Electroencephalogram Effect Measures and Relationships Between Pharmacokinetics and Pharmacodynamics of Centrally Acting Drugs

Über das Elektrenkephalogramm des Menschen

1929 • 3,938 citations

Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations

1988 • 822 citations

Animal models of the epilepsies

1989 • 636 citations

Kinetics of pharmacologic response

1982 • 508 citations

EEG Quantitation of Narcotic Effect

1985 • 499 citations

Methods of Analysis of Brain Electrical and Magnetic Signals

1987 • 447 citations

Decreased Fentanyl and Alfentanil Dose Requirements with Age. A Simultaneous Pharmacokinetic and Pharmacodynamic Evaluation

1987 • 416 citations

COMPARATIVE PHARMACOLOGY OF THE KETAMINE ISOMERS

1985 • 382 citations

Electroencephalographic Quantitation of Opioid Effect

1991 • 325 citations

Novel anxiolytics that act as partial agonists at benzodiazepine receptors

1990 • 276 citations

Zolpidem, a novel nonbenzodiazepine hypnotic. I. Neuropharmacological and behavioral effects.

1986 • 274 citations

Topics in Pharmaceutical Sciences

1982 • 264 citations

CLOSED-LOOP FEEDBACK CONTROL OF PROPOFOL ANAESTHESIA BY QUANTITATIVE EEG ANALYSIS IN HUMANS

1989 • 232 citations

[3H]sufentanil, a superior ligand for μ-opiate receptors: Binding properties and regional distribution in rat brain and spinal cord

1983 • 223 citations

Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of midazolam and its main metabolite α-hydroxymidazolam in healthy volunteers

1992 • 214 citations

CEAN-computerized EEG analysis

1977 • 186 citations

Closed-loop Feedback Control of Methohexital Anesthesia by Quantitative EEG Analysis in Humans

1987 • 181 citations

Pharmacodynamic modeling of the EEG effects of ketamine and its enantiomers in man

1987 • 170 citations

The Effect of Increasing Age on Thiopental Disposition and Anesthetic Requirement

1985 • 169 citations

A Model for Studying Depth of Anesthesia and Acute Tolerance to Thiopental

1983 • 169 citations

Pharmacological profile of the imidazopyridine zolpidem at benzodiazepine receptors and electrocorticogram in rats

1985 • 168 citations

Pharmacokinetic and electroencephalographic study of intravenous diazepam, midazolam, and placebo

1989 • 166 citations

Plasma protein binding and distribution of fentanyl, sufentanil, alfentanil and lofentanil in blood.

1982 • 159 citations

Electrophysiological studies on the specific benzodiazepine antagonist Ro 15-1788

1981 • 156 citations

The Benzodiazepine Receptor in Normal and Pathological Human Brain

1978 • 149 citations

Population Pharmacokinetics and Pharmacodynamics of Thiopental

1990 • 147 citations

Increased Sensitivity to Etomidate in the Elderly

1986 • 147 citations

Electroencephalographic effects of benzodiazepines. II. Pharmacodynamic modeling of the electroencephalographic effects of midazolam and diazepam

1990 • 138 citations

Chloride channels and their modulation by neurotransmitters and drugs.

1988 • 134 citations

Antiepileptic Drugs and the Electroencephalogram

1987 • 128 citations

Clinical, Electroencephalographic, and Pharmacokinetic Studies of a Water-soluble Benzodiazepine, Midazolam Maleate

1979 • 125 citations

Spectral Analysis of the EEG

1987 • 119 citations

Relationship between plasma concentration and effect of midazolam after oral and intravenous administration.

1983 • 112 citations

Pharmacokinetic-pharmacodynamic modeling of the electroencephalographic effects of benzodiazepines. Correlation with receptor binding and anticonvulsant activity.

1991 • 110 citations

Pentobarbital: Stereospecific Actions of (+) and (-) Isomers Revealed on Cultured Mammalian Neurons

1980 • 104 citations

Pharmacodynamic modeling of thiopental anesthesia

1984 • 100 citations

Severe hypertension and raised haematocrit: unusual presentation of Guillain-Barré syndrome

1985 • 98 citations

Clinical and EEG effects of GB-94, a "tetracyclic" antidepressant (EEG model in discovery of a new psychotropic drug).

1972 • 98 citations

Topographic EEG changes with benzodiazepine administration in generalized anxiety disorder

1985 • 97 citations

Relation of sedation and amnesia to plasma concentrations of midazolam in surgical patients

1988 • 97 citations

QUANTITATIVE EEG ANALYSIS DURING ANAESTHESIA WITH ISOFLURANE IN NITROUS OXIDE AT 1.3 AND 1.5 MAC

1987 • 97 citations

Kinetic and dynamic study of intravenous lorazepam: comparison with intravenous diazepam.

