Plasma and cerebrospinal fluid 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) as indices of brain norepinephrine metabolism in primates

Stereotaxic Mapping of the Monoamine Pathways in the Rat Brain*

1971 • 3,816 citations

The organization of the ascending catecholamine neuron systems in the rat brain as revealed by the glyoxylic acid fluorescence method.

1974 • 1,130 citations

Noradrenergic neurons of the locus coeruleus: inhibition by epinephrine and activation by the α-antagonist piperoxane

1976 • 638 citations

Afferent projections to the rat locus coeruleus as determined by a retrograde tracing technique

1978 • 537 citations

A new major projection from locus coeruleus: The main source of noradrenergic nerve terminals in the ventral and dorsal columns of the spinal cord

1977 • 476 citations

Feedback Inhibition of Brain Noradrenaline Neurons by Tricyclic Antidepressants: α-Receptor Mediation

1978 • 396 citations

Different alpha-adrenoreceptors in the central nervous system mediating biochemical and functional effects of clonidine and receptor blocking agents

1976 • 378 citations

Metabolism of normetanephrine-H3 in rat brain—identification of conjugated 3-methoxy-4-hydrophenylglycol as the major metabolite

1968 • 368 citations

Increased turnover of norepinephrine in the rat cerebral cortex during stress: Role of the locus coeruleus

1973 • 313 citations

Stimulation and destruction of the locus coeruleus: Opposite effects on 3-methoxy-4-hydroxyphenylglycol sulfate levels in the rat cerebral cortex

1973 • 258 citations

3-Methoxy-4-hydroxyphenylglycol sulfate in brain and cerebrospinal fluid

1968 • 229 citations

Conversion of MHPG to Vanillylmandelic Acid

1980 • 199 citations

3-Methoxy-4-Hydroxyphenethyleneglycol Production by Human Brain in Vivo

1979 • 179 citations

THE METABOLISM OF [C¹⁴]NORADRENALINE BY CAT BRAIN IN VIVO*

1963 • 166 citations

Locus coeruleus complex: elicitation of a pressor response and a brain stem region necessary for its occurence

1976 • 151 citations

The rate of formation of 3-methoxy-4-hydroxyphenylethyleneglycol sulfate in brain as an estimate of the rate of formation of norepinephrine.

1973 • 136 citations

The determination of a brain arteriovenous difference for 3-methoxy-4-hydroxyphenethyleneglycol (MHPG)

1976 • 134 citations

Spinal projections from the nucleus locus coeruleus and nucleus subcoeruleus in the cat and monkey as demonstrated by the retrograde transport of horseradish peroxidase

1976 • 132 citations

Presence of free, sulfate and glucuronide conjugated 3-methoxy-4-hydroxyphenylglycol (MHPG) in human brain, cerebrospinal fluid and plasma

1977 • 120 citations

NOREPINEPHRINE METABOLISM IN THE CENTRAL NERVOUS SYSTEM OF MAN: STUDIES USING 3‐METHOXY‐4‐HYDROXYPHENYLETHYLENE GLYCOL LEVELS IN CEREBROSPINAL FLUID

1973 • 114 citations

Origin and distribution of 3-methoxy-4-hydroxyphenylglycol in body fluids

1979 • 111 citations

Central Noradrenergic Control of Blood Pressure

1976 • 107 citations

INCREASE OF NORADRENALINE METABOLISM FOLLOWING ELECTRICAL STIMULATION OF THE LOCUS COERULEUS IN THE RAT¹

1973 • 79 citations

A direct method for studying 3-methoxy-4-hydroxyphenethyleneglycol (MHPG) production by brain in awake animals

1977 • 78 citations

Alterations in turnover and endogenous levels of norepinephrine in cerebral cortex following electrical stimulation and acute axotomy of cerebral noradrenergic pathways

1973 • 78 citations

Clonidine reverses the increased norepinephrine turnover during morphine withdrawal in rats

1980 • 76 citations

3-Methoxy-4-hydroxyphenethyleneglycol increase in plasma after stimulation of the nucleus locus coeruleus

1978 • 75 citations

Quantitative determination of 4-hydroxy-3-methoxyphenyl glycol and its conjugates in cerebrospinal fluid by mass fragmentography

1973 • 74 citations

Effect of stress on sulfated glycol metabolites of brain norepinephrine

1975 • 60 citations

Mass fragmentographic determination of 4-hydroxy-3-methoxymndelic acid in human urine, cerebrospinal fluid, brain and serum using a deuterium-labelled internal standard

1975 • 53 citations

Plasma and CSF MHPG in normals [proceedings].

1981 • 52 citations

Evidence against specificity of electrical stimulation of the nucleus locus coeruleus in activating the sympathetic nervous system in the rat

1980 • 48 citations

DISTRIBUTION AND TURNOVER RATE OF VANILLYL‐MANDELIC ACID AND 3‐METHOXY‐ 4‐ HYDROXYPHENYLGLYCOL IN RAT BRAIN

1976 • 47 citations

3-Methoxy-4-hydroxyphenylethyleneglycol (MHPG) transport from the spinal cord during spinal subarachnoid perfusion

1976 • 43 citations

Biochemical evidence for simultaneous activation of multiple locus coeruleus efferents

1980 • 41 citations

Central noradrenergic activity and the formation of glycol sulfate metabolites of brain norepinephrine

1976 • 40 citations

The occurrence of free vs. conjugated MHPG in non-human and human primate brain.

1976 • 29 citations

Lesions of the locus ceruleus and noradrenaline metabolism in cerebral cortex

1973 • 29 citations

ON THE ORIGIN OF VANILLYLMANDELIC ACID AND 3‐METHOXY‐4‐HYDROXY‐PHENYLGLYCOL IN THE RAT BRAIN

1978 • 28 citations

Origin of free 3-methoxy-4-hydroxyphenylethyleneglycol in rat cerebrospinal fluid

1979 • 25 citations

Comparison of two α-noradrenergic agonists (clonidine and guanfacine) on norepinephrine turnover in the cortex of rats during morphine abstinence

1981 • 23 citations