Non-Small Cell Lung Cancer: Epidemiology, Risk Factors, Treatment, and Survivorship

Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib

2004 • 11,185 citations

Cancer Statistics, 2008

2008 • 10,165 citations

EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy

2004 • 9,201 citations

EGF receptor gene mutations are common in lung cancers from “never smokers” and are associated with sensitivity of tumors to gefitinib and erlotinib

2004 • 4,293 citations

Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomised clinical trials

1995 • 2,804 citations

Randomized trial of lobectomy versus limited resection for T1 N0 non-small cell lung cancer

1995 • 2,739 citations

Chemotherapy in non-small cell lung cancer: A meta-analysis using updated data on individual patients from 52 randomised clinical trials

1996 • 2,541 citations

Efficacy of Gefitinib, an Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase, in Symptomatic Patients With Non–Small Cell Lung Cancer

2003 • 2,522 citations

Early Lung Cancer Action Project: overall design and findings from baseline screening

1999 • 2,484 citations

Cisplatin-Based Adjuvant Chemotherapy in Patients with Completely Resected Non–Small-Cell Lung Cancer

2004 • 2,270 citations

Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)

2005 • 2,102 citations

Vinorelbine plus Cisplatin vs. Observation in Resected Non–Small-Cell Lung Cancer

2005 • 1,755 citations

Survival of Patients with Stage I Lung Cancer Detected on CT Screening

2006 • 1,623 citations

Gefitinib-Sensitizing EGFR Mutations in Lung Cancer Activate Anti-Apoptotic Pathways

2004 • 1,600 citations

Phase III Study of Concurrent Versus Sequential Thoracic Radiotherapy in Combination With Mitomycin, Vindesine, and Cisplatin in Unresectable Stage III Non–Small-Cell Lung Cancer

1999 • 1,501 citations

A variant associated with nicotine dependence, lung cancer and peripheral arterial disease

2008 • 1,497 citations

American Society of Clinical Oncology Treatment of Unresectable Non–Small-Cell Lung Cancer Guideline: Update 2003

2003 • 1,448 citations

Carotenoid actions and their relation to health and disease

2005 • 1,309 citations

Effects of Concomitant Cisplatin and Radiotherapy on Inoperable Non-Small-Cell Lung Cancer

1992 • 1,287 citations

Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1

2008 • 1,287 citations

A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

2008 • 1,264 citations

Status of Epidermal Growth Factor Receptor Antagonists in the Biology and Treatment of Cancer

2003 • 1,248 citations

Preoperative Staging of Non–Small-Cell Lung Cancer with Positron-Emission Tomography

2000 • 1,130 citations

Determinants of Tumor Response and Survival With Erlotinib in Patients With Non—Small-Cell Lung Cancer

2004 • 1,080 citations

Video-Assisted Thoracic Surgery Lobectomy: Experience With 1,100 Cases

2006 • 1,006 citations

Stereotactic hypofractionated high‐dose irradiation for stage I nonsmall cell lung carcinoma

2004 • 874 citations

American Cancer Society Guidelines for the Early Detection of Cancer: Update of Early Detection Guidelines for Prostate, Colorectal, and Endometrial Cancers: ALSO: Update 2001--Testing for Early Lung Cancer Detection

2001 • 849 citations

A Randomized Trial of Adjuvant Chemotherapy with Uracil–Tegafur for Adenocarcinoma of the Lung

2004 • 792 citations

The accumulated evidence on lung cancer and environmental tobacco smoke

1997 • 733 citations

Radiation Therapy Oncology Group (RTOG) 88-08 and Eastern Cooperative Oncology Group (ECOG) 4588: Preliminary Results of a Phase III Trial in Regionally Advanced, Unresectable Non-Small-Cell Lung Cancer

1995 • 721 citations

Physical Activity and Cancer Prevention: Etiologic Evidence and Biological Mechanisms

2002 • 704 citations

Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers

2005 • 640 citations

Morbidity and Mortality of Major Pulmonary Resections in Patients With Early-Stage Lung Cancer: Initial Results of the Randomized, Prospective ACOSOG Z0030 Trial

2006 • 632 citations

Epidemiology of Lung Cancer: Looking to the Future

2005 • 473 citations

Physical Activity and Cancer Prevention???Data from Epidemiologic Studies

2003 • 457 citations

Small Cell Lung Cancer

2008 • 450 citations

Toxicity and outcome results of RTOG 9311: A phase I–II dose-escalation study using three-dimensional conformal radiotherapy in patients with inoperable non–small-cell lung carcinoma

2005 • 445 citations

Cisplatin Biochemical Mechanism of Action: From Cytotoxicity to Induction of Cell Death Through Interconnections Between Apoptotic and Necrotic Pathways

2003 • 417 citations

Epidermal Growth Factor Receptor Mutations in Non–Small-Cell Lung Cancer: Implications for Treatment and Tumor Biology

2005 • 403 citations

The genetic basis of common diseases.

