Interleukin-22 (IL-22) Activates the JAK/STAT, ERK, JNK, and p38 MAP Kinase Pathways in a Rat Hepatoma Cell Line

Interleukin-10 and the Interleukin-10 Receptor

2001 • 6,422 citations

The acute phase response

1994 • 2,927 citations

pEF-BOS, a powerful mammalian expression vector

1990 • 1,641 citations

Serine phosphorylation of STATs

2000 • 873 citations

Interleukin 6 and its Receptor: Ten Years Later

1998 • 774 citations

Two Signals Are Necessary for Cell Proliferation Induced by a Cytokine Receptor gp130: Involvement of STAT3 in Anti-Apoptosis

1996 • 661 citations

Interleukin 20

2001 • 542 citations

Interleukin (IL)-22, a Novel Human Cytokine That Signals through the Interferon Receptor-related Proteins CRF2–4 and IL-22R

2000 • 531 citations

Cloning and Characterization of IL-10-Related T Cell-Derived Inducible Factor (IL-TIF), a Novel Cytokine Structurally Related to IL-10 and Inducible by IL-9

2000 • 497 citations

Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity.

1995 • 423 citations

IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes.

1995 • 420 citations

Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways.

1993 • 411 citations

Cutting Edge: STAT Activation By IL-19, IL-20 and mda-7 Through IL-20 Receptor Complexes of Two Types

2001 • 394 citations

Identification of the Functional Interleukin-22 (IL-22) Receptor Complex

2001 • 390 citations

Identification and functional characterization of a second chain of the interleukin-10 receptor complex

1997 • 376 citations

p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons

1999 • 373 citations

Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway.

1989 • 373 citations

Human interleukin-10-related T cell-derived inducible factor: Molecular cloning and functional characterization as an hepatocyte-stimulating factor

2000 • 352 citations

Activation of Jak2 Catalytic Activity Requires Phosphorylation of Y¹⁰⁰⁷ in the Kinase Activation Loop

1997 • 343 citations

The interleukin-10 family of cytokines

2002 • 323 citations

The interleukin-6-activated acute-phase response factor is antigenically and functionally related to members of the signal transducer and activator of transcription (STAT) family.

1994 • 251 citations

Cloning and Characterization of IL-22 Binding Protein, a Natural Antagonist of IL-10-Related T Cell-Derived Inducible Factor/IL-22

2001 • 248 citations

Serine Phosphorylation and Negative Regulation of Stat3 by JNK

1999 • 219 citations

A JAK1/JAK2 Chimera Can Sustain Alpha and Gamma Interferon Responses

1997 • 216 citations

Jak-Stat signal transduction pathway through the eyes of cytokine class II receptor complexes

2000 • 201 citations

Acinar Cells of the Pancreas Are a Target of Interleukin-22

2001 • 170 citations

IL‐10 induces DNA binding activity of three STAT proteins (Stat1, Stat3, and Stat5) and their distinct combinatorial assembly in the promoters of selected genes

1996 • 170 citations

Extracellular signal-regulated kinase, stress-activated protein kinase/c-Jun N-terminal kinase, and p38mapk are involved in IL-10-mediated selective repression of TNF-alpha-induced activation and maturation of human peripheral blood monocyte-derived dendritic cells.

1999 • 162 citations

STAT3 Is a Serine Kinase Target in T Lymphocytes

1997 • 139 citations

Monocyte deactivation by interleukin 10 via inhibition of tyrosine kinase activity and the Ras signaling pathway.

1994 • 136 citations

Extracellular Signal-Regulated Kinase, Stress-Activated Protein Kinase/c-Jun N-Terminal Kinase, and p38mapkAre Involved in IL-10-Mediated Selective Repression of TNF-α-Induced Activation and Maturation of Human Peripheral Blood Monocyte-Derived Dendritic Cells

1999 • 121 citations

Ser727‐dependent transcriptional activation by association of p300 with STAT3 upon IL‐6 stimulation

2001 • 119 citations

Interleukin-10 Stimulation of Phosphatidylinositol 3-Kinase and p70 S6 Kinase Is Required for the Proliferative but Not the Antiinflammatory Effects of the Cytokine

1996 • 101 citations

Interleukin-6-induced STAT3 transactivation and Ser727 phosphorylation involves Vav, Rac-1 and the kinase SEK-1/MKK-4 as signal transduction components

2000 • 101 citations

Regulation of Stat3 Activation by MEK Kinase 1

2001 • 94 citations

Sequential Activation of Rac-1, SEK-1/MKK-4, and Protein Kinase Cδ Is Required for Interleukin-6-induced STAT3 Ser-727 Phosphorylation and Transactivation

2001 • 86 citations

The MKK6/p38 Mitogen-Activated Protein Kinase Pathway Is Capable of Inducing SOCS3 Gene Expression and Inhibits IL-6-Induced Transcription

2001 • 71 citations

The YXXQ motif in gp 130 is crucial for STAT3 phosphorylation at Ser727 through an H7-sensitive kinase pathway

2001 • 66 citations

Viral and cellular interleukin-10 (IL-10)-related cytokines: from structures to functions.

2002 • 64 citations

Synergistic Activity of STAT3 and c-Jun at a Specific Array of DNA Elements in the α2-Macroglobulin Promoter

2001 • 64 citations

Interleukin 9 induces expression of three cytokine signal inhibitors: cytokine-inducible SH2-containing protein, suppressor of cytokine signalling (SOCS)-2 and SOCS-3, but only SOCS-3 overexpression suppresses interleukin 9 signalling

2000 • 51 citations

Cytokine and Growth Factor Reviews to be published six times a year

2002 • 3 citations