Endorphins in Psychiatry

Identification of two related pentapeptides from the brain with potent opiate agonist activity

1975 • 3,780 citations

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

1976 • 2,883 citations

Endogenous opioid peptides: multiple agonists and receptors

1977 • 2,494 citations

Opiate Receptor: Demonstration in Nervous Tissue

1973 • 2,364 citations

Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activity.

1973 • 1,272 citations

Common precursor to corticotropins and endorphins

1977 • 1,106 citations

Stereospecific Binding of the Potent Narcotic Analgesic [ ³ H]Etorphine to Rat-Brain Homogenate

1973 • 1,055 citations

Receptor activity and turnover of dopamine and noradrenaline after neuroleptics

1970 • 1,041 citations

Substance P: Localization in the Central Nervous System and in Some Primary Sensory Neurons

1975 • 1,029 citations

Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine

1975 • 981 citations

Endorphins: Profound Behavioral Effects in Rats Suggest New Etiological Factors in Mental Illness

1976 • 811 citations

Immunohistochemical studies using antibodies to leucine-enkephalin: Initial observations on the nervous system of the rat

1976 • 767 citations

Antagonism of acupuncture analgesia in man by the narcotic antagonist naloxone

1977 • 742 citations

Pain Relief by Electrical Stimulation of the Central Gray Matter in Humans and Its Reversal by Naloxone

1977 • 740 citations

Antagonism of Stimulation-Produced Analgesia by Naloxone, a Narcotic Antagonist

1976 • 664 citations

Stereospecific Interaction Between Narcotic Analgesics and a Synaptic Plasma Membrane Fraction of Rat Cerebral Cortex

1973 • 650 citations

Isolation and structure of an untriakontapeptide with opiate activity from camel pituitary glands.

1976 • 639 citations

Naloxone blockade of acupuncture analgesia: Endorphin implicated

1976 • 615 citations

Foot-shock induced stress increases β-endorphin levels in blood but not brain

1977 • 576 citations

Opioid Peptides Endorphins in Pituitary and Brain

1976 • 518 citations

Measurement of Subjective Responses: Quantitative Effects of Drugs

1960 • 491 citations

beta-endorphin is a potent analgesic agent.

1976 • 465 citations

Dopamine-Sensitive Adenylate Cyclase in Mammalian Brain: A Possible Site of Action of Antipsychotic Drugs

1974 • 450 citations

Pain reduction by electrical brain stimulation in man

1977 • 432 citations

Pain reduction by electrical brain stimulation in man

1977 • 432 citations

The C-Fragment of β-Lipotropin: An Endogenous Neuroleptic or Antipsychotogen?

1976 • 427 citations

Depressant action of TRH, LH-RH and somatostatin on activity of central neurones

1975 • 427 citations

Distribution of thyroptropin-releasing hormone (TRH) in the central nervous system as revealed with immunohistochemistry

1975 • 425 citations

Stereospecific and Nonspecific Interactions of the Morphine Congener Levorphanol in Subcellular Fractions of Mouse Brain

1971 • 413 citations

Role of proteolytic enzymes in biological regulation (a review).

1976 • 410 citations

Prolonged relief of pain by brief, intense transcutaneous somatic stimulation

1975 • 402 citations

A synthetic enkephalin analogue with prolonged parenteral and oral analgesic activity

1977 • 395 citations

Naltrexone, an Antagonist for the Treatment of Heroin Dependence

1973 • 395 citations

An endogenous morphine-like factor in mammalian brain

1975 • 393 citations

Morphine catalepsy in the rat: relation to striatal dopamine metabolism

1972 • 338 citations

Hypothermia and intolerance to cold induced by intracisternal administration of the hypothalamic peptide neurotensin

1976 • 312 citations

Narcotic Analgesics and Antagonists

1971 • 309 citations

Naloxone alters pain perception and somatosensory evoked potentials in normal subjects

1977 • 287 citations

Isolation

1975 • 286 citations

Biosynthesis of adrenocorticotropic hormone in mouse pituitary tumor cells.

1976 • 284 citations

The Somatomedins: A Family of Insulinlike Hormones under Growth Hormone Control

1974 • 281 citations

Morphine-like ligand for opiate receptors in human CSF

1975 • 281 citations

β-Endorphin as a potent analgesic by intravenous injection

1976 • 279 citations

The human pharmacology and abuse potential of N-allylnoroxymorphone (naloxone).

1967 • 278 citations

Naltrexone: Disposition, metabolism, and effects after acute and chronic dosing

1976 • 275 citations

Endorphins are located in the intermediate and anterior lobes of the pituitary gland, not in the neurohypophysis

1977 • 273 citations

Peptides and behavior

1977 • 272 citations

Paradoxical Effects after Microinjection of Morphine in the Periaqueductal Gray Matter in the Rat

1974 • 268 citations

The regional distribution of a morphine-like factor enkephalin in monkey brain

1976 • 266 citations

Drug dependence: its significance and characteristics.

