Molecular aspects of ATP-sensitive K+ channels in the cardiovascular system and K+ channel openers

ATP-regulated K+ channels in cardiac muscle

1983 • 2,350 citations

Physiological roles and properties of potassium channels in arterial smooth muscle

1995 • 2,146 citations

Reconstitution of I _KATP : An Inward Rectifier Subunit Plus the Sulfonylurea Receptor

1995 • 1,703 citations

Cloning of the β Cell High-Affinity Sulfonylurea Receptor: a Regulator of Insulin Secretion

1995 • 1,310 citations

Intracellular ATP directly blocks K+ channels in pancreatic B-cells

1984 • 1,199 citations

Hyperpolarizing Vasodilators Activate ATP-sensitive K ⁺ Channels in Arterial Smooth Muscle

1989 • 1,197 citations

Primary structure and functional expression of a mouse inward rectifier potassium channel

1993 • 1,004 citations

A Family of Sulfonylurea Receptors Determines the Pharmacological Properties of ATP-Sensitive K+ Channels

1996 • 968 citations

Cloning and expression of an inwardly rectifying ATP-regulated potassium channel

1993 • 935 citations

Determination of the subunit stoichiometry of a voltage-activated potassium channel

1991 • 925 citations

Adenosine 5'-Triphosphate-Sensitive Potassium Channels

1988 • 888 citations

Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gβγ

1998 • 886 citations

The G-protein-gated atrial K+ channel IKAch is a heteromultimer of two inwardly rectifying K+-channel proteins

1995 • 830 citations

ATP-sensitive and inwardly rectifying potassium channels in smooth muscle

1997 • 827 citations

Mutations in the Sulfonylurea Receptor Gene in Familial Persistent Hyperinsulinemic Hypoglycemia of Infancy

1995 • 812 citations

Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor

1997 • 757 citations

Association and Stoichiometry of KATP Channel Subunits

1997 • 697 citations

Properties and functions of ATP-sensitive K-channels

1990 • 690 citations

Regulation of Cardiac Na ⁺ ,Ca ²⁺ Exchange and K _ATP Potassium Channels by PIP ₂

1996 • 655 citations

Primary structure and functional expression of a rat G-protein-coupled muscarinic potassium channel

1993 • 600 citations

Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic ?-cells

1986 • 572 citations

Membrane Phospholipid Control of Nucleotide Sensitivity of K _ATP Channels

1998 • 569 citations

A Novel Sulfonylurea Receptor Forms with BIR (Kir6.2) a Smooth Muscle Type ATP-sensitive K+ Channel

1996 • 539 citations

Adenosine Diphosphate as an Intracellular Regulator of Insulin Secretion

1996 • 532 citations

The Pharmacology of ATP-Sensitive Potassium Channels

1993 • 530 citations

PIP ₂ and PIP as Determinants for ATP Inhibition of K _ATP Channels

1998 • 517 citations

Octameric Stoichiometry of the KATP Channel Complex

1997 • 495 citations

Arterial dilations in response to calcitonin gene-related peptide involve activation of K+ channels

1990 • 458 citations

Cloning and functional expression of the cDNA encoding a novel ATP‐sensitive potassium channel subunit expressed in pancreatic β‐cells, brain, heart and skeletal muscle

1995 • 417 citations

Molecular biology of voltage-dependent potassium channels

1992 • 412 citations

Cloning and Functional Characterization of a Novel ATP-sensitive Potassium Channel Ubiquitously Expressed in Rat Tissues, including Pancreatic Islets, Pituitary, Skeletal Muscle, and Heart

1995 • 405 citations

Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea‐sensitive but ATP‐insensitive K+ channel.

1997 • 390 citations

Correlating structure and function in ATP-sensitive K+ channels

1998 • 388 citations

The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide

1997 • 343 citations

Inward-rectifying channels in isolated patches of the heart cell membrane: ATP-dependence and comparison with cell-attached patches

1984 • 333 citations

Pulling springs to tune transduction: Adaptation by hair cells

1994 • 323 citations

Cardiac ATP-sensitive K+ channels: regulation by intracellular nucleotides and K+ channel-opening drugs

1995 • 309 citations

Antidiabetic sulfonylureas control action potential properties in heart cells via high affinity receptors that are linked to ATP-dependent K+ channels.

1988 • 292 citations

Cloning provides evidence for a family of inward rectifier and G‐protein coupled K⁺ channels in the brain

1994 • 280 citations

Potassium channels and their evolving gates

1994 • 278 citations

Subunit stoichiometry of the pancreatic β‐cell ATP‐sensitive K⁺ channel

1997 • 271 citations

Structural Elements Involved in Specific K+ Channel Functions

1992 • 268 citations

Cloning, Tissue Expression, and Chromosomal Localization of SUR2, the Putative Drug-Binding Subunit of Cardiac, Skeletal Muscle, and Vascular KATP Channels

1996 • 266 citations

A Novel ATP-dependent Inward Rectifier Potassium Channel Expressed Predominantly in Glial Cells

1995 • 265 citations

ATP-sensitive potassium channel modulation of the guinea pig ventricular action potential and contraction.

