The Toxicology of Molecular Oxygen

Superoxide Dismutase

1969 • 12,578 citations

Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a Convenient Assay for Superoxide Dismutase

1974 • 9,660 citations

The Role of Superoxide Anion in the Autoxidation of Epinephrine and a Simple Assay for Superoxide Dismutase

1972 • 8,501 citations

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

Biological Defense Mechanisms. THE PRODUCTION BY LEUKOCYTES OF SUPEROXIDE, A POTENTIAL BACTERICIDAL AGENT

1973 • 2,955 citations

LXXIII.—Oxidation of tartaric acid in presence of iron

1894 • 2,887 citations

Fenton's reagent revisited

1975 • 2,778 citations

Oxygen-Dependent Microbial Killing by Phagocytes

1978 • 2,519 citations

The catalytic decomposition of hydrogen peroxide by iron salts

1934 • 2,483 citations

Free Radicals in Biology

1976 • 1,879 citations

The aging process.

1981 • 1,871 citations

Inhibition of nitrite formation from hydroxylammoniumchloride: A simple assay for superoxide dismutase

1976 • 1,664 citations

Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria

1980 • 1,609 citations

Oxidation of tartaric acid in presence of iron

1894 • 1,515 citations

Superoxide radical inhibits catalase.

1982 • 1,274 citations

Effect of covalent attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver catalase.

1977 • 1,239 citations

Superoxide radicals in feline intestinal ischemia

1981 • 1,213 citations

The Reduction of Cytochrome c by Milk Xanthine Oxidase

1968 • 1,201 citations

The Generation of Superoxide Radical during the Autoxidation of Hemoglobin

1972 • 1,162 citations

Oxygen radicals mediate endothelial cell damage by complement-stimulated granulocytes. An in vitro model of immune vascular damage.

1978 • 1,117 citations

Free Radicals and Inflammation: Protection of Synovial Fluid by Superoxide Dismutase

1974 • 1,109 citations

An Enzyme-Based Theory of Obligate Anaerobiosis: The Physiological Function of Superoxide Dismutase

1971 • 979 citations

Role of superoxide dismutase in cancer: a review.

1979 • 976 citations

Glutathione: Metabolism and function

1978 • 971 citations

Oxygen Poisoning and X-irradiation: A Mechanism in Common

1954 • 917 citations

The Generation of Hydrogen Peroxide, Superoxide Radical, and Hydroxyl Radical by 6-Hydroxydopamine, Dialuric Acid, and Related Cytotoxic Agents

1974 • 894 citations

Superoxide Dismutase

1973 • 887 citations

Superoxide‐dependent production of hydroxyl radical catalyzed by iron—EDTA complex

1978 • 876 citations

Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria

1977 • 854 citations

Interaction of bovine erythrocyte superoxide dismutase with hydrogen peroxide. Inactivation of the enzyme

1975 • 777 citations

Ischemic injury in the cat small intestine: Role of superoxide radicals

1982 • 771 citations

Superoxide and Superoxide Dismutases

1978 • 754 citations

Human copper-containing superoxide dismutase of high molecular weight.

1982 • 751 citations

Superoxide‐dependent formation of hydroxyl radicals in the presence of iron chelates

1978 • 748 citations

Electronic spectra, photochemistry, and autoxidation mechanism of the sulfite-bisulfite-pyrosulfite systems. SO2-, SO3-, SO4-, and SO5- radicals

1972 • 715 citations

Oxygen Activation and Oxygen Toxicity

1982 • 713 citations

A Mechanism for the Production of Ethylene from Methional

1970 • 668 citations

Role of ubiquinone in the mitochondrial generation of hydrogen peroxide

1976 • 656 citations

Inhibition of the iron-catalysed formation of hydroxyl radicals from superoxide and of lipid peroxidation by desferrioxamine

1979 • 637 citations

Free radicals and inflammation: superoxide-dependent activation of a neutrophil chemotactic factor in plasma.

1980 • 628 citations

Superoxide radicals as precursors of mitochondrial hydrogen peroxide

1974 • 627 citations

Intracellular production of superoxide radical and of hydrogen peroxide by redox active compounds

1979 • 595 citations

Role of hydrogen peroxide in neutrophil-mediated destruction of cultured endothelial cells.

1981 • 587 citations

Generation of Superoxide Free Radical during the Autoxidation of Thiols

1974 • 558 citations

Oxygen and oxy‐radicals in chemistry and biology

1982 • 557 citations

Superoxide Dismutase from Escherichia coli B

1970 • 551 citations

Do Mitochondria Produce Oxygen Radicals in vivo?

1978 • 530 citations

Extreme Prematurity and Fibroblastic Overgrowth of Persistent Vascular Sheath Behind Each Crystalline Lens* *From the Massachusetts Eye and Ear Infirmary. This investigation is made possible through the Special Fund for Research for Pathology Laboratory.

1942 • 530 citations

Production of formaldehyde during metabolism of dimethyl sulfoxide by hydroxyl radical-generating systems

1981 • 498 citations

Superoxide-dependent formation of hydroxyl radicals in the presence of iron salts. Detection of ‘free’ iron in biological systems by using bleomycin-dependent degradation of DNA

1981 • 469 citations

Mechanism of the disproportionation of superoxide radicals

1977 • 466 citations

Superoxide dismutase and pulmonary oxygen toxicity

1974 • 462 citations

In vivo inhibition of superoxide dismutase in mice by diethyldithiocarbamate.

