Stress versus depression

Psychopharmacology: The third generation of progress

1988 • 3,403 citations

Behavioural despair in rats: A new model sensitive to antidepressant treatments

1978 • 3,035 citations

Psychopharmacology: The Third Generation of Progress.

1988 • 1,973 citations

Psychopharmacology : a generation of progress

1978 • 1,168 citations

Selective activation of the mesocortical DA system by stress

1976 • 1,037 citations

Psychopharmacology: A generation of progress

1978 • 785 citations

Effects of stress on the immune system

1990 • 666 citations

Behavioral depression produced by an uncontrollable stressor: Relationship to norepinephrine, dopamine, and serotonin levels in various regions of rat brain

1981 • 659 citations

Use of plasma norepinephrine for evaluation of sympathetic neuronal function in man

1976 • 548 citations

Stress and immunity: An integrated view of relationships between the brain and the immune system

1989 • 533 citations

Plasma Catecholamines in Stress and Exercise

1980 • 513 citations

Treatment of depression : old controversies and new approaches

1983 • 463 citations

Psychopharmacology of Aversively Motivated Behavior

1978 • 445 citations

Presynaptic modulation of beta adrenergic receptors in rat cerebral cortex after treatment with antidepressants.

1978 • 440 citations

Suppression of firing activity of 5-HT neurons in the dorsal raphe by alpha-adrenoceptor antagonists

1980 • 435 citations

Depression: The predisposing influence of stress

1982 • 431 citations

Treatment of Depression: Old Controversies and New Approaches

1983 • 428 citations

Differential effects of inescapable footshocks and of stimuli previously paired with inescapable footshocks on dopamine turnover in cortical and limbic areas of the rat

1982 • 424 citations

Zur Serotonin-Hypothese der Depression*

1990 • 397 citations

Catecholamines and Stress

1976 • 390 citations

Effect of clonidine on growth hormone release in psychiatric patients and controls

1980 • 377 citations

A Review of REM Sleep Deprivation

1975 • 361 citations

The Efficacy of Antidepressant Drugs

1974 • 353 citations

Fluoxetine

1986 • 319 citations

Growth Hormone and other Responses to Clonidine in Patients with Endogenous Depression

1981 • 300 citations

Learned helplessness and animal models of depression

1984 • 286 citations

Serotonergic Function in Depression

1984 • 280 citations

Plasma catecholamine, corticosterone and glucose responses to repeated stress in rats: Effect of interstressor interval length

1990 • 260 citations

Adrenergic receptor control mechanism for growth hormone secretion

1968 • 260 citations

Neurochemical basis of the action of antidepressants on learned helplessness

1980 • 253 citations

Adrenergic Receptor Sensitivity in Depression

1982 • 253 citations

Resting Plasma Catecholamine Concentrations in Patients With Depression and Anxiety

1971 • 249 citations

Serotonergic innervation of the locus coeruleus from the dorsal raphe and its action on responses to noxious stimuli.

1979 • 247 citations

High plasma norepinephrine levels in patients with major affective disorder

1982 • 246 citations

The Stress Response: A New Perspective

1979 • 238 citations

Catecholamine depletion in mice upon reexposure to stress: Mediation of the escape deficits produced by inescapable shock.

1979 • 238 citations

Neuroregulators and psychiatric disorders

1978 • 233 citations

Tricyclic antidepressants: Effects on the firing rate of brain noradrenergic neurons

1975 • 224 citations

Dissociation of sympathetic nervous system and adrenal medullary responses

1984 • 220 citations

Stress-induced enhancement of dopamine and acetylcholine release in limbic structures: role of corticosterone

1989 • 211 citations

Epinephrine, norepinephrine, dopamine and serotonin: Differential effects of acute and chronic stress on regional brain amines

1982 • 210 citations

Platelet activation and secretion associated with emotional stress.

1985 • 198 citations

Deficits of escape performance following catecholamine depletion: Implications for behavioral deficits induced by uncontrollable stress

1979 • 196 citations

Controllable and uncontrollable stress in humans: alterations in mood and neuroendocrine and psychophysiological function

1987 • 192 citations

Growth hormone response to clonidine as a probe of noradrenergic receptor responsiveness in affective disorder patients and controls

1982 • 190 citations

Coping with stress, norepinephrine depletion and escape performance

1980 • 187 citations

Plasma Norepinephrine Level in Affective Disorders

1985 • 187 citations

Effect of stressor intensity on habituation of the adrenocortical stress response

1988 • 187 citations

Reevaluation of the indoleamine hypothesis of depression. Evidence for a reduction of functional activity of central 5-HT systems by antidepressant drugs

1979 • 181 citations

Pimozide Therapy for Trigeminal Neuralgia

1989 • 175 citations

Stress adaptation and adrenal activity in isolated and crowded rats

1986 • 168 citations

Effects of chronic guanethidine treatment and adrenal medullectomy on plasma levels of catecholamines and corticosterone in forcibly immobilized rats.

