Kinetics of pharmacologic response

The possible effects of the aggregation of the molecules of haemoglobin on its dissociation curves

1910 • 2,184 citations

Simultaneous modeling of pharmacokinetics and pharmacodynamics: Application to d‐tubocurarine

1979 • 1,136 citations

DESIGN OF EXPERIMENTS IN NON-LINEAR SITUATIONS

1959 • 692 citations

Rational Intravenous Doses of Theophylline

1973 • 666 citations

Digitalis Intoxication

1971 • 579 citations

Studies on an Intermittent Corticosteroid Dosage Regimen

1963 • 342 citations

Cocaine Plasma Concentration: Relation to Physiological and Subjective Effects in Humans

1978 • 335 citations

Kinetics of pharmacologic response I. Proposed relationships between response and drug concentration in the intact animal and man

1968 • 303 citations

Daily and Alternate-Day Corticosteroid Regimens in Treatment of Giant Cell Arteritis

1975 • 297 citations

D-Optimality for Regression Designs: A Review

1975 • 279 citations

Pharmacokinetics and pharmacodynamics of the enantiomers of warfarin in man

1974 • 265 citations

Drill's Pharmacology in Medicine.

1972 • 230 citations

Kinetics of pharmacologic effects in man: The anticoagulant action of warfarin

1969 • 230 citations

Studies on the optical enantiomorphs of warfarin in man

1974 • 215 citations

Oral Cocaine: Plasma Concentrations and Central Effects

1978 • 206 citations

Pharmacological evaluation of cimetidine, a new histamine H2‐receptor antagonist, in healthy man.

1975 • 198 citations

A PHARMACODYNAMIC MODEL FOR PANCURONIUM

1978 • 197 citations

Kinetics of pharmacologic effects

1966 • 195 citations

A molecular basis for drug action

1964 • 175 citations

Relationship between the pharmacokinetics and pharmacodynamics of procainamide

1976 • 155 citations

Role of Pharmacokinetics in Drug Dosage Adjustment. I. Pharmacologic Effect Kinetics and Apparent Volume of Distribution of Digoxin

1973 • 149 citations

The effect of quinidine and its metabolites on the electrocardiogram and systolic time intervals: concentration‐effect relationships.

1981 • 126 citations

Pharmacokinetics and Pharmacodynamics of d-Tubocurarine during Nitrous Oxide–Narcotic and Halothane Anesthesia in Man

1979 • 106 citations

Assay of digitalis glycosides in man

1966 • 104 citations

Relationship of Plasma Digitoxin and Digoxin to Cardiac Response Following Intravenous Digitalization in Man

1970 • 102 citations

Nephrotoxicity of gentamicin and tobramycin given once daily or continuously in dogs

1978 • 101 citations

A pharmacodynamic model for cell-cycle-specific chemotherapeutic agents

1973 • 97 citations

Effects of verapamil on P-R-intervals in relation to verapamil plasma levels following single i.v. and oral administration and during chronic treatment

1980 • 97 citations

Cimetidine treatment for the prevention of recurrence of duodenal ulcer: an international collaborative study

1980 • 95 citations

Relation between morphine pharmacokinetics and analgesia

1978 • 90 citations

Computer-aided long-term anticoagulation therapy

1969 • 86 citations

Pharmacodynamics of Propranolol in Renal Failure

1972 • 82 citations

Quantitative analysis of the disopyramide concentration‐effect relationship.

1980 • 76 citations

Plasma concentrations and the time‐course of beta blockade due to propranolol

1975 • 75 citations

Pharmacokinetics and pharmacodynamics of warfarin at steady state.

