Insulin‐like growth factor II binding and action in human fetal fibroblasts

Preparation of Iodine-131 Labelled Human Growth Hormone of High Specific Activity

1962 • 6,970 citations

The subunit structures of two distinct receptors for insulin-like growth factors I and II and their relationship to the insulin receptor.

1982 • 709 citations

Monoclonal antibodies to receptors for insulin and somatomedin-C.

1983 • 423 citations

Insulin-like growth factor-II gene expression in Wilms' tumour and embryonic tissues

1985 • 413 citations

Demonstration of two subtypes of insulin-like growth factor receptors by affinity cross-linking.

1981 • 332 citations

Increased levels of multiplication-stimulating activity, an insulin-like growth factor, in fetal rat serum.

1980 • 313 citations

Purification and primary structure of a polypeptide with multiplication-stimulating activity from rat liver cell cultures. Homology with human insulin-like growth factor II.

1981 • 298 citations

Monoclonal antibody to the type I insulin-like growth factor (IGF-I) receptor blocks IGF-I receptor-mediated DNA synthesis: clarification of the mitogenic mechanisms of IGF-I and insulin in human skin fibroblasts.

1986 • 269 citations

Developmental patterns of insulin-like growth factor-I and -II synthesis and regulation in rat fibroblasts

1983 • 269 citations

Insulin Receptors in Human Circulating Cells and Fibroblasts

1972 • 228 citations

The Type II Insulin-Like Growth Factor (IGF) Receptor Has Low Affinity for IGF-I Analogs: Pleiotypic Actions of IGFs on Myoblasts Are Apparently Mediated by the Type I Receptor*

1987 • 204 citations

Ontogenesis of somatomedin and insulin receptors in the human fetus.

1983 • 197 citations

The Actions of Insulin-Like Growth Factors I and II on Cultured Sertoli Cells*

1984 • 193 citations

Levels of Insulin-like Growth Factors I and II in Human Cord Blood*

1983 • 187 citations

Evidence from Monoclonal Antibody Studies that Insulin Stimulates Deoxyribonucleic Acid Synthesis through the Type I Somatomedin Receptor*

1985 • 160 citations

Characterization of the Somatomedin-C/Insulin-Like Growth Factor I (SM-C/IGF-I) Receptor on Cultured Human Fibroblast Monolayers: Regulation of Receptor Concentrations by SM-C/IGF-I and Insulin*

1982 • 154 citations

The type II insulin-like growth factor receptor does not mediate increased DNA synthesis in H-35 hepatoma cells.

1984 • 145 citations

Insulin-like growth factors (IGF) 1 and 2 in human foetal plasma and relationship to gestational age and foetal size during midpregnancy

1985 • 126 citations

Monoclonal antibodies to the human insulin receptor block insulin binding and inhibit insulin action.

1982 • 122 citations

Binding properties and biological potencies of insulin-like growth factors in L6 myoblasts

1986 • 120 citations

The Type II Insulin-Like Growth Factor Receptor Does Not Mediate Deoxyribonucleic Acid Synthesis in Human Fibroblasts*

1987 • 108 citations

Insulin-like growth factor II binding to the type I somatomedin receptor. Evidence for two high affinity binding sites.

1986 • 104 citations

Effect of an anti-insulin-like growth factor I receptor antibody on insulin-like growth factor II stimulation of DNA synthesis in human fibroblasts

1986 • 98 citations

Insulin and insulinlike growth factor receptors and responses in cultured human muscle cells

1986 • 81 citations

Regulation of Amino Acid Uptake and Deoxyribonucleic Acid Synthesis in Isolated Human Fetal Fibroblasts and Myoblasts: Effect of Human Placental Lactogen, Somatomedin-C, Multiplication-Stimulating Activity, and Insulin*

1986 • 79 citations

Interaction of the Monoclonal AntibodiesαlR-1 andαIR-3 with Insulin and Somatomedin-C Receptors

1986 • 78 citations

The human placenta contains two distinct binding and immunoreactive species of insulin-like growth factor-I receptors.

1985 • 78 citations

Insulin‐like growth factor I/somatomedin‐C (IGF‐I/SM‐C) and glucocorticoids synergistically regulate mitosis in competent human fibroblasts

1983 • 70 citations

Class II Major Histocompatibility Complex Antigen Expression and Cellular Interactions in Thyroid Glands of Graves' Disease

1986 • 70 citations

Comparative effects of somatomedin C and insulin on the metabolism and growth of cultured human fibroblasts

1985 • 66 citations

Insulin Stimulation of Aminoisobutyric Acid Transport in Human Skin Fibroblasts Is Mediated Through Both Insulin and Type I Insulin-Like Growth Factor Receptors*

1986 • 45 citations

Identification of a monoclonal antibody which can distinguish between two distinct species of the type I receptor for insulin-like growth factor

1986 • 45 citations

Hormonal control of the replication of human fetal fibroblasts: Role of somatomedin C/insulin‐like growth factor I

1986 • 42 citations

Purification of the Insulin-like growth factor II (IGF-II) receptor from an IGF-II-producing cell line, and generation of an antibody which both immunoprecipitates and blocks the type 2 IGF receptor

1986 • 40 citations

Stimulation by Somatomedin-C of Aminoisobutyric Acid Uptake in Human Fibroblasts: A Possible Test for Cellular Responsiveness to Somatomedin*

1984 • 24 citations

Synthetic insulin-like growth factor II

1985 • 18 citations

Somatomedin-C Binding to Cultured Human Fibroblasts is Dependent onDonor Age and Culture Density*

1986 • 15 citations

Characterization of Insulin-Like Growth Factor II Binding to Human Fibroblast Monolayer Cultures*

1985 • 12 citations