Prognostic Value of Vascular Endothelial Growth Factor Expression in Patients with Lung Cancer: A Systematic Review with Meta-Analysis

Bias in meta-analysis detected by a simple, graphical test

1997 • 47,526 citations

Meta-analysis in clinical trials

1986 • 36,193 citations

Operating Characteristics of a Rank Correlation Test for Publication Bias

1994 • 15,160 citations

Tumor Angiogenesis: Therapeutic Implications

1971 • 9,898 citations

Paclitaxel–Carboplatin Alone or with Bevacizumab for Non–Small-Cell Lung Cancer

2006 • 5,595 citations

Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints

1998 • 4,679 citations

Beta blockade during and after myocardial infarction: An overview of the randomized trials

1985 • 3,248 citations

Role of the Vascular Endothelial Growth Factor Pathway in Tumor Growth and Angiogenesis

2004 • 2,891 citations

Non-Small Cell Lung Cancer: Epidemiology, Risk Factors, Treatment, and Survivorship

2008 • 2,782 citations

Transplacental Carcinogenesis by Stilbestrol

1971 • 2,595 citations

Non-Small Cell Lung Cancer: Epidemiology, Risk Factors, Treatment, and Survivorship

2008 • 2,548 citations

Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer

2004 • 2,481 citations

VEGF and the quest for tumour angiogenesis factors

2002 • 1,467 citations

Epidemiology of Lung Cancer

2010 • 1,094 citations

Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis

2005 • 1,025 citations

Publication Bias: A Problem in Interpreting Medical Data

1988 • 773 citations

Epidemiology of Lung Cancer*

2003 • 733 citations

Epidemiology of Lung Cancer

2007 • 621 citations

The role of RAS oncogene in survival of patients with lung cancer: a systematic review of the literature with meta-analysis

2004 • 602 citations

Small Cell Lung Cancer

2008 • 450 citations

Role of p53 as a prognostic factor for survival in lung cancer: a systematic review of the literature with a meta-analysis

2001 • 409 citations

Prognostic factors for survival in advanced non-small-cell lung cancer: univariate and multivariate analyses including recursive partitioning and amalgamation algorithms in 1,052 patients. The European Lung Cancer Working Party.

1995 • 396 citations

Vascular Endothelial Cell Growth Factor Receptor 3–Mediated Activation of Lymphatic Endothelium Is Crucial for Tumor Cell Entry and Spread via Lymphatic Vessels

2005 • 393 citations

Vascular endothelial growth factor is associated with neovascularization and influences progression of non-small cell lung carcinoma.

1997 • 305 citations

High pre-treatment serum level of vascular endothelial growth factor (VEGF) is associated with poor outcome in small-cell lung cancer

1998 • 275 citations

Vascular endothelial growth factor, platelet-derived endothelial cell growth factor and angiogenesis in non-small-cell lung cancer

2000 • 275 citations

The role of EGF-R expression on patient survival in lung cancer: a systematic review with meta-analysis

2002 • 267 citations

Ki-67 expression and patients survival in lung cancer: systematic review of the literature with meta-analysis

2004 • 265 citations

The role of microvessel density on the survival of patients with lung cancer: a systematic review of the literature with meta-analysis

2002 • 237 citations

Contour-Enhanced Funnel Plots for Meta-Analysis

2008 • 225 citations

Prognostic value of vascular endothelial growth factor and its receptor Flt-1 in squamous cell lung cancer

1997 • 223 citations

Correlation of Glut-1 glucose transporter expression with [18F]FDG uptake in non-small cell lung cancer

2000 • 217 citations

Prognostic impact of VEGF, CD31, CD34, and CD105 expression and tumour vessel invasion after radical surgery for IB-IIA non-small cell lung cancer

2004 • 192 citations

Vascular endothelial growth factor expression in non-small-cell lung cancer: Prognostic significance in squamous cell carcinoma

1998 • 175 citations

Role of Bcl-2 as a prognostic factor for survival in lung cancer: a systematic review of the literature with meta-analysis

2003 • 163 citations

Expression of HIF-1α, CA IX, VEGF, and MMP-9 in surgically resected non-small cell lung cancer

2005 • 162 citations

Prognostic value of expression of vascular endothelial growth factor and its flt-1 and KDR receptors in stage I non-small-cell lung cancer

2006 • 160 citations

Clinical significance of vascular endothelial growth factor C and vascular endothelial growth factor receptor 3 in patients with nonsmall cell lung carcinoma

2003 • 160 citations

Expression of angiopoietins and its clinical significance in non-small cell lung cancer.

