Oxygen toxicity and reactive oxygen metabolites in mammals

Superoxide Dismutase

1969 • 12,578 citations

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

Biology of disease: free radicals and tissue injury.

1982 • 3,078 citations

The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

1973 • 2,608 citations

The Concentration of Oxygen Dissolved in Tissues at the Time of Irradiation as a Factor in Radiotherapy

1953 • 2,102 citations

Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts

1986 • 2,052 citations

Protein damage and degradation by oxygen radicals. I. general aspects.

1987 • 1,618 citations

Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria

1980 • 1,609 citations

The Generation of Superoxide Radical during the Autoxidation of Hemoglobin

1972 • 1,162 citations

Quantitative Aspects of the Production of Superoxide Anion Radical by Milk Xanthine Oxidase

1970 • 1,037 citations

Oxy-Radicals and Related Species: Their Formation, Lifetimes, and Reactions

1986 • 958 citations

Oxygen Poisoning and X-irradiation: A Mechanism in Common

1954 • 917 citations

Protein damage and degradation by oxygen radicals. II. Modification of amino acids.

1987 • 840 citations

Hyperoxia increases oxygen radical production in rat lungs and lung mitochondria.

1981 • 757 citations

Superoxide and Superoxide Dismutases

1978 • 754 citations

Superoxide‐dependent formation of hydroxyl radicals in the presence of iron chelates

1978 • 748 citations

Structural and biochemical changes in rat lungs occurring during exposures to lethal and adaptive doses of oxygen.

1980 • 678 citations

Role of ubiquinone in the mitochondrial generation of hydrogen peroxide

1976 • 656 citations

Pulmonary oxygen toxicity: a review.

1971 • 619 citations

Role of hydrogen peroxide in neutrophil-mediated destruction of cultured endothelial cells.

1981 • 587 citations

The involvement of iron in lipid peroxidation. Importance of ferric to ferrous ratios in initiation.

1986 • 579 citations

Protein damage and degradation by oxygen radicals. III. Modification of secondary and tertiary structure.

1987 • 572 citations

Free radicals, lipids and protein degradation

1986 • 556 citations

The requirement for iron (III) in the initiation of lipid peroxidation by iron (II) and hydrogen peroxide.

1987 • 547 citations

Do Mitochondria Produce Oxygen Radicals in vivo?

1978 • 530 citations

Chemicals, Drugs, and Lipid Peroxidation

1976 • 520 citations

Cellular mechanisms of oxygen toxicity.

1968 • 515 citations

The regional distribution and cellular localization of iron in the rat brain

1984 • 487 citations

Protein damage and degradation by oxygen radicals. IV. Degradation of denatured protein.

1987 • 482 citations

Protection against oxygen toxicity by intravenous injection of liposome-entrapped catalase and superoxide dismutase.

1984 • 478 citations

Superoxide dismutase and pulmonary oxygen toxicity

1974 • 462 citations

In vivo inhibition of superoxide dismutase in mice by diethyldithiocarbamate.

1976 • 457 citations

The effect of hyperoxia on superoxide production by lung submitochondrial particles

1982 • 442 citations

Mitochondrial Production of Superoxide Radical and Hydrogen Peroxide

1977 • 415 citations

Oxygen radicals stimulate intracellular proteolysis and lipid peroxidation by independent mechanisms in erythrocytes.

1987 • 414 citations

DEVELOPMENT OF FINE STRUCTURAL DAMAGE TO ALVEOLAR AND CAPILLARY LINING CELLS IN OXYGEN-POISONED RAT LUNGS

1967 • 393 citations

Role of Oxygen in Modifying the Radiosensitivity of E. Coli B.

1956 • 389 citations

The Relation of Free Radical Production to Hyperoxia

1986 • 382 citations

Normobaric Oxygen Toxicity of the Lung

1980 • 375 citations

In vivo damage of rat lungs by oxygen metabolites.

1981 • 360 citations

Hyperoxia increases H2O2 release by lung mitochondria and microsomes

1982 • 336 citations

Proteins damaged by oxygen radicals are rapidly degraded in extracts of red blood cells.

1987 • 336 citations

Physiology of oxygen radicals

1986 • 330 citations

Prevention of granulocyte-mediated oxidant lung injury in rats by a hydroxyl radical scavenger, dimethylthiourea.

1984 • 322 citations

Organ chemiluminescence: noninvasive assay for oxidative radical reactions.

