Dairy products and breast cancer: the IGF-I, estrogen, and bGH hypothesis

Growth Factors and Cancer

1991 • 2,044 citations

Growth factors: Mechanism of action and relation to oncogenes

1984 • 885 citations

Cellular Localization of Somatomedin (Insulin-Like Growth Factor) Messenger RNA in the Human Fetus

1987 • 663 citations

Insulin-like growth factors and cancer

1992 • 622 citations

Role of life-style and dietary habits in risk of cancer among seventh-day adventists.

1975 • 588 citations

Somatomedin-C/insulin-like growth factor-I and insulin-like growth factor-II mRNAs in rat fetal and adult tissues.

1986 • 531 citations

A REVIEW OF THE EPIDEMIOLOGY OF HUMAN BREAST CANCER

1979 • 461 citations

Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation.

1990 • 404 citations

Analysis of Insulin-Like Growth Factor I Gene Expression in Malignancy: Evidence for a Paracrine Role in Human Breast Cancer

1989 • 403 citations

Intestinal absorption of peptides

1975 • 353 citations

GROWTH FACTORS AND CANCER

1985 • 352 citations

Insulin-like growth factor receptor expression and function in human breast cancer.

1990 • 321 citations

Evidence suggesting that the direct growth-promoting effect of growth hormone on cartilage in vivo is mediated by local production of somatomedin.

1986 • 310 citations

Free insulin‐like growth factors (IGF‐I and IGF‐II) in human serum

1994 • 310 citations

Plasma insulin-like growth factor-1 (IGF-1) concentrations in human breast cancer

1993 • 276 citations

Altered body composition and increased frequency of diverse malignancies in insulin-like growth factor-II transgenic mice.

1994 • 274 citations

Estrogen-Induced Factors of Breast Cancer Cells Partially Replace Estrogen to Promote Tumor Growth

1986 • 273 citations

Insulin-Like Growth Factors/Somatomedins: Structure, Secretion, Biological Actions and Physiological Role

1986 • 240 citations

Growth inhibition of human breast cancer cells in vitro with an antibody against the type I somatomedin receptor.

1989 • 233 citations

Receptors for epidermal growth factor and insulin-like growth factor I and their relation to steroid receptors in human breast cancer.

1988 • 208 citations

Epidermal Growth Factor: Chemical and Biological Characterization,

1974 • 207 citations

The Insulin-Like Growth Factors (IGF) of Human Serum: Chemical and Biological Characterization and Aspects of Their Possible Physiological Role

1981 • 207 citations

Insulin-like growth factors I and II in fetal and adult bovine serum. Purification, primary structures, and immunological cross-reactivities.

1986 • 197 citations

Dietary factors and breast cancer risk

1981 • 197 citations

Bovine Growth Hormone: Human Food Safety Evaluation

1990 • 192 citations

Calorie-Providing Nutrients and Risk of Breast Cancer

1989 • 192 citations

Diet, Nutrition, and Cancer A Critical Evaluation

1985 • 189 citations

Nutrient Balance and Stage of Lactation Affect Responses of Insulin, Insulin-Like Growth Factors I and II, and Insulin-Like Growth Factor-Binding Protein 2 to Somatotropin Administration in Dairy Cows

1991 • 180 citations

Serum concentrations of total and non‐protein‐bound oestradiol in patients with breast cancer and in normal controls

1982 • 179 citations

Consumption of fermented milk products and breast cancer: a case-control study in The Netherlands.

1989 • 178 citations

Milk antigen absorption in the preterm and term neonate.

1982 • 174 citations

Insulin-like growth factor 1 receptors in human breast cancer and their relation to estradiol and progesterone receptors.

1988 • 173 citations

Multihormonal Regulation of Insulin-Like Growth Factor-I-Related Protein in MCF-7 Human Breast Cancer Cells

1988 • 161 citations

Consumption of Dairy Produce and Alcohol in a Case-Control Study of Breast Cancer2

1986 • 159 citations

The role of fat, animal protein and some vitamin consumption in breast cancer: A case control study in Southern France

1991 • 155 citations

Insulin‐like growth factor‐binding protein enhancement of insulin‐like growth factor‐i (IGF‐I)–mediated DNA synthesis and IGF‐I binding in a human breast carcinoma cell line

1994 • 154 citations

Search for Role of Milk-Borne Biologically Active Peptides for the Suckling

1989 • 150 citations

Social factors, diet and breast cancer in a northern Italian population

1984 • 145 citations

CLINICAL STUDIES WITH RECOMBINANT-DNA-DERIVED METHIONYL HUMAN GROWTH HORMONE IN GROWTH HORMONE DEFICIENT CHILDREN

1986 • 145 citations

Breast cancer and diet among the Japanese in Hawaii

1978 • 142 citations

Antigenicity of infant formulas: Role of immatureintestine on protein permeability

1978 • 141 citations

Immunoreactive Somatomedin-C/Insulin-Like Growth Factor I and Its Binding Protein in Human Milk*

