent verapamil-sensitive Ca2+ influx in vascular smooth muscle cells

1993 • 31 citations

Involvement of lipoproteins, free radicals, and calcium in cardiovascular disease processes

1995 • 30 citations

Migration of vascular smooth muscle cells is enhanced in cultures derived from spontaneously hypertensive rat

1997 • 29 citations

Lipoperoxidative injury to macrophages by oxidatively modified low density lipoprotein may play an important role in foam cell formation

1996 • 27 citations

ADP-ribosylation factors, 20,000 Mr guanine nucleotide-binding protein activators of cholera toxin and components of intracellular vesicular transport systems

1993 • 26 citations

Mildly Oxidized LDL Evokes a Sustained Ca ²⁺ -Dependent Retraction of Vascular Smooth Muscle Cells

1996 • 26 citations

Interaction of lysophosphatidylcholine with aortic endothelial cells

1992 • 25 citations

Lipoprotein-like Phospholipid Particles Inhibit the Smooth Muscle Cell Cytotoxicity of Lysophosphatidycholine and Platelet-Activating Factor

1998 • 25 citations

Oxidized LDLs But Not Native LDLs Augment Ba2+ Currents Through L-Type Ca2+ Channels of the A7r5 Smooth Muscle-Derived Cell Line

1997 • 5 citations

P107 Oxidized low density lipoprotein (OXLDL) and lysophosphatidylcholine (lysoPC) could induce apoptosis of cultured vascular smooth muscle cells (VSMC)

1998 • 1 citations