2002 • 402 citations

Thoracoscopic Lobectomy Is a Safe and Versatile Procedure

2006 • 395 citations

Staging Non-Small Cell Lung Cancer with Whole-Body PET

1999 • 392 citations

Clinical Features of 5,628 Primary Lung Cancer Patients

2005 • 392 citations

Platinum-Based Versus Non-Platinum-Based Chemotherapy in Advanced Non-Small-Cell Lung Cancer: A Meta-Analysis of the Published Literature

2005 • 369 citations

Randomized phase II/III trial of paclitaxel (P) plus carboplatin (C) with or without bevacizumab (NSC #704865) in patients with advanced non-squamous non-small cell lung cancer (NSCLC): An Eastern Cooperative Oncology Group (ECOG) Trial - E4599

2005 • 364 citations

Effect of tumor size on prognosis in patients with non–small cell lung cancer: The role of segmentectomy as a type of lesser resection

2004 • 331 citations

Staging non—small cell lung cancer by whole-body positron emission tomographic imaging

1995 • 314 citations

A Major Lung Cancer Susceptibility Locus Maps to Chromosome 6q23–25

2004 • 306 citations

Environmental tobacco smoke and risk of respiratory cancer and chronic obstructive pulmonary disease in former smokers and never smokers in the EPIC prospective study

2005 • 300 citations

Transesophageal Endoscopic Ultrasound-Guided Fine-Needle Aspiration (EUS-FNA) and Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (EBUS-TBNA) Biopsy: a Combined Approach in the Evaluation of Mediastinal Lesions

2005 • 299 citations

XPD and XRCC1 Genetic Polymorphisms Are Prognostic Factors in Advanced Non—Small-Cell Lung Cancer Patients Treated With Platinum Chemotherapy

2004 • 296 citations

Air pollution and cancer: biomarker studies in human populations †

2005 • 275 citations

Gender differences in non–small-cell lung cancer survival: an analysis of 4,618 patients diagnosed between 1997 and 2002

2004 • 268 citations

A randomized placebo-controlled trial of erlotinib in patients with advanced non-small cell lung cancer (NSCLC) following failure of 1^st line or 2^nd line chemotherapy. A National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) trial

2004 • 261 citations

The impact of tobacco on lung health in China

2003 • 242 citations

Human cancer from environmental pollutants: The epidemiological evidence

2006 • 242 citations

Detection of extrathoracic metastases by positron emission tomography in lung cancer

1998 • 238 citations

Endoscopic Ultrasound-Guided Fine Needle Aspiration of Mediastinal Lymph Node in Patients With Suspected Lung Cancer After Positron Emission Tomography and Computed Tomography Scans

2004 • 220 citations

Surgical treatment of non-small cell lung cancer 1 cm or less in diameter

2002 • 214 citations

Second Primary Cancers Related to Smoking and Treatment of Small-Cell Lung Cancer

1997 • 212 citations

Carbon ion radiotherapy for stage I non-small cell lung cancer

2003 • 206 citations

Hypofractionated Proton Beam Radiotherapy for Stage I Lung Cancer

2004 • 193 citations

Adjuvant chemotherapy in stage IB non-small cell lung cancer (NSCLC): Update of Cancer and Leukemia Group B (CALGB) protocol 9633

2006 • 181 citations

Lung Cancer Risk Reduction After Smoking Cessation: Observations From a Prospective Cohort of Women

2003 • 174 citations

Leisure-time physical activity and lung cancer: a meta-analysis

2005 • 174 citations

ANITA: Phase III adjuvant vinorelbine (N) and cisplatin (P) versus observation (OBS) in completely resected (stage I-III) non-small-cell lung cancer (NSCLC) patients (pts): Final results after 70-month median follow-up. On behalf of the Adjuvant Navelbine International Trialist Association

2005 • 165 citations

Long-term Survivorship in Lung Cancer

2006 • 157 citations

Ethnic Differences in Response to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors

2006 • 153 citations

Air pollution: from lung to heart

2005 • 149 citations

Repair of radiation damage to DNA

2004 • 146 citations

Early results of a prospective study of limited resection for bronchioloalveolar adenocarcinoma of the lung

2001 • 141 citations

Epidemiology of environmental and occupational cancer

2004 • 141 citations

β-Carotene breakdown products may impair mitochondrial functions — potential side effects of high-dose β-carotene supplementation

2005 • 141 citations

Histologic grade is an independent prognostic factor for survival in non–small cell lung cancer: An analysis of 5018 hospital- and 712 population-based cases

2006 • 136 citations

Induction cisplatin/vinblastine and irradiation vs. irradiation in unresectable squamous cell lung cancer: Failure patterns by cell type in rtog 88-08/ECOG 4588

1997 • 135 citations

Temporal trends in small cell lung cancer: Analysis of the national Surveillance, Epidemiology, and End-Results (SEER) database

2006 • 122 citations

Lung Cancer Screening: Recommendation Statement

2004 • 121 citations

Alcohol consumption and risk of lung cancer: a pooled analysis of cohort studies

2005 • 120 citations

Transcervical extended mediastinal lymphadenectomy?the new operative technique and early results in lung cancer staging

2005 • 119 citations

Association Between Exclusive Pipe Smoking and Mortality From Cancer and Other Diseases

2004 • 114 citations

Lung cancer risk in germline p53 mutation carriers: association between an inherited cancer predisposition, cigarette smoking, and cancer risk

2003 • 112 citations

Bronchogenic carcinoma: incidence of metastases to normal sized lymph nodes.

