Free Radicals in Ischemic and Reperfusion Myocardial Injury: Is this the Time for Clinical Trials?

Oxygen-Derived Free Radicals in Postischemic Tissue Injury

1985 • 5,488 citations

The Biology of Oxygen Radicals

1978 • 3,361 citations

The wavefront phenomenon of ischemic cell death. 1. Myocardial infarct size vs duration of coronary occlusion in dogs.

1977 • 1,927 citations

Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions.

1982 • 1,241 citations

Direct measurement of free radical generation following reperfusion of ischemic myocardium.

1987 • 1,185 citations

Reduction of the extent of ischemic myocardial injury by neutrophil depletion in the dog.

1983 • 1,168 citations

Role of metals in oxygen radical reactions

1985 • 1,149 citations

Canine myocardial reperfusion injury. Its reduction by the combined administration of superoxide dismutase and catalase.

1984 • 915 citations

Oxygen Metabolism and the Toxic Properties of Phagocytes

1980 • 886 citations

Demonstration of free radical generation in "stunned" myocardium of intact dogs with the use of the spin trap alpha-phenyl N-tert-butyl nitrone.

1988 • 691 citations

Xanthine oxidase as a source of free radical damage in myocardial ischemia

1985 • 678 citations

Reduction of experimental canine myocardial reperfusion injury by a monoclonal antibody (anti-Mo1, anti-CD11b) that inhibits leukocyte adhesion.

1988 • 650 citations

Measurement of superoxide-derived free radicals in the reperfused heart. Evidence for a free radical mechanism of reperfusion injury.

1988 • 629 citations

Direct detection of free radicals in the reperfused rat heart using electron spin resonance spectroscopy.

1987 • 628 citations

Free radicals and inflammation: superoxide-dependent activation of a neutrophil chemotactic factor in plasma.

1980 • 628 citations

Redox cycling of anthracyclines by cardiac mitochondria. I. Anthracycline radical formation by NADH dehydrogenase.

1986 • 608 citations

Role of oxygen in the cellular damage induced by re-oxygenation of hypoxic heart

1980 • 550 citations

Mechanisms of lipid peroxidation

1985 • 542 citations

Role of leukocytes in response to acute myocardial ischemia and reflow in dogs

1986 • 507 citations

Reperfusion of the ischemic myocardium

1977 • 469 citations

Role of leukocytes in acute myocardial infarction in anesthetized dogs: relationship to myocardial salvage by anti-inflammatory drugs.

1984 • 468 citations

Localization of xanthine oxidase in mammary-gland epithelium and capillary endothelium

1981 • 435 citations

Pathological mechanisms in carbon tetrachloride hepatotoxicity

1985 • 422 citations

Mitochondrial Production of Superoxide Radical and Hydrogen Peroxide

1977 • 415 citations

Free Radicals in Medicine. I. Chemical Nature and Biologic Reactions

1988 • 398 citations

Iron mobilization from ferritin by superoxide derived from stimulated polymorphonuclear leukocytes. Possible mechanism in inflammation diseases.

1984 • 392 citations

Oxygen-derived radicals: a link between reperfusion injury and inflammation.

1987 • 389 citations

THE PHLOGISTIC ROLE OF C3 LEUKOTACTIC FRAGMENTS IN MYOCARDIAL INFARCTS OF RATS

1971 • 388 citations

Identification of free radicals in myocardial ischemia/reperfusion by spin trapping with nitrone DMPO

1987 • 357 citations

Superoxide dismutase plus catalase enhances the efficacy of hypothermic cardioplegia to protect the globally ischemic, reperfused heart

1982 • 355 citations

Conversion of xanthine dehydrogenase to oxidase in ischemic rat tissues.

1987 • 350 citations

Reduction in experimental infarct size by recombinant human superoxide dismutase: insights into the pathophysiology of reperfusion injury.

1986 • 344 citations

Free Radicals in Medicine. II. Involvement in Human Disease

1988 • 344 citations

Free radicals and myocardial ischemia and reperfusion injury.

1987 • 307 citations

Free radicals and myocardial injury: pharmacologic implications.