1976 • 457 citations

The effect of hyperoxia on superoxide production by lung submitochondrial particles

1982 • 442 citations

Superoxide dismutase in extracellular fluids

1982 • 434 citations

DNA strand scission by enzymically generated oxygen radicals

1981 • 428 citations

The Univalent Reduction of Oxygen by Reduced Flavins and Quinones

1972 • 418 citations

The scavenging of superoxide radical by manganous complexes: In vitro

1982 • 416 citations

Mitochondrial Production of Superoxide Radical and Hydrogen Peroxide

1977 • 415 citations

Cleavage of double helical DNA by methidium-propyl-EDTA-iron(II)

1982 • 403 citations

Isozymes of superoxide dismutase from wheat germ

1973 • 403 citations

Mitochondrial production of superoxide anions and its relationship to the antimycin insensitive respiration

1975 • 403 citations

Regulation of the synthesis of superoxide dismutase in Escherichia coli. Induction by methyl viologen.

1977 • 396 citations

The Structure of Biological Membranes

1976 • 393 citations

Low oxygen concentration extends the lifespan of cultured human diploid cells

1977 • 387 citations

Superoxide dismutase: correlation with life-span and specific metabolic rate in primate species.

1980 • 385 citations

Defective Superoxide Production by Granulocytes from Patients with Chronic Granulomatous Disease

1974 • 375 citations

Manganese and Defenses against Oxygen Toxicity in Lactobacillus plantarum

1981 • 367 citations

Hydrogen peroxide metabolism in human monocytes during differentiation in vitro.

1981 • 361 citations

Mechanism of the antibiotic action pyocyanine

1980 • 350 citations

On the Stability of Bovine Superoxide Dismutase

1973 • 348 citations

Lactoferrin enhances hydroxyl radical production by human neutrophils, neutrophil particulate fractions, and an enzymatic generating system.

1981 • 338 citations

The use of acetylated ferricytochrome C for the detection of superoxide radicals produced in biological membranes

1975 • 333 citations

Reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent formation and breakdown of hydrogen peroxide during mixed function oxidation reactions in liver microsomes

1975 • 330 citations

Induction of Superoxide Dismutase by Molecular Oxygen

1973 • 321 citations

A pulse radiolysis study of superoxide dismutase

1972 • 321 citations

Manganese, superoxide dismutase, and oxygen tolerance in some lactic acid bacteria

1981 • 319 citations

Univalent Reduction of Molecular Oxygen by Spinach Chloroplasts on Illumination

1974 • 301 citations

Superoxide radical and the oxygen enhancement of the toxicity of paraquat in Escherichia coli.

1978 • 298 citations

A role for ferrous ion and oxygen in the degradation of DNA by bleomycin

1976 • 291 citations

Superoxide‐dependent formation of hydroxyl radicals in the presence of iron salts

1983 • 289 citations

Hepatic Aldehyde Oxidase

1962 • 287 citations

Paraquat and Escherichia coli. Mechanism of production of extracellular superoxide radical.

1979 • 285 citations

Hydrogen peroxide kills Staphylococcus aureus by reacting with staphylococcal iron to form hydroxyl radical.

1981 • 280 citations

Generation of Hydroxyl Radical by Enzymes, Chemicals, and Human Phagocytes In Vitro

1979 • 280 citations

Pattern of hydroxyl radical addition to uracil and methyl- and carboxyl-substituted uracils. Electron transfer of hydroxyl adducts with N,N,N',N'-tetramethyl-p-phenylenediamine and tetranitromethane

1981 • 279 citations

Superoxide dismutases from a blue-green alga, Plectonema boryanum.

1975 • 279 citations

Oxygen-mediated heterogeneity of apo-low-density lipoprotein.

1978 • 276 citations

Oxygen Toxicity and the Superoxide Dismutase

1973 • 273 citations

Mutagenicity of oxygen free radicals.

1982 • 270 citations

Mutation Caused by Human Phagocytes

1981 • 264 citations

Free radicals and inflammation. Protection of phagocytosine leukocytes by superoxide dismutase.

1975 • 264 citations

Enzymatic defenses against the toxicity of oxygen and of streptonigrin in Escherichia coli

1977 • 263 citations

Evidence for hydroxyl radical production by human neutrophils.

1977 • 257 citations

DNA Strand Breakage in Human Leukocytes Exposed to a Tumor Promoter, Phorbol Myristate Acetate

1982 • 255 citations

Kinetics of the interaction of perhydroxyl and superoxide radicals with hydrogen peroxide. The Haber-Weiss reaction

1979 • 255 citations

Pulse radiolytic investigations of superoxide catalyzed disproportionation. Mechanism for bovine superoxide dismutase

1973 • 252 citations

Characteristics of the cofactor requirements for the superoxide-generating NADPH oxidase of human polymorphonuclear leukocytes

1981 • 251 citations

Alloxan-induced diabetes—evidence for hydroxyl radical as a cytotoxic intermediate

1976 • 249 citations

SUPEROXIDE RADICALS, SUPEROXIDE DISMUTASES and OXYGEN TOXICITY IN PLANTS

1983 • 223 citations

Direct demonstration of superoxide anion production during the oxidation of reduced flavin and of its catalytic decomposition by erythrocuprein

1969 • 223 citations

The oxidation of phenylhydrazine: superoxide and mechanism

1976 • 221 citations

Bovine Erythrocyte Superoxide Dismutase

1974 • 220 citations

Superoxide-dependent formation of hydroxyl radicals and lipid peroxidation in the presence of iron salts. Detection of ‘catalytic’ iron and anti-oxidant activity in extracellular fluids

1982 • 216 citations

Superoxide‐dependent formation of hydroxyl radicals in the presence of thiol compounds

1982 • 214 citations

Electrostatic interactions in the reaction mechanism of bovine erythrocyte superoxide dismutase.