1984 • 141 citations

Dietary factors and breast‐cancer risk in Denmark

1990 • 140 citations

Periparturient Changes in Secretion and Mammary Uptake of Insulin and in Concentrations of Insulin and Insulin-Like Growth Factors in Milk of Dairy Cows

1987 • 123 citations

Critical Appraisal of the Evidence That Dietary Fat Intake Is Related to Breast Cancer Risk in Humans

1987 • 122 citations

Type 1 IGF receptor in human breast diseases

1992 • 120 citations

Insulin-like growth factor-1 receptors and insulin-like growth factor-1-like activity in human primary breast cancer

1989 • 119 citations

Impact of development of the gastrointestinal tract on infant feeding

1983 • 118 citations

Effect of luminal growth factor preservation on intestinal growth

1993 • 117 citations

Tamoxifen reduces serum insulin-like growth factor I (IGF-I)

1992 • 115 citations

Effects of caseinomacropeptide (CMP) on digestion regulation

1994 • 115 citations

Liberation of Immunoreactive Somatomedin-C from Its Binding Proteins by Proteolytic Enzymes and Heparin*

1983 • 105 citations

Insulin-like growth factor expression in breast cancer epithelium and stroma

1992 • 105 citations

Influence of tamoxifen on plasma levels of insulin-like growth factor I and insulin-like growth factor binding protein I in breast cancer patients.

1992 • 103 citations

Interference of the IGF system as a strategy to inhibit breast cancer growth

1992 • 100 citations

Serum somatomedin-C in hypopituitarism and in other disorders of growth

1977 • 99 citations

Insulin-like growth factor-I (IGF-I) and IGF-binding protein-2 are increased in cyst fluids of epithelial ovarian cancer.

1994 • 97 citations

Insulin and Insulin-Like Growth Factor-I Stimulate DNA Synthesis in Bovine Mammary Tissue in Vitro

1989 • 92 citations

Free Insulin-Like Growth Factor I (IGF-I) and IGF-II in Human Saliva*

1988 • 91 citations

Autocrine and paracrine growth regulation of breast cancer: Clinical implications

1990 • 90 citations

Effects of recombinant bovine somatotrophin, insulin-like growth factor-I and insulin on the proliferation of bovine granulosa cells in vitro

1993 • 90 citations

Premenopausal Estradiol Levels and the Risk of Breast Cancer: A New Method of Controlling for Day of the Menstrual Cycle

1994 • 89 citations

Somatomedin-C and the Assessment of Growth

1980 • 87 citations

Measurement of Estrogens in Cow's Milk, Human Milk, and Dairy Products

1979 • 84 citations

A case-control study of breast cancer among Japanese women: with special reference to family history and reproductive and dietary factors

1992 • 84 citations

Effects of Insulin-Like Growth Factors (IGFs) and IGF Receptor Antibodies on the Proliferation of Human Breast Cancer Cells

1992 • 83 citations

Regulation of insulin-like growth factor-binding proteins in serum and lymph of lactating cows by somatotropin.

1992 • 82 citations

Characterization of insulin-like growth factor I (IGF-I) receptors of human breast cancer cells

1988 • 76 citations

The Insulin-Like Growth Factor I Content in Human Milk Increases Between Early and Full Lactation*

1988 • 71 citations

Increased secretion of insulin-like growth factor I into milk of cows treated with recombinantly derived bovine growth hormone

1989 • 70 citations

Insulin-like growth factors act synergistically withbasic fibroblast growth factor and nerve growth factor to promote chromaffincell proliferation.

1994 • 67 citations

ANIMAL PRODUCT CONSUMPTION AND SUBSEQUENT FATAL BREAST CANCER RISK AMONG SEVENTH-DAY ADVENTISTS

1988 • 65 citations

Breast cancer mortality and diet in the United States.

1979 • 65 citations

Action of Growth Hormone: Current Views

1988 • 64 citations

Insulin-like growth factor-I and its association with binding proteins in bovine milk

1989 • 63 citations

Changes in diet and mortality from selected cancers in southern Mediterranean countries, 1960-1989.

1993 • 58 citations

The effect of westernization on urine estrogens, frequency of ovulation, and breast cancer risk. A study of ethnic chinese women in the orient and the USA

1984 • 56 citations

Oestrogen production in early pregnancy.

1981 • 54 citations

Biotechnology in growth regulation

1990 • 52 citations

Trophic action of local intraileal infusion of insulin-like growth factor I: polyamine dependence

1992 • 51 citations

Suppression of serum insulin-like growth factor-1 levels in breast cancer patients during adjuvant tamoxifen therapy

1993 • 51 citations

Somatotropin and insulin-like growth factor-I concentrations in plasma and milk after daily or sustained-release exogenous somatotropin administrations

1994 • 47 citations

Hormones in Milk

1986 • 45 citations

The Israeli Breast‐Cancer Anomaly^a

1990 • 44 citations

Biology of human milk

1988 • 44 citations

Abomasal Infusion of Casein Enhances Nitrogen Retention in Somatotropin-Treated Steers

1992 • 42 citations

Effect of Dose of Bovine Somatotropin on Nutrient Utilization in Growing Dairy Heifers

1990 • 42 citations

Protein and Fat Metabolism in Cows Given Somavubove Before Parturition

1994 • 40 citations

Bioavailability of estradiol as a marker for breast cancer risk assessment.

