Dissociation of impairment between spatial memory, and motor function and emotional behavior in aged rats

Developments of a water-maze procedure for studying spatial learning in the rat

1984 • 6,896 citations

Behavioural despair in rats: A new model sensitive to antidepressant treatments

1978 • 3,035 citations

Hippocampus, space, and memory

1979 • 2,033 citations

Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor

1987 • 1,031 citations

Validity of head-dipping as a measure of exploration in a modified hole-board

1975 • 661 citations

Ibotenate Lesions of Hippocampus and/or Subiculum: Dissociating Components of Allocentric Spatial Learning

1990 • 650 citations

Spatial learning and motor deficits in aged rats

1984 • 509 citations

Degenerative Changes in Forebrain Cholinergic Nuclei Correlate with Cognitive Impairments in Aged Rats

1989 • 335 citations

The effects of aging on hippocampal and cortical projections of the forebrain cholinergic system

1987 • 318 citations

Age-related spatial reference and working memory deficits assessed in the water maze

1995 • 314 citations

Progressive decline in spatial learning and integrity of forebrain cholinergic neurons in rats during aging

1992 • 294 citations

Formation of a place learning-set by the rat: A new paradigm for neurobehavioral studies

1985 • 209 citations

Movement Disorders of Aged Rats: Reversal by Dopamine Receptor Stimulation

1979 • 207 citations

Relationship of age-related decline across several behavioral domains

1989 • 195 citations

Habituation of exploratory activity in mice: A screening test for memory enhancing drugs

1982 • 171 citations

Forced swimming test in rats: effect of desipramine administration and the period of exposure to the test on struggling behavior, swimming, immobility and defecation rate

1988 • 150 citations

Aged rats need a preserved complement of perforated axospinous synapses per hippocampal neuron to maintain good spatial memory

1986 • 149 citations

Age-related structural changes in the rat hippocampus: correlation with working memory deficiency

1990 • 147 citations

Age-related impairments in spatial memory are independent of those in sensorimotor skills

1989 • 140 citations

Loss of place specificity in hippocampal complex spike cells of senescent rat

1983 • 119 citations

Stability of numbers but not size of mouse forebrain cholinergic neurons to 53 months

1985 • 111 citations

Early stimulation effects on novelty-induced behavior in two psychogenetically-selected rat lines with divergent emotionality profiles

1992 • 103 citations

Learning by Mature-young and Aged Wistar Albino Rats As a Function of Test Complexity

1972 • 102 citations

Chapter 31 Chapter Hippocampal plasticity in normal aging and decreased plasticity in Alzheimer's disease

1990 • 83 citations

Short forms of the “reference-” and “working-memory” Morris water maze for assessing age-related deficits

1992 • 79 citations

Reversal of age-related cognitive impairments by an M1 cholinergic agonist, AF102B

1990 • 77 citations

Relationship between performance in the morris water task, visual acuity, and thermoregulatory function in aged F-344 rats

1991 • 75 citations

Stability of neuronal number in the human nucleus basalis of Meynert with age

1984 • 72 citations

Reduction in the number of NADPH-diaphorase-positive cells in the cerebral cortex and striatum in aged rats

1996 • 69 citations

Effects of age on water escape behavior and on repeated acquisition in rats

1993 • 65 citations

Improvement of cognitive function by MAO-B inhibitor L-deprenyl in aged rats

1991 • 63 citations

Age, sex and strain differences in activity and habituation in SHR and WKY Rats

1985 • 61 citations

Anxiolytic potential of sulpiride, clozapine and derivatives in the open-field test

1990 • 54 citations

Tetrahydroaminoacridine alleviates medial septal lesion-induced and age-related spatial reference but not working memory deficits

1991 • 48 citations

Degeneration of hippocampal fibers and spatial memory deficit in the aged rat

1987 • 44 citations

Enhanced functional responsiveness of the dopaminergic system—the mechanism of anti-immobility effects of antidepressants in the behavioural despair test in the rat

1988 • 44 citations

Changes in muscarinic cholinergic, PCP, GABAA, D1, and 5-HT2A receptor binding, but not in benzodiazepine receptor binding in the brains of aged rats

1994 • 43 citations

Pharmacologic characterization of GABAA/benzodiazepine receptor in rat hippocampus during aging.

1991 • 41 citations

Oxotremorine infusions into the medial septal area of middle-aged rats affect spatial reference memory and ChAT activity

1996 • 28 citations

Aged-Related Changes in Learning and Memory, Choline Acetyltransferase Activity and Number of Neuronal Cells in Rats.

1991 • 25 citations

Age-related changes in the motor response to environmental novelty in the rat

1989 • 20 citations

Region selective increase in activities of CNS cholinergic marker enzymes during learning of memory tasks in aged rats

1989 • 19 citations

Effects of the subacute administration of nefiracetam on abnormal behavior in aged rats

1996 • 13 citations

Atipamezole, an α2 antagonist, stabilizes age-related high-voltage spindle and passive avoidance defects

1992 • 13 citations

[Impairment of learning and memory and the accessory symptom in aged rats as senile dementia model (1)--Emotional behavior].

1993 • 11 citations

Drug interactions between imipramine and benzodiazepines in rats

1988 • 9 citations

[Impairment of learning and memory and the accessory symptom in aged rats as senile dementia model (2)--Learning and memory].

1993 • 9 citations

Loss of cholinergic neurons in the basal ganglia of aged rats

1986 • 4 citations