1982 • 213 citations

The Generation of Superoxide Radical during the Autoxidation of Ferredoxins

1971 • 209 citations

Superoxide dismutase, catalase and scavengers of hydroxyl radical protect against the toxic action of alloxan on pancreatic islet cells in vitro

1979 • 206 citations

Tumour promoter phorbol-12-myristate-13-acetate induces chromosomal damage via indirect action

1981 • 205 citations

Biological defense mechanisms. Evidence for the participation of superoxide in bacterial killing by xanthine oxidase.

1975 • 202 citations

Biochemical and medical aspects of active oxygen

1977 • 199 citations

Free-radical damage to lipids, amino acids, carbohydrates and nucleic acids determined by thiobarbituric acid reactivity

1982 • 197 citations

Chemical and biochemical aspects of superoxide and superoxide dismutase

1981 • 197 citations

Dimethyl sulfoxide prevents DNA nicking mediated by ionizing radiation or iron/hydrogen peroxide-generated hydroxyl radical.

1981 • 192 citations

Human granulocyte generation of hydroxyl radical.

1978 • 191 citations

The involvement of hydroxyl radical derived from hydrogen peroxide in lignin degradation by the white rot fungus Phanerochaete chrysosporium.

1982 • 186 citations

Melanin photoreactions in aerated media: Electron spin resonance evidence for production of superoxide and hydrogen peroxide

1978 • 184 citations

Isolation and characterization of a manganese-containing superoxide dismutase from yeast.

1975 • 183 citations

Increased DNA chain breakage by combined action of bleomycin and superoxide radical

1975 • 183 citations

Subcellular Location of Superoxide Dismutase in Spinach Leaves and Preparation and Properties of Crystalline Spinach Superoxide Dismutase

1973 • 182 citations

A quantitative test for superoxide radicals produced in biological systems

1982 • 182 citations

The role of superoxide and hydroxyl radicals in the degradation of hyaluronic acid induced by metal ions and by ascorbic acid

1981 • 180 citations

Superoxide formation in spinach chloroplasts: Electron spin resonance detection by spin trapping

1975 • 179 citations

Biological protection by superoxide dismutase

1973 • 179 citations

Copper‐dependent hydroxyl radical damage to ascorbic acid

1982 • 176 citations

[26] Indoleamine 2,3-dioxygenase

1987 • 176 citations

Superoxide Dismutase and Oxygen Toxicity in a Eukaryote

1974 • 173 citations

Isolation of a new copper — Containing superoxide dismutase bacteriocuprein

1974 • 172 citations

Rat-Liver Superoxide Dismutase. Purification and Age-Related Modifications

1976 • 170 citations

Influence of Mitochondrial Radical Formation on Energy‐Linked Respiration

1978 • 168 citations

Comparison of the capacities of the perhydroxyl and the superoxide radicals to initiate chain oxidation of linoleic acid

1981 • 168 citations

Superoxide dismutase is a prophylactic against alloxan diabetes

1981 • 166 citations

Comparison of the effects of hydrogen peroxide and X-ray irradiation on toxicity, mutation, and DNA damage/repair in mammalian cells (V-79)

1981 • 163 citations

Synthesis of either Fe- or Mn-superoxide dismutase with an apparently identical protein moiety by an anaerobic bacterium dependent on the metal supplied.

1982 • 161 citations

Superoxide dismutase activities of an iron porphyrin and other iron complexes

1979 • 161 citations

The Rate of Oxidation of Sulfite Ions by Oxygen

1941 • 161 citations

Oxidation of arachidonic acid in micelles by superoxide and hydrogen peroxide.

1981 • 160 citations

Inhibition of Alloxan Action in Isolated Pancreatic Islets by Superoxide Dismutase, Catalase, and a Metal Chelator

1980 • 159 citations

Oxygen production by endosymbiotic algae controls superoxide dismutase activity in their animal host

1982 • 159 citations

Distribution of Iron-Containing Superoxide Dismutase in Vascular Plants

1981 • 158 citations

Superoxide Dismutase and Oxygen Metabolism inStreptococcus faecalisand Comparisons with Other Organisms

1978 • 156 citations

Generation of superoxide anion as a source of hydrogen peroxide in a reconstituted monooxygenase system

1978 • 155 citations

The O2–producing enzyme of human neutrophils. Further properties.

1981 • 153 citations

The oxidation of tiron by superoxide anion. Kinetics of the reaction in aqueous solution and in chloroplasts

1975 • 153 citations

Evidence for hydroxyl radical generation by human Monocytes.

1977 • 152 citations

Inhibition of superoxide dismutases by azide

1978 • 149 citations

Oxygen species in paraquat toxicity: the crypto‐OH radical

1981 • 149 citations

Superoxide dismutase in anaerobic bacteria of clinical significance

1977 • 148 citations

The sites of superoxide anion generation in higher plant mitochondria

1978 • 148 citations

Reaction of iron-EDTA chelates with the superoxide radical

1982 • 146 citations

THE IMPORTANCE OF IRON IN RHEUMATOID DISEASE

1981 • 145 citations

Mechanisms of Oxidation with Oxygen

1965 • 144 citations

Superoxide dismutase and the oxygen enhancement of radiation lethality

1976 • 140 citations

Induction of superoxide dismutase by oxygen in neonatal rat lung.