1987 • 40 citations

Bioactivity of Milk from bST-Treated Cows

1990 • 39 citations

Presence of Multiple Forms of Peptidase Inhibitors in Rat Milk

1993 • 38 citations

Chemistry, structure, and function of insulin-like growth factors and their receptors: a review

1984 • 37 citations

Mammary Transfer of Hormones and Constituents into Secretions when Cows Were Milked or Secretions Were Sampled Prepartum

1977 • 37 citations

Insulin-like growth factor-I (IGF-I) and IGF-binding protein-2 are increased in cyst fluids of epithelial ovarian cancer

1994 • 35 citations

Regulation of insulin-like growth factor-binding proteins in serum and lymph of lactating cows by somatotropin

1992 • 34 citations

Distribution of estradiol and percentage of free testosterone in sera of Japanese women: preoperative breast cancer patients and normal controls.

1987 • 32 citations

A rapid direct radioimmunoassay for the measurement of oestrone sulphate in the milk of dairy cows and its use in pregnancy diagnosis

1982 • 31 citations

Acute effects of growth factors on T-47D breast cancer cell cycle progression

1993 • 30 citations

Insulin-like growth factor 1 receptors in human breast tumour: Localisation and quantification by histo-autoradiographic analysis

1992 • 29 citations

Breast Cancer Anomalies

1970 • 28 citations

Equivalent Potency and Pharmacokinetics of Recombinant Human Growth Hormones with or without an N-Terminal Methionine

1988 • 28 citations

Modulation of oestrone sulphatase activity in breast cancer cell lines by growth factors

1992 • 27 citations

Retinoic Acid Inhibition of Insulin-like Growth Factor I Stimulation of c-fos mRNA Levels in a Breast Carcinoma Cell Line

1994 • 26 citations

Isolation of Escherichia coli synthesized recombinant eukaryotic proteins that contain 6‐N‐acetyllysine

1994 • 25 citations

Relation of food consumption to cancer mortality in Japan, with special reference to international figures.

1977 • 24 citations

Suramin-induced growth inhibition and insulinlike growth factor-I binding blockade in human breast carcinoma cell lines: potentially related events

1993 • 23 citations

Plasma profiles of somatotropin and IGF-I in diary cows following application of two preparations of recombinant bovine somatotropin in a sustained release vehicle.

1994 • 22 citations

Nitrogen retention in man produced by chymotrypsin digests of bovine somatotropin.

1958 • 21 citations

Macromolecular absorption of food antigens in health and disease.

1984 • 21 citations

Oestrogens in milk

1983 • 17 citations

Carcinogens in Israeli Milk: A Study in Regulatory Failure

1993 • 17 citations

Enzymatic maturation of the gastrointestinal tract and its relevance to food allergy and intolerance in infancy.

1984 • 17 citations

Changes in concentrations of insulin-like growth factor 1, insulin and growth hormone in bovine mammary gland secretion ante and post partum

1991 • 15 citations

Age at First Birth, Dietary Practices and Breast Cancer Mortality in Various Italian Regions

1986 • 15 citations

Dietary Fat and Mammary Cancer

2018 • 14 citations

Food safety and pharmacokinetic studies which support a zero (0) meat and milk withdrawal time for use of sometribove in dairy cows.

1990 • 14 citations

Liposomes as a Proposed Vehicle for the Persorption of Bovine Xanthine Oxidase

1980 • 13 citations

Effect of Recombinant Bovine Somatotropin (BST) on Physiological Parameters and on Milk Production in German Fleckvieh Cows

1991 • 11 citations

bSTH and IGF‐I Levels in Blood and Milk of Black and White Dairy Cows before and after Application of Recombinantly Derived Bovine Somatotropin

1990 • 10 citations

Dietary fat and cancer in Italy.

1993 • 8 citations

Macronutrients and Cancer

1984 • 7 citations

Effects of recombinant bovine somatotropin implants on serum concentrations of somatotropin, insulin-like growth factor-I and blood urea nitrogen in steers.

1994 • 6 citations

Somatotropin safety--a short regulatory overview.

1988 • 5 citations

BIOLOGICAL ACTIVITY OF AMINO-TERMINAL AMINO ACID VARIANTS OF BOVINE SOMATOTROPIN

1989 • 3 citations

Changing patterns in the dairy industry.

1986 • 2 citations

Changing patterns in the dairy industry.

1986 • 1 citations