Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of heptabarbital using aperiodic EEG analysis

The Pharmacological Basis of Therapeutics

1986 • 1,413 citations

Simultaneous modeling of pharmacokinetics and pharmacodynamics: Application to d‐tubocurarine

1979 • 1,136 citations

Understanding the Dose-Effect Relationship

1981 • 1,111 citations

Hypnotics and sedatives

1981 • 712 citations

The Pharmacological Basis of Therapeutics, 7th ed

1986 • 621 citations

Barbiturate receptor sites are coupled to benzodiazepine receptors.

1980 • 234 citations

Topics in Pharmaceutical Sciences

1983 • 226 citations

Barbiturate enhancement of GABA-mediated inhibition and activation of chloride ion conductance: correlation with anticonvulsant and anesthetic actions

1981 • 198 citations

Pharmacodynamic modeling of the EEG effects of ketamine and its enantiomers in man

1987 • 170 citations

The Effect of Increasing Age on Thiopental Disposition and Anesthetic Requirement

1985 • 169 citations

A Model for Studying Depth of Anesthesia and Acute Tolerance to Thiopental

1983 • 169 citations

Pharmacokinetic and electroencephalographic study of intravenous diazepam, midazolam, and placebo

1989 • 166 citations

Pharmacokinetic and pharmacodynamic modeling in vivo.

1981 • 148 citations

Increased Sensitivity to Etomidate in the Elderly

1986 • 147 citations

Variability in drug therapy: description, estimation and control

1986 • 119 citations

Simultaneous modeling of pharmacokinetics and pharmacodynamics with nonparametric kinetic and dynamic models

1986 • 119 citations

Kinetics of drug action in disease states. I. Effect of infusion rate on phenobarbital concentrations in serum, brain and cerebrospinal fluid of normal rats at onset of loss of righting reflex.

1984 • 108 citations

Pentobarbital: Stereospecific Actions of (+) and (-) Isomers Revealed on Cultured Mammalian Neurons

1980 • 104 citations

Anticonvulsant and anesthetic barbiturates

1979 • 104 citations

Pharmacodynamic modeling of thiopental anesthesia

1984 • 100 citations

Barbiturates: Their in vivo effects and potential biochemical mechanisms

1982 • 96 citations

A study of the excitatory effects of barbiturates.

1970 • 84 citations

Pharmacokinetic-pharmacodynamic modeling of CNS drug effects: An overview

1988 • 83 citations

Anesthetic and convulsant barbiturates alter gamma-aminobutyric acid-stimulated chloride flux across brain membranes.

1986 • 77 citations

Quantitation of the EEG and pharmacodynamic modelling of hypnotic drugs: etomidate as an example.

1985 • 71 citations

An electroencephalographic processing algorithm specifically intended for analysis of cerebral electrical activity

1986 • 68 citations

Age-associated stereoselective alterations in hexobarbital metabolism

1988 • 62 citations

Dual Action of Pentobarbitone on GABA Binding: Role of Binding Site Integrity

1981 • 59 citations

The effects of general anaesthetics on gabaergic synaptic transmission

1987 • 58 citations

Pharmacokinetic-pharmacodynamic modeling of midazolam effects on the human central nervous system

1988 • 49 citations

Stereospecificity of anesthetic activity, distribution, inactivation and protein binding of the optical antipodes of two N-methylated barbiturates.

1970 • 40 citations

Separate site(s) of action of optical isomers of 1-methyl-5-phenyl-5-propylbarbituric acid with opposite pharmacological activities at the GABA receptor complex

1985 • 35 citations

TRANSDERMAL ADMINISTRATION OF FENTANYL FOR POSTOPERATIVE ANALGESIA

1986 • 28 citations

Barbiturate effects on hippocampal excitatory synaptic responses are selective and pathway specific

1987 • 24 citations

An Absolute Must in Clinico-Pharmacological Research: Pharmaco-Electroencephalography, its Possibilities and Limitations

1983 • 24 citations

Pharmacological comparison of R(+), S(−) and racemic secobarbital in mice

1970 • 24 citations

A review of the continuum of drug-induced states of excitation and depression

1982 • 23 citations

Kinetics of drug action in disease states. V. Acute effect of urea infusion on phenobarbital concentrations in rats at onset of loss of righting reflex.

1985 • 22 citations

A comparative investigation in the rat of the anesthetic effects of the isomers of two barbiturates

1984 • 21 citations

Dose-related Changes in the Rate of Cerebrospinal Fluid Formation and Resistance to Reabsorption of Cerebrospinal Fluid Following Administration of Thiopental, Midazolam, and Etomidate in Dogs

1988 • 20 citations

Anesthetic and lethal activity in mice of the stereoisomers of 5-ethyl-5-(1-methylbutyl)barbituric acid (pentobarbital).

1973 • 18 citations

Hypothalamic evoked responses altered by pentobarbital in freely behaving rats

1974 • 16 citations

Unequal Anaesthetic Potency Despite Equal Brain Concentration of Hexobarbital Antipodes

1970 • 16 citations

Disposition of hexobarbital enantiomers in the rat.

1983 • 15 citations

Strategy to Assess the Role of (Inter)active Metabolites in Pharmacodynamic Studies In-vivo: a Model Study with Heptabarbital

1988 • 15 citations

Differential effects of anesthetic agents on regional blood flow and central hemodynamic parameters in rats

1988 • 11 citations