2002 • 151 citations

Vascular endothelial growth factor/KDR activated microvessel density versus CD31 standard microvessel density in non-small cell lung cancer.

2000 • 146 citations

Small cell lung carcinoma (SCLC): the angiogenic phenomenon

2002 • 136 citations

Survival impact of epidermal growth factor receptor overexpression in patients with non-small cell lung cancer: a meta-analysis

2005 • 135 citations

A high vascular count and overexpression of vascular endothelial growth factor are associated with unfavourable prognosis in operated small cell lung carcinoma

2002 • 133 citations

Vascular endothelial growth factor, wild-type p53, and angiogenesis in early operable non-small cell lung cancer.

1998 • 132 citations

Neoangiogenesis and p53 protein in lung cancer: their prognostic role and their relation with vascular endothelial growth factor (VEGF) expression

1997 • 131 citations

The intratumoral expression of vascular endothelial growth factor and interleukin-8 associated with angiogenesis in nonsmall cell lung carcinoma patients

2001 • 123 citations

The role of HER-2/neu expression on the survival of patients with lung cancer: a systematic review of the literature

2003 • 112 citations

Increased vascular endothelial growth factor and vascular endothelial growth factor–c and decreased nm23 expression associated with microdissemination in the lymph nodes in stage i non–small cell lung cancer

2000 • 107 citations

Inverse Prognostic Impact of Angiogenic Marker Expression in Tumor Cells versus Stromal Cells in Non–Small Cell Lung Cancer

2007 • 105 citations

The influence of dendritic cell infiltration and vascular endothelial growth factor expression on the prognosis of non-small cell lung cancer.

2002 • 97 citations

Clinical application of biological markers for treatments of resectable non-small-cell lung cancers

2005 • 97 citations

Expression of vascular endothelial growth factor mRNA in non-small-cell lung carcinomas

1998 • 96 citations

Vascular endothelial growth factor expression and neovascularisation in non-small cell lung cancer

2000 • 95 citations

Tumor angiogenesis and vascular endothelial growth factor expression in stage I lung adenocarcinoma.

1998 • 94 citations

Influence of angiogenetic factors and matrix metalloproteinases upon tumour progression in non-small-cell lung cancer

2001 • 87 citations

Clinical significance of VEGF-C status in tumour cells and stromal macrophages in non-small cell lung cancer patients

2004 • 83 citations

The clinical significance of lymphangiogenesis and angiogenesis in non-small cell lung cancer patients

2008 • 81 citations

Expression of cell-associated isoform of vascular endothelial growth factor 189 and its prognostic relevance in non-small cell lung cancer.

1998 • 80 citations

Total cyclooxygenase‐2 mRNA levels correlate with vascular endothelial growth factor mRNA levels, tumor angiogenesis and prognosis in non‐small cell lung cancer patients

2005 • 76 citations

Prognostic significance of p53, Ki-67, VEGF and Glut-1 in resected stage I adenocarcinoma of the lung

2002 • 73 citations

Basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) levels, as prognostic indicators in NSCLC

2004 • 70 citations

Vascular endothelial growth factor and its receptor correlate with angiogenesis and survival in pulmonary adenocarcinoma.

1997 • 70 citations

Elevated preoperative serum levels of angiogenic cytokines correlate to larger primary tumours and poorer survival in non-small cell lung cancer patients

2002 • 69 citations

Role of Serum Vascular Endothelial Growth Factor in the Prediction of Angiogenesis and Prognosis for Non-small Cell Lung Cancer

2005 • 67 citations

[VEGF and survival of patients with lung cancer: a systematic literature review and meta-analysis].