1986 • 294 citations

Production of free radicals and lipid peroxides in early experimental myocardial ischemia

1983 • 288 citations

Role of oxygen radicals in cardiac injury due to reoxygenation*

1984 • 276 citations

FREE RADICAL BIOLOGY: XENOBIOTICS, CANCER, AND AGING*

1982 • 252 citations

Improvement of postischemic myocardial function and metabolism induced by administration of deferoxamine at the time of reflow: the role of iron in the pathogenesis of reperfusion injury.

1987 • 249 citations

Evidence for a reversible oxygen radical-mediated component of reperfusion injury: reduction by recombinant human superoxide dismutase administered at the time of reflow.

1987 • 246 citations

The independent effects of oxygen radical scavengers on canine infarct size. Reduction by superoxide dismutase but not catalase.

1985 • 234 citations

Oxygen Free Radical Induced Damage in Kidneys Subjected to Warm Ischemia and Reperfusion

1985 • 232 citations

Potential Oxidative Pathways of Catecholamines in the Formation of Lipid Peroxides and Genesis of Heart Disease

1983 • 226 citations

Free radical-mediated reperfusion injury: a selective review.

1987 • 218 citations

Inhibition of surgically induced ischemia/reperfusion injury by oxygen free radical scavengers

1983 • 207 citations

Spin-trapping evidence that graded myocardial ischemia alters post-ischemic superoxide production

1987 • 205 citations

Role of xanthine oxidase inhibitor as free radical scavenger: A novel mechanism of action of allopurinol and oxypurinol in myocardial salvage

1987 • 203 citations

Ultrastructural damage associated with reoxygenation of the anoxic myocardium

1975 • 202 citations

Myocardial ischemia and reperfusion: direct evidence for free radical generation by electron spin resonance spectroscopy.

1988 • 200 citations

Free radical-producing enzyme, xanthine oxidase, is undetectable in human hearts

1987 • 199 citations

The effect of ibuprofen on accumulation of indium-111-labeled platelets and leukocytes in experimental myocardial infarction.

1982 • 199 citations

Reduction of the size of infarction by allopurinol in the ischemic-reperfused canine heart.

1986 • 193 citations

Recombinant superoxide dismutase reduces oxygen free radical concentrations in reperfused myocardium.

1987 • 190 citations

Failure of superoxide dismutase and catalase to alter size of infarction in conscious dogs after 3 hours of occlusion followed by reperfusion.

1986 • 189 citations

Failure of the xanthine oxidase inhibitor allopurinol to limit infarct size after ischemia and reperfusion in dogs.

1985 • 180 citations

Complement Localization and Mediation of Ischemic Injury in Baboon Myocardium

1980 • 172 citations

Involvement of hydrogen peroxide and hydroxyl radical in the ‘oxygen paradox’: Reduction of creatine kinase release by catalase, allopurinol or deferoxamine, but not by superoxide dismutase**

1985 • 168 citations

Possible role for cytotoxic oxygen metabolites in the pathogenesis of cardiac ischemic injury.

1982 • 160 citations

Prostacyclin protects ischemic reperfused myocardium in the dog by inhibition of neutrophil activation

1987 • 159 citations

Free radicals and myocardial ischemia. The role of xanthine oxidase.

1985 • 153 citations

Neutrophil accumulation in experimental myocardial infarcts: relation with extent of injury and effect of reperfusion.

1987 • 149 citations

The oxygen free radical system: Potential mediator of myocardial injury

1985 • 146 citations

Leukocyte-derived metabolites of arachidonic acid in ischemia-induced myocardial injury.

1987 • 144 citations

Generation of reactive oxygen radicals through bioactivation of mitomycin antibiotics.

1986 • 144 citations

Myocardial neutrophil accumulation during reperfusion after reversible or irreversible ischemic injury

1988 • 142 citations

Nafazatrom-induced salvage of ischemic myocardium in anesthetized dogs is mediated through inhibition of neutrophil function.

1985 • 137 citations

Superoxide dismutase reduces reperfusion arrhythmias but fails to salvage regional function or myocardium at risk in conscious dogs.