1979 • 164 citations

Neuroendocrinological and neurophysiological studies in major depressive disorders: are there biological markers for the endogenous subtype?

1982 • 159 citations

New studies and perspectives on the noradrenergic receptor system in depression: effects of the alpha 2-adrenergic agonist clonidine.

1984 • 158 citations

Interactions of pharmacological agents which alter biogenic amine metabolism and depression

1979 • 147 citations

Adrenocortical and behavioral responses to repeated stressors: toward an animal model of chronic stress and stress-related mental illness

1989 • 147 citations

Stress‐Related Changes in Cerebral Catecholamine and Indoleamine Metabolism: Lack of Effect of Adrenalectomy and Corticosterone

1988 • 145 citations

Changes in plasma and brain tryptophan and brain serotonin and 5-hydroxyindoleacetic acid after footshock stress

1988 • 143 citations

The development of cortical β-adrenoceptor subsensitivity in the rat by chronic treatment with trazodone, doxepin and mianserine

1978 • 138 citations

Relationship between norepinephrine in blood and cerebrospinal fluid in the presence of a blood cerebrospinal fluid barrier for norepinephrine

1977 • 136 citations

Increased Levels of Free Serotonin in Plasma of Symptomatic Asthmatic Patients

1996 • 135 citations

Cytokine production in major depressed patients before and after clomipramine treatment

1994 • 124 citations

Serotonin. Current aspects of neurochemistry and function.

1981 • 124 citations

Adrenal hormonal indices of stress in laboratory rats

1987 • 123 citations

Altered platelet function during mental stress and adrenaline infusion in humans: evidence for an increased aggregability in vivo as measured by filtragometry

1989 • 122 citations

Plasma and cerebrospinal fluid 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) as indices of brain norepinephrine metabolism in primates

1982 • 121 citations

Neurochemical Changes Elicited by Stress

1978 • 119 citations

Effect of various antidepressant drugs on the spontaneous firing rate of locu coeruleus and dorsal raphe neurons of the rat

1979 • 115 citations

The effects of alpha adrenergic agents on human platelet aggregation.

1979 • 112 citations

Plasma neurotransmitters, blood pressure, and heart rate during supine-resting, orthostasis, and moderate exercise conditions in major depressed patients

1995 • 110 citations

Response to Phenelzine and Imipramine in Placebo Nonresponders With Atypical Depression

1991 • 109 citations

Psychic distress and the immune response

1985 • 108 citations

Neuroendocrine and neurochemical measurements in depression

1981 • 105 citations

Plasma catecholamine and corticosterone as well as brain catecholamine changes during coping in rats exposed to stressful footshock

1983 • 103 citations

Effects of immobilization stress on dopamine and its metabolites in different brain areas of the mouse: role of genotype and stress duration

1988 • 99 citations

Cerebrospinal fluid amine metabolites, tryptophan and clinical parameters in depression

1981 • 99 citations

Influence of stressor predictability and behavioral control on lymphocyte reactivity, antibody responses and neuroendocrine activation in rats

1988 • 99 citations

Postsynaptic action by four antidepressive drugs in an animal model of depression

1981 • 97 citations

Habituation of sympathetic-adrenal medullary responses following exposure to chronic intermittent stress

1989 • 96 citations

Escape deficits induced by uncontrollable stress: Antagonism by dopamine and norepinephrine agonists

1980 • 93 citations

New Results in Depression Research

1986 • 91 citations

CATECHOLAMINES IN INDIVIDUAL HYPOTHALAMIC NUCLEI IN STRESSED RATS11This work was supported in part by The Foundation's Fund for Research in Psychiatry, New Haven, Conn., USA, Research Grant Number G 71 − 498.