1977 • 138 citations

Generation of a chemotactic lipid from arachidonic acid by exposure to a superoxide-generating system

1980 • 134 citations

The mechanism of the oxidation of ascorbate and Mn2+ by chloroplasts: The role of the radical superoxide

1973 • 134 citations

Arrangement of the respiratory burst oxidase in the plasma membrane of the neutrophil.

1981 • 133 citations

The Use of Heavy Oxygen in the Study of Reactions of Hydrogen Peroxide¹

1952 • 133 citations

Isolation and characterization of the iron-containing superoxide dismutase of Methanobacterium bryantii

1981 • 131 citations

The Purification and Properties of Superoxide Dismutase from Neurospora crassa

1972 • 129 citations

Radioprotective effect of superoxide dismutase on model phospholipid membranes

1976 • 129 citations

Effects of Oxygen on Acetylene Reduction, Cytochrome Content and Respiratory Activity of Azotobacter chroococcum

1970 • 128 citations

Superoxide dismutase in some obligately anaerobic bacteria

1975 • 127 citations

The superoxide dismutase activity of iron complexes

1975 • 127 citations

Effect of acute ethanol intoxication on the content of reduced glutathione of the liver in relation to its lipoperoxidative capacity in the rat

1980 • 126 citations

Superoxide Dismutase in the Rat and Mouse as a Function of Age and Longevity

1976 • 125 citations

Catalytic mechanism of the manganese-containing superoxide dismutase of Escherichia coli studied by pulse radiolysis

1974 • 123 citations

Role of iron and ethylenediaminetetraacetic acid in the bactericidal activity of a superoxide anion-generating system

1981 • 123 citations

An active intermediate formed in the reaction of bleomycin-Fe(II) complex with oxygen.

1981 • 122 citations

Ethylene formation by polymorphonuclear leukocytes. Role of myeloperoxidase.

1978 • 121 citations

Inactivation of biologically active DNA by γ-ray-induced superoxide radicals and their dismutation products singlet molecular oxygen and hydrogen peroxide

1975 • 119 citations

Stopped flow spectrophotometric observation of superoxide dismutation in aqueous solution

1976 • 118 citations

Isolation and characterization of the cytosolic and mitochondrial superoxide dismutases of maize

1981 • 117 citations

Regulation of Superoxide Dismutase Activity by Dietary Manganese

1980 • 116 citations

An attempt to demonstrate a reaction between superoxide and hydrogen peroxide

1976 • 116 citations

Optical measurement of the catalase-hydrogen peroxide intermediate (Compound I) in the liver of anaesthetized rats and its implication to hydrogen peroxide production in situ

1975 • 116 citations

Indoleamine 2,3-dioxygenase. Characterization and properties of enzyme. O2- complex.

1977 • 115 citations

Microsomal metabolism of hydroxyl radical scavenging agents: Relationship to the microsomal oxidation of alcohols

1980 • 113 citations

Unique aspects of the modulation of human neutrophil function by 12-L-hydroperoxy-5,8,10,14-eicosatetraenoic acid

1980 • 112 citations

Effect of β-lapachone on superoxide anion and hydrogen peroxide production in Trypanosoma cruzi

1978 • 112 citations

Superoxide dismutase and glutathione peroxidase activities in tumors

1977 • 110 citations

Superoxide production and electron transport in mitochondrial oxidation of dihydroorotic acid

1975 • 109 citations

Evidence for a natural gene transfer from the ponyfish to its bioluminescent bacterial symbiont Photobacter leiognathi. The close relationship between bacteriocuprein and the copper-zinc superoxide dismutase of teleost fishes.

1981 • 109 citations

Generation of the Superoxide Radical during Autoxidation of Oxymyoglobin

1976 • 108 citations

The purification and properties of superoxide dismutase from Saccharomyces cerevisiae

1972 • 108 citations

Chemical modification of arginine at the active site of the bovine erythrocyte superoxide dismutase

1979 • 107 citations

On the formation of the superoxide anion radical during the reaction of reduced iron-sulfur proteins with oxygen

1969 • 105 citations

Neutrophil-mediated methemoglobin formation in the erythrocyte. The role of superoxide and hydrogen peroxide.

1982 • 105 citations

Production of superoxide radicals by soluble hydrogenase from Alcaligenes eutrophus H16

1981 • 104 citations

Hypoxia and oxygen toxicity.

1979 • 103 citations

Effects of superoxide radicals on myoblast growth and differentiation

1974 • 102 citations

Sequence Homologies Among Bacterial and Mitochondrial Superoxide Dismutases

1973 • 101 citations

Superoxide Dismutase in the Anaerobic Flagellates, Tritrichomonas foetus and Monocercomonas sp

1974 • 101 citations

Molecular mechanisms of binding and single-strand scission of DNA by the antitumor antibiotics saframycins A and C

1982 • 100 citations

Suppression by superoxide dismutase of immune-complex--induced pulmonary alveolitis and dermal inflammation.

1981 • 100 citations

Mating behavior, physical activity and aging in the housefly, Musca domestica

1973 • 98 citations

Copper-zinc superoxide dismutase from Caulobacter crescentus CB15. A novel bacteriocuprein form of the enzyme.

