The neuroprotective pharmacology of methylprednisolone

Goodman and Gilman's the Pharmacological Basis of Therapeutics

1986 • 6,964 citations

A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury

1990 • 2,629 citations

Glucocorticoids Potentiate Ischemic Injury to Neurons: Therapeutic Implications

1985 • 677 citations

The free radical pathology and the microcirculation in the major central nervous system disorders.

1980 • 660 citations

Efficacy of Methylprednisolone in Acute Spinal Cord Injury

1984 • 546 citations

Novel 21-amino steroids as potent inhibitors of iron-dependent lipid peroxidation.

1987 • 474 citations

Relation of steroid structure to enzyme induction in hepatoma tissue culture cells

1970 • 399 citations

Methylprednisolone and neurological function 1 year after spinal cord injury

1985 • 332 citations

Effect of high-dose corticosteroid therapy on blood flow, evoked potentials, and extracellular calcium in experimental spinal injury

1982 • 319 citations

Effects of the 21-aminosteroid U74006F on experimental head injury in mice

1988 • 296 citations

Hemoglobin potentiates central nervous system damage.

1987 • 262 citations

Effects of intravenous methylprednisolone on spinal cord lipid peroxidation and (Na+ + K+)-ATPase activity

1982 • 249 citations

Megadose steroids in severe head injury

1983 • 241 citations

Glucocorticoid mechanisms in acute spinal cord injury: A review and therapeutic rationale

1982 • 239 citations

A pharmacological analysis of the pathophysiological mechanisms of posttraumatic spinal cord ischemia

1986 • 228 citations

High-dose glucocorticoid treatment improves neurological recovery in head-injured mice

1985 • 219 citations

Lipid Hydrolysis and Peroxidation in Injured Spinal Cord: Partial Protection with Methylprednisolone or Vitamin E and Selenium

1985 • 206 citations

Correlation of methylprednisolone levels in cat spinal cord with its effects on (Na+ + K+)-ATPase, lipid peroxidation, and alpha motor neuron function

1982 • 201 citations

Effects of multi-dose methylprednisolone sodium succinate administration on injured cat spinal cord neurofilament degradation and energy metabolism

1984 • 200 citations

Effect of methylprednisolone in compression trauma to the feline spinal cord

1981 • 196 citations

Evaluation of an intensive methylprednisolone sodium succinate dosing regimen in experimental spinal cord injury

1987 • 195 citations

Effects of a single large dose of methylprednisolone sodium succinate on experimental posttraumatic spinal cord ischemia

1984 • 193 citations

Further studies on free-radical pathology in the major central nervous system disorders: effect of very high doses of methylprednisolone on the functional outcome, morphology, and chemistry of experimental spinal cord impact injury

1982 • 187 citations

Microvascular perfusion and metabolism in injured spinal cord after methylprednisolone treatment

1982 • 181 citations

Lipid Peroxidation‐Induced Inhibition of γ‐Aminobutyric Acid Uptake in Rat Brain Synaptosomes: Protection by Glucocorticoids

1985 • 161 citations

The effect of nimodipine and dextran on axonal function and blood flow following experimental spinal cord injury

1989 • 160 citations

Lactate and pyruvate metabolism in injured cat spinal cord before and after a single large intravenous dose of methylprednisolone

1983 • 158 citations

Failure of high-dose steroid therapy to influence intracranial pressure in patients with severe head injury

1979 • 151 citations

Current application of “high-dose” steroid therapy for CNS injury

1985 • 147 citations

Prevention of chronic experimental cerebral vasospasm with ibuprofen and high-dose methylprednisolone

1983 • 146 citations

Role of Lipid Peroxidation in Post-Traumatic Spinal Cord Degeneration: A Review

1986 • 141 citations

A new 21-aminosteroid antioxidant lacking glucocorticoid activity stimulates adrenocorticotropin secretion and blocks arachidonic acid release from mouse pituitary tumor (AtT-20) cells.

1988 • 138 citations

Acute effects of intravenous glucocorticoid pretreatment on the in vitro peroxidation of cat spinal cord tissue

1981 • 133 citations

Lipid Peroxidation as a Cause of Cerebral Vasospasm

1980 • 123 citations

High Dose Glucocorticoids in the Management of Severe Head Injury

1984 • 118 citations

Glucocorticoid Effects on Central Nervous Excitability and Synaptic Transmission

1982 • 111 citations

A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury

1991 • 102 citations

Preliminary Report: Effects of High Dose Methylprednisolone on Delayed Cerebral Ischemia in Patients at High Risk for Vasospasm after Aneurysmal Subarachnoid Hemorrhage

1987 • 102 citations

A nonglucocorticoid steroid analog of methylprednisolone duplicates its high-dose pharmacology in models of central nervous system trauma and neuronal membrane damage.

1987 • 98 citations

Neuroprotective effect of MK-801 and U-50488H after contusive spinal cord injury

1989 • 95 citations

Iron-induced lipid peroxidation in spinal cord: Protection with mannitol and methylprednisolone

1985 • 86 citations

A comparative study of steroid therapy in acute experimental spinal cord injury.

1980 • 77 citations

Methylprednisolone in Spinal Cord Injury: The Possible Mechanism of Action

1990 • 58 citations

Effect of methylprednisolone on motor function and spinal cord blood flow after spinal cord compression in rats

2009 • 55 citations

Pharmacological therapy of acute spinal cord injury: studies of high dose methylprednisolone and naloxone.

1988 • 52 citations

Uptake and elimination of methylprednisolone from contused cat spinal cord following intravenous injection of the sodium succinate ester

1983 • 52 citations

Protective action by methylprednisolone, allopurinol and indomethacin against stroke-induced damage to adenylate cyclase in gerbil cerebral cortex.

1984 • 50 citations

Response of chronic experimental cerebral vasospasm to methylprednisolone and dexamethasone

1984 • 42 citations

Morphometric assessment of drug effects in experimental spinal cord injury

1986 • 40 citations

Classification of ischemic-induced damage to Na+, K+-ATPase in gerbil forebrain

1985 • 34 citations

Attenuation of progressive brain hypoperfusion following experimental subarachnoid hemorrhage by large intravenous doses of methylprednisolone

1988 • 28 citations

Strategies in the Design of Solution-Stable, Water-Soluble Prodrugs Ill: Influence of the Pro-Moiety on the Bioconversion of 21-Esters of Corticosteroids

1985 • 27 citations

Glucocorticoid receptors in the spinal cord

1981 • 26 citations

The Effects of Large Doses of Methylprednisolone on Neurologic Recovery and Survival in the Mongolian Gerbil Following Three Hours of Unilateral Carotid Occlusion

1986 • 24 citations

High-dose methylprednisolone and 'ex vivo' release of eicosanoids after experimental subarachnoid haemorrhage

1990 • 17 citations

High dose glucocorticoids in the management of severe head injury

1985 • 17 citations

High-performance liquid chromatographic determination of methylprednisolone and methylprednisolone 21-[8-[methyl-(2-sulfoethyl) amino]-8-oxoctanoate] sodium salt in human plasma

1987 • 7 citations

Comparison of Two Ester Prodrugs of Methylprednisolone on Early Neurologic Recovery in a Murine Closed Head Injury Model

1989 • 6 citations