1976 • 90 citations

Noradrenergic and dopaminergic interactions in escape behavior: Analysis of uncontrollable stress effects

1981 • 89 citations

Differential effects of controllable and uncontrollable acute stress on lymphocyte proliferation and leukocyte percentages in humans

1990 • 85 citations

Serotonin: Current aspects of neurochemistry and function

1982 • 84 citations

Persistent neuroendocrine dysregulation in major depressive disorder: a marker for early relapse.

1984 • 80 citations

SELECTIVE ALTERATIONS OF CATECHOLAMINES AND TYROSINE HYDROXYLASE ACTIVITY IN THE HYPOTHALAMUS FOLLOWING ACUTE AND CHRONIC STRESS

1976 • 80 citations

Changes in rat brain monoamine turnover following chronic antidepressant administration

1980 • 79 citations

Hypersensitive Serotonergic Receptors: A New Hypothesis for One Subgroup of Unipolar Depression Derived from an Animal Model

1981 • 75 citations

Autoimmunity in depression: increased antiphospholipid autoantibodies

1993 • 75 citations

Short-term responses of plasma norepinephrine, epinephrine, glucocorticoid and testosterone titers to social and non-social stressors in male guinea pigs of different social status

1987 • 74 citations

The novel antidepressant, tianeptine, reduces stress-evoked stimulation of the hypotalamo-pituitary-adrenal axes

1991 • 74 citations

Chronic treatment with desipramine caused a sustained decrease of 3,4-dihydroxyphenylglycol-sulphate and total 3-methoxy-4-hydroxyphenylglycol in the rat brain

1977 • 74 citations

Treatment of Ulcerative Colitis With Clonidine

1985 • 72 citations

Effect of the chronic ingestion of chlorimipramine and desipramine on the hole board response to acute stresses in male rats

1987 • 72 citations

Net effect of acute administration of desipramine on the locus coeruleus — hippocampal system

1979 • 70 citations

Central norepinephrine and plasma corticosterone following acute and chronic stressors: Influence of social isolation and handling

1986 • 68 citations

Modulation of the immune response by emotional stress

1987 • 67 citations

Learned helplessness induction decreases in vivo cortical serotonin release

1983 • 66 citations

Chronic administration of antidepressant drugs increases the density of cortical [3H]prazosin binding sites in the rat

1984 • 66 citations

Interactions between putative neurotransmitters in the brain

1978 • 66 citations

Natural Killer Cell Activity in Patients Undergoing Upper Abdominal Surgery: Relationship to the Endocrine Stress Response

1984 • 64 citations

Platelet activation by circulating levels of hormones: A possible link in coronary heart disease

1984 • 63 citations

Up- and down-regulation of central postsynaptic ?2 receptors reflected in the growth hormone response to clonidine in reserpine-pretreated rats

1982 • 62 citations

A Biochemical and Neuroendocrine Study of the Serotonergic System in Depression

1986 • 62 citations

Consistent evidence for a biological subtype of depression characterized by low CSF monoamine levels

1986 • 62 citations

Stress-induced Impairment of Macrophage Tumoricidal Function

1980 • 62 citations

Moclobemide Versus Clomipramine in Endogenous Depression

1992 • 61 citations

Monoaminergic Control of Episodic Growth Hormone Secretion in the Rat: Effects of Reserpine, a-Methyl-p-Tyrosine, p-Chlorophenylalanine, and Haloperidol*

1979 • 58 citations

MHPG as a predictor of antidepressant response to imipramine and maprotiline

1980 • 57 citations

Effects of Clonidine on Blood Pressure, Noradrenaline, Cortisol, Growth Hormone, and Prolactin Plasma Levels in High and Low Intestinal Tone Depressed Patients

1985 • 57 citations

Plasma neurotransmitters and cortisol in chronic illness: role of stress.

1994 • 56 citations

Cerebrospinal fluid 5-hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA) following probenecid in unipolar depressives treated with amitriptyline

1972 • 56 citations

Comparative study of the effects of mianserin, a tetracyclic antidepressant, and of imipramine on uptake and release of neurotransmitters in synaptosomes

1976 • 56 citations

Plasma catecholamines associated with hypothalamically-elicited flight behavior

1986 • 55 citations

A comparison of the acute and chronic effects of four antidepressant drugs on the turnover of serotonin, dopamine and noradrenaline in the rat brain

1976 • 54 citations

Clinical pharmacology and therapeutics

1982 • 53 citations

Effect of Emotional Stress on Platelet Aggregation in Humans

1976 • 49 citations

Neurogenic hypertension after depletion of norepinephrine in anterior hypothalamus induced by 6-hydroxydopamine administration into the ventral pons: Role of serotonin

1983 • 48 citations

Effects of restraint stress on inoculated tumor growth and immune response in rats.