1966 • 264 citations

Naloxone-induced reversal of schizophrenic hallucinations

1977 • 262 citations

β-Endorphin-Induced Changes in Schizophrenic and Depressed Patients

1977 • 253 citations

Evidence for analgesic activity of enkephalin in the mouse

1976 • 252 citations

Stimulation-produced Analgesia: Development of Tolerance and Cross-Tolerance to Morphine

1975 • 250 citations

Medical Safety and Side Effects of Methadone in Tolerant Individuals

1973 • 242 citations

Function of the Male Sex Organs in Heroin and Methadone Users

1975 • 242 citations

Purification and properties of enkephalin — The possible endogenous ligand for the morphine receptor

1975 • 240 citations

Dopamine turnover in the corpus striatum and the limbic system after treatment with neuroleptic and anti-acetylcholine drugs

1972 • 235 citations

Footshock induced analgesia in mice: Its reversal by naloxone and cross tolerance with morphine

1977 • 234 citations

The Relationship of Pharmacokinetics to Pharmacological Activity

1976 • 231 citations

Neuropeptide influences on the brain and behavior

1977 • 225 citations

Physical Dependence of Opiate-Like Peptides

1976 • 219 citations

Isolation, primary structure, and synthesis of α-endorphin and γ-endorphin, two peptides of hypothalamic-hypophysial origin with morphinomimetic activity

1976 • 216 citations

PITUITARY–ADRENAL SYSTEM HORMONES AND BEHAVIOR

1978 • 215 citations

Thyrotropin releasing hormone: Antagonism of pentobarbital in rodents

1974 • 213 citations

Catecholamine Biosynthesis in Brains of Rats Treated with Morphine

1970 • 197 citations

Heroin Use as an Attempt To Cope: Clinical Observations

1974 • 194 citations

Opiate receptor in normal and drug altered brain function*

1975 • 184 citations

Intravenous Naloxone Administration in Schizophrenia and Affective Illness

1977 • 170 citations

A psychodynamic study of a patient during experimental self-regulated re-addiction to morphine

1952 • 161 citations

High molecular weight forms of adrenocorticotropic hormone are glycoproteins.

1976 • 154 citations

Effects of morphine and haloperidol on the electrical activity of rat nigrostriatal neurons.

1977 • 149 citations

AN EPIDEMIOLOGIC EVALUATION OF LONG-TERM METHADONE MAINTENANCE TREATMENT FOR HEROIN ADDICTION

1974 • 147 citations

Comparative study on analgesic effect of Met5-enkephalin and related lipotropin fragments

1976 • 146 citations

Thyrotrophin-releasing hormone and shaking behaviour in rat

1975 • 143 citations

CLINICAL MEASUREMENT OF PAIN

1979 • 141 citations

Neurohypophyseal hormones, analogs, and fragments: their effect on puromycin-induced amnesia.

1975 • 139 citations

Indication of an Antipsychotic Action of the Opiate Antagonist Naloxone

1977 • 128 citations

Sudden Death and Phenothiazines

1968 • 126 citations

Naloxone in Chronic Schizophrenia

1977 • 126 citations

The use of hemodialysis in chronic schizophrenia

1977 • 122 citations

Antipsychotic Drugs

1977 • 121 citations

Morphine-induced increases in the incorporation of 14 C-Tyrosine into 14 C-Dopamine and 14 C-norepinephrine in the mouse brain: antagonism by naloxone and tolerance.

1972 • 117 citations

Dopamine-sensitive adenylate cyclase of the caudate nucleus of rats treated with morphine or haloperidol

1975 • 110 citations

Analgesia following transcutaneous electrical stimulation and its partial reversal by a narcotic antagonist

1977 • 106 citations

An inability to antagonize with naloxone the elevated nociceptive thresholds resulting from electrical stimulation of the mesencephalic central gray

1976 • 106 citations

Comparison between naloxone reversal of morphine and electrical stimulation induced analgesia in the rat mesencephalon

1976 • 105 citations

Opiate Addiction: A Critique of Theory and Some Implications for Treatment

1974 • 104 citations

Preliminary clinical studies with L-prolyl-L-leucyl-glycine amide in Parkinson's disease.

1972 • 101 citations

Neuropharmacological actions of enkephalin after systemic administration

1976 • 99 citations

Lack of effect on naloxone on schizophrenic symptoms

1977 • 99 citations

Naloxone (Narcan�) treatment in depression: Clinical observations and effects on CSF endorphins and monoamine metabolites

1977 • 98 citations

Phylogenetic distribution of a morphine-like peptide ‘enkephalin’

1976 • 98 citations

Acute effects of morphine on dopamine synthesis and release and tyrosine metabolism in the rat striatum

1973 • 88 citations

Psychiatric aspects of drug addiction

1953 • 79 citations

Human sleep and EEG through a cycle of methadone dependence

1975 • 74 citations

Demonstration of tolerance to and physical dependence of N-allylnormorphine (nalorphine).

