Protein kinase D: an intracellular traffic regulator on the move

The PI3K–PDK1 connection: more than just a road to PKB

2000 • 1,563 citations

Active and Inactive Protein Kinases: Structural Basis for Regulation

1996 • 1,361 citations

Protein Kinase C: Structural and Spatial Regulation by Phosphorylation, Cofactors, and Macromolecular Interactions

2001 • 966 citations

Determination of the Specific Substrate Sequence Motifs of Protein Kinase C Isozymes

1997 • 557 citations

Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid

1999 • 536 citations

The PI3K‒PDK1 connection: more than just a road to PKB

2000 • 503 citations

A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity

1998 • 471 citations

Role of Diacylglycerol in PKD Recruitment to the TGN and Protein Transport to the Plasma Membrane

2002 • 408 citations

Molecular cloning and characterization of protein kinase D: a target for diacylglycerol and phorbol esters with a distinctive catalytic domain.

1994 • 406 citations

Protein Kinase D Regulates the Fission of Cell Surface Destined Transport Carriers from the Trans-Golgi Network

2001 • 357 citations

An invasion-related complex of cortactin, paxillin and PKCμ associates with invadopodia at sites of extracellular matrix degradation

1999 • 355 citations

Gβγ-Mediated Regulation of Golgi Organization Is through the Direct Activation of Protein Kinase D

1999 • 275 citations

Characterization of Serine 916 as an in Vivo Autophosphorylation Site for Protein Kinase D/Protein Kinase Cμ

1999 • 211 citations

The structural basis for substrate recognition and control by protein kinases¹

1998 • 204 citations

PKCν, a new member of the protein kinase C family, composes a fourth subfamily with PKCμ1The nucleotide sequence data reported in this paper have been deposited in the DDBJ, EMBL and GenBank databases under the accession number AB015982.1

1999 • 191 citations

Molecular Cloning and Characterization of the Human Protein Kinase D2

2001 • 175 citations

Identification of in Vivo Phosphorylation Sites Required for Protein Kinase D Activation

1998 • 170 citations

Expression and Characterization of PKD, a Phorbol Ester and Diacylglycerol-stimulated Serine Protein Kinase

1995 • 170 citations

Recruitment of protein kinase D to the trans-Golgi network via the first cysteine-rich domain

2001 • 166 citations

Bombesin, Vasopressin, Endothelin, Bradykinin, and Platelet-derived Growth Factor Rapidly Activate Protein Kinase D through a Protein Kinase C-dependent Signal Transduction Pathway

1997 • 166 citations

Activation Loop Ser744 and Ser748 in Protein Kinase D Are Transphosphorylated in Vivo

2001 • 161 citations

Identification and Cloning of Kidins220, a Novel Neuronal Substrate of Protein Kinase D

2000 • 153 citations

The RAS Effector RIN1 Directly Competes with RAF and Is Regulated by 14-3-3 Proteins

2002 • 150 citations

Protein Kinase D Activation by Mutations within Its Pleckstrin Homology Domain

1998 • 142 citations

Protein Kinase C μ (PKCμ) Associates with the B Cell Antigen Receptor Complex and Regulates Lymphocyte Signaling

1996 • 130 citations

Protein Kinase C (PKC)η-mediated PKCμ Activation Modulates ERK and JNK Signal Pathways

2002 • 126 citations

Spatial and temporal regulation of protein kinase D (PKD)

2000 • 123 citations

Oxidative Stress Induces Protein Kinase D Activation in Intact Cells

2000 • 119 citations

Regulation of Golgi Structure through Heterotrimeric G Proteins

1997 • 117 citations

The Pleckstrin Homology Domain of Protein Kinase D Interacts Preferentially with the η Isoform of Protein Kinase C

1999 • 109 citations

Rapid Protein Kinase D Translocation in Response to G Protein-coupled Receptor Activation

2001 • 106 citations

The organisation of the Golgi apparatus

1998 • 106 citations

Protein Kinase C μ Is Negatively Regulated by 14-3-3 Signal Transduction Proteins

1999 • 103 citations

Protein Kinase D Potentiates DNA Synthesis and Cell Proliferation Induced by Bombesin, Vasopressin, or Phorbol Esters in Swiss 3T3 Cells

2001 • 99 citations

Association of Protein Kinase Cμ with Type II Phosphatidylinositol 4-Kinase and Type I Phosphatidylinositol-4-phosphate 5-Kinase

1998 • 97 citations

Proteolytic Cleavage and Activation of Protein Kinase C μ by Caspase-3 in the Apoptotic Response of Cells to 1-β-d-Arabinofuranosylcytosine and Other Genotoxic Agents

2000 • 96 citations

Regulated Nucleocytoplasmic Transport of Protein Kinase D in Response to G Protein-coupled Receptor Activation

2001 • 91 citations

Cell-type specific phosphorylation of threonines T654 and T669 by PKD defines the signal capacity of the EGF receptor

1999 • 90 citations

Regulation of Protein Kinase D by Multisite Phosphorylation

2000 • 86 citations

Protein Kinase C μ Is Regulated by the Multifunctional Chaperon Protein p32

2000 • 84 citations

Structural requirements for localization and activation of protein kinase C μ (PKCμ) at the Golgi compartment

2002 • 83 citations

Protein kinase Cμ downregulation of tumor‐necrosis‐factor‐induced apoptosis correlates with enhanced expression of nuclear‐factor‐κB‐dependent protective genes

1998 • 76 citations

Protein-kinase-C? expression correlates with enhanced keratinocyte proliferation in normal and neoplastic mouse epidermis and in cell culture

1999 • 75 citations

Platelet-derived Growth Factor Stimulates Protein Kinase D through the Activation of Phospholipase Cγ and Protein Kinase C

1998 • 75 citations

Bryostatin 1 Induces Biphasic Activation of Protein Kinase D in Intact Cells

1997 • 74 citations

Dynamic re‐distribution of protein kinase D (PKD) as revealed by a GFP‐PKD fusion protein: dissociation from PKD activation

1999 • 72 citations

Dissimilar phorbol ester binding properties of the individual cysteine‐rich motifs of protein kinase D

1998 • 62 citations

Protein kinase C μ selectively activates the mitogen‐activated protein kinase (MAPK) p42 pathway

2001 • 62 citations

Cis-polyunsaturated fatty acids stimulate beta1 integrin-mediated adhesion of human breast carcinoma cells to type IV collagen by activating protein kinases C-epsilon and -mu.

2001 • 51 citations

Bruton's tyrosine kinase (Btk) associates with protein kinase C μ

1999 • 47 citations

Protein kinase D activation by deletion of its cysteine‐rich motifs

1999 • 47 citations

Common and distinct signaling pathways mediate the induction of TNF-alpha and IL-5 in IgE plus antigen-stimulated mast cells.

1998 • 42 citations

Protein Kinase D Is Sufficient to Suppress EGF-Induced c-Jun Ser 63 Phosphorylation

2001 • 36 citations

Common and Distinct Signaling Pathways Mediate the Induction of TNF-α and IL-5 in IgE Plus Antigen-Stimulated Mast Cells

1998 • 32 citations

Phosphoinositide 4- and 5-Kinases and the Cellular Roles of Phosphatidylinositol 4, 5-Bisphosphate

1998 • 23 citations