Silent 5-HT1A receptor antagonists: utility as research tools and therapeutic agents

Distribution of serotonin-immunoreactivity in the central nervous system of the rat—Cell bodies and terminals

1981 • 2,392 citations

Multiple serotonin receptors: differential binding of [3H]5-hydroxytryptamine, [3H]lysergic acid diethylamide and [3H]spiroperidol.

1979 • 1,321 citations

8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site

1983 • 869 citations

Identification of presynaptic serotonin autoreceptors using a new ligand: 3H-PAT

1983 • 759 citations

A proposed new nomenclature for 5-HT receptors

1993 • 551 citations

COMPARISON OF DISSOCIATION CONSTANTS AND OF RELATIVE EFFICACIES OF SELECTED AGONISTS ACTING ON PARASYMPATHETIC RECEPTORS*

1967 • 517 citations

Suppression of firing activity of 5-HT neurons in the dorsal raphe by alpha-adrenoceptor antagonists

1980 • 435 citations

Presynaptic 5-HT autoreceptors on serotonergic cell bodies and/or dendrites but not terminals are of the 5-HT1A subtype

1985 • 383 citations

5-HT and anxiety

1984 • 325 citations

Activity of brain serotonergic neurons in the behaving animal.

1991 • 265 citations

Evidence that the amygdala is involved in benzodiazepine and serotonergic effects on punished responding but not on discrimination

1987 • 242 citations

Cortical Pyramidal Neurone Loss May Cause Glutamatergic Hypoactivity and Cognitive Impairment in Alzheimer's Disease: Investigative and Therapeutic Perspectives

1993 • 233 citations

Antidepressant-like action of 5-HT1A agonists and conventional antidepressants in an animal model of depression

1987 • 230 citations

Receptor reserve for 5-hydroxytryptamine1A-mediated inhibition of serotonin synthesis: possible relationship to anxiolytic properties of 5-hydroxytryptamine1A agonists.

1990 • 227 citations

WAY100135: a novel, selective antagonist at presynaptic and postsynaptic 5-HT1A receptors

1993 • 223 citations

Serotonin receptor subtypes : basic and clinical aspects

1991 • 217 citations

Electrophysiological evidence for a functional differentiation between subtypes of the 5-HT1 receptor

1988 • 174 citations

Single administration of 5-HT1A agonists decreases 5-HT1A presynaptic, but not postsynaptic receptor-mediated responses: relationship to antidepressant-like action

1987 • 173 citations

Increase in serotonin 5-HT1A receptors in prefrontal and temporal cortices of brains from patients with chronic schizophrenia

1991 • 169 citations

The 5-HT1A receptor selective ligands, (R)-8-OH-DPAT and (S)-UH-301, differentially affect the activity of midbrain dopamine neurons

1993 • 165 citations

Centrally acting hypotensive agents with affinity for 5‐HT_1A binding sites inhibit forskolin‐stimulated adenylate cyclase activity in calf hippocampus

1988 • 151 citations

Pharmacology of 5-hydroxytryptamine-1A receptors which inhibit cAMP production in hippocampal and cortical neurons in primary culture.

1988 • 150 citations

Novel anxiolytics discriminate between postsynaptic serotonin receptors mediating different physiological responses on single neurons of the rat hippocampus

1987 • 144 citations

BMY 7378, a buspirone analog with high affinity, selectivity and low intrinsic activity at the 5-HT1A receptor in rat and guinea pig hippocampal membranes

1987 • 128 citations

Pustative anxiolytics 8-OH-DPAT, buspirone and TVX Q 7821 are agonists at 5-HT1A autoreceptors in the raphé nuclei

1986 • 128 citations

Differential properties of pre- and postsynaptic 5-hydroxytryptamine1A receptors in the dorsal raphe and hippocampus: I. Effect of spiperone.

1993 • 112 citations

Thymosthenic Agents, A Novel Approach in the Treatment of Schizophrenia

1989 • 109 citations

Antidepressant-like action of 8-OH-DPAT, a 5-HT1A agonist, in the learned helplessness paradigm: evidence for a postsynaptic mechanism

1990 • 107 citations

Lack of apparent receptor reserve at postsynaptic 5-hydroxytryptamine1A receptors negatively coupled to adenylyl cyclase activity in rat hippocampal membranes.

1992 • 105 citations

Spiroxatrine: A selective serotonin1A receptor antagonist

1986 • 104 citations

Agonist/antagonist interactions with cloned human 5-HT1A receptors: variations in intrinsic activity studied in transfected HeLa cells

1992 • 104 citations

3H-DOB (4-bromo-2,5-dimethoxyphenylisopropylamine) labels a guanyl nucleotide-sensitive state of cortical 5-HT2 receptors.

1987 • 103 citations

Brain amino acid concentrations and Ca2+-dependent release in intractable depression assessed antemortem

1989 • 99 citations

Arylpiperazine derivatives as high-affinity 5-HT1A serotonin ligands

1988 • 98 citations

Blockade of the central 5-HT autoreceptor by β-adrenoceptor antagonists

1986 • 90 citations

Neurochemical profile of the selective and silent 5-HT1A receptor antagonist WAY100135: an in vivo microdialysis study

1993 • 88 citations

The putative 5-HT1A receptor antagonists NAN-190 and BMY 7378 are partial agonists in the rat dorsal raphe nucleus in vitro

1992 • 84 citations

(S)-N-tert-Butyl-3-(4-(2-methoxyphenyl)piperazin-1-yl)-2-phenylpropanamide [(S)-WAY-100135]: a selective antagonist at presynaptic and postsynaptic 5-HT1A receptors

1993 • 81 citations

Electrophysiological evidence that spiperone is an antagonist of 5-HT1A receptors in the dorsal raphe nucleus

1988 • 69 citations

Behavioral profile of the 5HT1A receptor antagonist (S)-UH-301 in rodents and monkeys

1992 • 58 citations

Treatment of Alzheimer's Disease

1990 • 57 citations

SDZ 216–525, a selective and potent 5-HT1A receptor antagonist

1993 • 56 citations

Effect of the putative 5-HT1A receptor antagonist NAN-190 on rat brain serotonergic transmission

1991 • 54 citations

Selective inhibition of agonist‐induced but not shear stress‐dependent release of endothelial autacoids by thapsigargin

1993 • 51 citations

Characterization of a novel and potent 5-hydroxytryptamine1A receptor antagonist

1991 • 46 citations

WAY 100,135 and (−)-tertatolol act as antagonists at both 5-HT1A autoreceptors and postsynaptic 5-HT1A receptors in vivo

1993 • 40 citations

The novel 5-HT1A receptor antagonist (S)-UH-301 prevents (R)-8-OH-DPAT-induced decrease in interstitial concentrations of serotonin in the rat hippocampus

1992 • 36 citations

Determination of Daily Variations of Brain 5‐Hydroxytryptamine and Dopamine Turnovers and of the Clearance of Their Acidic Metabolites in Conscious Rats by Repeated Sampling of Cerebrospinal Fluid

1984 • 30 citations

MDL 72832 and MDL 73005EF: Novel, potent and selective 5-HT1A receptor ligands with different pharmacological properties

1990 • 18 citations

Effects of hyperkalaemia on the depression of maximum rate of depolarization by class I antiarrhythmic agents in guinea‐pig myocardium

1993 • 10 citations

S14063: a new potent 5-HT1A receptor antagonist devoid of β-adrenoceptor blocidng properties

1991 • 6 citations