Cloning and expression of an inwardly rectifying ATP-regulated potassium channel

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

1989 • 7,327 citations

Ionic channels of excitable membranes

1985 • 7,199 citations

Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.

1982 • 5,284 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

A simple and very efficient method for generating cDNA libraries

1983 • 4,606 citations

Ionic Channels of Excitable Membranes

1985 • 3,014 citations

The P-loop — a common motif in ATP- and GTP-binding proteins

1990 • 2,029 citations

Structural features in eukaryotic mRNAs that modulate the initiation of translation.

1991 • 1,849 citations

Biophysical and Molecular Mechanisms of Shaker Potassium Channel Inactivation

1990 • 1,528 citations

Structural parts involved in activation and inactivation of the sodium channel

1989 • 1,189 citations

Structure and Function of Voltage-Sensitive Ion Channels

1988 • 1,171 citations

Structural model of ATP-binding proteing associated with cystic fibrosis, multidrug resistance and bacterial transport

1990 • 1,149 citations

Subunit stoichiometry of a mammalian K+ channel determined by construction of multimeric cDNAs

1992 • 1,067 citations

[3] Protein kinase phosphorylation site sequences and consensus specificity motifs: Tabulations

1991 • 1,036 citations

Inactivation of the sodium channel. II. Gating current experiments.

1977 • 943 citations

Determination of the subunit stoichiometry of a voltage-activated potassium channel

1991 • 925 citations

Existence of distinct sodium channel messenger RNAs in rat brain

1986 • 909 citations

Adenosine 5'-Triphosphate-Sensitive Potassium Channels

1988 • 888 citations

Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain.

1989 • 765 citations

Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors.

1989 • 742 citations

Cloning of Genomic and Complementary DNA from Shaker , a Putative Potassium Channel Gene from Drosophila

1987 • 721 citations

Cloning and Expression in Yeast of a Plant Potassium Ion Transport System

1992 • 694 citations

Properties and functions of ATP-sensitive K-channels

1990 • 690 citations

Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel

1989 • 663 citations

Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel

1991 • 658 citations

Functional expression of a probable Arabidopsis thaliana potassium channel in Saccharomyces cerevisiae.

1992 • 651 citations

Primary structure and functional expression of a cyclic nucleotide-activated channel from olfactory neurons

1990 • 650 citations

Sequence of a Probable Potassium Channel Component Encoded at Shaker Locus of Drosophila

1987 • 645 citations

Mutations Affecting Internal TEA Blockade Identify the Probable Pore-Forming Region of a K ⁺ Channel

1991 • 634 citations

A Component of Calcium-activated Potassium Channels Encoded by the Drosophila slo Locus

1991 • 629 citations

Predicting the orientation of eukaryotic membrane-spanning proteins.

1989 • 596 citations

Mutations Affecting Tea Blockade and Ion Permeation in Voltage-activated K ⁺ Channels

1990 • 569 citations

Phosphorylation-regulated CI− channel in CHO cells stably expressing the cystic fibrosis gene

1991 • 564 citations

Patch clamp measurements onXenopus laevis oocytes: currents through endogenous channels and implanted acetylcholine receptor and sodium channels

1986 • 534 citations

Nucleoside triphosphates are required to open the CFTR chloride channel

1991 • 520 citations

Cloning of a Membrane Protein That Induces a Slow Voltage-Gated Potassium Current

1988 • 511 citations

Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence

1991 • 507 citations

Multiple potassium–channel components are produced by alternative splicing at the Shaker locus in Drosophila

1988 • 495 citations

Calcium-activated potassium channels expressed from cloned complementary DNAs

1992 • 488 citations

A Functional Connection Between the Pores of Distantly Related Ion Channels as Revealed by Mutant K ⁺ Channels

1992 • 479 citations

A novel potassium channel with delayed rectifier properties isolated from rat brain by expression cloning

1989 • 457 citations

The aromatic binding site for tetraethylammonium ion on potassium channels

1992 • 446 citations

Alteration of ionic selectivity of a K+ channel by mutation of the H5 region

1991 • 445 citations

Shaker encodes a family of putative potassium channel proteins in the nervous system of Drosophila.

1988 • 443 citations

Molecular characterization of Shaker, a Drosophila gene that encodes a potassium channel

1987 • 412 citations

Expression of functional potassium channels from Shaker cDNA in Xenopus oocytes

1988 • 396 citations

The anomalous rectification and cation selectivity of the membrane of a starfish egg cell

1974 • 394 citations

Exchange of Conduction Pathways Between Two Related K ⁺ Channels

1991 • 387 citations

A Distinct Potassium Channel Polypeptide Encoded by the Drosophila eag Locus

1991 • 361 citations

Mutant Potassium Channels with Altered Binding of Charybdotoxin, a Pore-Blocking Peptide Inhibitor

1989 • 351 citations

Inward-rectifying channels in isolated patches of the heart cell membrane: ATP-dependence and comparison with cell-attached patches

1984 • 333 citations

Atomic scale structure and functional models of voltage-gated potassium channels

1992 • 332 citations

Multiple products of the drosophila Shaker gene may contribute to potassium channel diversity

1988 • 324 citations

K ⁺ Current Diversity Is Produced by an Extended Gene Family Conserved in Drosophila and Mouse

1990 • 323 citations

Functional Modulation of GABA _A Receptors by cAMP-Dependent Protein Phosphorylation

1992 • 322 citations

Cloning and expression of cDNA and genomic clones encoding three delayed rectifier potassium channels in rat brain

1990 • 317 citations

Cloning of a probable potassium channel gene from mouse brain

1988 • 304 citations

GABA _A -Receptor Function in Hippocampal Cells Is Maintained by Phosphorylation Factors

1988 • 303 citations

Nucleotide modulation of the activity of rat heart ATP‐sensitive K+ channels in isolated membrane patches.

