Role of Polycomb Group Proteins in Stem Cell Self-Renewal and Cancer

Translating the Histone Code

2001 • 9,488 citations

Stem cells, cancer, and cancer stem cells

2001 • 9,488 citations

Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing

2002 • 3,546 citations

The polycomb group protein EZH2 is involved in progression of prostate cancer

2002 • 2,600 citations

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

2003 • 1,851 citations

EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

2003 • 1,587 citations

Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein

2002 • 1,566 citations

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

1999 • 1,549 citations

Histone Methyltransferase Activity of a Drosophila Polycomb Group Repressor Complex

2002 • 1,515 citations

Drosophila Enhancer of Zeste/ESC Complexes Have a Histone H3 Methyltransferase Activity that Marks Chromosomal Polycomb Sites

2002 • 1,494 citations

Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

2003 • 1,435 citations

Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation

2003 • 1,303 citations

Polycomb silencers control cell fate, development and cancer

2006 • 1,283 citations

EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer

2003 • 1,147 citations

Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF

1999 • 1,068 citations

The INK4a/ARF network in tumour suppression

2001 • 956 citations

SUZ12 Is Required for Both the Histone Methyltransferase Activity and the Silencing Function of the EED-EZH2 Complex

2004 • 779 citations

Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene.

1994 • 775 citations

Identification of cooperating oncogenes in Eμ-myc transgenic mice by provirus tagging

1991 • 765 citations

A Complex with Chromatin Modifiers That Occupies E2F- and Myc-Responsive Genes in G ₀ Cells

2002 • 748 citations

E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis

2001 • 747 citations

Tumor suppression by Ink4a–Arf: progress and puzzles

2003 • 700 citations

Establishment of Histone H3 Methylation on the Inactive X Chromosome Requires Transient Recruitment of Eed-Enx1 Polycomb Group Complexes

2003 • 646 citations

Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27

2003 • 622 citations

Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas

2004 • 532 citations

The INK4A/ARF locus and its two gene products

1999 • 532 citations

Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation

1999 • 518 citations

Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in Eμ-myc transgenic mice

1991 • 516 citations

Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27

2004 • 485 citations

Telomeres, stem cells, senescence, and cancer

2004 • 480 citations

Different Ezh2-Containing Complexes Target Methylation of Histone H1 or Nucleosomal Histone H3

2004 • 441 citations

Control of the Replicative Life Span of Human Fibroblasts by p16 and the Polycomb Protein Bmi-1

2002 • 425 citations

Use of Chromatin Immunoprecipitation To Clone Novel E2F Target Promoters

2001 • 387 citations

The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells.

2002 • 357 citations

Mechanisms of transcriptional memory

2001 • 354 citations

Polycomb CBX7 has a unifying role in cellular lifespan

2003 • 334 citations

Rnf2 ( Ring1b ) deficiency causes gastrulation arrest and cell cycle inhibition

2003 • 327 citations

Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development

2003 • 316 citations

Polycomb complexes and silencing mechanisms

2004 • 305 citations

Male-to-female sex reversal in M33 mutant mice

1998 • 303 citations

The bmi-1 oncoprotein is differentially expressed in non-small cell lung cancer and correlates with INK4A-ARF locus expression

2001 • 299 citations

BMI-1 gene amplification and overexpression in hematological malignancies occur mainly in mantle cell lymphomas.

2001 • 284 citations

Polycomb Silencing Blocks Transcription Initiation

2004 • 284 citations

Multiplex Biomarker Approach for Determining Risk of Prostate-Specific Antigen-Defined Recurrence of Prostate Cancer

2003 • 277 citations

Genome-Wide Prediction of Polycomb/Trithorax Response Elements in Drosophila melanogaster

2003 • 268 citations

Altered cellular proliferation and mesoderm patterning in Polycomb-M33-deficient mice

1997 • 266 citations

Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma

2001 • 263 citations

A role for mel-18, a Polycomb group-related vertebrate gene, during the anteroposterior specification of the axial skeleton

1996 • 256 citations

The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex

2001 • 248 citations

Genome imprinting regulated by the mouse Polycomb group protein Eed

2003 • 235 citations

The Polycomb group protein EZH2 is upregulated in proliferating, cultured human mantle cell lymphoma

2001 • 224 citations

Functional antagonism of the Polycomb-Group genes eed and Bmi1 in hemopoietic cell proliferation

1999 • 219 citations

Characterization of Interactions between the Mammalian Polycomb-Group Proteins Enx1/EZH2 and EED Suggests the Existence of Different Mammalian Polycomb-Group Protein Complexes

1998 • 219 citations

Su(z)12, a novelDrosophilaPolycomb group gene that is conserved in vertebrates and plants

2001 • 214 citations

The Polycomb-group gene eed is required for normal morphogenetic movements during gastrulation in the mouse embryo

1998 • 198 citations

Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects

1997 • 196 citations

Poorly Differentiated Breast Carcinoma is Associated with Increased Expression of the Human Polycomb Group EZH2 Gene

2003 • 191 citations

Linking the Rb and Polycomb Pathways

2001 • 188 citations

Polycomb Group Gene rae28 Is Required for Sustaining Activity of Hematopoietic Stem Cells

2002 • 184 citations

Mice doubly deficient for the Polycomb Group genes Mel18 and Bmi1 reveal synergy and requirement for maintenance but not initiation of Hox gene expression

2001 • 183 citations

Polycomb-Group Oncogenes EZH2, BMI1, and RING1 Are Overexpressed in Prostate Cancer With Adverse Pathologic and Clinical Features

2006 • 180 citations

Establishment of Polycomb silencing requires a transient interaction between PC and ESC

2001 • 174 citations

Gene repression by Polycomb group protein complexes: a distinct complex for every occasion?