1982 • 98 citations

Regulation of superoxide dismutase synthesis in Escherichia coli: glucose effect

1977 • 97 citations

Myeloperoxidase of the leukocyte of normal blood III. The reaction of ferric myeloperoxidase with superoxide anion

1972 • 97 citations

Oxygen toxicity in the newborn. The effect of chronic continuous 100 percent oxygen exposure on the lungs of newborn mice.

1976 • 97 citations

An attempt to evaluate the rate of the haber‐weiss reaction by using ·OH radical scavengers

1977 • 96 citations

Production of bactericidal concentrations of hydrogen peroxide by Streptococcus sanguis

1973 • 95 citations

Superoxide Dismutase Activity of Normal Murine Liver, Regenerating Liver, and H6 Hepatoma<xref ref-type="fn" rid="FN2">2</xref>

1978 • 94 citations

Inhibition by superoxide dismutase of methemoglobin formation from oxyhemoglobin.

1976 • 94 citations

The chloroplast at work a review of modern developments in our understanding of chloroplast metabolism

1979 • 93 citations

Distinguishing between Mn-containing and Fe-containing superoxide dismutases in crude extracts of cells

1980 • 93 citations

A pulse-radiolysis study of the catalytic mechanism of the iron-containing superoxide dismutase from Photobacterium leiognathi

1977 • 92 citations

Superoxide lon as the cause of the oxygen effect.

1976 • 91 citations

Chemical Evidence for Production of Hydroxyl Radicals During Microsomal Electron Transfer

1979 • 90 citations

Lipid peroxidation and paraquat toxicity

1979 • 90 citations

Enhanced production of hydroxyl radicals by the xanthine-xanthine oxidase reaction in the presence of lactoferrin

1982 • 90 citations

A new method for the detection of hydroxyl radical production by phagocytic cells

1980 • 89 citations

Isolation and characterization of a manganese-containing superoxide dismutase from rat liver

1978 • 89 citations

Ethylene from 2-keto-4-thiomethyl butyric acid: The Haber-Weiss reaction

1980 • 88 citations

Oxidation by superoxide of tocopherols dispersed in aqueous media with deoxycholate

1980 • 88 citations

Mitochondria and plastids as endosymbionts: a revival of special creation?

1974 • 87 citations

Superoxide, hydrogen peroxide, and oxygen toxicity in two free-living nematode species

1983 • 87 citations

The apparent production of superoxide and hydroxyl radicals by hematoporphyrin and light as seen by spin‐trapping

1980 • 85 citations

Superoxide and hydrogen peroxide production and NADPH oxidation stimulated by nitrofurantoin in lung microsomes: Possible implications for toxicity

1979 • 85 citations

Superoxide anion as a mediator of drug-induced oxidative hemolysis.

1976 • 84 citations

Fifth Stenhouse‐Williams Memorial Lecture Oxygen and the Obligate Anaerobe

1976 • 83 citations

Catalytic Mechanism of Cytochrome Oxidase

1970 • 83 citations

Evidence for the production of hydroxyl radicals from the adriamycin semiquinone and H₂O₂

1981 • 83 citations

Relationship between superoxide dismutase and pathogenic mechanisms of Listeria monocytogenes

1979 • 82 citations

Antitumor Effect of a Copper Coordination Compound With Superoxide Dismutase-Like Activity2

1981 • 82 citations

Ferric and manganic superoxide dismutases in Euglena gracilis

1979 • 81 citations

Protection of Post-irradiated Mice by Superoxide Dismutase

1976 • 80 citations

Tetrahydropterin Oxidation without Hydroxylation Catalyzed by Rat Liver Phenylalanine Hydroxylase

1973 • 80 citations

Are physiological oxygen concentrations mutagenic?

1978 • 79 citations

Superoxide Dismutase from Thermus aquaticus

1977 • 76 citations

Superoxide dismutase activity of copper-penicillamine: Possible involvement of Cu(I) stabilized sulphur radical

1977 • 75 citations

Changes with age in copper and superoxide dismutase levels in brains of C57BL/6J mice

1979 • 74 citations

Oxygen toxicity in Streptococcus sanguis. The relative importance of superoxide and hydroxyl radicals.

1982 • 74 citations

Physiological function of superoxide dismutase in glucose-limited chemostat cultures of Escherichia coli

1977 • 74 citations

Relationship between Metabolic Rate, Aging, Lipid Peroxidation, and Fluorescent Age Pigment in Milkweed Bug, Oncopeltus fasciatus (Hemiptera)

1982 • 73 citations

Effects of vitamin E, ascorbic acid and mannitol on alloxan-induced lipid peroxidation in rats

1982 • 73 citations

Phagocyte-Produced Free Radicals: Roles in Cytotoxicity and Inflammation

2008 • 72 citations

Effects of Reducing and Oxidizing Agents on the Action of Bleomycin1

1975 • 71 citations

The damaging action of hydrogen peroxide on DNA of human fibroblasts is mediated by a non-dialyzable compound

1980 • 70 citations

Stimulus-specific deactivation of chemotactic factor-induced cyclic AMP response and superoxide generation by human neutrophils.

1980 • 69 citations

A new oxygenase, 2-nitropropane dioxygenase of Hansenula mrakii. Enzymologic and spectrophotometric properties.