2002 • 65 citations

Clinical significance of vascular endothelial growth factor‐C and vascular endothelial growth factor receptor 3 in patients with T1 lung adenocarcinoma

2005 • 62 citations

Vascular endothelial growth factor and other biological predictors related to the postoperative survival rate on non-small cell lung cancer

2001 • 60 citations

The K-ras gene regulates vascular endothelial growth factor gene expression in non-small cell lung cancers.

2000 • 60 citations

Altered Tissue 3′-Deoxy-3′-[18F]Fluorothymidine Pharmacokinetics in Human Breast Cancer following Capecitabine Treatment Detected by Positron Emission Tomography

2009 • 58 citations

Microvessel density: correlation with 18F-FDG uptake and prognostic impact in lung adenocarcinomas.

2006 • 58 citations

The role of survivin on overall survival of non-small cell lung cancer, a meta-analysis of published literatures

2008 • 58 citations

Correlation of angiogenesis with ¹⁸F‐FMT and ¹⁸F‐FDG uptake in non‐small cell lung cancer

2009 • 55 citations

VEGF et survie des patients atteints d'un cancer pulmonaire. Revue systématique avec méta-analyse.

2002 • 55 citations

Expression of vascular endothelial growth factor (VEGF) in non-small cell lung cancer (NSCLC): association with p53 gene mutation and prognosis

2001 • 52 citations

CALGB 30306: A phase II study of cisplatin (C), irinotecan (I) and bevacizumab (B) for untreated extensive stage small cell lung cancer (ES-SCLC)

2007 • 50 citations

Immunohistochemical Analysis of Non-Small Cell Lung Cancer: Correlation with Clinical Parameters and Prognosis

2007 • 48 citations

Expression of hypoxia-inducible factor-1 alpha and its prognostic significance in small-sized adenocarcinomas of the lung

2006 • 43 citations

Prognostic significance of HER2/neu, p53, and vascular endothelial growth factor expression in early stage conventional adenocarcinoma and bronchioloalveolar carcinoma of the lung

2004 • 43 citations

A phase II study of cisplatin (P) plus etoposide (E) plus bevacizumab (B) for previously untreated extensive stage small cell lung cancer (SCLC) (E3501): A trial of the Eastern Cooperative Oncology Group

2007 • 39 citations

Correlation between lymph node metastasis and the expression of VEGF-C, VEGF-D and VEGFR-3 in T1 lung adenocarcinoma.

2007 • 37 citations

Cell binding isoforms of vascular endothelial growth factor-A (VEGF189) contribute to blood flow-distant metastasis of pulmonary adenocarcinoma

2005 • 35 citations

Vascular Endothelial Growth Factor Level as a Prognostic Determinant of Small Cell Lung Cancer in Japanese Patients

2005 • 33 citations

Survival in small cell lung cancer is independent of tumor expression of VEGF and COX-2.

2004 • 32 citations

Squamous Cell Carcinoma Related Oncogene Regulates Angiogenesis through Vascular Endothelial Growth Factor-A

2004 • 25 citations

Vascular Endothelial Growth Factor Immunostaining Correlates with Postoperative Relapse and Survival in Non-Small Cell Lung Cancer

2007 • 18 citations

Angiogenesis and the efficacy of postoperative administration of UFT in pathologic stage I non‐small cell lung cancer

2004 • 17 citations

Predicting recurrence following curative surgery in stage I non-small cell lung cancer patients using an angiogenesis-associated factor.

2007 • 14 citations

Vascular endothelial growth factor expression in pN2 non‐small cell lung cancer: Lack of prognostic value

2005 • 13 citations

Prognostic value of vascular endothelial growth factor expression in primary lung carcinoma.

2000 • 11 citations

The ratio of membrane-bound form Flt-1 mRNA to VEGF mRNA correlates with tumor angiogenesis and prognosis in non-small cell lung cancer

2006 • 9 citations

[Expression of cyclin D1 and vascular endothelial growth factor(VEGF) in non-small cell lung carcinoma and their association with the prognosis].

2003 • 5 citations