Activin A Maintains Self-Renewal and Regulates Fibroblast Growth Factor, Wnt, and Bone Morphogenic Protein Pathways in Human Embryonic Stem Cells

Embryonic Stem Cell Lines Derived from Human Blastocysts

1998 • 15,541 citations

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

1994 • 7,043 citations

Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells

2000 • 3,564 citations

Functional Expression Cloning of Nanog, a Pluripotency Sustaining Factor in Embryonic Stem Cells

2003 • 3,230 citations

The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells

2003 • 3,179 citations

Hedgehog signaling in animal development: paradigms and principles

2001 • 2,919 citations

BMP Induction of Id Proteins Suppresses Differentiation and Sustains Embryonic Stem Cell Self-Renewal in Collaboration with STAT3

2003 • 2,079 citations

Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor

2003 • 2,064 citations

Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells

1988 • 2,004 citations

Feeder-free growth of undifferentiated human embryonic stem cells

2001 • 1,860 citations

Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides

1988 • 1,848 citations

Multicolor Spectral Karyotyping of Human Chromosomes

1996 • 1,780 citations

Clonally Derived Human Embryonic Stem Cell Lines Maintain Pluripotency and Proliferative Potential for Prolonged Periods of Culture

2000 • 1,488 citations

BMP4 initiates human embryonic stem cell differentiation to trophoblast

2002 • 1,107 citations

Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells

2003 • 1,028 citations

Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells

2005 • 979 citations

Activin-Binding Protein from Rat Ovary Is Follistatin

1990 • 886 citations

TGFβ/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells

2005 • 867 citations

Feeder Layer- and Serum-Free Culture of Human Embryonic Stem Cells1

2004 • 664 citations

Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A

1990 • 660 citations

Nodal Signaling in Vertebrate Development

2003 • 627 citations

Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures

1990 • 600 citations

Functional analysis of activins during mammalian development

1995 • 579 citations

Hematopoietic stem cells convert into liver cells within days without fusion

2004 • 556 citations

Self-renewal of teratocarcinoma and embryonic stem cells

2004 • 538 citations

Nodal signalling in the epiblast patterns the early mouse embryo

2001 • 532 citations

Activin A Maintains Pluripotency of Human Embryonic Stem Cells in the Absence of Feeder Layers

2005 • 495 citations

Molecular signature of human embryonic stem cells and its comparison with the mouse

2003 • 485 citations

LIF/STAT3 Signaling Fails to Maintain Self‐Renewal of Human Embryonic Stem Cells

2004 • 457 citations

Basic Fibroblast Growth Factor Supports Undifferentiated Human Embryonic Stem Cell Growth Without Conditioned Medium

2005 • 424 citations

Nodal inhibits differentiation of human embryonic stem cells along the neuroectodermal default pathway

2004 • 349 citations

Defining the Role of Wnt/β‐Catenin Signaling in the Survival, Proliferation, and Self‐Renewal of Human Embryonic Stem Cells

2005 • 337 citations

Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation

2004 • 331 citations

Noggin and bFGF cooperate to maintain the pluripotency of human embryonic stem cells in the absence of feeder layers

2005 • 220 citations

Transcriptome Profiling of Human and Murine ESCs Identifies Divergent Paths Required to Maintain the Stem Cell State

2005 • 210 citations

Expression of Nodal, Lefty-A, and Lefty-B in Undifferentiated Human Embryonic Stem Cells Requires Activation of Smad2/3

2004 • 188 citations

Two Modes by which Lefty Proteins Inhibit Nodal Signaling

2004 • 184 citations

Transient pluripotent cell populations during primitive ectoderm formation: correlation of in vivo and in vitro pluripotent cell development.

2002 • 184 citations

Human embryonic stem cells maintained in the absence of mouse embryonic fibroblasts or conditioned media are capable of hematopoietic development

2005 • 175 citations

Targeted disruption of NDST‐1 gene leads to pulmonary hypoplasia and neonatal respiratory distress in mice

2000 • 166 citations

Regulatory Principles of Developmental Signaling

2002 • 155 citations

MPSS profiling of human embryonic stem cells

2004 • 139 citations

Morphogen gradients, positional information, and Xenopus: Interplay of theory and experiment

2002 • 101 citations

Transcriptional profiling of initial differentiation events in human embryonic stem cells

2004 • 45 citations

Noggin and bFGF cooperate to maintain the pluripotency of human embryonic stem cells in the absence of feeder layers

2006 • 32 citations