1980 • 322 citations

Induction of Superoxide Dismutase by Molecular Oxygen

1973 • 321 citations

The Hippocampus

1964 • 315 citations

Oxygen in the Animal Organism

1964 • 303 citations

The pathological effects due to increase of oxygen tension in the air breathed

1899 • 295 citations

Oxidation in the NADP system and release of GSSG from hemoglobin‐free perfused rat liver during peroxidatic oxidation of glutathione by hydroperoxides

1972 • 257 citations

Granulocytes mediate acute edematous lung injury in rabbits and in isolated rabbit lungs perfused with phorbol myristate acetate: role of oxygen radicals.

1982 • 257 citations

Biochemical mechanisms accounting for the toxic action of oxygen on living organisms: The key role of superoxide dismutase

1978 • 249 citations

Biochemical and metabolic changes in the lung with oxygen, ozone, and nitrogen dioxide toxicity.

1978 • 247 citations

Regional lipid peroxidation in rat brain in vitro: Possible role of endogenous iron

1985 • 244 citations

Oxygen toxicity

1980 • 238 citations

Liposome-mediated augmentation of superoxide dismutase in endothelial cells prevents oxygen injury.

1983 • 230 citations

Oxygen-radical-mediated permeability edema and vasoconstriction in isolated perfused rabbit lungs.

1982 • 222 citations

Oxygen toxicity: augmentation of antioxidant defense mechanisms in rat lung

1976 • 216 citations

Superoxide‐dependent formation of hydroxyl radicals in the presence of thiol compounds

1982 • 214 citations

Pulmonary inflammation due to oxygen toxicity: involvement of chemotactic factors and polymorphonuclear leukocytes.

1981 • 211 citations

Antioxidant Defenses in the Lung

1986 • 210 citations

The Generation of Superoxide Radical during the Autoxidation of Ferredoxins

1971 • 209 citations

Hyperoxia increases oxygen radical production in rat lung homogenates

1982 • 207 citations

Hydrogen Peroxide Production by Rat Brain In Vivo

1980 • 197 citations

Oxidant injury of lung parenchymal cells.

1981 • 185 citations

Protection from Oxygen Toxicity with Endotoxin

1980 • 173 citations

Oxygen and Living Processes

1981 • 171 citations

Reduction of the edema of acute hyperoxic lung injury by granulocyte depletion

1982 • 168 citations

Use of salicylate with high pressure liquid chromatography and electrochemical detection (LCE) as a sensitive measure of hydroxyl free radicals in adriamycin treated rats

1986 • 164 citations

Lipid Peroxidation‐Induced Inhibition of γ‐Aminobutyric Acid Uptake in Rat Brain Synaptosomes: Protection by Glucocorticoids

1985 • 161 citations

The toxic effects of oxygen on brain metabolism and on tissue enzymes

1946 • 142 citations

INTRAMITOCHONDRIAL FILAMENTOUS BODIES IN THE THICK LIMB OF HENLE OF THE RAT KIDNEY

1967 • 141 citations

The ability of scavengers to distinguish OH· production in the iron-catalyzed Haber-Weiss reaction: Comparison of four assays for OH·

1987 • 138 citations

The role of endotoxin in protection of adult rats from oxygen-induced lung toxicity.

1978 • 137 citations

Oxygen and Living Processes: An Interdisciplinary Approach

2011 • 130 citations

Energy-Linked Pyridine Nucleotide Reduction: Inhibitory Effects of Hyperbaric Oxygen In Vitro and In Vivo

1965 • 128 citations

Oxygen toxicity in the perfused rat liver and lung under hyperbaric conditions

1976 • 127 citations

Effect of Oxygen and Nitric Oxide on the Radiosensitivity of Human Cells in Tissue Culture

1960 • 122 citations

Lung Cell Oxidant Injury

1982 • 121 citations

Optical measurement of the catalase-hydrogen peroxide intermediate (Compound I) in the liver of anaesthetized rats and its implication to hydrogen peroxide production in situ

1975 • 116 citations

Measurement of oxygen tensions in cerebral tissues of rats exposed to high pressures of oxygen

1963 • 115 citations

Patterns of accumulation of platelets and neutrophils in rat lungs during exposure to 100% and 85% oxygen.

1985 • 112 citations

Oxygen- or organic hydroperoxide-induced chemiluminescence of brain and liver homogenates

1981 • 111 citations

Lipid Peroxide Distribution in Brain and the Effect of Hyperbaric Oxygen

1983 • 109 citations

Potentiation of oxygen toxicity in rats by dietary protein or amino acid deficiency

1983 • 103 citations

Structural and biochemical adaptive changes in rat lungs after exposure to hypoxia.

