Abnormal Mitochondrial Morphology in Sporadic Parkinson's and Alzheimer's Disease Cybrid Cell Lines
Data up to Jan 2025
Total Citations Per Year
Abstract
References (70)
Methods in Enzymology , Vol
1966 • 26,261 citations
Parkinsonism
1967 • 11,463 citations
Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1.
1991 • 1,505 citations
Neuropathology of Parkinsonʼs Disease
1996 • 1,457 citations
Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.
1997 • 1,016 citations
Studies on the mechanisms of autophagy: formation of the autophagic vacuole.
1990 • 789 citations
[29] Mitochondrial membrane potential monitored by JC-1 dye
1995 • 668 citations
Origin and functional consequences of the complex I defect in Parkinson's disease
1996 • 629 citations
Cytochrome oxidase deficiency in Alzheimer's disease
1990 • 581 citations
Brain Cytochrome Oxidase in Alzheimer's Disease
1992 • 526 citations
Cortical Cytochrome Oxidase Activity Is Reduced in Alzheimer's Disease
1994 • 502 citations
Electron transport chain defects in Alzheimer's disease brain
1994 • 483 citations
The permeability transition pore as a mitochondrial calcium release channel: A critical appraisal
1996 • 466 citations
Mitochondrial DNA and Disease
1995 • 444 citations
Pathology and Biology of the Lewy Body
1993 • 394 citations
Bioenergetic and oxidative stress in neurodegenerative diseases
1995 • 365 citations
Studies on the mechanisms of autophagy: maturation of the autophagic vacuole.
1990 • 352 citations
RETRACTED: Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease
1997 • 345 citations
Mitochondrial DNA transmission of the mitochondrial defect in Parkinson's disease
1998 • 313 citations
Disruption of the outer mitochondrial membrane as a result of large amplitude swelling: the impact of irreversible permeability transition
1998 • 294 citations
Cybrids in Alzheimer's disease: A cellular model of the disease?
1997 • 266 citations
Elevated reactive oxygen species and antioxidant enzyme activities in animal and cellular models of Parkinson's disease
1997 • 263 citations
Cybrids in Alzheimer's disease: A cellular model of the disease?
1998 • 260 citations
Calcium Homeostasis and Reactive Oxygen Species Production in Cells Transformed by Mitochondria from Individuals with Sporadic Alzheimer’s Disease
1997 • 253 citations
Mitochondria in the etiology and pathogenesis of parkinson's disease
1998 • 243 citations
Mitochondrial Permeability Transition in the Central Nervous System: Induction by Calcium Cycling‐Dependent and ‐Independent Pathways
1997 • 231 citations
Mitochondrial DNA mutations in human degenerative diseases and aging
1995 • 224 citations
Functional Heterogeneity of an Isolated Mitochondrial Population Revealed by Cytofluorometric Analysis at the Single Organelle Level
1996 • 212 citations
Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer disease
1994 • 203 citations
Organelle motility and metabolism in axons vs dendrites of cultured hippocampal neurons
1996 • 202 citations
Reduced platelet cytochrome c oxidase activity in Alzheimer's disease
1994 • 199 citations
Mitochondrial alterations Alzheimer's disease
2004 • 199 citations
Release of apoptogenic proteins from the mitochondrial intermembrane space during the mitochondrial permeability transition
1997 • 179 citations
Mitochondria in Sporadic Amyotrophic Lateral Sclerosis
1998 • 179 citations
Ultrastructure of Lewy bodies in the stellate ganglion
1976 • 154 citations
Altered Calcium Homeostasis in Cells Transformed by Mitochondria from Individuals with Parkinson's Disease
1997 • 151 citations
Apoptosis in dopaminergic neurons of the human substantia nigra during normal aging.
1997 • 149 citations
Mitochondrial myopathies
1984 • 146 citations
Dynamics, structure, and function are coupled in the mitochondrial matrix.
1991 • 146 citations
Transfer of beta-amyloid precursor protein gene using adenovirus vector causes mitochondrial abnormalities in cultured normal human muscle.
1996 • 142 citations
Reactive, degenerative, and proliferative Schwann cell responses in experimental galactose and human diabetic neuropathy
1998 • 122 citations
Creation and Characterization of Mitochondrial DNA‐Depleted Cell Lines with “Neuronal‐Like” Properties
1996 • 121 citations
Synaptic Plasticity in the Caudate Nucleus of Patients with Parkinson's Disease
1996 • 112 citations
Mitochondrial Dysfunction in Idiopathic Parkinson Disease
1998 • 97 citations
Mitochondrial creatine kinase: a major constituent of pathological inclusions seen in mitochondrial myopathies.
1994 • 90 citations
Mitochondria in neurodegenerative apoptosis: An opportunity for therapy?
1998 • 84 citations
Functional and morphological abnormalities of mitochondria in human cells containing mitochondrial DNA with pathogenic point mutations in tRNA genes.
1994 • 82 citations
Adult rat cardiomyocytes cultured in creatine-deficient medium display large mitochondria with paracrystalline inclusions, enriched for creatine kinase.
1991 • 81 citations
Retinal pathology in the Kearns-Sayre syndrome.
1985 • 69 citations
Chronic progressive external ophthalmoplegia (CPEO)
1983 • 65 citations
Caudate nucleus pathology in Parkinson's disease: ultrastructural and biochemical findings in biopsy material
1992 • 63 citations
Morphological observations in skeletal muscle from patients with a mitochondrial myopathy
1987 • 59 citations
Mitochondrial abnormalities in cortical dendrites from patients with Alzheimer's disease.
1985 • 56 citations
Two types of mitochondrial crystals in diseased human skeletal muscle fibers
1988 • 40 citations
Release of Mitochondrial Glutathione and Calcium by a Cyclosporine A-Sensitive Mechanism Occurs without Large Amplitude Swelling
1994 • 36 citations
Neurodegeneration and aging: Role of the second genome
1998 • 34 citations
Neuropathological study on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine of the crab-eating monkey
1988 • 32 citations
Methylmercury poisoning of the developing nervous system: Morphological changes in neuronal mitochondria
1983 • 29 citations
Hereditary mitochondrial hypertrophic cardiomyopathy with mitochondrial myopathy of skeletal muscle, congenital cataract and lactic acidosis
1987 • 28 citations
Mitochondrial intermembrane inclusion bodies: The common denominator between human mitochondrial myopathies and creatine depletion, due to impairment of cellular energetics
1997 • 24 citations
Untitled
1997 • 21 citations
Mitochondrial Dysfunction in Parkinson’s Disease
1998 • 21 citations
Light- and electron-microscopic studies of intracytoplasmic acidophilic granules in the human locus ceruleus and substantia nigra
1982 • 20 citations
Effects of MPTP on the fine structure of neurons in substantia nigra of dogs
1990 • 19 citations
Focal cytochrome c oxidase deficiency in the brain and dorsal root ganglia in a case with mitochondrial encephalomyopathy (tRNAIle 4269 mutation): histochemical, immunohistochemical, and ultrastructural study
1995 • 18 citations
Ultrastructural changes of the substantia nigra, ventral tegmental area and striatum in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice.
1990 • 16 citations
Mitochondrial Morphology and Intracellular Calcium Homeostasis in Cytochrome Oxidase-Deficient Human Fibroblasts
1997 • 15 citations
Ultrastructural alterations induced by 1-methyl-4-phenylpyridinium (MPP+) in canine substantia nigra and rat mesencephalon in vitro
1989 • 11 citations
Untitled
1997 • 8 citations
Multiple mitochondrial tRNALeu[UUR] mutations associated with infantile myopathy
1997 • 7 citations