1989 • 297 citations

A Family of Putative Potassium Channel Genes in Drosophila

1989 • 281 citations

Effect of Deleting the R Domain on CFTR-Generated Chloride Channels

1991 • 271 citations

1990: Annus Mirabilis of Potassium Channels

1991 • 261 citations

Structure of the voltage-dependent potassium channel is highly conserved from Drosophila to vertebrate central nervous systems.

1988 • 252 citations

A Phosphorylation Site in the Na ⁺ Channel Required for Modulation by Protein Kinase C

1991 • 252 citations

?Run-down? of the Ca current during long whole-cell recordings in guinea pig heart cells: role of phosphorylation and intracellular calcium

1988 • 239 citations

Tracing the roots of ion channels

1992 • 235 citations

Phosphorylation of ligand‐gated ion channels: a possible mode of synaptic plasticity

1992 • 231 citations

Regulation by ATP and ADP of CFTR Chloride Channels That Contain Mutant Nucleotide-Binding Domains

1992 • 231 citations

A-type potassium channels expressed from Shaker locus cDNA.

1988 • 225 citations

Mapping the receptor site for charybdotoxin, a pore-blocking potassium channel inhibitor

1990 • 220 citations

Polyadenylation of mRNA precursors

1988 • 210 citations

A role for hydrophobic residues in the voltage-dependent gating of Shaker K+ channels.

1991 • 204 citations

Expression of a Cloned Rat Brain Potassium Channel in Xenopus Oocytes

1989 • 202 citations

Potassium channels from NG108‐15 neuroblastoma‐glioma hybrid cells

1989 • 189 citations

Protein Kinase Activity Closely Associated with a Reconstituted Calcium-Activated Potassium Channel

1991 • 178 citations

Alternative splicing contributes to K+ channel diversity in the mammalian central nervous system.

1991 • 172 citations

mShal, a subfamily of A-type K+ channel cloned from mammalian brain.

1991 • 166 citations

Molecular organization of the maternal effect region of the Shaker complex of Drosophila : characterization of an I_A channel transcript with homology to vertebrate Na⁺ channel

1987 • 163 citations

Dual effects of ATP on K+ currents of mouse pancreatic ?-cells

1987 • 158 citations

A Family of Three Mouse Potassium Channel Genes with Intronless Coding Regions

1990 • 150 citations

Interaction between tetraethylammonium and amino acid residues in the pore of cloned voltage-dependent potassium channels.

1991 • 146 citations

Eukaryotic protein kinases

1991 • 140 citations

Positively charged residues are important determinants of membrane protein topology

1990 • 132 citations

Renal Potassium Channels and Their Regulation

1992 • 123 citations

Dual effect of adenosine triphosphate on the apical small conductance K+ channel of the rat cortical collecting duct.

1991 • 120 citations

Effects of antidiuretic hormone on cellular conductive pathways in mouse medullary thick ascending limbs of Henle: II. Determinants of the ADH-mediated increases in transepithelial voltage and in net Cl− absorption

1984 • 108 citations

Identification of an intracellular domain of the sodium channel having multiple cAMP-dependent phosphorylation sites.

1987 • 106 citations

Differences between the deep pores of K+ channels determined by an interacting pair of nonpolar amino acids

1992 • 104 citations

Dendrotoxin-binding brain membrane protein displays a potassium channel activity that is stimulated by both cAMP-dependent and endogenous phosphorylations

1989 • 94 citations

Dihydropyridine-sensitive calcium channels from skeletal muscle. II. Functional effects of differential phosphorylation of channel subunits.

1991 • 75 citations

A single nonpolar residue in the deep pore of related K+ channels acts as a K+:Rb+ conductance switch

1992 • 75 citations

Modulation of acetylcholine‐activated K+ channel function in rat atrial cells by phosphorylation.

1991 • 68 citations

External K+ increases Na+ conductance of the hyperpolarization-activated current in rabbit cardiac pacemaker cells

1992 • 67 citations

Ca2+ and Mg-ATP activated potassium channels from rat pulmonary artery

1992 • 49 citations

Phosphorylation modulates potassium conductance and gating current of perfused giant axons of squid.

1990 • 47 citations

Potassium conductance of the squid giant axon is modulated by ATP.

1986 • 33 citations

Single channel studies of the phosphorylation of K+ channels in the squid giant axon. I. Steady-state conditions.

1991 • 28 citations