1989 • 95 citations

Etomidate

1977 • 92 citations

Ro 16-6028: A Novel Anxiolytic Acting as a Partial Agonist at the Benzodiazepine Receptor

1988 • 91 citations

Clinical Applications of Computer Analysis of EEG and Other Neurophysiological Signals

1987 • 91 citations

Electroencephalography in drug research

1982 • 89 citations

Plasma Levels of Thiopental Necessary for Anesthesia

1978 • 88 citations

Pharmacokinetic and pharmacodynamic modelling of propofol ('Diprivan') in volunteers and surgical patients.

1985 • 87 citations

Pharmacological and Behavioral Profile of Alpidem as an Anxiolytic

1990 • 83 citations

Pharmacokinetic-pharmacodynamic modeling of CNS drug effects: An overview

1988 • 83 citations

Pharmacokinetic‐pharmacodynamic modelling of the EEG effects of midazolam in individual rats: influence of rate and route of administration

1991 • 83 citations

Antiepileptic drug evaluation in a new animal model: spontaneous petit mal epilepsy in the rat.

1985 • 82 citations

Estimation of Brain Sensitivity to Hexobarbitone (Enhexymal NFN) in Rats by an EEG Threshold

1966 • 77 citations

Intraoperative EEG Patterns

1984 • 74 citations

Differences in intrinsic efficacy of benzodiazepines are reflected in their concentration‐EEG effect relationship

1992 • 73 citations

Selectivity for Omega-Receptor Subtypes as a Strategy for the Development of Anxiolytic Drugs

1990 • 71 citations

Quantitation of the EEG and pharmacodynamic modelling of hypnotic drugs: etomidate as an example.

1985 • 71 citations

CNS receptors : from molecular pharmacology to behavior

1983 • 71 citations

Pharmacology of the benzodiazepine receptor

1989 • 71 citations

Pharmacodynamic Interaction Between Midazolam and a Specific Benzodiazepine Antagonist in Humans

1985 • 70 citations

An electroencephalographic processing algorithm specifically intended for analysis of cerebral electrical activity

1986 • 68 citations

Several new benzodiazepines selectively interact with a benzodiazepine receptor subtype

1983 • 66 citations

Functional in vivo correlates of the benzodiazepine agonist-inverse agonist continuum

1988 • 65 citations

A pharmacodynamic evaluation of midazolam as an antiepileptic compound.

1986 • 64 citations

Quantification of the EEG Effect of Midazolam by Aperiodic Analysis in Volunteers

1990 • 63 citations

Intravenous Anaesthetic Agents

1987 • 62 citations

Reevaluation of Potency and Pharmacokinetic Properties of some Lipid‐soluble Barbiturates with an EEG‐threshoJd Method

1984 • 60 citations

Intrinsic and antagonistic effects of β-carboline FG 7142 on behavioral and EEG actions of benzodiazepines and pentobarbital in cats

1983 • 57 citations

Tolerance to alprazolam after intravenous bolus and continuous infusion: Psychomotor and EEG effects

1988 • 56 citations

COMSTAT Rule for Vigilance Classification Based on Spontaneous EEG Activity

1987 • 55 citations

Blood levels and electroencephalographic effects of diazepam and bromazepam

1976 • 54 citations

[Methods of sleep research].

1984 • 54 citations

Electroencephalographic effects of benzodiazepines. I. Choosing an electroencephalographic parameter to measure the effect of midazolam on the central nervous system

1990 • 53 citations

PHARMACOLOGICAL PROFILE OF TWO BENZODIAZEPINE PARTIAL AGONISTS

1984 • 49 citations

In vivo characterization of the pharmacodynamic interaction of a benzodiazepine agonist and antagonist: midazolam and flumazenil.

1992 • 49 citations

Pharmacokinetic-pharmacodynamic modeling of midazolam effects on the human central nervous system

1988 • 49 citations

Pharmacodynamic characterization of the electroencephalographic effects of thiopental in rats

1991 • 48 citations

Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of heptabarbital using aperiodic EEG analysis

1990 • 42 citations

Chronic Alcohol Intake Does Not Change Thiopental Anesthetic Requirement, Pharmacokinetics, or Pharmacodynamics

1990 • 41 citations

Stereospecificity of anesthetic activity, distribution, inactivation and protein binding of the optical antipodes of two N-methylated barbiturates.

1970 • 40 citations

The EEC as a Monitor of Midazolam Amnesia

1991 • 40 citations

The discovery of psychotropic drugs by computer‐analyzed cerebral bioelectrical potentials (CEEG)

1981 • 38 citations

Pharmacokinetic-Pharmacodynamic Modelling of the Interaction between Flumazenil and Midazolam in Volunteers by Aperiodic EEG Analysis

1991 • 38 citations

Quantitation, modelling and control in anaesthesia

1985 • 38 citations

Partial agonists of the benzodiazepine receptor: from animal data to results in patients.