1991 • 254 citations

Membrane topology distinguishes a subfamily of the ATP‐binding cassette (ABC) transporters

1997 • 237 citations

Loss of functional KATP channels in pancreatic β–cells causes persistent hyperinsulinemic hypoglycemia of infancy

1996 • 225 citations

Determination of the subunit stoichiometry of an inwardly rectifying potassium channel

1995 • 222 citations

K channel activation by nucleotide diphosphates and its inhibition by glibenclamide in vascular smooth muscle cells

1993 • 203 citations

Properties of cloned ATP‐sensitive K+ currents expressed in Xenopus oocytes.

1997 • 198 citations

On the mechanism of G protein beta gamma subunit activation of the muscarinic K+ channel in guinea pig atrial cell membrane. Comparison with the ATP-sensitive K+ channel.

1992 • 195 citations

ATP-sensitive K+ channels that are blocked by hypoglycemia-inducing sulfonylureas in insulin-secreting cells are activated by galanin, a hyperglycemia-inducing hormone.

1988 • 193 citations

A Novel Inward Rectifier K+ Channel with Unique Pore Properties

1998 • 185 citations

Subunit positional effects revealed by novel heteromeric inwardly rectifying K+ channels.

1996 • 185 citations

Cloning and expression of a family of inward rectifier potassium channels.

1994 • 170 citations

MgADP Antagonism to Mg2+-independent ATP Binding of the Sulfonylurea Receptor SUR1

1997 • 169 citations

Regulation of ATP-sensitive K+ channels in insulinoma cells: activation by somatostatin and protein kinase C and the role of cAMP.

1989 • 163 citations

Guanosine diphosphate activates an adenosine 5'‐triphosphate‐sensitive K+ channel in the rabbit portal vein.

1991 • 160 citations

Promiscuous coupling between the sulphonylurea receptor and inwardly rectifying potassium channels

1996 • 159 citations

Dual effects of ATP on K+ currents of mouse pancreatic ?-cells

1987 • 158 citations

Endothelin blocks ATP-sensitive K+ channels and depolarizes smooth muscle cells of porcine coronary artery.

1992 • 157 citations

ATP‐sensitive K+ channels in rat pancreatic beta‐cells: modulation by ATP and Mg2+ ions.

1989 • 152 citations

The Epithelial Inward Rectifier Channel Kir7.1 Displays Unusual K⁺Permeation Properties

1998 • 146 citations

ATP-sensitive inward rectifier and voltage- and calcium-activated K+ channels in cultured pancreatic islet cells

1985 • 144 citations

ATP maintains ATP-inhibited K+ channels in an operational state

1986 • 139 citations

On the mechanism of nucleotide diphosphate activation of the ATP‐sensitive K+ channel in ventricular cell of guinea‐pig.

1991 • 132 citations

The effect of intracellular anions on ATP‐dependent potassium channels of rat skeletal muscle.

1994 • 129 citations

Molecular cloning, functional expression and localization of a novel inward rectifier potassium channel in the rat brain

1994 • 124 citations

Molecular cloning and functional expression of cDNA encoding a second class of inward rectifier potassium channels in the mouse brain.

1994 • 117 citations

Potassium channel openers act through an activation of ATP-sensitive K+ channels in guinea-pig cardiac myocytes

1989 • 116 citations

Action potential duration and activation of ATP-sensitive potassium current in isolated guinea-pig ventricular myocytes

1990 • 114 citations

Molecular cloning and functional expression of a novel brain‐specific inward rectifier potassium channel

1994 • 105 citations

Two types of ATP‐sensitive potassium channels in rat portal vein smooth muscle cells

1996 • 104 citations

Actin microfilament disrupters enhance K(ATP) channel opening in patches from guinea‐pig cardiomyocytes.

1996 • 104 citations

Kir2.4: A Novel K⁺Inward Rectifier Channel Associated with Motoneurons of Cranial Nerve Nuclei

1998 • 103 citations

Inhibition of ATP-sensitive K+ channels in cardiac muscle by the sulphonylurea drug glibenclamide.

1992 • 102 citations

Enhancement of potassium-sensitive current in heart cells by pinacidil. Evidence for modulation of the ATP-sensitive potassium channel.