1983 • 93 citations

Effect of diethyldithiocarbamate on oxygen toxicity and lung enzyme activity in immature and adult rats

1978 • 91 citations

The properties of hydrogen peroxide production under hyperoxic and hypoxic conditions of perfused rat liver

1975 • 87 citations

Iron-induced lipid peroxidation in spinal cord: Protection with mannitol and methylprednisolone

1985 • 86 citations

Liposome-mediated augmentation of brain SOD and catalase inhibits CNS O2 toxicity

1984 • 85 citations

A comparative study of some more important experimental animal peroxide metabolism enzymes

1977 • 84 citations

INCREASED NON-PROTEIN-BOUND IRON AND DECREASED PROTECTION AGAINST SUPEROXIDE-RADICAL DAMAGE IN CEREBROSPINAL FLUID FROM PATIENTS WITH NEURONAL CEROID LIPOFUSCINOSES

1982 • 84 citations

Transient depletion of lung glutathione by diethylmaleate enhances oxygen toxicity

1985 • 83 citations

Low-Level Chemiluminescence of Biological Systems

1984 • 83 citations

Effect of Various Substances On Survival Times of Mice Exposed to Different High Oxygen Tensions

1958 • 83 citations

BIOLOGICAL EFFECTS OF IONIZING RADIATION ON MOLECULAR LEVEL

1962 • 82 citations

The Initiation and Development of Cellular Damage by Ionizing Radiations The Thirty—Second Silvanus Thompson Memorial Lecture

1953 • 81 citations

Toxic effects of oxygen and of hydrogen peroxide on brain metabolism

1946 • 78 citations

Endogenous free radical generation may influence proteolysis in Mitochondria

1985 • 76 citations

Protection from O2 toxicity by preexposure to hypoxia: lung antioxidant enzyme role

1982 • 75 citations

Partial Inactivation of Na,K‐ATPase in Cortical Brain Slices Incubated in Normal Krebs‐Ringer Phosphate Medium at 1 and at 10 Atm Oxygen Pressures

1981 • 72 citations

Mechanisms of pulmonary oxygen toxicity

1984 • 72 citations

Inhibition of cellular antioxidants: a possible mechanism of toxic cell injury.

1984 • 71 citations

Singlet oxygen and biological systems

1971 • 69 citations

Pharmacological alteration of oxygen-induced lung toxicity

1979 • 68 citations

OXYGEN POISONING

1945 • 67 citations

Hyperoxia Damages Cultured Endothelial Cells Causing Increased Neutrophil Adherence

1983 • 66 citations

Mechanism for the potentiation of oxygen toxicity by disulfiram.

1980 • 66 citations

Superoxide dismutase (SOD) activity in hypoxic mammalian systems

1977 • 65 citations

Oxygen-induced lung microvascular injury in neutropenic rabbits and lambs

1985 • 64 citations

Tolerance and cross-tolerance using NO2 and O2. I. Toxicology and biochemistry

1978 • 64 citations

Radical driven fenton reactions—Evidence from paraquat radical studies for production of tetravalent iron in the presence and absence of ethylenediaminetetraacetic acid

1987 • 60 citations

OXYGEN TOXICITY AND VITAMIN E.

1964 • 58 citations

OXYGEN POISONING

1946 • 58 citations

Oxygen poisoning in the unanesthetized brain: Correlation of the oxidation-reduction state of pyridine nucleotide with electrical activity

1974 • 58 citations

Mechanisms of hyperoxic injury to the pulmonary microcirculation.

1983 • 56 citations

STUDIES ON THE METABOLISM OF BRAIN SUSPENSIONS

1942 • 56 citations

Production of superoxide anions and hydrogen peroxide in Ehrlich ascites tumour cell nuclei

1977 • 52 citations

Hydrogen peroxide-mediated corneal endothelial damage. Induction by oxygen free radical.

1984 • 51 citations

Barometric Pressure: Researches in Experimental Physiology

1944 • 50 citations

Partial spectral analysis of the hydroperoxide‐induced chemiluminescence of the perfused lung

1980 • 49 citations

The effects of antioxidants on high pressure oxygen toxicity

1964 • 49 citations

Reaction of the lung cells to a high concentration of oxygen.

1968 • 48 citations

Antioxidant Activity in Cells and Organs

1987 • 46 citations

Regional cerebral blood flow, O2, and EEG in exposures to O2 at high pressure.

1971 • 46 citations

The failure of aerosolized superoxide dismutase to modify pulmonary oxygen toxicity.

1977 • 46 citations

Protective effect of interferon inducers against hyperoxic pulmonary damage.

