VASCULAR REMODELLING AND MOLECULAR BIOLOGY: NEW CONCEPTS AND THERAPEUTIC POSSIBILITIES

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

Suppression of experimental glomerulonephritis by antiserum against transforming growth factor β1

1990 • 1,002 citations

Natural inhibitor of transforming growth factor-β protects against scarring in experimental kidney disease

1992 • 984 citations

TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors.

1994 • 937 citations

Proliferation of smooth muscle cells after vascular injury is inhibited by an antibody against basic fibroblast growth factor.

1991 • 722 citations

Hypoxia induces endothelin gene expression and secretion in cultured human endothelium.

1991 • 691 citations

Human Endothelial Cell Growth Factor: Cloning, Nucleotide Sequence, and Chromosome Localization

1986 • 679 citations

Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-β receptor system

1991 • 661 citations

Expression cloning and characterization of the TGF-β type III receptor

1991 • 638 citations

Platelet-derived growth factor B chain promoter contains a cis-acting fluid shear-stress-responsive element.

1993 • 638 citations

Human basic fibroblast growth factor: nucleotide sequence and genomic organization.

1986 • 604 citations

Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin.

1994 • 584 citations

Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma

1991 • 523 citations

Role of basic fibroblast growth factor in vascular lesion formation.

1991 • 521 citations

Novel activin receptors: Distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors

1992 • 495 citations

Complexity of FGF receptors: genetic basis for structural diversity and functional specificity

1992 • 441 citations

Expression of transforming growth factor-beta 1 is increased in human vascular restenosis lesions.

1992 • 383 citations

Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites

1994 • 379 citations

Proliferation in primary and restenotic coronary atherectomy tissue. Implications for antiproliferative therapy.

1993 • 361 citations

An antisense mRNA directs the covalent modification of the transcript encoding fibroblast growth factor in Xenopus oocytes

1989 • 305 citations

Antibodies against transforming growth factor-beta 1 suppress intimal hyperplasia in a rat model.

1994 • 303 citations

TGF-β-receptor-mediated signaling

1994 • 274 citations

Repression of myogenic differentiation by aFGF, bFGF, and K-FGF is dependent on cellular heparan sulfate.

1992 • 241 citations

Kinetics of basic fibroblast growth factor binding to its receptor and heparan sulfate proteoglycan: a mechanism for cooperativity

1992 • 236 citations

Growth factor expression in aorta of normotensive and hypertensive rats.

1989 • 195 citations

Distinct patterns of expression of fibroblast growth factors and their receptors in human atheroma and nonatherosclerotic arteries. Association of acidic FGF with plaque microvessels and macrophages.

1993 • 194 citations

Expression of basic fibroblast growth factor and its receptor by smooth muscle cells and endothelium in injured rat arteries. An en face study.

1993 • 174 citations

Inhibition of smooth muscle cell proliferation in injured rat arteries. Interaction of heparin with basic fibroblast growth factor.

1992 • 159 citations

Mechanoreception by the Endothelium: Mediators and Mechanisms of Pressure- and Flow-Induced Vascular Responses

1990 • 155 citations

Basic fibroblast growth factor: its role in the control of smooth muscle cell migration.

1993 • 139 citations

Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors.

1991 • 135 citations

Elimination of smooth muscle cells in experimental restenosis: targeting of fibroblast growth factor receptors.

1992 • 134 citations

Vascular derived growth factors: cell biology, pathophysiology, and pharmacology.

1993 • 133 citations

Tumor growth and angiogenesis induced by a secreted binding protein for fibroblast growth factors.

1994 • 125 citations

Control of Fibroblast Growth Factor Receptor Kinase Signal Transduction by Heterodimerization of Combinatorial Splice Variants

1993 • 124 citations

Biochemical evidence for the autophosphorylation and transphosphorylation of transforming growth factor beta receptor kinases.

1995 • 116 citations

Plasma immunoreactive endothelin-1 in experimental malignant hypertension.

1991 • 107 citations

Targeted expression of transforming growth factor-beta 1 in intracardiac grafts promotes vascular endothelial cell DNA synthesis.

1995 • 97 citations

Direct effect of basic fibroblast growth factor on gene transcription in a cell-free system.

1992 • 97 citations

Three forms of rat basic fibroblast growth factor are made from a single mRNA and localize to the nucleus

1991 • 94 citations

Control of BEK and K-SAM splice sites in alternative splicing of the fibroblast growth factor receptor 2 pre-mRNA.

1993 • 93 citations

Functional Characterization of the Human Basic Fibroblast Growth Factor Gene Promoter

1991 • 93 citations

Deamidation and isoaspartate formation during in vitro aging of recombinant tissue plasminogen activator.

1994 • 83 citations

Role of transforming growth factor-beta 1 in the cellular growth response to angiotensin II.

1993 • 82 citations

Fibroblast growth factor stimulates angiotensin converting enzyme expression in vascular smooth muscle cells. Possible mediator of the response to vascular injury.

1995 • 81 citations

Control of fibroblast growth factor receptor kinase signal transduction by heterodimerization of combinatorial splice variants.

1993 • 79 citations

The genes for basic and acidic fibroblast growth factors are on different human chromosomes

1986 • 78 citations

Gene transfer and vascular disease

1994 • 76 citations

High-affinity binding sites for related fibroblast growth factor ligands reside within different receptor immunoglobulin-like domains.

1994 • 72 citations

Different electrical responses to vasoactive agonists in morphologically distinct smooth muscle cell types.

1994 • 69 citations

Basic Fibroblast Growth Factor Sense (FGF) and Antisense (GFG) RNA Transcripts Are Expressed in Unfertilized Human Oocytes and in Differentiated Adult Tissues

1994 • 62 citations

Cytotoxic effects of a recombinant chimeric toxin on rapidly proliferating vascular smooth muscle cells.

1991 • 62 citations

Effects of hypertension and aging on platelet-derived growth factor and platelet-derived growth factor receptor expression in rat aorta and heart.

1991 • 54 citations

A single heteromeric receptor complex is sufficient to mediate biological effects of transforming growth factor-beta ligands.

1994 • 54 citations

Transforming growth factor-beta 1 gene activation and growth of smooth muscle from hypertensive rats.

1994 • 53 citations

Expression of growth factor receptors on arterial smooth muscle cells. Dependency on cell phenotype and serum factors

1995 • 44 citations

TGF-beta 1 potentiates growth factor-stimulated proliferation of vascular smooth muscle cells in genetic hypertension

1992 • 39 citations

Modification of alternative messenger RNA splicing of fibroblast growth factor receptors in human cardiac allografts during rejection.

1994 • 34 citations

Differential regulation of acidic and basic fibroblast growth factor gene expression in fibroblast growth factor-treated rat aortic smooth muscle cells.

1994 • 31 citations

Control of BEK and K-SAM Splice Sites in Alternative Splicing of the Fibroblast Growth Factor Receptor 2 Pre-mRNA

1993 • 24 citations