1989 • 101 citations

ATP4− and ATP·Mg inhibit the ATP-sensitive K+ channel of rat ventricular myocytes

1988 • 99 citations

Effects of putative activators of K⁺ channels in mouse pancreatic β‐cells

1989 • 98 citations

Effects of tolbutamide, glibenclamide and diazoxide upon action potentials recorded from rat ventricular muscle

1989 • 94 citations

Pharmacology of ATP-sensitive K+ currents in smooth muscle cells from rabbit mesenteric artery

1995 • 92 citations

Single channel and whole‐cell K‐currents evoked by levcromakalim in smooth muscle cells from the rabbit portal vein

1993 • 92 citations

The effects of nucleotides and potassium channel openers on the SUR2A/Kir6.2 complex K + channel expressed in a mammalian cell line, HEK293T cells

1998 • 88 citations

G proteins activate ATP-sensitive K+ channels by antagonizing ATP-dependent gating

1994 • 88 citations

Expression of an atrial G-protein-activated potassium channel in Xenopus oocytes.

1993 • 85 citations

ATP-dependent decay and recovery of K+ channels in guinea pig cardiac myocytes

1990 • 83 citations

Skeletal muscle ATP-sensitive K+ channels recorded from sarcolemmal blebs of split fibers: ATP inhibition is reduced by magnesium and ADP

1991 • 82 citations

Intracellular ATP can regulate afferent arteriolar tone via ATP-sensitive K+ channels in the rabbit.

1992 • 78 citations

ATP-sensitive potassium channels in adult mouse skeletal muscle: Characterization of the ATP-binding site

1989 • 76 citations

Multiple blocking mechanisms of ATP‐sensitive potassium channels of frog skeletal muscle by tetraethylammonium ions.

1989 • 74 citations

Activation by intracellular GDP, metabolic inhibition and pinacidil of a glibenclamide‐sensitive K‐channel in smooth muscle cells of rat mesenteric artery

1995 • 72 citations

Dualistic behavior of ATP-sensitive K+ channels toward intracellular nucleoside diphosphates

1994 • 69 citations

Intracellular nucleotide‐mediated gating of SUR/Kir6.0 complex potassium channels expressed in a mammalian cell line and its modification by pinacidil

1998 • 62 citations

Molecular cloning, functional expression and localization of an inward rectifier potassium channel in the mouse brain

1993 • 62 citations

A Novel Ubiquitously Distributed Isoform of GIRK2 (GIRK2B) Enhances GIRK1 Expression of the G-Protein-Gated K+ Current inXenopusOocytes

1996 • 61 citations

Inhibition of ATP-sensitive potassium channels of adult rat heart cells by antiarrhythmic drugs.

1989 • 61 citations

Nucleotide regulation of ATP sensitive potassium channels

1994 • 60 citations

Cloning, tissue expression, and chromosomal localization of SUR2, the putative drug-binding subunit of cardiac, skeletal muscle, and vascular KATP channels

1996 • 57 citations

Regulation of ATP-sensitive K+ channels by ATP and nucleotide diphosphate in rabbit portal vein

1994 • 52 citations

ATP-sensitive K+ channels from aortic smooth muscle incorporated into planar lipid bilayers

1991 • 51 citations

Activation of ATP‐dependent K+ channels by metabolic poisoning in adult mouse skeletal muscle: role of intracellular Mg(2+) and pH.

1995 • 48 citations

Specificity of photolabeling of beta-cell membrane proteins with an 125I-labeled glyburide analog.

1992 • 47 citations

Pharmacological properties of ATP-sensitive K+ channels in mammalian skeletal muscle cells

1993 • 46 citations

Modulation of reconstituted ATP‐sensitive K⁺ channels by GTP‐binding proteins in a mammalian cell line

1998 • 46 citations

Characterization of the ATP-inhibited K+ current in canine coronary smooth muscle cells

1994 • 45 citations

Surface charge and properties of cardiac ATP-sensitive K+ channels.

1994 • 43 citations

Effects of potassium channel openers on single potassium channels in mouse skeletal muscle

1990 • 42 citations

Glibenclamide Specifically Blocks ATP-Sensitive K<+ Channel Current in Atrial Myocytes of Guinea Pig Heart

1990 • 39 citations

Immunological and Physical Characterization of the Brain G Protein-Gated Muscarinic Potassium Channel

1995 • 35 citations

Pinacidil inhibits the ryanodine‐sensitive outward current and glibenclamide antagonizes its action in cells from the rabbit portal vein

1991 • 21 citations

Effects of cromakalim on the membrane potassium permeability of frog skeletal muscle in vitro

1992 • 10 citations

Functions of Cardiac Ion Channels under Normal and Pathological Conditions.

1996 • 8 citations

Sur2 and Kcnj8 genes are tightly linked on the distal region of mouse Chromosome 6

1997 • 6 citations