1984 • 45 citations

Free radicals and environmental toxins

1986 • 45 citations

The mechanism of toxic action of hyperbaric oxygenation on the mitochondria of rat-heart cells

1981 • 45 citations

Electrode size and tissue pO₂ measurement in rats exposed to air or high pressure oxygen

1965 • 44 citations

OXYGEN POISONING

1945 • 44 citations

Seizures, H 2 O 2 formation and lipid peroxides in brain during exposure to oxygen under high pressure.

1973 • 44 citations

Proposed mechanism for neonatal rat tolerance to normobaric hyperoxia.

1980 • 43 citations

Free radical formation and lipid peroxidation in rat and mouse cerebral cortex slices exposed to high oxygen pressure

1982 • 43 citations

The effects of vitamin E and of methylene blue on the manifestations of oxygen poisoning in the rat

1956 • 42 citations

Blood flow in rat brain during exposure to high oxygen pressure.

1978 • 42 citations

The Limits of the Target Theory of the Biological Action of Radiation

1952 • 42 citations

PULMONARY DAMAGE DUE TO HIGH PRESSURE OXYGEN BREATHING IN RATS

1962 • 42 citations

Involvement of glutathione enzymes in O2 tolerance development by diethyldithiocarbamate

1980 • 40 citations

Enhanced lung toxicity of O2 in selenium-deficient rats.

1977 • 38 citations

Studies of Mechanisms of Chemical Radiation Protectionin vivo

1962 • 36 citations

PULMONARY DAMAGE DUE TO HIGH PRESSURE OXYGEN BREATHING IN RATS

1962 • 36 citations

Hyperoxia inhibits stimulated superoxide release by rat alveolar macrophages

1982 • 34 citations

Interaction ofN-acetylcysteine and bleomycin on hyperbaric oxygen-induced lung damage in mice

1987 • 34 citations

The Effect of Oxygen-Derived Free Radicals on Pulmonary Endothelial Cell Function in the Isolated Perfused Rat Lung

1982 • 33 citations

Potential adverse effects of lung macrophages and neutrophils.

1979 • 33 citations

Cerebral O 2 , CO 2 , regional cerebral vascular control, and hyperbaric oxygenation.

1972 • 32 citations

Effects of hyperoxia on alveolar permeability of neutropenic rabbits

1986 • 32 citations

OXYGEN POISONING

1945 • 32 citations

Oxygen free radicals in shock

1987 • 31 citations

Changes in the electrical activity and Po2 of the rat's brain under high oxygen pressure

1976 • 30 citations

Oxidative Stress in Human Neutrophilic Granulocytes: Host Defence and Self-Defence

1985 • 30 citations

OXYGEN POISONING

1945 • 29 citations

Radiation-induced lipid peroxidation and the fluidity of erythrocyte membrane lipids

1987 • 29 citations

Studies of oxygen toxicity in the central nervous system.

1965 • 28 citations

Mechanisms of interaction between oxygen and granulocytes in hyperoxic lung injury

1985 • 28 citations

Oxygen Toxicity and Protective Systems

1985 • 28 citations

PULMONARY DAMAGE DUE TO HIGH PRESSURE OXYGEN BREATHING IN RATS

1963 • 26 citations

TISSUE RESPONSES TO HYPEROXIA

1987 • 24 citations

Importance of two iron-reducing systems in lipid peroxidation of rat brain: implications for oxygen toxicity in the central nervous system.

1987 • 24 citations

Oxygen toxicity of hippocampal tissue in vitro

1983 • 24 citations

Protection with disulfiram from central and pulmonary oxygen toxicity

1971 • 23 citations

Enhancement by disulfiram (Antabuse) of toxic effects of 95 to 97% O2 on the rat lung.

1979 • 22 citations

Effect of high pressure oxygen on the steady state of cytochromes in rat-liver mitochondria

1966 • 21 citations

Studies on Oxygen Poisoning: Protective Effect of -Mercaptoethylamine

1954 • 20 citations

Oxygen poisoning; the effect of high oxygen pressure upon enzymes; uricase, xanthine oxidase, and alpha-amino acid oxidase.

1945 • 19 citations

The role of toxicological interactions in lung injury.

1984 • 19 citations

OXYGEN POISONING

1945 • 18 citations

Interacting effects of hypoxia adaptation and acute hypercapnia on oxygen tolerance in rats

1984 • 16 citations

Comparative effects of hyperbaric oxygen and pentylenetetrazol on lung weight and non-protein sulfhydryl content of experimental animals

1968 • 16 citations

Effect of oxygen-rich atmospheres on cerebral lipid peroxides.

