Comparison of the cytotoxicity in vitro of temozolomide and dacarbazine, prodrugs of 3-methyl-(triazen-1-yl)imidazole-4-carboxamide

AN EXTENSION OF THE51Cr-RELEASE ASSAY FOR THE ESTIMATION OF MOUSE CYTOTOXINS

1968 • 707 citations

Antitumor activity and pharmacokinetics in mice of 8-carbamoyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M & B 39831), a novel drug with potential as an alternative to dacarbazine.

1987 • 386 citations

Antitumour imidazotetrazines. 1. Synthesis and chemistry of 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one, a novel broad-spectrum antitumor agent

1984 • 212 citations

Imidazoles. I. Coupling Reactions of 5-Diazoimidazole-4-carboxamide^1,2

1962 • 135 citations

Tumour inhibitory triazenes: Structural requirements for an active metabolite

1976 • 122 citations

Synthesis of Potential Anticancer Agents. XXIX. 5-Diazoimidazole-4-carboxamide and 5-Diazo-v-triazole-4-carboxamide^1,2

1961 • 118 citations

Monoalkyltriazenes

1978 • 73 citations

Characterisation of urinary metabolites of temozolomide in humans and mice and evaluation of their cytotoxicity

1990 • 65 citations

5-(3-Hydroxymethyl-3-methyl-1-triazeno imidazole-4-carboxamide is a metabolite of 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (DIC, DTIC NSC-45388)

1980 • 41 citations

The metabolism of triazene antitumor drugs

1987 • 27 citations

Antitumour imidazotetrazines. Part 12. Reactions of mitozolomide and its 3-alkyl congeners with oxygen, nitrogen, halogen, and carbon nucleophiles

1987 • 25 citations

Induction of haemoglobin synthesis in the human leukaemia cell line K562 by monomethyltriazenes and imidazotetrazinones

1985 • 19 citations

Effects of N-methylformamide on the growth, cell cycle, and glutathione status of murine TLX5 lymphoma cells.

1988 • 17 citations

The Analysis and Murine Pharmacokinetics of a New Antitumour Agent: CCRG81045

1986 • 4 citations

Metabolism and murine pharmacokinetics of the 8-(N,N-dimethylcarboxamide) analogue of the experimental antitumor drug mitozolomide (NSC353451).

1989 • 3 citations

9β-Methylcarbacyclin, a stable prostacyclin analogue, in prevention of platelet losses during charcoal haemoperfusion

1986 • 2 citations