Detection of mutant K-ras DNA in plasma or serum of patients with colorectal cancer

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

Avoiding false positives with PCR

1989 • 3,564 citations

Prevalence of ras gene mutations in human colorectal cancers

1987 • 1,866 citations

Free DNA in the serum of cancer patients and the effect of therapy.

1977 • 1,708 citations

Detection of high incidence of K-ras oncogenes during human colon tumorigenesis

1987 • 1,074 citations

Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history.

1993 • 796 citations

Identification of ras Oncogene Mutations in the Stool of Patients with Curable Colorectal Tumors

1992 • 703 citations

Neoplastic Characteristics of the DNA Found in the Plasma of Cancer Patients

1989 • 687 citations

Detection of melanoma cells in peripheral blood by means of reverse transcriptase and polymerase chain reaction

1991 • 658 citations

Microsatellite alterations in plasma DNA of small cell lung cancer patients

1996 • 656 citations

Microsatellite alterations in serum DNA of head and neck cancer patients

1996 • 653 citations

Soluble normal and mutated DNA sequences from single-copy genes in human blood.

1994 • 478 citations

Sensitive detection of occult breast cancer by the reverse-transcriptase polymerase chain reaction.

1994 • 443 citations

Determination of circulating DNA levels in patients with benign or malignant gastrointestinal disease

1983 • 398 citations

Point mutations of the N‐ras gene in the blood plasma DNA of patients with myelodysplastic syndrome or acute myelogenous leukaemia

1994 • 392 citations

Detection of ras gene mutations in pancreatic juice and peripheral blood of patients with pancreatic adenocarcinoma.

1993 • 380 citations

Detection of hematogenous micrometastasis in patients with prostate cancer.

1992 • 374 citations

Isolation and characterization of DNA from the plasma of cancer patients

1987 • 352 citations

Detection of occult melanoma cells in blood with a multiple-marker polymerase chain reaction assay.

1995 • 338 citations

Interference of heparin with the polymerase chain reaction.

1990 • 275 citations

Spontaneous release of DNA by human blood lymphocytes as shown in an in vitro system.

1975 • 233 citations

Detection of circulating tumor cells in patients with localized and metastatic prostatic carcinoma: clinical implications.

1995 • 220 citations

Rapid and sensitive nonradioactive detection of mutant K-ras genes via 'enriched' PCR amplification.

1991 • 184 citations

Detection of residual lymphoma cells by polymerase chain reaction in peripheral blood is significantly less predictive for relapse than detection in bone marrow

1994 • 182 citations

Excretion of Deoxyribonucleic Acid by Lymphocytes Stimulated with Phytohemagglutinin or Antigen

1972 • 158 citations

Sensitive detection of circulating hepatocellular carcinoma cells in peripheral venous blood

1995 • 133 citations

Detection of Circulating Tumor Cells in Colorectal Cancer by Immunobead-PCR Is a Sensitive Prognostic Marker for Relapse of Disease

1995 • 117 citations

Circulating Nucleic Acids in Higher Organisms

1977 • 106 citations

High frequency of K‐ras mutations in normal appearing lung tissues and sputum of patients with lung cancer

1995 • 83 citations

Cell-surface-associated nucleic acid in tumorigenic cells made visible with platinum-pyrimidine complexes by electron microscopy.

1975 • 79 citations

GENOMIC INSTABILITY IN COLORECTAL CARCINOMAS: COMPARISON OF DIFFERENT EVALUATION METHODS AND THEIR BIOLOGICAL SIGNIFICANCE

1996 • 70 citations

Actions of cis-diamminedichloroplatinum on cell surface nucleic acids in cancer cells as determined by cell electrophoresis techniques.

1982 • 37 citations

Persistence of myeloid progenitor cells expressing BCR-ABL mRNA after allogeneic bone marrow transplantation for chronic myelogenous leukemia

1994 • 37 citations

Recovery of nanogram quantities of DNA from plasma and quantitative measurement using labeling by nick translation

1986 • 27 citations

A comparison of DNA and DNA-binding protein levels in malignant disease

1981 • 16 citations

Detection of residual lymphoma cells by polymerase chain reaction in peripheral blood is significantly less predictive for relapse than detection in bone marrow

1994 • 16 citations

DNA assay in human blood plasma

1986 • 6 citations

GENOMIC INSTABILITY IN COLORECTAL CARCINOMAS: COMPARISON OF DIFFERENT EVALUATION METHODS AND THEIR BIOLOGICAL SIGNIFICANCE

1996 • 5 citations

Persistence of myeloid progenitor cells expressing BCR-ABL mRNA after allogeneic bone marrow transplantation for chronic myelogenous leukemia

1994 • 3 citations