1976 • 69 citations

Bovine Erythrocyte Superoxide Dismutase

1974 • 68 citations

Identification of free hydroxyl radicals in respiring rat heart mitochondria by spin trapping with the nitrone DMPO

1981 • 68 citations

Superoxide dismutase: An enzyme system for the study of micronutrient interactions in plants

1978 • 67 citations

The mechanism of cytochrome P-450-dependent oxidation of ethanol in reconstituted membrane vesicles.

1981 • 67 citations

The Effects of Methyl Viologen on Gloeocapsa sp. LB795 and Their Relationship to the Inhibition of Acetylene Reduction (Nitrogen Fixation) by Oxygen

1979 • 67 citations

Effect of acute ethanol ingestion on lipoperoxidation and on the activity of the enzymes related to peroxide metabolism in rat liver

1980 • 67 citations

OXYGEN POISONING

1945 • 67 citations

Superoxide Ion as the Cause of the Oxygen Effect

1976 • 66 citations

Superoxide dismutase activity of macrocyclic polyamine complexes

1981 • 65 citations

Dissociation of microsomal oxygen reduction and lipid peroxidation with the electron acceptors, paraquat and menadione

1979 • 64 citations

Superoxide involvement in the bactericidal effects of negative air ions on Staphylococcus albus

1979 • 64 citations

EPR studies on reduction of oxygen to superoxide by some biochemical systems

1969 • 63 citations

Lethal action and metabolic effects of streptonigrin on Escherichia coli.

1968 • 62 citations

The role of superoxide in xanthine oxidase-induced autooxidation of linoleic acid.

1982 • 62 citations

Deoxyribonucleic acid-protein and deoxyribonucleic acid interstrand crosslinks induced in isolated chromatin by hydrogen peroxide and ferrous ethylenediaminetetraacetate chelates

1982 • 60 citations

Nonenzymatic hydroxylations of proline and lysine by reduced oxygen derivatives

1981 • 60 citations

The Role of Oxygen-Derived Free Radicals in Radiation-Induced Damage and Death of Nondividing Eucaryotic Cells

1980 • 59 citations

Intracellular utilization of superoxide anion by indoleamine 2,3-dioxygenase of rabbit enterocytes.

1977 • 59 citations

A COMPARATIVE STUDY OF HYPERBARIC OXYGENINDUCED AND DRUG‐INDUCED CONVULSIONS WITH PARTICULAR REFERENCE TO γ‐AMINOBUTYRIC ACID METABOLISM*

1966 • 58 citations

Assignment of the Murine Interferon Sensitivity and Cytoplasmic Superoxide Dismutase Genes to Chromosome 16

1980 • 58 citations

The generation of superoxide anion in the reaction of tetrahydropteridines with molecular oxygen

1975 • 58 citations

MUTAGENIC EFFECTS OF HIGH OXYGEN TENSIONS ON ESCHERICHIA COLI

1957 • 56 citations

Radioprotection of bone marrow stem cells by superoxide dismutase

1975 • 56 citations

Hepatic microsomal dealkylations. Inhibition by a tyrosine-copper (II) complex provided with superoxide dismutase activity.

1977 • 55 citations

A two-step mechanism for the photosynthetic reduction of oxygen by ferredoxin

1975 • 55 citations

The relationship of oxygen uptake to electron transport in photosystem I of isolated chloroplasts: The role of superoxide and ascorbate

1974 • 54 citations

Identification of malondialdehyde as the TBA‐reactant formed by bleomycin‐iron free radical damage to DNA

1979 • 54 citations

Altered sensitivity to oxygen toxicity.

1977 • 52 citations

Spin trap evidence for production of superoxide radical anions by purified NADPH-cytochrome P-450 reductase

1981 • 51 citations

The radiolysis of aqueous solutions of cysteine in the presence of oxygen

1974 • 51 citations

The effect of dietary fatty acids on the composition of adult rat lung lipids: Relationship to oxygen toxicity

1978 • 51 citations

Superoxide dismutase and O2 lethality in Bacteroides fragilis

1979 • 50 citations

Oxygen toxicity in the newborn

1974 • 50 citations

Longevity and protein intake

1968 • 49 citations

Light‐dependent ethylene production by isolated chloroplasts

1974 • 49 citations

A reaction of the superoxide radical with tetrapyrroles

1982 • 48 citations

A new iron-containing superoxide dismutase from Escherichia coli.

1978 • 48 citations

Kinetic study by pulse radiolysis of the lactate dehydrogenase-catalyzed chain oxidation of nicotinamide adenine dinucleotide by HO2 and O2-RADICALS.

1975 • 48 citations

Mitochondrial Formation of OH˙ Radicals by an Ubisemiquinone-Dependent Reaction An Alternative Pathway to the Iron-Catalysed Haber-Weiss Cycle

1982 • 46 citations

Absence of superoxide dismutase in some strains of Neisseria gonorrhoeae

1979 • 45 citations

Chromosome instability in human and murine autoimmune disease: anticlastogenic effect of superoxide dismutase.

1980 • 44 citations

Role of hydroxyl radicals in the iron-ethylenediaminetetraacetic acid mediated stimulation of microsomal oxidation of ethanol

1980 • 44 citations

The utilization of copper and its role in the biosynthesis of copper-containing proteins in the fungus, Dactylium dendroides

1978 • 44 citations

The effect of superoxide dismutase and catalase on radiation-induced chromosome breaks

2009 • 44 citations

Nitrofuran enhancement of microsomal electron transport, superoxide anion production and lipid peroxidation

1981 • 44 citations

Factors influencing the induction of sister chromatid exchanges in mammalian cells by 12-O-tetradecanoyl-phorbol-13-acetate

1981 • 43 citations

Mycoplasma pneumoniae: A prokaryote which consumes oxygen and generates superoxide but which lacks superoxide dismutase

1980 • 43 citations

Superoxide production by purified hamster hepatic nuclei.