1979 • 71 citations

Problems Associated with Analysis of Pharmacokinetic Models

1971 • 68 citations

Pathophysiologic and pharmacokinetic determinants of the antihypertensive response to propranolol

1977 • 67 citations

Lorcainide; II. Plasma concentration‐effect relationship

1979 • 66 citations

Correlation of performance test scores with “tissue concentration” of lysergic acid diethylamide in human subiects

1968 • 64 citations

Pharmacokinetics of digoxin: Relationship between response intensity and predicted compartmental drug levels in man

1979 • 64 citations

A molecular basis for drug action.: The interaction of one or more drugs with different receptors

1964 • 64 citations

The Onset and Magnitude of the Contractile Response to Commonly Used Digitalis Glycosides in Normal Subjects

1974 • 64 citations

Pharmacokinetics of prednisolone and endogenous hydrocortisone levels in cushingoid and non-cushingoid patients

1981 • 61 citations

Pharmacokinetics and pharmacodynamics in young normal and elderly hypertensive subjects: a study using sotalol as a model drug.

1980 • 56 citations

Pharmacokinetic analysis of the effect of barbiturate on the anticoagulant action of warfarin in man

1970 • 56 citations

Response optimization of drug dosage: Antiarrhythmie studies with tocainide

1977 • 54 citations

Cell kinetics and chemotherapy in acute leukemia.

1972 • 54 citations

Theoretical and computational basis for drug bioavailability determinations using pharmacological data. I. General considerations and procedures

1976 • 50 citations

Relationship between concentration and anticoagulant effect of heparin in plasma of normal subjects: Magnitude and predictability of interindividual differences*

1980 • 49 citations

Pharmacokinetic Analysis of Potentiating Effect of Phenylbutazone on Anticoagulant Action of Warfarin in Man

1970 • 48 citations

Kinetics of the Elimination and Neuromuscular Blocking Effect of d-Tubocurarine in Man

1972 • 48 citations

Modeling of drug response in individual subjects

1980 • 47 citations

Multiple receptor responses: A new concept to describe the relationship between pharmacological effects and pharmacokinetics of a drug: Studies on clonidine in the rat and cat

1979 • 41 citations

Comparison of the intrarenal disposition of tobramycin and gentamicin: therapeutic and toxicologic answers

1978 • 41 citations

Some effects of disopyramide and its N-dealkylated metabolite on isolated nerve and cardiac muscle

1978 • 36 citations

RELATIONSHIP BETWEEN RATE OF ELIMINATION OF TUBOCURARINE AND RATE OF DECLINE OF ITS PHARMACOLOGICAL ACTIVITY

1964 • 36 citations

A standard approach to compiling clinical pharmacokinetic data

1981 • 33 citations

Dose-Dependent Decline of Pharmacologic Effects of Drugs with Linear Pharmacokinetic Characteristics

1972 • 30 citations

Theoretical Relationship Between Dose, Elimination Rate, and Duration of Pharmacologic Effect of Drugs

1965 • 28 citations

The effect of dosage regimen on the diuretic efficacy of chlorothiazide in human subjects.

1961 • 27 citations

Systems analysis in enzyme kinetics.

1977 • 26 citations

Kinetics of the anticoagulant effect of bishydroxycoumarin in man

1970 • 25 citations

Plasma levels and effects of metoprolol after single and multiple oral doses

1980 • 22 citations

Systems and Microcomputer Approach to Anticoagulant Therapy

1980 • 18 citations

Plasma timolol levels and systolic time intervals

1980 • 18 citations

The interaction of morphine and d‐tubocurarine on respiration and grip strength in man

1964 • 15 citations

Tiotidine and cimetidine—kinetics and dynamics

1981 • 14 citations

Kinetics of psycho-motor stimulant drug action

1968 • 14 citations

One and three doses of propranolol a day in hypertension

1980 • 13 citations

Apparent Potentiating Effect of a Second Dose of Drug

1965 • 12 citations

Warfarin sensitivity in the elderly

1979 • 9 citations

Pharmacodynamic and spirometric responses to a sustained-release theophylline capsule.

1979 • 6 citations

Computers, models, and optimization in physiological kinetics.

1974 • 6 citations

Duration of Action of Beta-blocking Drugs

1973 • 4 citations