Substitution Pharmacotherapies for Opioid Addiction: From Methadone to LAAM and Buprenorphine

A JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

1909 • 6,516 citations

Drug Abuse Treatment: A National Study of Effectiveness

1989 • 1,065 citations

The Effectiveness of Methadone Maintenance Treatment: Patients, Programs, Services, and Outcome

1991 • 939 citations

Human Pharmacology and Abuse Potential of the Analgesic Buprenorphine

1978 • 787 citations

A Controlled Trial of Buprenorphine Treatment for Opioid Dependence

1992 • 534 citations

AGONIST AND ANTAGONIST PROPERTIES OF BUPRENORPHINE, A NEW ANTINOCICEPTIVE AGENT

1977 • 528 citations

Reducing the Risk of AIDS Through Methadone Maintenance Treatment

1988 • 410 citations

Mortality in heroin addiction: impact of methadone treatment

1990 • 302 citations

Buprenorphine Suppresses Heroin Use by Heroin Addicts

1980 • 302 citations

Buprenorphine versus Methadone Maintenance for Opioid Dependence

1993 • 280 citations

Narcotic Blockade

1966 • 276 citations

Untreated Opiate Addicts

1985 • 267 citations

Risk Reduction for the Acquired Immunodeficiency Syndrome Among Intravenous Drug Users

1985 • 249 citations

Buprenorphine

1985 • 236 citations

Methadone Treatment of Randomly Selected Criminal Addicts

1969 • 223 citations

Buprenorphine: dose-related blockade of opioid challenge effects in opioid dependent humans.

1988 • 223 citations

Methadyl Acetate and Methadone as Maintenance Treatments for Heroin Addicts

1976 • 213 citations

Use of buprenorphine in the treatment of opioid addiction. II. Physiologic and behavioral effects of daily and alternate-day administration and abrupt withdrawal

1990 • 195 citations

Methadone Treatment and Acquired Immunodeficiency Syndrome

1989 • 163 citations

Buprenorphine effects on human heroin self-administration: an operant analysis.

1982 • 156 citations

Treatment of cocaine abuse with buprenorphine

1989 • 133 citations

“It Takes Your Heart”: The Image of Methadone Maintenance in the Addict World and Its Effect on Recruitment into Treatment

1985 • 126 citations

Safety and side-effects of buprenorphine in the clinical management of heroin addiction

1990 • 112 citations

Actions and addiction liabilities of alpha-acetyl-methadols in man.

1952 • 100 citations

Consequences and costs of shutting off methadone

1989 • 98 citations

Methadyl Acetate vs Methadone

1972 • 90 citations

AIDS and Addiction in New York City

1986 • 89 citations

Use of buprenorphine in the treatment of opiate addiction. I. Physiologic and behavioral effects during a rapid dose induction

1989 • 89 citations

Treatment of Heroin Addicts Using Buprenorphine

1991 • 88 citations

Methadone and l-Methadyl Acetate

1971 • 84 citations

PHARMACOLOGY OF METHADONE AND RELATED COMPOUNDS

1948 • 81 citations

A Cooperative Clinical Study of Methadyl Acetate

1978 • 80 citations

Levomethadyl in Maintenance Treatment of Opiate Dependence

1972 • 67 citations

Assessment and management of opioid withdrawal symptoms in buprenorphine‐dependent subjects

1992 • 54 citations

Buprenorphine Treatment of Opiate and Cocaine Abuse: Clinical and Preclinical Studies

1993 • 54 citations

The Influence of Prolonged Stable Methadone Maintenance Treatment on Mortality and Employment: An 8-Year Follow-up

1990 • 51 citations

Levomethadyl Acetate

1973 • 48 citations

A comparison of thrice weekly LAAM and daily methadone in employed heroin addicts

1981 • 45 citations

Using Methadone Effectively: Achieving Goals by Application of Laboratory, Clinical, and Evaluation Research and by Development of Innovative Programs

1991 • 44 citations

Affinities of some common opioid analgesics towards four binding sites in mouse brain

1984 • 43 citations

Methadyl Acetate and Methadone

1977 • 42 citations

Methadone/LAAM maintenance: A comparison study

1976 • 40 citations

Clinical experiences with 959 opiod-dependent patients treated with levo-alpha-acetymethadol (LAAM)

1986 • 39 citations

Phase II clinical trials of buprenorphine: detoxification and induction onto naltrexone.

1992 • 34 citations

Relapse to use of heroin, cocaine, and other drugs in the first year after treatment.

1986 • 32 citations

Acceptability of methadyl acetate (LAAM) as compared with methadone in a treatment program for heroin addicts

1978 • 31 citations

Analgesic activity and toxic effects of acetylmethadol isomers in man.

1952 • 31 citations

A clinical, controlled study of l-alpha-acetylmethadol in the treatment of narcotic addiction

1981 • 24 citations

CLINICAL USE OF LAAM

1978 • 20 citations

New Perspectives on the Benefit-Cost and Cost-Effectiveness of Drug Abuse Treatment

1991 • 20 citations

CONTROL OF CHRONIC PAIN BY DL-ALPHA ACETYLMETHADOL

1956 • 17 citations

Development of buprenorphine for the treatment of opioid dependence.

1992 • 15 citations

Rx: 3x/week LAAM alternative to methadone.

1976 • 12 citations

Prolonged Nausea and Vomiting Associated with Buprenorphine

1991 • 12 citations

Human Laboratory Studies of Buprenorphine

1992 • 10 citations

Methadone Maintenance in the Management of Opioid Dependence: An International Review

1991 • 8 citations

The use of LAAM in treatment.

1976 • 8 citations

Addressing the diversion of take-home methadone: LAAM as the sole treatment choice for patients seeking maintenance therapy.

1983 • 7 citations

The Use of L-α-Acetylmethadol in Treatment of Heroin Addiction: An Open Study

1976 • 6 citations

Episodes of heroin use during maintenance treatment with stable dosage of (−)-α-acetylmethadol (methadyl acetate, LAAM)

1983 • 5 citations

Phase III clinical study of levo-alpha-acetylmethadol.

1976 • 4 citations

A clinical experience with LAAM.

1976 • 4 citations