1980 • 43 citations

Superoxide production by an unusual aldehyde oxidase in guinea pig granulocytes. Characterization and cytochemical localization.

1981 • 42 citations

Antioxidant Defenses

1981 • 40 citations

Superoxide anion production by liver microsomes from phenobarbital treated rat

1978 • 40 citations

Gas-phase reactions. 29. Thioacrolein

1982 • 39 citations

Establishment of the interferon-mediated antiviral state: possible role of superoxide dismutase.

1981 • 38 citations

Epinephrine and Neurogenic Factors in the Pulmonary Edema and CNS Reactions Induced by O₂ at High Pressure

1955 • 38 citations

Superoxide and hydrogen peroxide production in cyanide resistant Arum maculatum mitochondria

1978 • 38 citations

Superoxide Dismutases in Photosynthetic Organisms

1976 • 37 citations

Diet and life extension in animal model systems

1978 • 36 citations

The unlikelihood of an electron-transfer (Haber-Weiss) reaction between superoxide and peroxides

1979 • 36 citations

Antimycin‐ and cyanide‐resistant respiration and superoxide anion production in fresh and aged potato tuber mitochondria

1978 • 35 citations

Aniline is hydroxylated by the cytochrome P-450-dependent hydroxyl radical-mediated oxygenation mechanism

1982 • 34 citations

Enzymic formation of glycolate in Chromatium. Role of superoxide radical in a transketolase-type mechanism

1977 • 34 citations

Superoxide dismutase in Bacteroides fragilis and related Bacteroides species

1977 • 33 citations

Purification et propriétés de la superoxyde dismutase du champignon Pleurotus olearius

1974 • 32 citations

Bacteriocine-Like Activity of Group-A Streptococci Due to the Production of Peroxide

1974 • 32 citations

Purification and characterization of a manganese containing superoxide dismutase from bovine heart mitochondria

1978 • 32 citations

OXYGEN POISONING

1945 • 32 citations

A protective function of superoxide dismutase during respiratory chain activity

1975 • 30 citations

Inhibitors of superoxide dismutases: A cautionary tale

1980 • 30 citations

Relationship between fluorescent age pigment, physiological age and physical activity in the housefly, Musca domestica

1981 • 30 citations

The Photochemical Addition of Hydrogen Peroxide to the Double Bond

1937 • 30 citations

Putative superoxide dismutase activity of iron-EDTA: A reexamination

1980 • 29 citations

Coupled oxidation of NADPH with thiols at neutral pH

1978 • 29 citations

RESISTANCE TO HIGH OXYGEN TENSION, STREPTONIGRIN, AND ULTRAVIOLET IRRADIATION IN THE GREEN ALGA CHLORELLA SOROKINIANA STRAIN ORS

1974 • 28 citations

Autoxidation of soluble trypsin-cleaved microsomal ferrocytochrome b5 and formation of superoxide radicals

1976 • 28 citations

Pyridoxalphosphate‐dependent ethylene production from methionine by isolated chloroplasts

1976 • 28 citations

Ageing of Neurospora crassa. VIII. Lethality and mutagenicity of ferrous ions, ascorbic acid, and malondialdehyde

1979 • 28 citations

PHOTOGENERATION OF SUPEROXIDE ION and HYDROGEN PEROXIDE FROM TRYPTOPHAN and ITS PHOTOOXIDATION PRODUCTS: THE ROLE OF 3a‐HYDROPEROXYPYRROLIDINOINDOLE*

1982 • 27 citations

Pulmonary Oxygen Toxicity

1981 • 27 citations

An inducible iron-containing superoxide dismutase in Rhizobium japonicum

1981 • 26 citations

Superoxide dismutase, catalase, and glutathione peroxidase in the swim bladder of the physoclistous fish, Opsanus tau L

1981 • 26 citations

A Flash-Photometric Method for Determination of Reactivity of Superoxide: Application to Superoxide Dismutase Assay

1982 • 26 citations

A Simple and Effective Method for Homolysis with a Hypoxanthine-Xanthine Oxidase System and Alteration of Erythrocyte Phospholipid Composition during the Hemolysis

1981 • 25 citations

A High Molecular Weight Dihydro-orotate Dehydrogenase of Neurosporu crassa. Purification and Properties of the Enzyme

1975 • 25 citations

The reaction of superoxide anion radical with electron poor olefins

1977 • 24 citations

Alloxan and H2O2 action on glucose metabolism in cultured fibroblasts. Generation of oxygen-containing free radicals as a mechanism of alloxan action.

1981 • 24 citations

Inhibition of the microsomal oxidation of ethanol and 1-butanol by the free-radical, spin-trapping agent 5,5-dimethyl-1-pyrroline-1-oxide

1980 • 24 citations

Studies on Aggregated Multienzyme Systems

1972 • 23 citations

Does copper-d-penicillamine catalyze the dismutation of O2−?

