AIRE gene polymorphisms in systemic sclerosis associated with autoimmune thyroiditis

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

Positional cloning of the APECED gene

1997 • 1,385 citations

The Cellular Mechanism of Aire Control of T Cell Tolerance

2005 • 622 citations

Mutations in the AIRE Gene: Effects on Subcellular Location and Transactivation Function of the Autoimmune Polyendocrinopathy-Candidiasis–Ectodermal Dystrophy Protein

2000 • 358 citations

Gene Dosage–limiting Role ofAirein Thymic Expression, Clonal Deletion, and Organ-specific Autoimmunity

2004 • 291 citations

RETRACTED: Deficient Smad7 expression: A putative molecular defect in scleroderma

2002 • 247 citations

The Autoimmune Regulator Protein Has Transcriptional Transactivating Properties and Interacts with the Common Coactivator CREB-binding Protein

2000 • 239 citations

Common Mutations in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Patients of Different Origins

1998 • 171 citations

AIRE Functions As an E3 Ubiquitin Ligase

2004 • 145 citations

Characterization of mutations in patients with autoimmune polyglandular syndrome type 1 (APS1)

1998 • 136 citations

Expression of AIRE gene in peripheral monocyte/dendritic cell lineage

2002 • 130 citations

Association of fibrillin 1 single-nucleotide polymorphism haplotypes with systemic sclerosis in Choctaw and Japanese populations

2001 • 118 citations

Human skin cells support thymus-independent T cell development

2005 • 95 citations

Systematic mutagenesis of the functional domains of AIRE reveals their role in intracellular targeting

2002 • 94 citations

NMR Structure of the First PHD Finger of Autoimmune Regulator Protein (AIRE1)

2005 • 89 citations

Analysis of transforming growth factor beta1 gene polymorphisms in patients with systemic sclerosis

2002 • 86 citations

Role of the Autoimmune Regulator (AIRE) gene in alopecia areata: Strong association of a potentially functional AIRE polymorphism with alopecia universalis

2002 • 85 citations

Increased antigen presenting cell‐mediated T cell activation in mice and patients without the autoimmune regulator

2006 • 81 citations

High prevalence of polymorphisms of angiotensin-converting enzyme (I/D) and endothelial nitric oxide synthase (Glu298Asp) in patients with systemic sclerosis

2002 • 80 citations

The -2518 Promotor Polymorphism in the MCP-1 Gene Is Associated with Systemic Sclerosis

2005 • 80 citations

T and B cell collaboration is essential for the autoantibody response to DNA topoisomerase I in systemic sclerosis.

1995 • 67 citations

Interleukin 1alpha single-nucleotide polymorphism associated with systemic sclerosis.

2004 • 64 citations

Autoantibodies against Aromatic l-Amino Acid Decarboxylase Identifies a Subgroup of Patients with Addison’s Disease1

2000 • 57 citations

Common Mutations in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Patients of Different Origins

1998 • 45 citations

Autoantibodies against Aromatic L-Amino Acid Decarboxylase Identifies a Subgroup of Patients with Addison's Disease

2000 • 29 citations