Pharmacology of the pyrazolo-type compounds: Agonist, antagonist and inverse agonist actions

A Note on a Simple Apparatus for Detecting Neurological Deficit in Rats and Mice**College of Pharmacy, University of Nebraska, Lincoln 8.

1957 • 1,671 citations

Specific benzodiazepine receptors in rat brain characterized by high-affinity (3H)diazepam binding.

1977 • 1,246 citations

Selective antagonists of benzodiazepines

1981 • 1,235 citations

Interaction of Convulsive Ligands with Benzodiazepine Receptors

1982 • 549 citations

[35S]t-butylbicyclophosphorothionate binds with high affinity to brain-specific sites coupled to gamma-aminobutyric acid-A and ion recognition sites.

1983 • 544 citations

Properties of 3H-diazepam binding to benzodiazepine receptors in rat cerebral cortex

1977 • 323 citations

A three-state model of the benzodiazepine receptor explains the interactions between the benzodiazepine antagonist Ro 15-1788, benzodiazepine tranquilizers, ?-carbolines, and phenobarbitone

1982 • 312 citations

2-Arylpyrazolo[4,3-c]quinolin-3-ones: a novel agonist, a partial agonist and an antagonist of benzodiazepines

1982 • 215 citations

A preliminary procedure for the evaluation of central nervous system depressants.

1957 • 126 citations

An allosteric model for benzodiazepine receptor function

1983 • 102 citations

The neuropharmacology of various diazepam antagonists

1983 • 86 citations

CGS 9896: agonist-antagonist benzodiazepine receptor activity revealed by anxiolytic, anticonvulsant and muscle relaxation assessment in rodents.

1985 • 72 citations

In vitro characterization of benzodiazepine receptor agonists, antagonists, inverse agonists and agonist/antagonists.

1984 • 68 citations

CGS 9896: A nonbenzodiazepine, nonsedating potential anxiolytic

1984 • 68 citations

Differential modulation of [35S]TBPS binding by the occupancy of benzodiazepine receptors with its ligands

1983 • 61 citations

Proconvulsant action of CGS 8216

1983 • 56 citations

β-Carbolines with agonistic and inverse agonistic properties at benzodiazepine receptors of the rat

1984 • 51 citations

Effects of combined treatment with trifluoperazine-HCl and amobarbital on punished behavior in rats

1969 • 49 citations

Antagonism of discriminative stimuli produced by anxiogenic drugs as a novel approach to bioassay anxiolytics

1984 • 49 citations

Precipitated and spontaneous withdrawal in baboons after chronic dosing with lorazepam and CGS 9896

1984 • 45 citations

Behavioral pharmacological profile of CGS 9895: A novel anxiomodulator with selective benzodiazepine agonist and antagonist properties

1985 • 36 citations

Investigation of the actions of the benzodiazepine antagonists Ro 15-1788 and CGS 8216 using the schedule-controlled behavior of rats

1986 • 30 citations

Intracranial self-stimulation distinguishes between two benzodiazepine antagonists

1984 • 29 citations

Lack of tolerance or withdrawal effects in mice after chronic administration of the non-sedating anxiolytic, CGS 9896

1987 • 22 citations

Bidirectional effects on anxiety of ß-carbolines acting as benzodiazepine receptor ligands

1984 • 16 citations

Pharmacological characterization of CGS 17867A as a benzodiazepine receptor agonist devoid of limiting behavioral effects

1987 • 13 citations

Pyrazoloquinoline benzodiazepine receptor ligands: Effects on schedule-controlled behavior in dogs

1985 • 7 citations