1980 • 23 citations

Stoichiometric Studies on the Oxidation of Tetrahydropterin with Ferri-Cytochrome c

1978 • 23 citations

Paraquat toxicity and pulmonary superoxide dismutase: an enzymic deficiency of lung microsomes.

1977 • 22 citations

Tissue antioxidant status and related enzymes in rats with long-term vitamin E deficiency.

1980 • 20 citations

Continuous monitoring of oxygen consumption and superoxide production by particle‐stimulated human polymorphonuclear leukocytes

1980 • 20 citations

Role of superoxide radical in the autoxidation of cytochrome c

1975 • 19 citations

Enzyme response of cultured endothelial cells to hyperoxia.

1981 • 19 citations

Chemical and physical differentiation of superoxide dismutases in anaerobes

1980 • 19 citations

The production of hydroxyl radical by tallysomycin and copper(II)

1979 • 18 citations

Effect of Hyperbaric Oxygen on Aerobic Bacteria in vitro and in vivo.

1967 • 18 citations

Some Effects of Oxygen on the Physiology of Selenomonas ruminantium WPL 151/1 Grown in Continuous Culture

1982 • 18 citations

Effect of superoxide dismutase on the chromosomal instability of New Zealand black mice

1981 • 18 citations

Inhibition of iron-stimulated catecholamine degradation by the iron-chelators DETAFAC and Desferal

1981 • 17 citations

Mutagenicity of low molecular substances in various superoxide generation systems.

1981 • 17 citations

Analytical subcellular fractionation of rabbit alveolar macrophages with particular reference to the subcellular localisation of pyridine nucleotide-dependent superoxide-generating systems and superoxide dismutase

1980 • 17 citations

Biochemical Aspects of Oxygen Toxicity in the Metazoa

1981 • 16 citations

Production of superoxide anion by an nadph‐oxidase from rat pulmonary macrophages

1980 • 16 citations

Oxygen and „strictly anaerobic” intestinal bacteria II. Oxygen metabolism in strictly anaerobic bacteria

1978 • 16 citations

Toxicity of Hyperbaric Oxygen to Bacteria in Relation to the Cell Cycle and Catalase Synthesis

1968 • 16 citations

Effect of oxygen on the cyanobacterium Oscillatoria limnetica

1979 • 15 citations

A comparative study of oxygen toxicity in the retina, brain and liver of the teleost, amphibian and mammal

1973 • 14 citations

Cytosol superoxide dismutase from swordfish (Xiphias gladius L.) liver

1977 • 14 citations

Potential endogenous mutagens/carcinogens

1980 • 14 citations

Superoxide dismutase and catalase activities in normal and cancerous tissues

1981 • 13 citations

Mutagenicity of Low Molecular Substances in Various Superoxide Generating Systems

1981 • 12 citations

Electron Spin Resonance Studies on the Oxidation of Rifamycin SV Catalyzed by Metal Ions

1982 • 11 citations

An examination of the role of gamma-aminobutyric acid (GABA) in hyperbaric oxygen-induced convulsions in the rat. I. Effects of increased gamma-aminobutyric acid and protective agents.

1974 • 11 citations

Central nervous system toxicity of hyperbaric oxygen-effects of light, norepinephrine depletion and beta-adrenergic blockade☆

1977 • 10 citations

Unusual interaction of iron-bleomycin with cyanide

1980 • 10 citations

Effect of phagocytosis on superoxide anion production and superoxide dismutase levels in BCG-activated and normal rabbit alveolar macrophages.

1978 • 9 citations

Hyperbaric oxygen toxicity and ribosome destruction in Escherichia coli K12

1981 • 9 citations

Purification of superoxide dismutases from Mycobacterium phlei.

1975 • 9 citations

Reactivities of Enzymes toward Hydroxyl Radicals

1974 • 8 citations

⁶⁰Co-Gamma radiolysis of cysteine in aerated solutions at pH 5.5-6.0

1974 • 8 citations

The generation of the superoxide radical by 2-amino-4-hydroxy-6,7-dimethyl-5,6,7,8-tetrahydropteridine (DMPH4)

1975 • 8 citations

Albumin synthesis and catabolism following partial hepatectomy in the rat. The effects of amino acids and adrenocortical steroids on albumin synthesis after partial hepatectomy

1975 • 7 citations

Superoxide dismutase activity in Vibrio el tor in relation to oxygen toxicity and bactericidal action of nitrofurantoin.

1979 • 6 citations

The effects of interactions between sodium ascorbate and superoxide radicals generated by hypoxanthine and xanthine oxidase on 3T3 cells

1980 • 6 citations

Some clinical and laboratory studies of chemical radiosensitizers.

1957 • 5 citations

Effects of scavengers of superoxide radicals, hydrogen peroxide, singlet oxygen and hydroxyl radicals on malondialdehyde generation from arachidonic acid by bovine seminal vesicle microsomes

1980 • 5 citations

A manganese and iron-containing superoxide dismutase from Rhodococcus bronchialis.

1980 • 4 citations

Sensitivity to and site of oxygen poisoning in Escherichia coli

1979 • 4 citations

GENERATION AND PARTICIPATION OF O^‐₂ IN 2‐NITROPROPANE DIOXYGENASE REACTION

1978 • 4 citations

Oxygen Tension in the Clinical Situation

1981 • 3 citations

Effects of superoxide dismutase on cholesterol 7?-hydroxylation in swine

1980 • 3 citations

Effects of high oxygen pressures on adrenalectomized, treated and untreated rats.

1954 • 2 citations