Activation Loop Ser744 and Ser748 in Protein Kinase D Are Transphosphorylated in Vivo

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

Protein kinase C and lipid signaling for sustained cellular responses

1995 • 2,527 citations

The extended protein kinase C superfamily

1998 • 1,544 citations

Active and Inactive Protein Kinases: Structural Basis for Regulation

1996 • 1,361 citations

Protein Kinase C Isotypes Controlled by Phosphoinositide 3-Kinase Through the Protein Kinase PDK1

1998 • 1,118 citations

Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.

1993 • 966 citations

Protein kinase C - a question of specificity

1994 • 958 citations

Localization of Protein Kinases by Anchoring Proteins: a Theme in Signal Transduction

1995 • 911 citations

Activation of the Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Pathway by Conventional, Novel, and Atypical Protein Kinase C Isotypes

1998 • 765 citations

PKCu is a novel, atypical member of the protein kinase C family.

1994 • 519 citations

Molecular cloning and characterization of protein kinase D: a target for diacylglycerol and phorbol esters with a distinctive catalytic domain.

1994 • 406 citations

Protein Kinase D Regulates the Fission of Cell Surface Destined Transport Carriers from the Trans-Golgi Network

2001 • 357 citations

An invasion-related complex of cortactin, paxillin and PKCμ associates with invadopodia at sites of extracellular matrix degradation

1999 • 355 citations

Gβγ-Mediated Regulation of Golgi Organization Is through the Direct Activation of Protein Kinase D

1999 • 275 citations

Protein kinase C binding partners

2000 • 264 citations

Protein kinase D (PKD) activation in intact cells through a protein kinase C-dependent signal transduction pathway.

1996 • 244 citations

Tyrosine phosphorylation of phospholipase C induced by membrane immunoglobulin in B lymphocytes.

1991 • 205 citations

The structural basis for substrate recognition and control by protein kinases¹

1998 • 204 citations

PKCν, a new member of the protein kinase C family, composes a fourth subfamily with PKCμ1The nucleotide sequence data reported in this paper have been deposited in the DDBJ, EMBL and GenBank databases under the accession number AB015982.1

1999 • 191 citations

Molecular Cloning and Characterization of the Human Protein Kinase D2

2001 • 175 citations

Expression and Characterization of PKD, a Phorbol Ester and Diacylglycerol-stimulated Serine Protein Kinase

1995 • 170 citations

Identification of in Vivo Phosphorylation Sites Required for Protein Kinase D Activation

1998 • 170 citations

Bombesin, Vasopressin, Endothelin, Bradykinin, and Platelet-derived Growth Factor Rapidly Activate Protein Kinase D through a Protein Kinase C-dependent Signal Transduction Pathway

1997 • 166 citations

Protein kinase C-mediated regulation of the cell cycle

2000 • 154 citations

Spatial and temporal regulation of protein kinase D (PKD)

2000 • 123 citations

Oxidative Stress Induces Protein Kinase D Activation in Intact Cells

2000 • 119 citations

Protein Kinase D

2000 • 116 citations

The Pleckstrin Homology Domain of Protein Kinase D Interacts Preferentially with the η Isoform of Protein Kinase C

1999 • 109 citations

Aldosterone induces Ras methylation in A6 epithelia

2000 • 108 citations

Rapid Protein Kinase D Translocation in Response to G Protein-coupled Receptor Activation

2001 • 106 citations

Protein kinase C mu is located at the Golgi compartment.

1996 • 105 citations

Proteolytic Cleavage and Activation of Protein Kinase C μ by Caspase-3 in the Apoptotic Response of Cells to 1-β-d-Arabinofuranosylcytosine and Other Genotoxic Agents

2000 • 96 citations

Cell-type specific phosphorylation of threonines T654 and T669 by PKD defines the signal capacity of the EGF receptor

1999 • 90 citations

PKD in intestinal epithelial cells: rapid activation by phorbol esters, LPA, and angiotensin through PKC

2001 • 89 citations

Regulation of Protein Kinase D by Multisite Phosphorylation

2000 • 86 citations

Bryostatin 1 Induces Biphasic Activation of Protein Kinase D in Intact Cells

1997 • 74 citations

Dynamic re‐distribution of protein kinase D (PKD) as revealed by a GFP‐PKD fusion protein: dissociation from PKD activation

1999 • 72 citations

Protein kinase D: a novel target for diacylglycerol and phorbol esters

1997 • 68 citations

Phosphorylation-dependent protein kinase Dactivation

1999 • 66 citations

Activation of Protein Kinase D by Signaling through the α Subunit of the Heterotrimeric G Protein Gq

2000 • 58 citations

Protein kinase D (PKD): A novel target for diacylglycerol and phorbol esters

1995 • 57 citations

Protein kinase D in small cell lung cancer cells: rapid activation through protein kinase C.

1999 • 57 citations

Rapid activation of the novel serine/threonine protein kinase, protein kinase D by phorbol esters, angiotensin II and PDGF‐BB in vascular smooth muscle cells

1998 • 53 citations

Protein kinase D inhibits plasma membrane Na⁺/H⁺exchanger activity

1999 • 47 citations

Lysophosphatidic acid rapidly induces protein kinase D activation through a pertussis toxin-sensitive pathway

2000 • 47 citations

Protein Kinase D Is Sufficient to Suppress EGF-Induced c-Jun Ser 63 Phosphorylation

2001 • 36 citations

Proteolytic cleavage of protein kinase Cμ upon induction of apoptosis in U937 cells

1999 • 28 citations

CCK2 (CCK_B/gastrin) receptor mediates rapid protein kinase D (PKD) activation through a protein kinase C‐dependent pathway

2001 • 21 citations

Phorbol Ester, but not Ischemic Preconditioning, Activates Protein Kinase D in the Rat Heart

1997 • 11 citations