1995 • 112 citations

Lung Cancer in Octogenarians: Factors Affecting Morbidity and Mortality After Pulmonary Resection

2006 • 105 citations

Lung cancer in Asian women—the environment and genes*

2005 • 101 citations

A randomized trial comparing adjuvant chemotherapy versus surgery alone for completely resected pN2 non-small cell lung cancer (JCOG9304)

2004 • 94 citations

Phase III trial comparing chemotherapy plus once-daily or twice-daily radiotherapy in Stage III non-small-cell lung cancer 1 1This study was conducted as a collaborative trial of the North Central Cancer Treatment Group and Mayo Clinic. Additional participating institutions included Cedar Rapids Oncology Project CCOP, Cedar Rapids, IA; Meritcare Hospital CCOP, Fargo, ND; Sioux Community Cancer Consortium, Sioux Falls, SD; Geisinger Clinical Oncology Program, Danville, PA (Suresh Nair, M.D.); …

2002 • 92 citations

Malignant disease appearing late after operation for T1 N0 non-small-cell lung cancer

1993 • 89 citations

Evaluating health utility in patients with melanoma, breast cancer, colon cancer, and lung cancer: a nationwide, population-based assessment

2003 • 85 citations

Results of combined‐modality therapy for limited‐stage small cell lung carcinoma in the elderly

2005 • 84 citations

Inherited predisposition to early onset lung cancer according to histological type

2004 • 76 citations

Low incidence of pneumonitis on SWOG 0023: A preliminary analysis of an ongoing phase III trial of concurrent chemoradiotherapy followed by consolidation docetaxel and gefitinib/placebo maintenance in patients with inoperable stage III non-small cell lung cancer

2005 • 75 citations

Controlled study of survival of patients with clinically inoperable lung cancer treated with radiation therapy

1966 • 73 citations

A randomized trial of postoperative UFT therapy in p stage I, II non-small cell lung cancer: North-east Japan Study Group for Lung Cancer Surgery

2003 • 71 citations

Postoperative adjuvant therapy for stage IB non-small-cell lung cancer

2001 • 70 citations

The possible advantage of hyperfractionated thoracic radiotherapy in the treatment of locally advanced nonsmall cell lung carcinoma: results of a North Central Cancer Treatment Group Phase III Study.

1998 • 70 citations

The transcervical extended mediastinal lymphadenectomy versus cervical mediastinoscopy in non-small cell lung cancer staging

2006 • 67 citations

A randomized phase III trial of adjuvant chemotherapy with UFT for completely resected pathological stage I non-small-cell lung cancer: the West Japan Study Group for Lung Cancer Surgery (WJSG)—the 4th study

2004 • 66 citations

Pipe and cigar smoking and major cardiovascular events, cancer incidence and all-cause mortality in middle-aged British men

2003 • 59 citations

Antioxidant Vitamins and Risk of Lung Cancer

2006 • 53 citations

Physical Activity in Relation to All-Site and Lung Cancer Incidence and Mortality in Current and Former Smokers

2004 • 53 citations

Postoperative adjuvant cisplatin, vindesine, plus uracil-tegafur chemotherapy increased survival of patients with completely resected p-stage I non-small cell lung cancer

2005 • 51 citations

The Genetic Basis of Common Diseases, 2nd Edition

2004 • 45 citations

Influence of genetic markers on survival in non-small cell lung cancer

2003 • 36 citations

Environmental exposure to carcinogens causing lung cancer: Epidemiological evidence from the medical literature

2003 • 31 citations

Relevance and irrelevance of DNA damage response to radiotherapy

2004 • 30 citations

Adjuvant chemotherapy following radical surgery for non-small-cell lung cancer: a randomized study on 70 patients.

2000 • 20 citations

Combined bronchoscopy, mediastinoscopy, and thoracotomy for lung cancer: who benefits?

2004 • 17 citations

The possible advantage of hyperfractionated thoracic radiotherapy in the treatment of locally advanced nonsmall cell lung carcinoma

1998 • 15 citations

Should chemotherapy (Cx) for advanced non-small cell lung cancer (NSCLC) be platinum-based? A literature-based meta-analysis of randomized trials

2005 • 11 citations

Survival with inoperable lung cancer. Controlled national Veterans Administration study of radiation and chemotherapy.

1976 • 8 citations

Concurrent radiotherapy combined with carboplatin and etoposide in limited stage small cell lung cancer

2004 • 4 citations