1985 • 48 citations

Noradrenergic Regulation of Growth Hormone Secretion in the Baboon*

1983 • 47 citations

Treatment of depression by altering monoamine metabolism: precursors and metabolic inhibitors.

1984 • 47 citations

Immunity, major depression, and panic disorder comorbidity

1992 • 46 citations

Cholinergic Hypothesis of Depression

1989 • 43 citations

Role of stress in the exacerbation of chronic illness: Effects of clonidine administration on blood pressure and plasma norepinephrine, cortisol, growth hormone and prolactin concentrations

1987 • 42 citations

Controllable and uncontrollable footshock and monoaminergic activity in the frontal cortex of male and female rats

1991 • 41 citations

Foot-shock stress accelerates non-striatal dopamine synthesis without activating tyrosine hydroxylase

1979 • 41 citations

Psychoneuroendocrinological and immunological parameters in cancer patients: Involvement of stress and depression

1990 • 40 citations

Serotonin receptor sensitivity in major depression

1990 • 40 citations

Recent advances in pharmacology and therapeutics.

1948 • 40 citations

Effects of an Oral Glucose Load on Plasma Neurotransmitters in Humans: Involvement of REM Sleep?

1992 • 39 citations

Plasma catecholamines associated with hypothalamically-elicited defense behavior

1986 • 39 citations

Long-term treatment with zimelidine leads to a reduction in 5-hydroxytryptamine neurotransmission within the central nervous system of the mouse and rat

1981 • 38 citations

Effects of antidepressant treatments on 5-HT neurotransmission: electrophysiological and clinical studies.

1984 • 38 citations

Chronic treatment with some atypical antidepressants increases the brain level of 3-methoxy-4-hydroxyphenylglycol (MHPG) in rats

1981 • 36 citations

Absolute Number and Percentage of Circulating Natural Killer, Non-MHC-Restricted T Cytotoxic, and Phagocytic Cells in Unipolar Depression

1994 • 36 citations

Sympathetic-adrenal medullary response to stress in hyperactive and hypertensive rats

1988 • 36 citations

Plasma neurotransmitters and cortisol in duodenal ulcer patients

1990 • 35 citations

Plasma Neurotransmitters, Blood Pressure and Heart Rate during Supine Resting, Orthostasis and Moderate Exercise in Severely III Patients: A Model of Failing to Cope with Stress

1996 • 34 citations

Plasma neurotransmitters, blood pressure, and heart rate during supine resting, orthostasis, and moderate exercise in dysthymic depressed patients

1995 • 34 citations

Doxepin therapy for postprandial symptomatic hypoglycaemic patients: neurochemical, hormonal and metabolic disturbances

1991 • 33 citations

Depression: Biology, Psychodynamics, and Treatment

1978 • 33 citations

Immobilization stress‐induced changes in discrete hypothalamic catecholamine levels and turnover, their modulation by nicotine and relationship to neuroendocrine function

1983 • 33 citations

ADVANCES IN PHARMACOLOGY AND THERAPEUTICS

1979 • 32 citations

Met-enkephalin, injected during the early phase of stress, attenuates stress-induced increases in noradrenaline release in rat brain regions

1989 • 32 citations

Pharmacological therapy of dysthymia

1994 • 30 citations

The effects of chemical sympathectomy on dopamine, noradrenaline and adrenaline content in some peripheral tissues

1985 • 29 citations

Noradrenergic afferents to median eminence: Inhibitory role in rhythmic growth hormone secretion

1980 • 28 citations

Effects of Clonidine on Blood Pressure, Noradrenaline, Cortisol, Growth Hormone, and Prolactin Plasma Levels in High and Low Intestinal Tone Subjects

1985 • 28 citations

Neuroendocrine Dysfunction in Subtypes of Depression

1984 • 28 citations

Lesions of the ventromedial hypothalamic nucleus enhance sympatho-adrenal function

1985 • 27 citations

Plasma Neurotransmitters Throughout an Oral Glucose Tolerance Test in Non-Depressed Essential Hypertension Patients

1993 • 27 citations

The “Spastic Colon” Syndrome: Therapeutic and Pathophysiologic Considerations

1977 • 27 citations

Distal colon motility and clinical parameters in depression

1983 • 25 citations

Antidiarrheal Effects of Dihydroergotamine

1977 • 25 citations

Pharmacomanometric Studies of Colonic Motility as a Guide to the Chemotherapy of Schizophrenia

1980 • 24 citations

Moclobemide Versus Fluoxetine for Major Depressive Episodes

1994 • 24 citations

Central catecholamine depletion impairs in vivo immunity but not in vitro lymphocyte activation

1988 • 24 citations

Selective noradrenaline depletion markedly alters stress responses in rats

1985 • 23 citations

The effects of acute and chronic administration of tricyclic antidepressants on MHPG-SO4 in rat brain.

