PGH synthase isoenzyme selectivity: The potential for safer nonsteroidal antiinflammatory drugs

TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue

1991 • 1,814 citations

Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone

1990 • 1,605 citations

Human cyclooxygenase-2 cDNA.

1992 • 1,493 citations

Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.

1993 • 1,270 citations

Renal Syndromes Associated with Nonsteroidal Antiinflammatory Drugs

1984 • 1,098 citations

PRIMARY RESPONSE GENES INDUCED BY GROWTH FACTORS AND TUMOR PROMOTERS

1991 • 1,078 citations

cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase.

1992 • 838 citations

Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide.

1992 • 823 citations

Nonsteroidal Antiinflammatory Drugs — Differences and Similarities

1991 • 756 citations

Prostaglandin endoperoxide synthase: regulation of enzyme expression

1991 • 642 citations

Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence.

1988 • 604 citations

Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment

1991 • 580 citations

Cyclooxygenase is an immediate-early gene induced by interleukin-1 in human endothelial cells.

1990 • 484 citations

Endogenous glucocorticoids regulate an inducible cyclooxygenase enzyme.

1992 • 471 citations

The aspirin and heme-binding sites of ovine and murine prostaglandin endoperoxide synthases.

1990 • 429 citations

Dexamethasone inhibits mitogen induction of the TIS10 prostaglandin synthase/cyclooxygenase gene.

1992 • 412 citations

In vivo cyclooxygenase expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis and rats with adjuvant and streptococcal cell wall arthritis.

1992 • 353 citations

Purification and characterization of a novel, distinct isoform of prostaglandin endoperoxide synthase induced by human chorionic gonadotropin in granulosa cells of rat preovulatory follicles.

1992 • 312 citations

Hormonal regulation of messenger ribonucleic acid encoding a novel isoform of prostaglandin endoperoxide H synthase in rat preovulatory follicles. Induction in vivo and in vitro.

1992 • 260 citations

Immunohistochemical localization of the prostaglandin-forming cyclooxygenase in renal cortex

1978 • 232 citations

Tyrosine 385 of prostaglandin endoperoxide synthase is required for cyclooxygenase catalysis

1990 • 229 citations

Lipopolysaccharide priming of alveolar macrophages for enhanced synthesis of prostanoids involves induction of a novel prostaglandin H synthase.

1992 • 212 citations

Stoichiometry and kinetics of the interaction of prostaglandin H synthase with anti-inflammatory agents.

1985 • 185 citations

Expression of the protein product of the prostaglandin synthase-2/TIS10 gene in mitogen-stimulated Swiss 3T3 cells.

1993 • 171 citations

Concentrations of prostaglandin endoperoxide synthase and prostaglandin I2 synthase in the endothelium and smooth muscle of bovine aorta.

1983 • 148 citations

Prostaglandin endoperoxide synthase. The aspirin acetylation region.

1992 • 146 citations

Lipopolysaccharide induces prostaglandin H synthase-2 in alveolar macrophages

1992 • 129 citations

Essential histidines of prostaglandin endoperoxide synthase. His-309 is involved in heme binding.

1991 • 115 citations

Prostaglandins, Leukotrienes, Lipoxins, and PAF

1991 • 98 citations

Multiple Cyclooxygenases: Cloning of a Mitogen-Inducible Form

1991 • 89 citations

Prostaglandins and Related Compounds

1978 • 86 citations

Identification of an immediate early gene, pghs-B, whose protein product has prostaglandin synthase/cyclooxygenase activity.

1992 • 85 citations

cAMP-dependent induction of fatty acid cyclooxygenase mRNA in mouse osteoblastic cells (MC3T3-E1)

1991 • 59 citations

Low dose cyclosporine A in psoriatic arthritis: relation between soluble interleukin 2 receptors and response to therapy.

1992 • 49 citations

Regulation of Prostaglandin Endoperoxide Synthase Gene Expression in Cultured Rat Mesangial Cells: Induction by Serum via a Protein Kinase-C-Dependent Mechanism

1991 • 48 citations

Expression of the murine prostaglandin (PGH) synthase-1 and PGH synthase-2 isozymes in cos-1 cells.

1993 • 43 citations

Endoscopy-controlled study of the safety of nabumetone compared with naproxen in arthritis therapy

1987 • 33 citations

Prostaglandin endoperoxide synthase contains an EGF‐like domain

1989 • 23 citations

Upper gastrointestinal safety with nabumetone.

1992 • 21 citations

Clinical efficacy and safety of nabumetone in rheumatoid arthritis and osteoarthritis.

1992 • 19 citations

Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence

1988 • 18 citations

Serum induction and superinduction of PGG/H synthase mRNA levels in 3T3 fibroblasts.

1991 • 13 citations

Deleted Work

1955 • 0 citations