1989 • 129 citations

Relationship between Metabolic Rate, Free Radicals, Differentiation and Aging: A Unified Theory

1985 • 127 citations

Oxygen radicals: a commonsense look at their nature and medical importance.

1984 • 127 citations

Xanthine oxidase is not a source of free radicals in the ischemic rabbit heart

1987 • 127 citations

Superoxide dismutase conjugated to polyethylene glycol provides sustained protection against myocardial ischemia/reperfusion injury in canine heart.

1988 • 126 citations

Prevention of free radical-induced myocardial reperfusion injury with allopurinol

1985 • 122 citations

Protective effects of N-2-mercaptopropionyl glycine against myocardial reperfusion injury after neutrophil depletion in the dog: evidence for the role of intracellular-derived free radicals.

1986 • 114 citations

Glutathione redox pathway and reperfusion injury. Effect of N-acetylcysteine on infarct size and ventricular function.

1988 • 113 citations

The mechanism of mannitol in reducing ischemic injury: hyperosmolarity or hydroxyl scavenger?

1984 • 107 citations

Effects of allopurinol, propranolol and methylprednisolone on infarct size in experimental myocardial infarction

1976 • 104 citations

Reperfusion arrhythmias: dose-related protection by anti-free radical interventions

1989 • 102 citations

Superoxide dismutase enhances recovery following myocardial ischemia

1985 • 98 citations

Infarct size limitation by the xanthine oxidase inhibitor, allopurinol, in closed-chest dogs with small infarcts

1985 • 97 citations

Canine myocardial reperfusion injury: protection by a free radical scavenger, N-2-mercaptopropionyl glycine.

1986 • 95 citations

Evidence for a pathogenetic role of xanthine oxidase in the "stunned" myocardium

1987 • 93 citations

Effect of BW755C in an occlusion-reperfusion model of ischemic myocardial injury

1983 • 92 citations

Superoxide dismutase and catalase reduce infarct size in a porcine myocardial occlusion-reperfusion model

1986 • 91 citations

Free radicals in ischemic myocardial injury

1985 • 87 citations

Cardiac performance during reperfusion improved by pretreatment with oxygen free-radical scavengers

1986 • 85 citations

Oxypurinol limits myocardial stunning but does not reduce infarct size after reperfusion.

1987 • 77 citations

Sustained Limitation by Superoxide Dismutase of Canine Myocardial Injury Due to Regional Ischemia Followed by Reperfusion

1988 • 76 citations

A comparative study of free radical scavengers in cardioplegic solutions. Improved protection with peroxidase.

1986 • 75 citations

Oxypurinol as an inhibitor of xanthine oxidase-catalyzed production of superoxide radical

1988 • 74 citations

Oxygen free radicals play a role in cellular differentiation: An hypothesis

1986 • 70 citations

Myocardial xanthine oxidase/dehydrogenase

1983 • 67 citations

Effects of the free radical scavenger DMTU and mannitol on the oxygen paradox in perfused rat hearts*

1987 • 66 citations

Free-radical-mediated postischemic reperfusion injury in the kidney

1986 • 64 citations

Free Radicals and Cardioplegia: Allopurinol and Oxypurinol Reduce Myocardial Injury Following Ischemic Arrest

1987 • 64 citations

Superoxide dismutase: Rationale for use in reperfusion injury and inflammation

1986 • 61 citations

Ultrastructural changes induced in the isolated rat heart by enzymatically generated oxygen radicals

1987 • 59 citations

On the Specificity of Allopurinol and Oxypurinol as Inhibitors of Xanthine Oxidase. A Pulse Radiolysis Determination of Rate Constants for Reaction of Allopurinol and Oxypurinol with Hydroxyl Radicals

1988 • 59 citations

Vitamin E, physical exercise and tissue damage in animals.

1984 • 55 citations

Free Radical Scavengers and Myocardial Preservation during Transplantation

1986 • 52 citations

Allopurinol enhanced adenine nucleotide repletion after myocardial ischemia in the isolated rat heart.

1988 • 52 citations

Mechanism of antibacterial action: Electron transfer and oxy radicals

1986 • 51 citations

Demential syndromes and the lipid metabolism

2009 • 50 citations

Effect of oxygen-derived free radical scavengers on infarct size following six hours of permanent coronary artery occlusion: salvage or delay of myocyte necrosis?

