Regulation of epidermal growth factor receptor signal transduction. Role of gangliosides.

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

Glycosphingolipids in Cellular Interaction, Differentiation, and Oncogenesis

1981 • 1,650 citations

Epidermal Growth Factor and a New Derivative

1972 • 1,225 citations

Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.

1986 • 1,150 citations

INHIBITORS OF THE BIOSYNTHESIS AND PROCESSING OF N-LINKED OLIGOSACCHARIDE CHAINS

1987 • 1,122 citations

Ganglioside-mediated modulation of cell growth. Specific effects of GM3 on tyrosine phosphorylation of the epidermal growth factor receptor.

1986 • 702 citations

Lysosphingolipids Inhibit Protein Kinase C: Implications for the Sphingolipidoses

1987 • 593 citations

Ganglioside-mediated modulation of cell growth, growth factor binding, and receptor phosphorylation.

1984 • 501 citations

Epidermal growth factor-like transforming growth factor. II. Interaction with epidermal growth factor receptors in human placenta membranes and A431 cells.

1983 • 484 citations

THE PATTERN OF MAMMALIAN BRAIN GANGLIOSIDES‐II EVALUATION OF THE EXTRACTION PROCEDURES, POSTMORTEM CHANGES AND THE EFFECT OF FORMALIN PRESERVATION*

1965 • 425 citations

Reversible defects in O-linked glycosylation and LDL receptor expression in a UDP-GalUDP-GalNAc 4-epimerase deficient mutant

1986 • 334 citations

The epidermal growth factor receptor as a multifunctional allosteric protein

1988 • 286 citations

Tumor Formation Dependent on Proteoglycan Biosynthesis

1988 • 217 citations

A novel ganglioside, de-N-acetyl-GM3 (II3NeuNH2LacCer), acting as a strong promoter for epidermal growth factor receptor kinase and as a stimulator for cell growth.

1988 • 183 citations

sn-1,2-Dioctanoylglycerol. A cell-permeable diacylglycerol that mimics phorbol diester action on the epidermal growth factor receptor and mitogenesis.

1985 • 179 citations

Three types of low density lipoprotein receptor-deficient mutant have pleiotropic defects in the synthesis of N-linked, O-linked, and lipid-linked carbohydrate chains.

1986 • 174 citations

GM3 ganglioside induces hamster fibrobiast growth inhibition in chemically-defined medium: Ganglioside may regulate growth factor receptor function

1982 • 164 citations

Ganglioside-mediated modulation of cell growth. Specific effects of GM3 and lyso-GM3 in tyrosine phosphorylation of the epidermal growth factor receptor.

1988 • 162 citations

Independent mechanisms account for the regulation by protein kinase C of the epidermal growth factor receptor affinity and tyrosine-protein kinase activity.

1988 • 161 citations

Biosynthesis of the epidermal growth factor receptor in A431 cells.

1984 • 156 citations

beta-Adrenergic regulation of insulin and epidermal growth factor receptors in rat adipocytes.

1983 • 156 citations

Amiloride directly inhibits growth factor receptor tyrosine kinase activity.

1985 • 155 citations

Regulation of the epidermal growth factor receptor phosphorylation state by sphingosine in A431 human epidermoid carcinoma cells.

1988 • 151 citations

Exogenous glycosphingolipids suppress growth rate of transformed and untransformed 3T3 mouse cells

1975 • 135 citations

Incorporation of exogenous glycosphingolipids in plasma membranes of cultured hamster cells and concurrent change of growth behavior

1973 • 133 citations

Multisite phosphorylation of the epidermal growth factor receptor. Use of site-directed mutagenesis to examine the role of serine/threonine phosphorylation.

1990 • 113 citations

Transforming growth factor-β (TGF-β) receptor proteoglycan

1989 • 109 citations

The oligosaccharide moieties of the epidermal growth factor receptor in A-431 cells. Presence of complex-type N-linked chains that contain terminal N-acetylgalactosamine residues.

1985 • 106 citations

Further purification of epidermal growth factor by high-performance liquid chromatography

1982 • 103 citations

Effects of preventing O-glycosylation on the secretion of human chorionic gonadotropin in Chinese hamster ovary cells.

1987 • 102 citations

Glycosphingolipids as differentiation-dependent, tumor-associated markers and as regulators of cell proliferation

1984 • 98 citations

Mechanism of Phosphorylation of the Epidermal Growth Factor Receptor at Threonine 669

1989 • 93 citations

Activation of the Purified Protein Tyrosine Kinase Domain of the Epidermal Growth Factor Receptor

1989 • 93 citations

Two alternative mechanisms control the interconversion of functional states of the epidermal growth factor receptor.

1988 • 93 citations

Stimulation of epidermal growth factor receptor threonine 654 phosphorylation by platelet-derived growth factor in protein kinase C-deficient human fibroblasts.

1987 • 84 citations

Activation of the epidermal growth factor receptor tyrosine protein kinase in the absence of receptor oligomerization.

1988 • 84 citations

Abnormal Intracellular Sorting of O-Linked Carbohydrate-Deficient Interleukin-2 Receptors

1988 • 54 citations

Simple micro-method for the isolation of gangliosides by reversed-phase chromatography

1981 • 53 citations

Reconstitution of Epidermal Growth Factor Receptor Transmodulation by Platelet-derived Growth Factor in Chinese Hamster Ovary Cells

1989 • 36 citations