Binge Eating as a Major Phenotype of Melanocortin 4 Receptor Gene Mutations

Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice

1997 • 2,992 citations

Congenital leptin deficiency is associated with severe early-onset obesity in humans

1997 • 2,900 citations

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

1998 • 2,333 citations

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

1998 • 1,666 citations

A leptin missense mutation associated with hypogonadism and morbid obesity

1998 • 1,187 citations

Candidate-gene approaches for studying complex genetic traits: practical considerations

2002 • 1,071 citations

Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain.

1994 • 1,059 citations

PolyPhred: automating the detection and genotyping of single nucleotide substitutions using fluorescence-based resequencing

1997 • 946 citations

Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity

2000 • 896 citations

Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency

2000 • 795 citations

Binge eating disorder: A multisite field trial of the diagnostic criteria

1992 • 781 citations

Binge eating disorder: Its further validation in a multisite study

1993 • 755 citations

Proopiomelanocortin Neurons Are Direct Targets for Leptin in the Hypothalamus

1997 • 731 citations

Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain

1994 • 703 citations

The Search for Human Obesity Genes

1998 • 570 citations

Several Mutations in the Melanocortin-4 Receptor Gene Including a Nonsense and a Frameshift Mutation Associated with Dominantly Inherited Obesity in Humans

1999 • 439 citations

Partial leptin deficiency and human adiposity

2001 • 402 citations

A metabolic defect promotes obesity in mice lacking melanocortin-4 receptors

2000 • 360 citations

Binge Eating Among Gastric Bypass Patients at Long-term Follow-up

2002 • 300 citations

Binge eating disorder should be included in DSM-IV: A reply to Fairburn et al.'s “The classification of recurrent overeating: The binge eating disorder proposal”

1993 • 292 citations

Use of dual-energy X-ray absorptiometry in obese individuals

1995 • 258 citations

Proopiomelanocortin Neurons Are Direct Targets for Leptin in the Hypothalamus

1997 • 226 citations

Binge eating disorder in extreme obesity

2002 • 215 citations

Identification and functional analysis of novel human melanocortin-4 receptor variants.

1999 • 198 citations

Mutational analysis of melanocortin-4 receptor, agouti-related protein, and α-melanocyte-stimulating hormone genes in severely obese children

2001 • 197 citations

The Human Obesity Gene Map: The 2001 Update

2002 • 189 citations

Phenotypes in Three Pedigrees with Autosomal Dominant Obesity Caused by Haploinsufficiency Mutations in the Melanocortin-4 Receptor Gene

1999 • 150 citations

Binge Size Increases with Body Mass Index in Women with Binge‐Eating Disorder

2002 • 150 citations

MORBIDITY OF SEVERE OBESITY

2001 • 131 citations

RAPID COMMUNICATION: A Novel Melanocortin 4 Receptor (MC4R) Gene Mutation Associated with Morbid Obesity

2001 • 129 citations

Melanocortin 4 Receptor Sequence Variations Are Seldom a Cause of Human Obesity: The Swedish Obese Subjects, the HERITAGE Family Study, and a Memphis Cohort

2002 • 123 citations

Effect of sex and age on bone mass, body composition and fuel metabolism in humans

1997 • 121 citations

Several Mutations in the Melanocortin-4 Receptor Gene Including a Nonsense and a Frameshift Mutation Associated with Dominantly Inherited Obesity in Humans

1999 • 120 citations

A Novel Homozygous Missense Mutation of Melanocortin-4 Receptor (MC4R) in a Japanese Woman With Severe Obesity

2002 • 107 citations

Soluble leptin receptor in serum of subjects with complete resistance to leptin: relation to fat mass.

2000 • 95 citations

Imipramine and diet counseling with psychological support in the treatment of obese binge eaters: A randomized, placebo-controlled double-blind study

1999 • 70 citations

A missense mutation in the human melanocortin-4 receptor gene in relation to abdominal obesity and salivary cortisol

2001 • 66 citations

Monogenic disorders of obesity and body fat distribution

1999 • 59 citations

Chronic Application of MTII in a Rat Model of Obesity Results in Sustained Weight Loss

2002 • 52 citations

Is there another binge eating disorder? A review of the literature on overeating in the absence of bulimia nervosa

1992 • 51 citations

Are leptin levels dependent on body fat distribution in obese men and women?

1998 • 40 citations

RAPID COMMUNICATION: A Novel Melanocortin 4 Receptor (MC4R) Gene Mutation Associated with Morbid Obesity

2001 • 38 citations

Mutations in the Human Leptin and Leptin Receptor Genes as Models of Serum Leptin Receptor Regulation

2002 • 37 citations

Leptin Concentrations and their Relation to Body Fat Distribution and Weight Loss - A Prospective Study in Individuals with Impaired Glucose Tolerance

1999 • 27 citations