DNA base changes and alkylation following in vivo exposure of Escherichia coli to N-methyl-N-nitrosourea or N-ethyl-N-nitrosourea.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Experiments in molecular genetics

1972 • 28,260 citations

A rapid alkaline extraction procedure for screening recombinant plasmid DNA

1979 • 15,511 citations

Calcium-dependent bacteriophage DNA infection

1970 • 2,743 citations

Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli

1984 • 1,608 citations

Nature of Col E ₁ Plasmid Replication in Escherichia coli in the Presence of Chloramphenicol

1972 • 1,202 citations

Molecular basis of base substitution hotspots in Escherichia coli

1978 • 1,185 citations

Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase.

1981 • 1,048 citations

Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats

1985 • 829 citations

Molecular Biology of Mutagens and Carcinogens

1983 • 803 citations

Expression of a Bacterial Gene in Mammalian Cells

1980 • 788 citations

EQUILIBRIUM SEDIMENTATION OF MACROMOLECULES IN DENSITY GRADIENTS

1957 • 778 citations

Properties of a supercoiled deoxyribonucleic acid-protein relaxation complex and strand specificity of the relaxation event

1970 • 770 citations

Genetic studies of the lac repressor

1977 • 610 citations

Mechanisms of carcinogenesis induced by alkylating agents

1985 • 461 citations

In vivo mutagenesis by O6-methylguanine built into a unique site in a viral genome.

1984 • 437 citations

Local mutagenesis: a method for generating viral mutants with base substitutions in preselected regions of the viral genome.

1978 • 282 citations

Mutagenicity of carcinogenic methylating agents is associated with a specific DNA modification

1980 • 234 citations

MUTATIONAL SPECIFICITY IN BACTERIA

1983 • 208 citations

Specificity of mutagenesis resulting from the induction of the SOS system in the absence of mutagenic treatment

1984 • 146 citations

Rapid isolation of carcinogen-bound DNA and RNA by hydroxyapatite chromatography

1979 • 130 citations

Factors governing the expression of a bacterial gene in mammalian cells.

1981 • 126 citations

Induction of mutations and sister-chromatid exchanges in Chinese hamster ovary cells by ethylating agents

1982 • 103 citations

Site-directed mutagenesis: Generation of an extracistronic mutation in bacteriophage Qβ RNA

1974 • 92 citations

Comparison of the rates of repair of O6-alkylguanines in DNA by rat liver and bacterial O6-alkylguanine-DNA alkyltransferase.

1984 • 88 citations

Differential repair of O⁴-alkylthymidine following exposure to methylating and ethylating hepatocarcinogens

1985 • 86 citations

Cell specificity in hepatocarcinogenesis: preferential accumulation of O6-methylguanine in target cell DNA during continuous exposure to rats to 1,2-dimethylhydrazine.

1982 • 77 citations

O4-Methyl, -ethyl, or -isopropyl substituents on thymidine in poly(dA-dT) all lead to transitions upon replication.

1986 • 66 citations

Correlation between specific DNA-methylation products and mutation induction at the HGPRT locus in Chinese hamster ovary cells

1983 • 65 citations

DNA base sequence changes induced by bromouracil mutagenesis of lambda phage

1982 • 64 citations

Nucleotide sequence of the xanthine guanine phosphoribosyl transferase gene ofE. coli

1983 • 62 citations

Escherichia coli polymerase I can use O2-methyldeoxythymidine or O4-methyldeoxythymidine in place of deoxythymidine in primed poly(dA-dT).poly(dA-dT) synthesis.

1983 • 61 citations

Efficient recovery and sequencing of mutant genes from mammalian chromosomal DNA.

1986 • 50 citations

Factors Governing the Expression of a Bacterial Gene in Mammalian Cells

1981 • 45 citations

DNA sequence has an effect on the extent and kinds of alkylation of DNA by a potent carcinogen

1985 • 39 citations

Reaction of DNA with alkylating agents. Differential alkylation of poly[dA-dT] by methylnitrosourea and ethylnitrosourea

1978 • 31 citations

Mutagenicity of methyl-, ethyl-, propyl- and butylnitrosourea towards Escherichia coli WP2 strains with varying DNA repair capabilities

1979 • 26 citations

Repair of O⁶-methylguanine, by mammalian cell extracts, in alkylated DNA and poly(dG-m⁵ dC).(poly dG-m⁵ dC) in B and Z forms

1985 • 25 citations

Evidence for a major premutagenic ethyldeoxythymidine-DNA adduct in an in vivo system: N-nitroso-N-ethylurea-treated Salmonella typhimurium

1985 • 21 citations

Differential mutagenicities of 6 N-nitroso-N-alkylurea derivatives in Escherichia coli strains with different DNA-repair capacities

1980 • 18 citations

O4-methyl-, O4-ethyl-, and O4-isopropylthymidine 5'-triphosphates as analogs of thymidine 5'-triphosphate: kinetics of incorporation by Escherichia coli DNA polymerase I

1986 • 16 citations

The incorporation of O6-methyldeoxyguanosine monophosphate and O4-methyldeoxythymidine monophosphate into polynucleotide templates leads to errors during subsequent in vitro DNA synthesis

1985 • 15 citations

Sequence specificity of mutagenesis in the cI gene of bacteriophage lambda.

1985 • 7 citations