1987 • 48 citations

Safety evaluation of free radical scavengers peg-catalase and peg-superoxide dismutase

1986 • 48 citations

The role of free radical-mediated processes in oxygen-related damage in cultured murine myocardial cells.

1985 • 44 citations

Free radical scavengers improve functional recovery of stunned myocardium in a model of surgical coronary revascularization.

1987 • 43 citations

Action of Uric Acid, Allopurinol and Oxypurinol on the Myeloperoxidase-Derived Oxidant Hypochlorous Acid

1987 • 43 citations

Superoxide dismutase and the reduction of reperfusion-induced arrhythmias: In vivo dose-response studies in the rat

1987 • 43 citations

Oxygen Radicals and Vascular Damage

1983 • 41 citations

Augmentation of antioxidant enzymes in vascular endothelium

1986 • 41 citations

Therapeutic benefits of oxygen radical scavenger treatments remain unproven

1985 • 40 citations

Purine efflux after cardiac ischemia: relevance to allopurinol cardioprotection

1987 • 37 citations

Charge transfer and oxy radicals in antimalarial action. Quinones, dapsone metabolites, metal complexes, imunium ions, and peroxides

1985 • 34 citations

Protection against oxygen-induced reperfusion injury of the isolated canine heart by superoxide dismutase and catalase

1986 • 34 citations

Role of neutrophils in ischemic heart disease: pathophysiologic role in myocardial ischemia and coronary artery reperfusion.

1987 • 34 citations

Pathophysiology of Myocardial Reperfusion

1985 • 33 citations

An integrated concept of amebicidal action: Electron transfer and oxy radicals

1987 • 30 citations

Prevention of oxygen toxicity with superoxide dismutase and catalase in premature lambs

1986 • 29 citations

Therapeutic options to minimize free radical damage and thrombogenicity in ischemic/reperfused myocardium

1987 • 29 citations

Tissue damage by oxy-radicals: the possible involvement of iron and copper complexes.

1984 • 28 citations

A nonflow basis for the vulnerability of the subendocardium

1987 • 28 citations

Beneficial effects of nafazatrom on ischemic reperfused myocardium

1984 • 27 citations

Toxic properties of arachidonic acid on normal, ischemic and reperfused hearts. Indirect evidence for free radical involvement

1985 • 25 citations

Studies on the mechanism of action of quinone antitumor agents

1985 • 25 citations

The Role of Neutrophil Membrane Proteins in Neutrophil Emigration1

2015 • 25 citations

Preservation of myocardial function with mannitol reperfusate.

1985 • 24 citations

Enhancement of cardioplegic protection with the free-radical scavenger peroxidase.

1986 • 21 citations

Active Oxygen and Toxicity

1986 • 19 citations

Effect of superoxide dismutase and catalase on myocardial energy metabolism during ischemia and reperfusion.

1986 • 19 citations

Oxidant-mediated lung disease in newborn infants

1986 • 17 citations

Improvement in recovery of left ventricular function during reperfusion with coenzyme Q10 in isolated working rat heart

1985 • 15 citations

Role of free radicals in genetic damage (mutation).

1984 • 14 citations

Protective actions of propyl gallate, a lipoxygenase inhibitor, on the ischemic myocardium.

1985 • 14 citations

Biochemical changes in the intestine associated with anoxia and reoxygenation: In vivo and in vitro studies

1986 • 12 citations

Lipid peroxidation and myocardial ischaemic damage: cause or consequence?

1987 • 11 citations

How do phagocytic cells kill bacteria?

1984 • 10 citations

Allopurinol in prevention of reperfusion injury of hypoxically stored rat hearts.

1987 • 10 citations

Deleterious Effects of Oxygen Radicals on Reoxygenated Myocardial Cells

1984 • 4 citations

Superoxide Radicals (SR) in the Pathophysiology of Ischemic Acute Renal Failure (ARF)

1987 • 4 citations

An animated graphics program depicting the steps in lipid peroxidation

1985 • 2 citations