1962 • 16 citations

Inhibition of Cellular Antioxidants: A Possible Mechanism of Toxic Cell Injury

1984 • 16 citations

Oxygen tension in the globus pallidus and neostriatum of unanesthetized rats during exposure to hyperbaric oxygen

1978 • 16 citations

RED CHEMILUMINESCENCE FROM RAM SEMINAL VESICLE MICROSOMES: PITFALLS IN THE USE OF SPECTRALLY RESOLVED RED CHEMILUMINESCENCE AS A TEST FOR SINGLET OXYGEN IN BIOLOGICAL SYSTEMS

1988 • 15 citations

Effects of superoxide dismutase and catalase on central nervous system toxicity of hyperbaric oxygen

1980 • 15 citations

Effect of superoxide dismutase and succinate on the development of hyperbaric oxygen toxicity.

1977 • 15 citations

The biochemical pathology of toxic cell death.

1985 • 15 citations

The Aging Process

1988 • 14 citations

IV. A Review of the Evidence for the Production of Free Radicals in Water Consequent on the Absorption of Ionizing Radiations

1951 • 14 citations

New perspectives on hyperoxic pulmonary toxicity--a review.

1984 • 14 citations

OXYGEN POISONING

1945 • 13 citations

CNS and pulmonary damage in anesthetized rats exposed to hyperbaric oxygen.

1967 • 12 citations

The effect of in vivo hyperoxic exposure on the release of endogenous histamine from the rat isolated perfused lung

1984 • 11 citations

OXYGEN POISONING

1946 • 11 citations

In vivo formation of H2O2 in red cells during exposure to hyperoxia

1972 • 11 citations

Neutrophil kinetics in O2-exposed rabbits

1986 • 10 citations

Oxygen tensions measured in cat cerebral cortex under hyperbaric conditions

1979 • 10 citations

Oxygen poisoning; the effect of oxygen at eight atmospheres upon the oxygen consumption of the intact mouse.

1946 • 10 citations

PULMONARY DAMAGE DUE TO HIGH PRESSURE OXYGEN BREATHING IN RATS

1964 • 9 citations

Glutathione and non-protein sulfhydryl in cerebral cortex and lung in mice exposed to high oxygen pressure

1982 • 8 citations

Oxygen: toxicity and tolerance.

1986 • 8 citations

The effect of allopurinol on oxygen-induced seizures in mice.

1984 • 8 citations

Mechanisms of Oxygen Free Radicals Production in Granulocytes1

2015 • 8 citations

The effect of anaesthesia and CO2 on survival time and lung damage in rats exposed to high pressure oxygen

1966 • 7 citations

Comparison of protective agents against hyperbaric oxygen in large animals.

1973 • 7 citations

Cerebral oxidized and reduced nicotinamide-adenine dinucleotide phosphate and glucose 6-phosphate dehydrogenase in mice during exposure to high oxygen pressure

1978 • 7 citations

Changes in local brain tissue Po2 and electrocortical activity of unanesthetized rabbits under high oxygen pressure.

1977 • 7 citations

Effects of hyperbaric oxygen, the hyperbaric state, and rapid decompression on pulmonary surfactant

1968 • 6 citations

THE ROLE OF OXYGEN IN THE PHENOMENA OF CHEMICAL PROTECTION AGAINST IONIZING RADIATION

1964 • 6 citations

PEROXISOMAL FUNCTION IN PERFUSED LIVER AS STUDIED BY ORGAN PHOTOMETRY*

1982 • 5 citations

Insufflated red cells protect lungs from hyperoxic damage: role of red cell glutathione in scavenging toxic O2 radicals.

1984 • 5 citations

Effects of hyperbaric oxygenation on electrical activity of globus pallidus and neostriatum

1977 • 4 citations

The Pathologist and the environment

1985 • 4 citations

The Role of Toxicological Interactions in Lung Injury

1984 • 3 citations

Study of lipid oxidation in various rat tissues during and after hyperoxia

1981 • 2 citations

Alterations in Cultured Rat Pulmonary Artery Endothelial Cells with Hyperoxia; Effect of Age

1988 • 2 citations

Ozone (O3) and oxygen (O2) cross-tolerance: common biochemical adaptations

1981 • 1 citations

[Effect of hyperoxia on oxygen tension in the blood and brain tissue].

1979 • 1 citations

Effect of exogenous superoxide dismutase and 1,4-diazobicyclo-[2.2.2]octane on the resistance of mice to acute oxygen poisoning

1977 • 1 citations