1988 • 37 citations

New Perspectives in Benzodiazepine Receptor Pharmacology

1986 • 36 citations

Effects of benzodiazepines and non‐benzodiazepine compounds on the GABA‐induced response in frog isolated sensory neurones

1989 • 36 citations

Pharmacokinetic and Dynamic Studies with a New Anxiolytic Imidazo-Pyridine Alpidem Utilizing Pharmaco-EEG and Psychometry

1986 • 36 citations

Separate site(s) of action of optical isomers of 1-methyl-5-phenyl-5-propylbarbituric acid with opposite pharmacological activities at the GABA receptor complex

1985 • 35 citations

Hexobarbitone Sleeping Time in Rats Following Doses With Similar EEG Changes

1966 • 33 citations

Pharmacology of the pyrazolo-type compounds: Agonist, antagonist and inverse agonist actions

1987 • 31 citations

Relationships between quantitative EEG measures and pharmacodynamics of alfentanil in dogs

1988 • 26 citations

Pharmacoelectroencephalographic study of brotizolam, a novel hypnotic

1981 • 26 citations

Pharmacokinetics of (+)-, (−)- and (±)-hexobarbitone in man after oral administration

1973 • 26 citations

Drug Effects on the EEG of Various Species of Laboratory Animals

1983 • 25 citations

Effects of a Benzodiazepine Antagonist on the Diazepam-Induced Electrical Brain Activity Modifications

1984 • 24 citations

Classification of Psychotropic Drugs by Rat EEG Analysis: The Anxiolytic Profile in Comparison to the Antidepressant and Neuroleptic Profile

1987 • 24 citations

An Absolute Must in Clinico-Pharmacological Research: Pharmaco-Electroencephalography, its Possibilities and Limitations

1983 • 24 citations

Estimation of amobarbital plasma-effect site equilibration kinetics. Relevance of polyexponential conductance functions

1991 • 23 citations

A review of the continuum of drug-induced states of excitation and depression

1982 • 23 citations

In vivo modeling of the pharmacodynamic interaction between benzodiazepines which differ in intrinsic efficacy.

1992 • 23 citations

Autoradiographic demonstration of the selectivity of two 1-N-trifluoroethyl benzodiazepines for the BZD-1 receptors in the rat brain

1985 • 23 citations

Computer EEG drug data base in psychopharmacology and in drug development.

1982 • 22 citations

Hypnotics: Clinical Value of Pharmaco-EEG Methods

1986 • 22 citations

The antiseizure activity of dihydropyridine calcium channel antagonists in the conscious rat.

1990 • 21 citations

Anxiogenic effects of a benzodiazepine receptor partial inverse agonist, RO 19-4603, in a light/dark choice situation

1990 • 20 citations

Pharmacological studies with quazepam, a new benzodiazepine hypnotic.

1982 • 20 citations

Pharmaco-EEG and Psychometric Study of the Effect of Single Doses of Temazepam and Nitrazepam

1983 • 20 citations

Relationship Between EEG Dynamics and Pharmacokinetics of the Benzodiazepine Lormetazepam

1982 • 18 citations

Threshold hypnotic concentration of methohexitone

1987 • 16 citations

Activity of some benzodiazepine receptor ligands with reduced sedative and muscle relaxant properties on stress-induced electrocorticogram arousal in sleeping rats

1987 • 16 citations

Pharmacokinetics of the enantiomers of hexobarbital studied in the same intact rat and in the same isolated perfused rat liver

1974 • 16 citations

Age-related changes in CNS-sensitivity to hexobarbital and thiopental in the rat.

1984 • 16 citations

Disposition of hexobarbital enantiomers in the rat.

1983 • 15 citations

Quantitative pharmaco‐EEG and performance after administration of brotizolam to healthy volunteers.

1983 • 15 citations

A Comparative EEG Study of Some Benzodiazepine (BZD) and Non-BZD Sedative or Hypnotic Drugs

1985 • 14 citations

Anesthetic Action of Opiates

1988 • 14 citations

Differential effects of benzodiazepines on EEG activity and hypnogenic mechanisms of the brain stem in cats.

1983 • 14 citations

Modifications of brain electrical activity after activation of the benzodiazepine receptor types in rats and rabbits

1988 • 13 citations

Inhibition of photosensitive seizures in man by the β-carboline, ZK 95962, a selective benzodiazepine receptor agonist

1990 • 12 citations

Pharmaco‐EEG, behavioural methods and blood levels in the comparison of temazepam and flunitrazepam

1986 • 9 citations

Discrimination of Mode of Action of Anxiolytics using an Integrated Computer Data Bank and Dynamic Brain Mapping (CNS Effects of Diazepam and Lorazepam)

1989 • 9 citations

A391 USE OF EEG AS A MEASURE OF THIOPENTAL ANESTHETIC DEPTH

1990 • 2 citations

DOSE POTENCY COMPARISON OF THIOPENTAL AND ETOMIDATE

1985 • 2 citations

Deleted Work

1955 • 0 citations