Biochemical Analysis of Cybrids Expressing Mitochondrial DNA from Contursi Kindred Parkinson's Subjects

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

1993 • 7,941 citations

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

1997 • 7,814 citations

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1998 • 5,063 citations

Friedreich's Ataxia: Autosomal Recessive Disease Caused by an Intronic GAA Triplet Repeat Expansion

1996 • 2,667 citations

Oxidative Damage Linked to Neurodegeneration by Selective α-Synuclein Nitration in Synucleinopathy Lesions

2000 • 1,526 citations

Aging, energy, and oxidative stress in neurodegenerative diseases

1995 • 1,453 citations

Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation

1990 • 1,390 citations

Abnormalities of the electron transport chain in idiopathic parkinson's disease

1989 • 1,067 citations

Oxidative damage and metabolic dysfunction in Huntington's disease: Selective vulnerability of the basal ganglia

1997 • 866 citations

Mitochondrial defect in Huntington's disease caudate nucleus

1996 • 737 citations

Origin and functional consequences of the complex I defect in Parkinson's disease

1996 • 629 citations

Dityrosine Cross-linking Promotes Formation of Stable α-Synuclein Polymers

2000 • 561 citations

Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization

1999 • 546 citations

Mitochondrial abnormalities in non-alcoholic steatohepatitis

1999 • 494 citations

A susceptibility locus for Parkinson's disease maps to chromosome 2p13

1998 • 461 citations

Low platelet mitochondrial complex I and complex II/III activity in early untreated parkinson's disease

1995 • 430 citations

A large kindred with autosomal dominant Parkinson's disease

1990 • 411 citations

Platelet mitochondria function in Parkinson's disease

1992 • 350 citations

Deficit of in vivo mitochondrial ATP production in patients with Friedreich ataxia

1999 • 343 citations

Mitochondrial DNA transmission of the mitochondrial defect in Parkinson's disease

1998 • 313 citations

Abnormal Mitochondrial Morphology in Sporadic Parkinson's and Alzheimer's Disease Cybrid Cell Lines

2000 • 286 citations

Cybrids in Alzheimer's disease: A cellular model of the disease?

1997 • 266 citations

Elevated reactive oxygen species and antioxidant enzyme activities in animal and cellular models of Parkinson's disease

1997 • 263 citations

Cybrids in Alzheimer's disease: A cellular model of the disease?

1998 • 260 citations

Regional Mitochondrial Respiratory Activity in Huntington's Disease Brain

1985 • 255 citations

A chromosome 4p haplotype segregating with Parkinson's disease and postural tremor

1999 • 255 citations

Membrane Association and Protein Conformation of α-Synuclein in Intact Neurons

2000 • 239 citations

Evidence for a defect in NADH

1990 • 230 citations

Electron transfer complexes I and IV of platelets are abnormal in Parkinson's disease but normal in Parkinson-plus syndromes

1993 • 221 citations

Oxidative damage to mitochondrial DNA in Huntington's disease parietal cortex

1999 • 207 citations

Mitochondrial complex I and II activities of lymphocytes and platelets in Parkinson's disease

1992 • 192 citations

Enhanced vulnerability to oxidative stress by α-synuclein mutations and C-terminal truncation

2000 • 191 citations

Oxidative post‐translational modifications of α‐synuclein in the 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) mouse model of Parkinson's disease

2001 • 190 citations

Mitochondria in Sporadic Amyotrophic Lateral Sclerosis

1998 • 179 citations

Complex I Defect in muscle from patients with Huntington's disease

1998 • 173 citations

Matrilineal inheritance of complex I dysfunction in a multigenerational Parkinson's disease family

1998 • 146 citations

Familial multisystem degeneration with parkinsonism associated with the 11778 mitochondrial DNA mutation

1999 • 143 citations

Chronic levodopa administration alters cerebral mitochondrial respiratory chain activity

1993 • 140 citations

Platelet-mediated transformation of mtDNA-less human cells: analysis of phenotypic variability among clones from normal individuals--and complementation behavior of the tRNALys mutation causing myoclonic epilepsy and ragged red fibers.

1994 • 126 citations

Creation and Characterization of Mitochondrial DNA‐Depleted Cell Lines with “Neuronal‐Like” Properties

1996 • 121 citations

Marked increase in mitochondrial DNA deletion levels in the cerebral cortex of Huntington's disease patients

1995 • 109 citations

Mitochondrial Dysfunction in Cybrid Lines Expressing Mitochondrial Genes from Patients with Progressive Supranuclear Palsy

2000 • 92 citations

Sensitization of Neuronal Cells to Oxidative Stress with Mutated Human α‐Synuclein

2000 • 89 citations

Characterization of Cybrid Cell Lines Containing mtDNA from Huntington's Disease Patients

1999 • 34 citations