1977 • 22 citations

Intestinal pharmacomanometry and glucose tolerance: evidence for two antagonistic dopaminergic mechanisms in the human.

1981 • 20 citations

A double‐blind study of zimelidine, a serotonin uptake inhibitor, and desipramine, a noradrenaline uptake inhibitor, in endogenous depression

1982 • 20 citations

Distal Colon Motility in Schizophrenic Patients

1980 • 19 citations

Distal colon motility as a predictor of antidepressant response to fenfluramine, imipramine and clomipramine

1983 • 19 citations

Neurotransmitters and central regulation of adrenal functions

1985 • 17 citations

Moclobemide versus imipramine in depressed out-patients

1993 • 17 citations

Peripheral Blood Immunological Parameters in Long-Term Benzodiazepine Users

1994 • 16 citations

Depression: "Biology, Psychodynamics, And Treatment"

2012 • 15 citations

Age, cellular immunity and the HP axis in major depression

1988 • 15 citations

Performance and extinction of lever press behavior following chronic administration of desipramine to rats

1985 • 14 citations

Treatment of Ulcerative Colitis with Thioproperazine

1982 • 14 citations

Dramatic improvement with clonidine in acute pancreatitis with elevated catecholamine and cortisol plasma levels: report of five cases.

1992 • 14 citations

Physiological, Clinical and Therapeutical Basis of a New Hypothesis for Headache

1980 • 13 citations

Classification of Depressive Disorders

1978 • 13 citations

Colon motility and psychological traits in irritable bowel syndrome

1981 • 12 citations

Evidence for stabilization of cortical 5HT neurotransmission by chronic treatment with antidepressant drugs: induction of a high and a low affinity component in 3H‐5HT binding sites

1982 • 12 citations

Neurochemistry and Clinical Disorders: Circuitry of Some Psychiatric and Psychosomatic Syndromes

2020 • 12 citations

On the use of clonidine and thioproperazine in a woman with Gilles de la Tourette's disease.

1982 • 12 citations

Moclobemide versus clomipramine in the treatment of depression: a multicentre trial in Spain

1990 • 11 citations

Neurochemistry & Clinical Disorders

1988 • 11 citations

The Dopaminergic and Noradrenergic Blockades:

1978 • 10 citations

Noradrenergic or Dopaminergic Activity in Chronic Schizophrenia

1981 • 9 citations

The categorical and dimensional models of endogenous depression

1985 • 8 citations

Pharmacological Spectrum of Some New Antidepressants

1979 • 8 citations

RELATIONSHIP OF CATECHOLAMINES, HISTAMINE AND SEROTONIN IN MEN UNDER DIFFERENT KINDS OF STRESS**Presented by abstract only

1976 • 8 citations

Definite and sustained improvement with pimozide of two patients with severe trigeminal neuralgia. Some neurochemical, neurophysiological and neuroendocrinological findings.

1988 • 8 citations

5‐HYDROXYTRYPTAMINE UPTAKE INHIBITORS BLOCK para‐METHOXYAMPHETAMINE‐INDUCED 5‐HT RELEASE

1979 • 7 citations

Learned Helplessness — An Animal Model Revisited

1983 • 7 citations

A NEW TREATMENT FOR HEADACHE: PATHOPHYSIOLOGIC CONSIDERATIONS

1977 • 5 citations

The influence of mianserin and danitracen on the disappearance of noradrenaline in the rat brain.

1978 • 4 citations

Plasma 3,4-Dihydroxyphenylethyleneglycol and 3-Methoxy-4-Hydroxyphenylethyleneglycol as Indicators of Central Noradrenergic Activity

1988 • 3 citations

Catecholamine depletion in mice upon reexposure to stress : Mediation of the escape deficits produced by inscapable shock

1979 • 2 citations

Deleted Work

1955 • 0 citations