2003 • 172 citations

The Polycomb Group Protein EED Interacts with YY1, and Both Proteins Induce Neural Tissue in XenopusEmbryos

2001 • 170 citations

Loss- and gain-of-function mutations show a Polycomb group function for Ring1A in mice

2000 • 169 citations

Stage-Specific Expression of Polycomb Group Genes in Human Bone Marrow Cells

1998 • 165 citations

Coexpression of BMI-1 and EZH2 Polycomb Group Genes in Reed-Sternberg Cells of Hodgkin’s Disease

2000 • 164 citations

Ring1A is a transcriptional repressor that interacts with the Polycomb-M33 protein and is expressed at rhombomere boundaries in the mouse hindbrain

1997 • 146 citations

Identification of the polycomb group protein SU(Z)12 as a potential molecular target for human cancer therapy.

2003 • 140 citations

Development and differentiation of neural rosettes derived from human embryonic stem cells

2006 • 131 citations

mel-18, a Polycomb group-related mammalian gene, encodes a transcriptional negative regulator with tumor suppressive activity.

1995 • 130 citations

Stem cells and cancer: an intimate relationship

2006 • 128 citations

Interaction of Mouse Polycomb-Group (Pc-G) Proteins Enx1 and Enx2 with Eed: Indication for Separate Pc-G Complexes

1998 • 123 citations

RING1 Interacts with Multiple Polycomb-Group Proteins and Displays Tumorigenic Activity

1999 • 122 citations

Perturbation of B and T cell development and predisposition to lymphomagenesis in EμBmi1 transgenic mice require the Bmi1 RING finger

1997 • 121 citations

Interference with the Expression of a Novel Human Polycomb Protein, hPc2, Results in Cellular Transformation and Apoptosis

1997 • 112 citations

Polycomb Group Proteins in Cell Cycle Progression and Cancer

2004 • 100 citations

Polycomb group gene mel-18 modulates the self-renewal activity and cell cycle status of hematopoietic stem cells

2004 • 99 citations

The mouse PcG gene eed is required for Hox gene repression and extraembryonic development

2002 • 93 citations

Involvement of the Polycomb-group geneRing1Bin the specification of the anterior-posterior axis in mice

2002 • 91 citations

Selective Interactions between Vertebrate Polycomb Homologs and the SUV39H1 Histone Lysine Methyltransferase Suggest that Histone H3-K9 Methylation Contributes to Chromosomal Targeting of Polycomb Group Proteins

2002 • 90 citations

Bmi-1 Regulation of INK4A-ARF Is a Downstream Requirement for Transformation of Hematopoietic Progenitors by E2a-Pbx1

2003 • 88 citations

Transcriptional Coactivator Cited2 Induces Bmi1 and Mel18 and Controls Fibroblast Proliferation viaInk4a/ARF

2003 • 83 citations

Immunohistochemical analysis of pRb2/p130, VEGF, EZH2, p53, p16^INK4A, p27^KIP1, p21^WAF1, Ki‐67 expression patterns in gastric cancer

2006 • 76 citations

Polycomb Group Suppressor of Zeste 12 Links Heterochromatin Protein 1α and Enhancer of Zeste 2

2003 • 71 citations

Regulation of Polycomb group complexes by the sequence-specific DNA binding proteins Zeste and GAGA

2003 • 70 citations

mel-18 Negatively Regulates Cell Cycle Progression upon B Cell Antigen Receptor Stimulation through a Cascade Leading to c-myc/cdc25

1998 • 64 citations

Lack of the Polycomb-group gene rae28 causes maturation arrest at the early B-cell developmental stage

2001 • 59 citations

RNA and Protein Actors in X-Chromosome Inactivation

2006 • 48 citations

Defective long‐term repopulating ability in hematopoietic stem cells lacking the Polycomb‐group gene rae28

2004 • 47 citations

Molecular control of stem cell maintenance in shoot apical meristem

2005 • 45 citations

Telomeres, stem cells, senescence, and cancer

2004 • 45 citations

The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex

2001 • 45 citations

Tissue Engineering In Endodontics

2005 • 42 citations

PHC3, a component of the hPRC-H complex, associates with 2A7E during G0 and is lost in osteosarcoma tumors

2006 • 42 citations

N-Ethyl-N-nitrosourea-induced prenatally lethal mutations define at least two complementation groups within the embryonic ectoderm development (eed) locus in mouse Chromosome 7

1993 • 41 citations

A novel member of murine Polycomb-group proteins, Sex comb on midleg homolog protein, is highly conserved, and interacts with RAE28/mph1 in vitro

1999 • 40 citations

Polycomb group proteins

2003 • 39 citations

Chromatin Modification and Senescence: Linkage by Tumor Suppressors?

2006 • 21 citations

Mutation analysis of the mel-18 gene that shows decreased expression in human breast cancer cell lines

2002 • 14 citations

Structural Organization of the rae28 Gene, a Putative Murine Homologue of the Drosophila polyhomeotic Gene

1996 • 7 citations