1965 • 73 citations

Isolation of a novel endogenous opiate analgesic from human blood.

1976 • 73 citations

A Nonpeptide Morphine-Like Compound: Immunocytochemical Localization in the Mouse Brain

1978 • 71 citations

Some effects of morphine and morphine antagonists on schedule-controlled behavior.

1967 • 70 citations

Characterization of an endogenous morphine-like factor(enkephalin) in mammalian brain.

1976 • 67 citations

Performance differences between addicts and non-addicts

1977 • 66 citations

PEPTIDE TRANSMITTERS: A UNIFYING HYPOTHESIS FOR EUPHORIA, RESPIRATION, SLEEP, AND THE ACTION OF LITHIUM

1976 • 62 citations

Molecular mechanisms in the actions of morphine and viminol (R2) on rat striatum.

1975 • 61 citations

Self-Destructive Aspects of Hard Core Addiction

1973 • 61 citations

Role of central dopaminergic receptors in manic response of cats to morphine

1972 • 59 citations

Localized behavioral effects of vasopressin on maintenance of an active avoidance response in rats.

1974 • 57 citations

Endorphin analogs with potent and long-lasting analgesic effects

1977 • 54 citations

An oral opiate antagonist in chronic schizophrenia: a pilot study

1977 • 53 citations

The Drug Addict as a Patient

1956 • 51 citations

Blockade of morphine-withdrawal body shakes by haloperidol

1976 • 50 citations

Naltrexone: Physiological and psychological effects of single doses

1976 • 49 citations

Mortality of patients with tardive dyskinesia

1978 • 49 citations

Pharmacological analysis of central actions of synthetic substance P.

1973 • 45 citations

In vitro biosynthesis of beta-endorphin in pituitary glands.

1977 • 35 citations

The Value of Chemotherapy in Senile Mental Disturbances

1960 • 35 citations

Naloxone-induced mood and physiologic changes in normal volunteers

1979 • 34 citations

Catalepsy and stereotyped behaviour in rats treated chronically with methadone: relation to brain homovanillic acid content

1973 • 31 citations

Further characterization of morphine-like peptides (endorphins) from pituitary

1976 • 30 citations

Failure of Methadone and Levomethadyl Acetate (Levo-Alpha-Acetylmethadol, LAAM) Maintenance to Affect Memory

1977 • 29 citations

Psychological Aspects of Heroin and Other Drug Dependence

1971 • 26 citations

Possible role of endorphins in schizophrenia and other psychiatric disorders

1979 • 24 citations

Subjective effects of narcotic antagonists.

1973 • 24 citations

In vivo receptor occupation by opiates and correlation to the pharmacological effect.

1978 • 23 citations

Neuropharmacology of hypothalamic releasing factors

1976 • 23 citations

Methadone in schizophrenic rage: a case study

1978 • 21 citations

EFFECTS OF FRONTAL LOBOTOMY ON THE MORPHINEABSTINENCE SYNDROME IN MAN

1952 • 21 citations

The use of methadone as a psychotropic agent.

1973 • 19 citations

Physical symptom complaints of patients on methadone maintenance.

1973 • 18 citations

Human endorphin: Comparison with porcine endorphin, enkephalin and normorphine

1976 • 18 citations

Pharmacological studies with a tripeptide, prolyl-leucyl glycine amide.

1974 • 17 citations

Enkephalin and Drug Dependence*

1976 • 16 citations

The Psychotic Heroin Addict

1971 • 16 citations

Substance-P Pathways in Rat Brain

1977 • 15 citations

Pituitary peptides as modulators of neural functioning

1977 • 12 citations

Neurological assessment of patients on prolonged methadone maintenance

1976 • 11 citations

Treatment of depression with dexedrine and demerol.

1971 • 11 citations

The Eysenck Personality Inventory with Methadone Maintenance Patients

1974 • 10 citations

A comparison of level of anxiety, depression and hostility with methadone plasma concentration in opioid-dependent patients receiving methadone on a maintenance dosage schedule.

1973 • 9 citations

Recent developments in opiate research and their implications for psychiatry

1976 • 8 citations

Methadone and Chemotherapy in Drug Addiction

1974 • 8 citations

Emerging Trends of Heroin Abuse in the San Francisco Bay Area

1971 • 4 citations

Some Pharmacological Perspectives on the Opiate Narcotics with Special Consideration of Heroin

1971 • 4 citations

MORPHINE AS ANTIPSYCHOTIC DRUG

1977 • 3 citations

Addiction Induction—: Will It Be Tested?

1971 • 3 citations

Opiate dependence and the use of narcotics for the relief of pain.

1968 • 2 citations

Assays of antagonistic activity of narcotic antagonists in man.

1973 • 2 citations

Die psychiatrische Klinik

1891 • 2 citations

Chronic effects of select narcotic antagonists in mice.

1973 • 1 citations