Modafinil more effectively induces wakefulness in orexin-null mice than in wild-type littermates

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1994 • 505 citations

Hypothalamic Arousal Regions Are Activated during Modafinil-Induced Wakefulness

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Randomized trial of modafinil for the treatment of pathological somnolence in narcolepsy

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1995 • 389 citations

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Randomized trial of modafinil as a treatment for the excessive daytime somnolence of narcolepsy

2000 • 359 citations

Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice

2004 • 334 citations

Modafinil Binds to the Dopamine Uptake Carrier Site with Low Affinity

1994 • 317 citations

Orexins/hypocretins excite basal forebrain cholinergic neurones

2001 • 307 citations

Potential brain neuronal targets for amphetamine-, methylphenidate-, and modafinil-induced wakefulness, evidenced by c- fos immunocytochemistry in the cat

1996 • 305 citations

Wake-promoting and sleep-suppressing actions of hypocretin (orexin): basal forebrain sites of action

2001 • 302 citations

Evaluation of the Abuse Liability of Modafinil and Other Drugs for Excessive Daytime Sleepiness Associated with Narcolepsy

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Successful treatment of idiopathic hypersomnia and narcolepsy with modafinil

1988 • 271 citations

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1984 • 239 citations

Role of catecholamines in the modafinil and amphetamine induced wakefulness, a comparative pharmacological study in the cat

1992 • 207 citations

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Modafinil induces wakefulness without intensifying motor activity or subsequent rebound hypersomnolence in the rat.

1997 • 170 citations

Modafinil: A Double-Blind Multicentric Study

1994 • 161 citations

Cholinergic manipulations in the medial septal area: age-related effects on working memory and hippocampal electrophysiology

1995 • 154 citations

Exclusive Postsynaptic Action of Hypocretin-Orexin on Sublayer 6b Cortical Neurons

2004 • 153 citations

Variations in extracellular monoamines in the prefrontal cortex and medial hypothalamus after modafinil administration: a microdialysis study in rats

2001 • 148 citations

Modafinil: An antinarcoleptic drug with a different neurochemical profile to d-amphetamine and dopamine uptake blockers

1997 • 139 citations

The vigilance promoting drug modafinil increases dopamine release in the rat nucleus accumbens via the involvement of a local GABAergic mechanism

1996 • 137 citations

Decreased brain histamine content in hypocretin/orexin receptor-2 mutated narcoleptic dogs

2001 • 137 citations

Microdialysis perfusion of orexin-A in the basal forebrain increases wakefulness in freely behaving rats.

2001 • 134 citations

Hypocretin (Orexin) Induces Calcium Transients in Single Spines Postsynaptic to Identified Thalamocortical Boutons in Prefrontal Slice

2003 • 121 citations

Hypocretin Increases Impulse Flow in the Septohippocampal GABAergic Pathway: Implications for Arousal via a Mechanism of Hippocampal Disinhibition

2002 • 116 citations

Rhythmically Discharging Basal Forebrain Units Comprise Cholinergic, GABAergic, and Putative Glutamatergic Cells

2003 • 116 citations

Differential patterns of regional c-Fos induction in the rat brain by amphetamine and the novel wakefulness-promoting agent modafinil

1998 • 114 citations

Awakening properties of modafinil: effect on nocturnal activity in monkeys(Macaca mulatta) after acute and repeated administration

1991 • 101 citations

Non-amphetaminic mechanism of stimulant locomotor effect of modafinil in mice

1995 • 99 citations

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Comparative effects of modafinil and amphetamine on daytime sleepiness and cataplexy of narcoleptic dogs.

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Effect of modafinil and amphetamine on the rat catecholaminergic neuron activity

1991 • 75 citations

Modafinil Maintains Waking in the Fruit Fly Drosophila Melanogaster

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Non-amphetaminic mechanism of stimulant locomotor effect of modafinil in mice

1995 • 69 citations

Awakening properties of modafinil without paradoxical sleep rebound: comparative study with amphetamine in the rat

1995 • 69 citations

Electroencephalographic Effects of Modafinil, an Alpha-I-Adrenergic Psychostimulant, on the Sleep of Rhesus Monkeys

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Effects of amphetamine and modafinil on the sleep/wake cycle during experimental hypersomnia induced by sleep deprivation in the cat

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Clinical Applications of Modafinil in Stimulant Abusers: Low Abuse Potential

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Improvement of learning processes following chronic systemic administration of modafinil in mice

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Comparative Effects of Modafinil and Amphetamine on Daytime Sleepiness and Cataplexy of Narcoleptic Dogs

1995 • 40 citations

Analysis of stimulant locomotor effects of modafinil in various strains of mice and rats

1996 • 37 citations

Comparison of the effects of modafinil and sleep deprivation on sleep and cortical EEG spectra in mice

2002 • 33 citations

The SK‐N‐MC cell line expresses an orexin binding site different from recombinant orexin 1‐type receptor

2002 • 27 citations

Modafinil Decreases Hypersomnolence in the English Bulldog, a Natural Animal Model of Sleep-Disordered Breathing

1996 • 22 citations

Interaction of modafinil and clomipramine as comedication in a narcoleptic patient.

1998 • 15 citations