The Polycomb Group Protein EZH2 Is Required for Mammalian Circadian Clock Function

Translating the Histone Code

2001 • 9,488 citations

Coordination of circadian timing in mammals

2002 • 4,132 citations

The Orphan Nuclear Receptor REV-ERBα Controls Circadian Transcription within the Positive Limb of the Mammalian Circadian Oscillator

2002 • 2,045 citations

A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells

1998 • 1,954 citations

Resetting Central and Peripheral Circadian Oscillators in Transgenic Rats

2000 • 1,844 citations

Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein

2002 • 1,566 citations

mCRY1 and mCRY2 Are Essential Components of the Negative Limb of the Circadian Clock Feedback Loop

1999 • 1,558 citations

A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

2003 • 1,515 citations

Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms

1999 • 1,361 citations

Posttranslational Mechanisms Regulate the Mammalian Circadian Clock

2001 • 1,113 citations

Partitioning and Plasticity of Repressive Histone Methylation States in Mammalian Chromatin

2003 • 1,109 citations

A Functional Genomics Strategy Reveals Rora as a Component of the Mammalian Circadian Clock

2004 • 1,046 citations

Circadian Gene Expression in Individual Fibroblasts

2004 • 957 citations

MAMMALIAN CIRCADIAN BIOLOGY: Elucidating Genome-Wide Levels of Temporal Organization

2004 • 953 citations

Vernalization requires epigenetic silencing of FLC by histone methylation

2004 • 930 citations

A Molecular Mechanism Regulating Rhythmic Output from the Suprachiasmatic Circadian Clock

1999 • 894 citations

The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3

2004 • 872 citations

Vernalization in Arabidopsis thaliana is mediated by the PHD finger protein VIN3

2004 • 856 citations

The Polycomb-Group GeneEzh2 Is Required for Early Mouse Development

2001 • 855 citations

Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity

2004 • 853 citations

A transcription factor response element for gene expression during circadian night

2002 • 852 citations

SUZ12 Is Required for Both the Histone Methyltransferase Activity and the Silencing Function of the EED-EZH2 Complex

2004 • 779 citations

The key to development: interpreting the histone code?

2005 • 729 citations

Differential regulation of mammalian Period genes and circadian rhythmicity by cryptochromes 1 and 2

1999 • 668 citations

Rhythmic histone acetylation underlies transcription in the mammalian circadian clock

2002 • 665 citations

An epigenetic road map for histone lysine methylation

2003 • 631 citations

Light-Independent Role of CRY1 and CRY2 in the Mammalian Circadian Clock

1999 • 613 citations

The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation

2004 • 581 citations

Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions

2006 • 572 citations

Bimodal regulation of mPeriod promoters by CREB-dependent signaling and CLOCK/BMAL1 activity

2002 • 529 citations

Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation

1999 • 518 citations

Epigenetics and cancer

2004 • 486 citations

Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27

2004 • 485 citations

Molecular Mechanisms of the Biological Clock in Cultured Fibroblasts

2001 • 465 citations

The orphan nuclear receptor RORα regulates circadian transcription of the mammalian core-clock Bmal1

2005 • 453 citations

Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1

2003 • 384 citations

Feedback repression is required for mammalian circadian clock function

2006 • 363 citations

Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development

2003 • 316 citations

A noncanonical E-box enhancer drives mouse Period2 circadian oscillations in vivo

2005 • 293 citations

PERIOD1-Associated Proteins Modulate the Negative Limb of the Mammalian Circadian Oscillator

2005 • 274 citations

Light induces chromatin modification in cells of the mammalian circadian clock

2000 • 259 citations

Down-regulation of Human DAB2IP Gene Expression Mediated by Polycomb Ezh2 Complex and Histone Deacetylase in Prostate Cancer

2005 • 236 citations

Circadian and Light-Induced Transcription of Clock Gene Per1 Depends on Histone Acetylation and Deacetylation

2004 • 206 citations

Histone Acetyltransferase-dependent Chromatin Remodeling and the Vascular Clock

2004 • 203 citations

The Polycomb-group gene eed is required for normal morphogenetic movements during gastrulation in the mouse embryo

1998 • 198 citations

Direct Association between Mouse PERIOD and CKIε Is Critical for a Functioning Circadian Clock

2003 • 154 citations

Role of Polycomb Group Proteins in Stem Cell Self-Renewal and Cancer

2005 • 150 citations

Methylation of histones: playing memory with DNA

2005 • 127 citations

A Rhythmic Ror

2004 • 123 citations

The dissonance mutation at the no-on-transient-A locus of D. melanogaster: genetic control of courtship song and visual behaviors by a protein with putative RNA-binding motifs

1992 • 65 citations